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  1. Article ; Online: The microbiome, IgGs and schizophrenia. A R20+ adult-only story.

    D'Acquisto, Fulvio

    Brain, behavior, and immunity

    2022  Volume 107, Page(s) 397–398

    MeSH term(s) Humans ; Schizophrenia ; Microbiota
    Language English
    Publishing date 2022-11-15
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2022.11.009
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  2. Article: Editorial: Feelings of energy and fatigue: Two different moods.

    Boolani, Ali / Martin, Joel / D'Acquisto, Fulvio / Balestra, Costantino

    Frontiers in psychology

    2023  Volume 14, Page(s) 1180285

    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1180285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiovascular and immunological implications of social distancing in the context of COVID-19.

    D'Acquisto, Fulvio / Hamilton, Alice

    Cardiovascular research

    2020  Volume 116, Issue 10, Page(s) e129–e131

    MeSH term(s) Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/virology ; Coronavirus Infections/virology ; Humans ; Immune System Diseases/virology ; Pandemics ; Physical Distancing ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa167
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  4. Article ; Online: Peripheral control of psychiatric disorders: Focus on OCD. Are we there yet?

    D'Acquisto, Fulvio / D'Addario, Claudio / Cooper, Dianne / Pallanti, Stefano / Blacksell, Isobel

    Comprehensive psychiatry

    2023  Volume 123, Page(s) 152388

    Abstract: We are all in this together" - we often hear this phrase when we want to flag up a problem that is not for a single individual but concerns us all. A similar reflection has been recently made in the field of mental disorders where brain-centric ... ...

    Abstract "We are all in this together" - we often hear this phrase when we want to flag up a problem that is not for a single individual but concerns us all. A similar reflection has been recently made in the field of mental disorders where brain-centric scientists have started to zoom out their brain-focused graphical representations of the mechanisms regulating psychiatric diseases to include other organs or mediators that did not belong historically to the world of neuroscience. The brain itself - that has long been seen as a master in command secluded in its fortress (the blood brain barrier), has now become a collection of Airbnb(s) where all sorts of cells come in and out and sometimes even rearrange the furniture! Under this new framework of reference, mental disorders have become multisystem pathologies where different biological systems - not just the CNS -contribute 'all together' to the development and severity of the disease. In this narrative review article, we will focus on one of the most popular biological systems that has been shown to influence the functioning of the CNS: the immune system. We will specifically highlight the two main features of the immune system and the CNS that we think are important in the context of mental disorders: plasticity and memory.
    MeSH term(s) Humans ; Brain ; Obsessive-Compulsive Disorder/diagnosis
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/j.comppsych.2023.152388
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  5. Article ; Online: Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders.

    Gentile, Antonietta / D'Acquisto, Fulvio / Leposavić, Gordana

    Frontiers in immunology

    2021  Volume 12, Page(s) 781151

    MeSH term(s) Humans ; Immune System Diseases ; Mental Disorders ; Nervous System Diseases ; Neuroimmunomodulation ; Neurons
    Language English
    Publishing date 2021-10-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.781151
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  6. Article ; Online: Affective immunology: where emotions and the immune response converge.

    D'Acquisto, Fulvio

    Dialogues in clinical neuroscience

    2017  Volume 19, Issue 1, Page(s) 9–19

    Abstract: Affect and emotion are defined as "an essential part of the process of an organism's interaction with stimuli." Similar to affect, the immune response is the "tool" the body uses to interact with the external environment. Thanks to the emotional and ... ...

    Abstract Affect and emotion are defined as "an essential part of the process of an organism's interaction with stimuli." Similar to affect, the immune response is the "tool" the body uses to interact with the external environment. Thanks to the emotional and immunological response, we learn to distinguish between what we like and what we do not like, to counteract a broad range of challenges, and to adjust to the environment we are living in. Recent compelling evidence has shown that the emotional and immunological systems share more than a similarity of functions. This review article will discuss the crosstalk between these two systems and the need for a new scientific area of research called affective immunology. Research in this field will allow a better understanding and appreciation of the immunological basis of mental disorders and the emotional side of immune diseases.
    MeSH term(s) Emotions/physiology ; Humans ; Immune System Diseases/immunology ; Immune System Diseases/psychology ; Immunity ; Mood Disorders/immunology ; Receptor Cross-Talk/immunology
    Language English
    Publishing date 2017-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
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  7. Article ; Online: Editorial overview: Immunomodulation: Exploiting the circle between emotions and immunity: impact on pharmacological treatments.

    D'Acquisto, Fulvio

    Current opinion in pharmacology

    2016  Volume 29, Page(s) viii–xii

    MeSH term(s) Animals ; Emotions ; Humans ; Immunity/drug effects ; Immunomodulation
    Language English
    Publishing date 2016-07-26
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2016.07.008
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    Zs.A 5608: Show issues Location:
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  8. Article ; Online: Cardiovascular and immunological implications of social distancing in the context of COVID-19

    D’Acquisto, Fulvio / Hamilton, Alice

    Cardiovascular Research

    2020  Volume 116, Issue 10, Page(s) e129–e131

    Keywords Physiology (medical) ; Physiology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvaa167
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The immunomodulatory effects of social isolation in mice are linked to temperature control.

    Hamilton, Alice / Rizzo, Raffaella / Brod, Samuel / Ono, Masahiro / Perretti, Mauro / Cooper, Dianne / D'Acquisto, Fulvio

    Brain, behavior, and immunity

    2022  Volume 102, Page(s) 179–194

    Abstract: Living in isolation is considered an emerging societal problem that negatively affects the physical wellbeing of its sufferers in ways that we are just starting to appreciate. This study investigates the immunomodulatory effects of social isolation in ... ...

    Abstract Living in isolation is considered an emerging societal problem that negatively affects the physical wellbeing of its sufferers in ways that we are just starting to appreciate. This study investigates the immunomodulatory effects of social isolation in mice, utilising a two-week program of sole cage occupancy followed by the testing of immune-inflammatory resilience to bacterial sepsis. Our results revealed that mice housed in social isolation showed an increased ability to clear bacterial infection compared to control socially housed animals. These effects were associated with specific changes in whole blood gene expression profile and an increased production of classical pro-inflammatory cytokines. Interestingly, equipping socially isolated mice with artificial nests as a substitute for their natural huddling behaviour reversed the increased resistance to bacterial sepsis. Together these results suggest that the control of body temperature through social housing and huddling behaviour are important factors in the regulation of the host immune response to infection in mice and might provide another example of the many ways by which living conditions influence immunity.
    MeSH term(s) Animals ; Immunity ; Mice ; Sepsis ; Social Isolation ; Temperature
    Language English
    Publishing date 2022-02-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2022.02.022
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  10. Article ; Online: A possible role for G-quadruplexes formation and DNA methylation at IMOOD gene promoter in Obsessive Compulsive Disorder.

    Sabatucci, Annalaura / Girella, Antonio / Di Bartolomeo, Martina / Pucci, Mariangela / Vismara, Matteo / Benatti, Beatrice / Blacksell, Isobel Alice / Cooper, Dianne / Dainese, Enrico / D'Acquisto, Fulvio / Dell'Osso, Bernardo / D'Addario, Claudio

    Advances in biological regulation

    2023  Volume 89, Page(s) 100976

    Abstract: Obsessive Compulsive Disorder (OCD) is a mental health condition still classified and diagnosed with subjective interview-based assessments and which molecular clues have not completely been elucidated. We have recently identified a new regulator of ... ...

    Abstract Obsessive Compulsive Disorder (OCD) is a mental health condition still classified and diagnosed with subjective interview-based assessments and which molecular clues have not completely been elucidated. We have recently identified a new regulator of anxiety and OCD-like behavior called Immuno-moodulin (IMOOD) and, here, we report that IMOOD gene promoter is differentially methylated in OCD subjects when compared to genomic material collected from healthy controls and this alteration is significantly correlated with the increased expression of the gene in OCD. We also demonstrated that IMOOD promoter can form G-quadruplexes and we suggest that, in homeostatic conditions, these structures could evoke DNA-methylation silencing the gene, whereas in pathological conditions, like OCD, could induce gene expression making the promoter more accessible to transcriptional factors. We here thus further suggest IMOOD as a new biomarker for OCD and also hypothesize new mechanisms of gene regulation.
    MeSH term(s) Humans ; DNA Methylation ; G-Quadruplexes ; Obsessive-Compulsive Disorder/genetics ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/psychology ; Gene Expression Regulation ; Homeostasis
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2667413-0
    ISSN 2212-4934 ; 2212-4926
    ISSN (online) 2212-4934
    ISSN 2212-4926
    DOI 10.1016/j.jbior.2023.100976
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