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  1. Book ; Online: Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies

    Perretti, Mauro / Montero-Melendez, Trinidad / Norling, Lucy V.

    2019  

    Keywords Science: general issues ; Pharmacology ; Resolution Pharmacology ; vesicle-based therapies ; Inflammation Pharmacology
    Size 1 electronic resource (205 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231485
    ISBN 9782889630844 ; 2889630846
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Switching on resolution to treat RA moves closer to reality.

    Perretti, Mauro

    Nature reviews. Rheumatology

    2020  Volume 17, Issue 2, Page(s) 73–74

    MeSH term(s) Animals ; Antigens, CD/drug effects ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/drug effects ; Antigens, Differentiation, Myelomonocytic/metabolism ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/pathology ; Biological Variation, Population ; Disease Progression ; Dual Specificity Phosphatase 1/drug effects ; Dual Specificity Phosphatase 1/metabolism ; Fibroblasts/metabolism ; Glucocorticoids/pharmacology ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Macrophages/metabolism ; Mice ; Models, Animal ; Receptor, Melanocortin, Type 1/agonists ; Receptor, Notch3/metabolism ; Receptors, Cell Surface/drug effects ; Receptors, Cell Surface/metabolism ; Synoviocytes/metabolism
    Chemical Substances Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Glucocorticoids ; NOTCH3 protein, human ; Receptor, Melanocortin, Type 1 ; Receptor, Notch3 ; Receptors, Cell Surface ; DUSP1 protein, human (EC 3.1.3.48) ; Dual Specificity Phosphatase 1 (EC 3.1.3.48)
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-020-00549-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Resolution pharmacology - A fresh approach to the clinical management of human inflammatory diseases.

    Perretti, Mauro / Subramanian, Manikandan

    Seminars in immunology

    2022  Volume 65, Page(s) 101669

    MeSH term(s) Humans ; Inflammation
    Language English
    Publishing date 2022-12-22
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease.

    Walker, Mary E / De Matteis, Roberta / Perretti, Mauro / Dalli, Jesmond

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 975

    Abstract: While cardiovascular disease (CVD) is one of the major co-morbidities in patients with rheumatoid arthritis (RA), the mechanism(s) that contribute to CVD in patients with RA remain to be fully elucidated. Herein, we observe that plasma concentrations of ... ...

    Abstract While cardiovascular disease (CVD) is one of the major co-morbidities in patients with rheumatoid arthritis (RA), the mechanism(s) that contribute to CVD in patients with RA remain to be fully elucidated. Herein, we observe that plasma concentrations of 13-series resolvin (RvT)4 negatively correlate with vascular lipid load in mouse inflammatory arthritis. Administration of RvT4 to male arthritic mice fed an atherogenic diet significantly reduces atherosclerosis. Assessment of the mechanisms elicited by this mediator demonstrates that RvT4 activates cholesterol efflux in lipid laden macrophages via a Scavenger Receptor class B type 1 (SR-BI)-Neutral Cholesterol Ester Hydrolase-dependent pathway. This leads to the reprogramming of lipid laden macrophages yielding tissue protection. Pharmacological inhibition or knockdown of macrophage SR-BI reverses the vasculo-protective activities of RvT4 in vitro and in male mice in vivo. Together these findings elucidate a RvT4-SR-BI centered mechanism that orchestrates macrophage responses to limit atherosclerosis during inflammatory arthritis.
    MeSH term(s) Humans ; Male ; Mice ; Animals ; Cholesterol/metabolism ; Macrophages/metabolism ; Atherosclerosis/metabolism ; Biological Transport ; Arthritis/metabolism
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44868-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune Cell Plasticity in Inflammation: Insights into Description and Regulation of Immune Cell Phenotypes.

    Margraf, Andreas / Perretti, Mauro

    Cells

    2022  Volume 11, Issue 11

    Abstract: Inflammation is a life-saving immune reaction occurring in response to invading pathogens. Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading to chronic disease and organ damage. Mechanisms triggering an ... ...

    Abstract Inflammation is a life-saving immune reaction occurring in response to invading pathogens. Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading to chronic disease and organ damage. Mechanisms triggering an inflammatory response, hindering such a response, or leading to its resolution are well-studied but so far insufficiently elucidated with regard to precise therapeutic interventions. Notably, as an immune reaction evolves, requirements and environments for immune cells change, and thus cellular phenotypes adapt and shift, leading to the appearance of distinct cellular subpopulations with new functional features. In this article, we aim to highlight properties of, and overarching regulatory factors involved in, the occurrence of immune cell phenotypes with a special focus on neutrophils, macrophages and platelets. Additionally, we point out implications for both diagnostics and therapeutics in inflammation research.
    MeSH term(s) Cell Plasticity ; Humans ; Inflammation ; Macrophages ; Neutrophils ; Phenotype
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11111824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation.

    Perretti, Mauro / Dalli, Jesmond

    Annual review of pharmacology and toxicology

    2022  Volume 63, Page(s) 449–469

    Abstract: Chronic diseases that affect our society are made more complex by comorbidities and are poorly managed by the current pharmacology. While all present inflammatory etiopathogeneses, there is an unmet need for better clinical management of these diseases ... ...

    Abstract Chronic diseases that affect our society are made more complex by comorbidities and are poorly managed by the current pharmacology. While all present inflammatory etiopathogeneses, there is an unmet need for better clinical management of these diseases and their multiple symptoms. We discuss here an innovative approach based on the biology of the resolution of inflammation. Studying endogenous pro-resolving peptide and lipid mediators, how they are formed, and which target they interact with, can offer innovative options through augmenting the expression or function of pro-resolving pathways or mimicking their actions with novel targeted molecules. In all cases, resolution offers innovation for the treatment of the primary cause of a given disease and/or for the management of its comorbidities, ultimately improving patient quality of life. By implementing resolution pharmacology, we harness the whole physiology of inflammation, with the potential to bring a marked change in the management of inflammatory conditions.
    MeSH term(s) Humans ; Annexin A1/metabolism ; Annexin A1/therapeutic use ; Quality of Life ; Inflammation/drug therapy ; Inflammation/metabolism ; Lipids
    Chemical Substances Annexin A1 ; Lipids
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051821-042743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immune Cell Plasticity in Inflammation

    Andreas Margraf / Mauro Perretti

    Cells, Vol 11, Iss 1824, p

    Insights into Description and Regulation of Immune Cell Phenotypes

    2022  Volume 1824

    Abstract: Inflammation is a life-saving immune reaction occurring in response to invading pathogens. Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading to chronic disease and organ damage. Mechanisms triggering an ... ...

    Abstract Inflammation is a life-saving immune reaction occurring in response to invading pathogens. Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading to chronic disease and organ damage. Mechanisms triggering an inflammatory response, hindering such a response, or leading to its resolution are well-studied but so far insufficiently elucidated with regard to precise therapeutic interventions. Notably, as an immune reaction evolves, requirements and environments for immune cells change, and thus cellular phenotypes adapt and shift, leading to the appearance of distinct cellular subpopulations with new functional features. In this article, we aim to highlight properties of, and overarching regulatory factors involved in, the occurrence of immune cell phenotypes with a special focus on neutrophils, macrophages and platelets. Additionally, we point out implications for both diagnostics and therapeutics in inflammation research.
    Keywords immune phenomics ; inflammation ; phenotype ; neutrophil ; macrophage ; platelet ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Malignant Acute Colonic Obstruction: Multidisciplinary Approach for Endoscopic Management.

    Mauro, Aurelio / Scalvini, Davide / Borgetto, Sabrina / Fugazzola, Paola / Mazza, Stefano / Perretti, Ilaria / Gallotti, Anna / Pagani, Anna / Ansaloni, Luca / Anderloni, Andrea

    Cancers

    2024  Volume 16, Issue 4

    Abstract: Patients presenting with acute colonic obstruction are usually evaluated in the emergency department and multiple specialties are involved in the patients' management. Pre-treatment evaluation is essential in order to establish the correct endoscopic ... ...

    Abstract Patients presenting with acute colonic obstruction are usually evaluated in the emergency department and multiple specialties are involved in the patients' management. Pre-treatment evaluation is essential in order to establish the correct endoscopic indication for stent implantation. Contrast-enhanced imaging could allow the exclusion of benign causes of colonic obstruction and evaluation of the length of malignant stricture. Endoscopic stenting is the gold standard of treatment for palliative indications whereas there are still concerns about its use as a bridge to surgery. Different meta-analyses showed that stenting as a bridge to surgery improves short-term surgical outcomes but has no role in improving long-term outcomes. Multidisciplinary evaluation is also essential in patients that may be started on or are currently receiving antiangiogenic agents because endoscopic stenting may increase the risk of perforation. Evidence in the literature is weak and based on retrospective data. Here we report on how to correctly evaluate a patient with acute colonic malignant obstruction in collaboration with other essential specialists including a radiologist, surgeon and oncologist, and how to optimize the technique of endoscopic stenting.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16040821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology.

    Perretti, Mauro

    Seminars in immunology

    2015  Volume 27, Issue 3, Page(s) 145–148

    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation Mediators/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Inflammation Mediators
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2015.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neutrophil-T cell crosstalk and the control of the host inflammatory response.

    Bert, Serena / Nadkarni, Suchita / Perretti, Mauro

    Immunological reviews

    2022  Volume 314, Issue 1, Page(s) 36–49

    Abstract: While fundamental in their innate role in combating infection and responding to injury, neutrophils are emerging as key modulators of adaptive immune responses. Such functions are attained via both soluble and nonsoluble effectors that enable at least ... ...

    Abstract While fundamental in their innate role in combating infection and responding to injury, neutrophils are emerging as key modulators of adaptive immune responses. Such functions are attained via both soluble and nonsoluble effectors that enable at least two major downstream outcomes: first, to mediate and control acute inflammatory responses and second, to regulate adaptive immunity and ultimately promoting the development and maintenance of immune tolerance either by releasing immuno-modulatory factors, including cytokines, or by directly interacting with cells of the adaptive immune system. Herein, we review these novel properties of neutrophils and redefine the pathophysiological functions of these fascinating multi-tasking cells, exploring the different mechanisms through which neutrophils are able to either enhance and orchestrate T cell pro-inflammatory responses or inhibit T cell activity to maintain immune tolerance.
    MeSH term(s) Humans ; Neutrophils ; Immunity, Innate ; T-Lymphocytes ; Inflammation ; Adaptive Immunity
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13162
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