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Article ; Online: Relevance of

Meyer, Karisa M / Malhotra, Nipun / Kwak, Jung Seo / El Refaey, Mona

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Abnormalities in G-protein-gated inwardly rectifying potassium (GIRK) channels have been implicated in diseased states of the cardiovascular system; however, the role of GIRK4 (Kir3.4) in cardiac physiology and pathophysiology has yet to be completely ... ...

Abstract	Abnormalities in G-protein-gated inwardly rectifying potassium (GIRK) channels have been implicated in diseased states of the cardiovascular system; however, the role of GIRK4 (Kir3.4) in cardiac physiology and pathophysiology has yet to be completely understood. Within the heart, the K
MeSH term(s)	Humans ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; Heart ; Sick Sinus Syndrome ; Hyperaldosteronism ; Long QT Syndrome
Chemical Substances	G Protein-Coupled Inwardly-Rectifying Potassium Channels ; KCNJ5 protein, human
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310849
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Article ; Online: Comprehensive study on in vitro propagation of some imported peach rootstocks: in vitro explant surface sterilization and bud proliferation.

Eliwa, Galal I / El-Dengawy, El-Refaey F / Gawish, Mohamed S / Yamany, Mona M

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5586

Abstract: The present study was conducted in the Laboratory of Tissue Culture, Horticulture Department, Faculty of Agriculture, Damietta University, Egypt. The objective of this study was to establish a micropropagation protocol suitable for three imported peach ... ...

Abstract	The present study was conducted in the Laboratory of Tissue Culture, Horticulture Department, Faculty of Agriculture, Damietta University, Egypt. The objective of this study was to establish a micropropagation protocol suitable for three imported peach rootstocks: Okinawa (P. persica), Nemared (P. persica × P. davidiana) × P. persica), and Garnem (P. dulcis × P. persica) in vitro. The results showed that soaking the explants in sodium hypochlorite (NaOCl) at 20% for 15 min produced the highest responsiveness (82.81%), survival (96.61%), with the lowest mortality (3.14%) and contamination (0.24%). Explants of the Garnem genotype had the best response (89.12%), survival (90.62%), lowest mortality (0.00%), and highest contamination (9.37%) when compared to the other genotypes. In comparison with axillary buds, the shoot tip displayed the highest responsiveness, survival, and death (100, 87.40, and 12.59%, respectively), as well as the least significant contamination (0.00%). Additionally, the percentages of responsive, survived, dead, and contaminated explants at the various collection dates varied significantly. The 6-benzylaminopurine (BAP) concentrations used (3 to 5.0 mg/L) demonstrated similar behavior in terms of in vitro proliferation, with rates of 3.77 to 6.11, 4.33 to 8.88, and 3.33 to 7.44 shoot numbers per explant for the Okinawa, Nemared, and Garnem peach rootstocks, respectively, indicating that the number of shoot proliferations is genotype-dependent. Additionally, using 5.0 mg/L BAP in combination with 0.2 mg/L IBA significantly increased average shoot proliferation (96.29%), number of shoots per explant (7.48), and average leaf number/explant (16.33) compared to the other treatments. Based on these results, adventitious bud development was enhanced during in vitro multiplication of the Okinawa, Nemared, and Garnem peach rootstocks by the synergistic interaction of indole-butyric acid (IBA) and 6-benzylaminopurine (BAP).
MeSH term(s)	Humans ; Prunus persica ; Plant Shoots ; Benzyl Compounds ; Cell Proliferation ; Purines
Chemical Substances	benzylaminopurine (KXG6A989PS) ; Benzyl Compounds ; Purines
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55685-3
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Article ; Online: Relevance of KCNJ5 in Pathologies of Heart Disease

Karisa M. Meyer / Nipun Malhotra / Jung seo Kwak / Mona El Refaey

International Journal of Molecular Sciences, Vol 24, Iss 10849, p

2023 Volume 10849

Abstract	Abnormalities in G-protein-gated inwardly rectifying potassium (GIRK) channels have been implicated in diseased states of the cardiovascular system; however, the role of GIRK4 (Kir3.4) in cardiac physiology and pathophysiology has yet to be completely understood. Within the heart, the K ACh channel, consisting of two GIRK1 and two GIRK4 subunits, plays a major role in modulating the parasympathetic nervous system’s influence on cardiac physiology. Being that GIRK4 is necessary for the functional K ACh channel, KCNJ5 , which encodes GIRK4, it presents as a therapeutic target for cardiovascular pathology. Human variants in KCNJ5 have been identified in familial hyperaldosteronism type III, long QT syndrome, atrial fibrillation, and sinus node dysfunction. Here, we explore the relevance of KCNJ5 in each of these diseases. Further, we address the limitations and complexities of discerning the role of KCNJ5 in cardiovascular pathophysiology, as identical human variants of KCNJ5 have been identified in several diseases with overlapping pathophysiology.
Keywords	KCNJ5 ; atrial fibrillation ; sinus node dysfunction ; long QT ; familial hyperaldosteronism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Ankyrins and Spectrins in Cardiovascular Biology and Disease.

El Refaey, Mona M / Mohler, Peter J

Frontiers in physiology

2017 Volume 8, Page(s) 852

Abstract: Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements. Findings in humans and animal models have highlighted ... ...

Abstract	Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements. Findings in humans and animal models have highlighted the
Language	English
Publishing date	2017-10-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2017.00852
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Article ; Online: Protective effect of Petroselinum crispum methanolic extract against acrylamide-induced reproductive toxicity in male rats through NF-ĸB, kinesin, steroidogenesis pathways.

Shipa, Ahmed M E / Kahilo, Khaled A / Elshazly, Samir A / Taher, Ehab S / Nasr, Nasr E / Alotaibi, Badriyah S / Almadaly, Essam A / Assas, Mona / Abdo, Walied / Abouzed, Tarek K / Salem, Abdulati Elsanusi / Kirci, Damla / El-Seedi, Hesham R / Refaey, Mohamed S / Rizk, Nermin I / Shukry, Mustafa / Dorghamm, Doaa A

Reproductive toxicology (Elmsford, N.Y.)

2024 Volume 126, Page(s) 108586

Abstract: This study examined the protective effects of a Petroselinum crispum (P. crispum) methanolic extract on reproductive dysfunction induced by acrylamide in male rats. A total of 40 rats were divided into four groups (n=10). The control group received ... ...

Abstract	This study examined the protective effects of a Petroselinum crispum (P. crispum) methanolic extract on reproductive dysfunction induced by acrylamide in male rats. A total of 40 rats were divided into four groups (n=10). The control group received distilled water, the acrylamide group received 10 mg/kg of acrylamide, the P. crispum group received 100 mg/kg of P. crispum extract, and the combined group was pretreated with P. crispum for two weeks before co-administration of P. crispum and acrylamide. All administrations were administered orally using a gastric tube for eight weeks. Acrylamide decreased testosterone levels but did not affect levels of FSH or LH. It also increased testicular levels of (MDA) malondialdehyde and reduced activity of (SOD) superoxide dismutase and impairment of sperm parameters. Furthermore, the administration of acrylamide resulted in an elevation of tumor necrosis factor-alpha (TNF-α) levels and a reduction in the levels of steroidogenic acute regulatory protein (STAR) and cytochrome P450scc (P450scc). Acrylamide negatively affected the histopathological outcomes, Johnsen's score, the diameter of seminiferous tubules, and the thickness of the germinal epithelium. It also upregulated the expression of NF-ĸB P65 and downregulated the expression of kinesin motor protein. In contrast, treatment with P. crispum extract restored the levels of antioxidant enzymes, improved sperm parameters, and normalized the gene expression of TNF-α, IL-10, IL-6, iNOS, NF-ĸB, STAR, CYP17A1, 17β-HSD and P450scc. It also recovered testicular histological parameters and immunoexpression of NF-ĸB P65 and kinesin altered by acrylamide. P. crispum showed protective effects against acrylamide-induced reproductive toxicity by suppressing oxidative damage and inflammatory pathways.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2024.108586
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Article ; Online: Altered Expression of Zonula occludens-1 Affects Cardiac Na

Cells

2022 Volume 11, Issue 4

Abstract: Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart. There is clear evidence to support the central role of ... ...

Abstract	Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart. There is clear evidence to support the central role of intracellular auxiliary proteins in arrhythmogenesis and previous studies have found altered ZO-1 expression associated with atrioventricular conduction abnormalities. Here, using human cardiac tissues, we identified all three isoforms of ZO-1, canonical (Transcript Variant 1,
MeSH term(s)	Animals ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Mice ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Sodium/metabolism ; Tight Junctions/metabolism ; Zonula Occludens-1 Protein/metabolism
Chemical Substances	Zonula Occludens-1 Protein ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11040665
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Article ; Online: Expression pattern and prognostic implication of SALL4 gene in myeloid leukemias: a case-control study.

Farawela, Hala M / Zawam, Hamdy M / Al-Wakeel, Hanan A / El-Nagdy, Mona H / El-Refaey, Fatma A / Abdel-Rahman, Hala A

Scandinavian journal of clinical and laboratory investigation

2019 Volume 79, Issue 1-2, Page(s) 65–70

Abstract: SALL4 is a transcription factor that retains stem cells in an undifferentiated state and promotes its self-renewal. In addition, it is implicated in leukemogenesis via its effect on leukemic stem cells. This study aimed to characterize the expression ... ...

Abstract	SALL4 is a transcription factor that retains stem cells in an undifferentiated state and promotes its self-renewal. In addition, it is implicated in leukemogenesis via its effect on leukemic stem cells. This study aimed to characterize the expression pattern of SALL4 gene in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) at different progression phases of the leukemic process and to assess its prognostic significance. Real-time PCR was used in 106 patients: 54 AML patients; 43 de novo and 11 in complete remission (CR), 52 CML patients; 31 in chronic phase (CP), 11 in deep molecular response (MR
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Case-Control Studies ; Disease Progression ; Female ; Gene Expression ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Prognosis ; Remission Induction ; Survival Analysis ; Transcription Factors/blood ; Transcription Factors/genetics
Chemical Substances	Biomarkers, Tumor ; SALL4 protein, human ; Transcription Factors
Language	English
Publishing date	2019-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2018.1555854
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Article ; Online: Biochemical Structure and Function of TRAPP Complexes in the Cardiac System.

Papaioannou, Peter / Wallace, Michael J / Malhotra, Nipun / Mohler, Peter J / El Refaey, Mona

JACC. Basic to translational science

2023 Volume 8, Issue 12, Page(s) 1599–1612

Abstract: Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been associated with disorders in the nervous and cardiovascular systems, but ...

Abstract	Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been associated with disorders in the nervous and cardiovascular systems, but the majority of literature focuses on TRAPP function in the nervous system solely. Here, we highlight the known pathways of TRAPP and hypothesize potential impacts of TRAPP dysfunction on the cardiovascular system, particularly the role of TRAPP as a guanine-nucleotide exchange factor for Rab1 and Rab11. We also review the various cardiovascular phenotypes associated with changes in TRAPP complexes and their subunits.
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ISSN	2452-302X
ISSN (online)	2452-302X
DOI	10.1016/j.jacbts.2023.03.011
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Article ; Online: Inherited Variants in

Koenig, Sara N / Sucharski, Holly C / Jose, Elizabeth M / Dudley, Emma K / Madiai, Francesca / Cavus, Omer / Argall, Aaron D / Williams, Jordan L / Murphy, Nathaniel P / Keith, Caullin B R / El Refaey, Mona / Gumina, Richard J / Boudoulas, Konstantinos D / Milks, M Wesley / Sofowora, Gbemiga / Smith, Sakima A / Hund, Thomas J / Wright, Nathan T / Bradley, Elisa A /

Zareba, Karolina M / Wold, Loren E / Mazzaferri, Ernest L / Mohler, Peter J

Circulation research

2021 Volume 129, Issue 2, Page(s) 296–307

Abstract: Figure: see text]. ...

Abstract	[Figure: see text].
MeSH term(s)	Adult ; Age of Onset ; Animals ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic Variation ; HEK293 Cells ; Hep G2 Cells ; Hepatocytes/metabolism ; Heredity ; Heterozygote ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Male ; Mice, Inbred C57BL ; Middle Aged ; Pedigree ; Phenotype ; Risk Assessment ; Risk Factors ; Scavenger Receptors, Class B/genetics ; Scavenger Receptors, Class B/metabolism ; Severity of Illness Index ; Exome Sequencing ; Mice
Chemical Substances	SCARB1 protein, human ; Scarb1 protein, mouse ; Scavenger Receptors, Class B
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.120.318793
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incidence and Seroprevalence of Avian Influenza in a Cohort of Backyard Poultry Growers, Egypt, August 2015-March 2019.

Gomaa, Mokhtar R / El Rifay, Amira S / Abu Zeid, Dina / Elabd, Mona A / Elabd, Eman / Kandeil, Ahmed / Shama, Noura M Abo / Kamel, Mina N / Marouf, Mohamed A / Barakat, Ahmed / Refaey, Samir / Naguib, Amal / McKenzie, Pamela P / Webby, Richard J / Ali, Mohamed A / Kayali, Ghazi

Emerging infectious diseases

2020 Volume 26, Issue 9, Page(s) 2129–2136

Abstract: Currently enzootic avian influenza H5N1, H9N2, and H5N8 viruses were introduced into poultry in Egypt in 2006, 2011, and 2016, respectively. Infections with H5N1 and H9N2 were reported among poultry-exposed humans. We followed 2,402 persons from ... ...

Abstract	Currently enzootic avian influenza H5N1, H9N2, and H5N8 viruses were introduced into poultry in Egypt in 2006, 2011, and 2016, respectively. Infections with H5N1 and H9N2 were reported among poultry-exposed humans. We followed 2,402 persons from households raising backyard poultry from 5 villages in Egypt during August 2015-March 2019. We collected demographic, exposure, and health condition data and annual serum samples from each participant and obtained swab samples from participants reporting influenza-like illness symptoms. We performed serologic and molecular analyses and detected 4 cases of infection with H5N1 and 3 cases with H9N2. We detected very low seroprevalence of H5N1 antibodies and no H5N8 antibodies among the cohort; up to 11% had H9 antibodies. None of the exposure, health status, or demographic variables were related to being seropositive. Our findings indicate that avian influenza remains a public health risk in Eqypt, but infections may go undetected because of their mild or asymptomatic nature.
MeSH term(s)	Animals ; Egypt/epidemiology ; Humans ; Incidence ; Influenza A Virus, H5N1 Subtype ; Influenza A Virus, H9N2 Subtype ; Influenza in Birds/epidemiology ; Influenza, Human/epidemiology ; Poultry ; Seroepidemiologic Studies
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2609.200266
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