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  1. Article: Air pollution and increasing asthma hospitalizations: a looming healthcare crisis?

    Shaikh, Hamid Saeed / Muhammad, Arslan Irfan Pir / Ali, Arslan

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 3, Page(s) 739

    MeSH term(s) Humans ; Air Pollution/adverse effects ; Asthma/epidemiology ; Asthma/etiology ; Hospitalization ; Delivery of Health Care
    Language English
    Publishing date 2023-03-17
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.7545
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  2. Article ; Online: Diagnostic Accuracy of Transvaginal Ultrasound in Adenomyosis Taking MRI as a Gold Standard.

    Shaikh, Afshan / Masroor, Imrana / Masood, Aysha / Saeed, Shaista Afzal

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2023  Volume 33, Issue 10, Page(s) 1118–1123

    Abstract: Objective: To evaluate the accuracy of transvaginal ultrasound in the diagnosis of adenomyosis using MRI as the gold standard, and to characterise the most commonly seen and accurate ultrasonographic features and their combination.: Study design: ... ...

    Abstract Objective: To evaluate the accuracy of transvaginal ultrasound in the diagnosis of adenomyosis using MRI as the gold standard, and to characterise the most commonly seen and accurate ultrasonographic features and their combination.
    Study design: Cross-sectional, descriptive study. Place and Duration of the Study: Department of Radiology, The Aga Khan University Hospital, Karachi, from January 2018 to July 2021.
    Methodology: Transvaginal ultrasound examination was performed on patients (n = 208) who presented with symptoms related to menstrual cycles and pelvic abnormalities. Additionally, patients who sought infertility evaluation were also included in the study. The findings from the ultrasound examinations were assessed and tabulated alongside the results of the MRI scans. All examinations were conducted by senior radiologists / sonographers. The sensitivity, specificity, positive and negative predictive values (PPV and NPV, respectively) of ultrasound features were calculated individually and in combination, taking MRI as the gold standard. To enhance the accuracy of ultrasound findings, various variables were combined, and their sensitivities and specificities were calculated.
    Results: Overall, transvaginal ultrasound had a high specificity of 96.15% (95% CI: 85.67 - 99.33), a relatively low sensitivity of 74.36% (95% CI: 66.63 - 80.85), PPV of 98.31 (95% CI: 93.40 - 99.70) and NPV of 55.56 (95% CI: 44.73 - 65.90). The most sensitive dual variable used was a bulky uterus combined with altered myometrial echotexture, with a sensitivity of 72.97% (95% CI: 64.95 - 79.78) and specificity of 95.83% (95% CI: 84.57-99.27). The best combined triple variable was a bulky uterus with altered echotexture and streaky myometrium, with a sensitivity of 71.85% (95% CI: 63.35 - 79.10) and a specificity of 95.46% (95% CI: 83.30 - 99.21).
    Conclusion: Transvaginal ultrasound features can identify adenomyosis characteristics in most of the patients. This could reduce the number of pelvic MRIs performed for the detection of adenomyosis.
    Key words: Adenomyosis, Diagnosis, Magnetic resonance imaging, Bulky uterus, Altered myometrial, Echotexture, Ultrasound.
    MeSH term(s) Female ; Humans ; Adenomyosis/diagnostic imaging ; Cross-Sectional Studies ; Ultrasonography/methods ; Myometrium/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Sensitivity and Specificity ; Endometriosis/diagnosis
    Language English
    Publishing date 2023-10-06
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2023.10.1118
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  3. Article: Clinical efficacy of Platelet-Rich Plasma versus local Methylprednisolone Injection in Lateral Epicondylitis.

    Shaikh, Saeed A / Tahir, Muhammad / Ahmed, Nadeem

    Pakistan journal of medical sciences

    2023  Volume 39, Issue 5, Page(s) 1521–1525

    Abstract: Objective: To compare the results of local administration of platelet-rich plasma (PRP) with methylprednisolone in the treatment of tennis elbow.: Methods: This retrospective cohort was conducted at Jinnah Postgraduate Medical Center (JPMC) during ... ...

    Abstract Objective: To compare the results of local administration of platelet-rich plasma (PRP) with methylprednisolone in the treatment of tennis elbow.
    Methods: This retrospective cohort was conducted at Jinnah Postgraduate Medical Center (JPMC) during January 2017 to April 2018. Patients conservatively managed for lateral epicondylitis with local methylprednisolone injection or PRP injection were approached for possible inclusion in the study at 12 months of treatment. The primary outcome of the study was to determine the Numerical Pain Rating Score (NPRS) on resisted wrist extension. Whereas, the secondary outcomes were quick disability arm, shoulder, and hand score (qDASH), the grip strength and VAS for satisfaction. The baseline, six weeks and three month data on Grip strength, NPRS, and qDASH were extracted from the patients' medical records maintained at the hospital. The data were analyzed by using SPSS software.
    Results: A total of 91 patients were approached, of them 81 (89.01%) agreed to participate. There were 46 (56.79%) who received local methylprednisolone injection and 35 (43.20%) received PRP. At 12 months follow up, there was no difference in NPRS pain scores between the two groups (p=0.691); pain decreased in both groups at six weeks and at 12 months. There was no significant difference in the functional outcome (qDASH score) in both groups. Both groups were equally satisfied with the treatment they had received.
    Conclusion: The study concluded that there is no difference between outcome and efficacy of both treatment modalities used for the treatment of tennis elbow in alleviating pain at 12 months.
    Language English
    Publishing date 2023-09-07
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.39.5.6521
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    Zs.A 3948: Show issues Location:
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  4. Article: Robust and adaptive terrain classification and gait event detection system.

    Shaikh, Usman Qamar / Shahzaib, Muhammad / Shakil, Sadia / Bhatti, Farrukh A / Aamir Saeed, Malik

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21720

    Abstract: Real-time gait event detection (GED) system can be utilized for gait analysis and tracking fitness activities. GED for various types of terrains (e.g., stair-walk, uneven surfaces, etc.) is still an open research problem. This study presents an inertial ... ...

    Abstract Real-time gait event detection (GED) system can be utilized for gait analysis and tracking fitness activities. GED for various types of terrains (e.g., stair-walk, uneven surfaces, etc.) is still an open research problem. This study presents an inertial sensor-based approach for real-time GED system that works for diverse terrains in an uncontrolled environment. The GED system classifies three types of terrains, i.e., flat-walk, stair-ascend and stair-descend, with an average classification accuracy of 99%. It also accurately detects various gait events, including, toe-strike, heel-rise, toe-off, and heel-strike. It is computationally efficient, implemented on a low-cost microcontroller, works in real-time and can be used in portable rehabilitation devices for use in dynamic environments.
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21720
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  5. Article ; Online: Prevalence of

    Nisar, Tayyaba / Arshad, Kashan / Abbas, Zahid / Khan, Maira Ali / Safdar, Sohail / Shaikh, Rehan Sadiq / Saeed, Ali

    Journal of obesity

    2023  Volume 2023, Page(s) 6661858

    Abstract: The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and ... ...

    Abstract The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the
    MeSH term(s) Humans ; Adaptor Proteins, Signal Transducing/genetics ; Case-Control Studies ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/genetics ; Obesity/epidemiology ; Obesity/genetics ; Overweight ; Pakistan/epidemiology ; Polymorphism, Single Nucleotide/genetics ; Prevalence
    Chemical Substances Adaptor Proteins, Signal Transducing ; GCKR protein, human ; glucokinase regulatory protein
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2573566-4
    ISSN 2090-0716 ; 2090-0708
    ISSN (online) 2090-0716
    ISSN 2090-0708
    DOI 10.1155/2023/6661858
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  6. Article ; Online: Study of HCP (Hexagonal Close-Packed) Crystal Structure Lattice through Topological Descriptors.

    Zhang, Guoping / Saeed, Saadia / Aslam, Adnan / Kanwal, Salma / Idrees, Nazeran / Sumbal Shaikh, Tahira

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 6069666

    Abstract: Chemical graph theory is a multidisciplinary field where the structure of the molecule is analyzed as a graphical structure. Chemical descriptors are one of the most important ideas employed in chemical graph theory; this is to associate a numerical ... ...

    Abstract Chemical graph theory is a multidisciplinary field where the structure of the molecule is analyzed as a graphical structure. Chemical descriptors are one of the most important ideas employed in chemical graph theory; this is to associate a numerical value with a graph structure that often has correlation with corresponding chemical properties. In this paper, we investigate another very important closed-packed usual crystal structure defined as HCP (Hexagonal Close-Packed) crystal structure and its lattice formed by arranging its unit cells in a dimension for topological descriptors based on a neighborhood degree, reverse degree, and degree. Furthermore, we classify which descriptor is more dominating.
    Language English
    Publishing date 2022-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/6069666
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  7. Article: Gastric Electrical Stimulation for Refractory Gastroparesis: A Promising Treatment Modality for Symptom Control and Gastric Emptying.

    Saeed, Shahzeb / Kamran, Muhammad / Bhagwani, Kanwal / Shaikh, Nehal / Ekhator, Chukwuyem / Farahat, Mohammed / Abdelaziz, Ali M / Shehryar, Abdullah

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41630

    Abstract: Gastroparesis is a disorder with few available treatments and delayed stomach emptying. Gastric electrical stimulation (GES) has shown promise in treating the signs and symptoms of gastroparesis as well as gastric emptying by stimulating the stomach with ...

    Abstract Gastroparesis is a disorder with few available treatments and delayed stomach emptying. Gastric electrical stimulation (GES) has shown promise in treating the signs and symptoms of gastroparesis as well as gastric emptying by stimulating the stomach with high-frequency electrical impulses. In this case, a 43-year-old lady with refractory gastroparesis had a GES device laparoscopically implanted. Even though GES seems promising, more study is necessary to improve patient choice, technique, and long-term results. Patients with refractory gastroparesis who have not responded to traditional therapy should be considered for GES, with treatment decisions being made individually depending on clinical presentation and patient preferences.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41630
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  8. Article: COVID-19 related vascular complications in a pediatric patient: A case report.

    Hashemi, Huda Al / Saeed, Shaikh / Abedzadeh, Ayoub / Hashmi, Ahmed Al

    Radiology case reports

    2022  Volume 17, Issue 10, Page(s) 3801–3805

    Abstract: The novel coronavirus infection (COVID-19) caused by the SARS-CoV-2 virus is a relatively recent infection that has resulted in a global pandemic, appearing first at the end of 2019. While initially presenting as a predominantly respiratory disease, with ...

    Abstract The novel coronavirus infection (COVID-19) caused by the SARS-CoV-2 virus is a relatively recent infection that has resulted in a global pandemic, appearing first at the end of 2019. While initially presenting as a predominantly respiratory disease, with a classical picture of fever, dry cough, dyspnea and, in some cases anosmia and ageusia, recent cases have shown increasingly atypical and more systemic manifestation of the disease. A precise understanding of the extent and pathophysiology of COVID-19 remains underway to this day, particularly concerning its behavior in the pediatric population. Moreover, there has been an increasing number of COVID-19 reports with neurological complications and manifestations, prompting inquiry into neuroinvasion. Postulations include indirect invasion through a surge of inflammatory mediators "cytokine storm" and subsequent widespread endothelial injury; and direct neural tropism. We report the case of a previously healthy 12-year-old male presenting with acute right-sided hemiparesis, new-onset seizures and a generalized petechial rash. Laboratory tests revealed elevated inflammatory markers and radiological investigations confirmed an evolving left middle cerebral artery (MCA) infarct and large vessel vasculitis. Testing for SARS-CoV-2 infection was positive.
    Language English
    Publishing date 2022-08-08
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.07.051
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  9. Article ; Online: Enhanced In Vivo Wound Healing Efficacy of a Novel Piperine-Containing Bioactive Hydrogel in Excision Wound Rat Model.

    Alsareii, Saeed Ali / Ahmad, Javed / Umar, Ahmad / Ahmad, Mohammad Zaki / Shaikh, Ibrahim Ahmed

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 2

    Abstract: These days an extensive amount of the attention of researchers is focused towards exploring bioactive compounds of natural or herbal origin for therapeutic intervention in different ailments of significant importance. One such novel bioactive compound ... ...

    Abstract These days an extensive amount of the attention of researchers is focused towards exploring bioactive compounds of natural or herbal origin for therapeutic intervention in different ailments of significant importance. One such novel bioactive compound that has a variety of biological properties, including anti-inflammatory and antioxidant activities, is piperine. However, until today, piperine has not been explored for its potential to improve inflammation and enhance healing in acute and chronic wounds. Therefore, the present study aimed to investigate the wound healing potential of piperine hydrogel formulation after topical application. Hydrogels fit the need for a depot system at the wound bed, where they ensure a consistent supply of therapeutic agents enclosed in their cross-linked network matrices. In the present study, piperine-containing carbopol 934 hydrogels mixed with
    MeSH term(s) Rats ; Animals ; Hydrogels/pharmacology ; Skin/pathology ; Wound Healing ; Alkaloids/pharmacology ; Alkaloids/therapeutic use
    Chemical Substances Hydrogels ; piperine (U71XL721QK) ; Alkaloids
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020545
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  10. Article ; Online: The First Successfully Performed LDLT in the UAE: 13 Years of Follow-up.

    Obed, Aiman / Al Shaikh, Saeed / Bashir, Abdullah / Jarrad, Anwar

    Transplantation

    2021  Volume 105, Issue 8, Page(s) e79

    MeSH term(s) Follow-Up Studies ; Humans ; Liver Transplantation ; Living Donors
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003749
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