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Article ; Online: Palmitate Stimulates Expression of the von Willebrand Factor and Modulates Toll-like Receptors Level and Activity in Human Umbilical Vein Endothelial Cells (HUVECs).

Seliga, Agnieszka K / Zabłocki, Krzysztof / Bandorowicz-Pikuła, Joanna

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: An increased concentration of palmitate in circulation is one of the most harmful factors in obesity. The von Willebrand factor (vWF), a protein involved in haemostasis, is produced and secreted by the vascular endothelium. An increased level of vWF in ... ...

Abstract	An increased concentration of palmitate in circulation is one of the most harmful factors in obesity. The von Willebrand factor (vWF), a protein involved in haemostasis, is produced and secreted by the vascular endothelium. An increased level of vWF in obese patients is associated with thrombosis and cardiovascular disease. The aim of this study was to investigate a palmitate effect on vWF in endothelial cells and understand the mechanisms of palmitate-activated signalling. Human umbilical vein endothelial cells (HUVECs) incubated in the presence of palmitate, exhibited an increased
MeSH term(s)	Humans ; von Willebrand Factor/genetics ; Human Umbilical Vein Endothelial Cells ; NF-kappa B ; Toll-Like Receptor 4/genetics ; Toll-Like Receptors ; I-kappa B Proteins ; Obesity
Chemical Substances	von Willebrand Factor ; NF-kappa B ; Toll-Like Receptor 4 ; Toll-Like Receptors ; I-kappa B Proteins
Language	English
Publishing date	2023-12-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010254
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The roles of annexins in vascular endothelium dysfunction accompanying diabetes mellitus type 2.

Bandorowicz-Pikuła, Joanna

Postepy biochemii

2017 Volume 63, Issue 2, Page(s) 119–124

Abstract: Impairment in cellular transport, distribution and storage of cholesterol accompanies insulin resistance and diabetes mellitus type 2 as well as other diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease. Diabetes mellitus ... ...

Title translation	Udział aneksyn w nieprawidłowym funkcjonowaniu komórek śródbłonka naczyniowego towarzyszącemu cukrzycy typu 2.
Abstract	Impairment in cellular transport, distribution and storage of cholesterol accompanies insulin resistance and diabetes mellitus type 2 as well as other diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease. Diabetes mellitus type 2 is a metabolic disorder that is characterized by hyperglycemia in the context of insulin resistance and relative lack of insulin. Type 2 diabetes makes up about 90% of cases of diabetes. Several therapeutic strategies are today being considered to target diabetes mellitus type 2, and the accompanying endothelial dysfunction, but none as yet has proved satisfactory. Accumulating data suggest that annexins, as cholesterol binding proteins that participate in intracellular transport and storage of cholesterol and in the organization of plasma membrane, may participate in development and sustenance of diabetes mellitus type 2 and may serve as predictive markers of this disease.
MeSH term(s)	Annexins/physiology ; Diabetes Mellitus, Type 2/physiopathology ; Endothelium, Vascular/physiopathology ; Humans ; Hyperglycemia ; Insulin Resistance
Chemical Substances	Annexins
Language	English
Publishing date	2017
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article: Annexin A6 as a cholesterol and nucleotide binding protein involved in membrane repair and in controlling membrane transport during endo- and exocytosis.

Bandorowicz-Pikuła, Joanna / Seliga, Agnieszka Kinga

Postepy biochemii

2019 Volume 64, Issue 3, Page(s) 190–195

Abstract: Annexins, calcium- and membrane-binding proteins, have been extensively studied at the Nencki Institute since early 1990s, in terms of their structure, potential ligands and functions in the organism, with emphasis on mineralization processes in norm and ...

Title translation	Aneksyna A6, białko wiążące cholesterol i nukleotydy, uczestniczące w naprawie błon biologicznych i w transporcie pęcherzykowym.
Abstract	Annexins, calcium- and membrane-binding proteins, have been extensively studied at the Nencki Institute since early 1990s, in terms of their structure, potential ligands and functions in the organism, with emphasis on mineralization processes in norm and pathology. The results of recently performed studies have revealed that annexins are playing essential roles in membrane organization. In this review we characterize the largest member of the annexin family of proteins, annexin A6 (AnxA6), in respect to its cholesterol and nucleotide binding properties, as well as intracellular pH sensing and ability to change membrane permeability to ions. Furthermore, we discuss biological functions of AnxA6 such as participation in membrane lateral organization, cell membrane repair and regulation of vesicular transport.
MeSH term(s)	Animals ; Annexin A6/metabolism ; Biological Transport ; Cell Membrane/metabolism ; Cholesterol/metabolism ; Endocytosis ; Exocytosis ; Humans ; Nucleotides/metabolism
Chemical Substances	Annexin A6 ; Nucleotides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2019-01-18
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
DOI	10.18388/pb.2018_131
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Article: Udział aneksyn w procesie endocytozy i przekazywaniu sygnałów, w których uczestnicza receptory EGF.

Woś, Marcin / Bandorowicz-Pikuła, Joanna

Postepy biochemii

2014 Volume 60, Issue 1, Page(s) 55–61

Abstract: Annexins are a family of membrane interacting proteins, widely distributed in vertebrates. Their involvement in the endosomal transport is due to annexin capability of binding cellular constituents such as membrane phospholipids and intracellular protein ...

Title translation	Participation of annexins in endocytosis and EGFR-mediated signal transduction.
Abstract	Annexins are a family of membrane interacting proteins, widely distributed in vertebrates. Their involvement in the endosomal transport is due to annexin capability of binding cellular constituents such as membrane phospholipids and intracellular protein partners in a calcium dependent manner. Furthermore, annexins, through endosomal transport of particular receptors and specific cargo, may regulate various processes involved in signal transduction. Cell surface receptors after activation by signal molecule are internalized during endocytosis and transduce signal downstream the signaling pathway. The optimal conditions to modulate the signal are provided by the compartment specific membrane platforms carrying signal transducing complexes. In this review we describe a role of some members of the annexin family, annexin A1 (AnxA1), annexin A2 (AnxA2), annexin A6 (AnxA6) and annexin A8 (AnxA8) in the epidermal growth factor (EGF) signal transduction pathway. Annexins due to their specialized structure and specific localization in the cell may modulate signal transduction either directly, by interacting with EGF receptor (EGFR) or indirectly by interacting with EGF pathway regulators and effectors, by participating in formation and stabilization of the cholesterol enriched signal transduction platforms and by participating in EGFR transport and degradation.
MeSH term(s)	Animals ; Annexins/metabolism ; Biological Transport ; Calcium/metabolism ; Endocytosis/physiology ; Epidermal Growth Factor/metabolism ; Humans ; Membrane Proteins/metabolism ; Signal Transduction/physiology
Chemical Substances	Annexins ; Membrane Proteins ; Epidermal Growth Factor (62229-50-9) ; Calcium (SY7Q814VUP)
Language	Polish
Publishing date	2014
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article: Homeostaza wapnia w komórce zwierzecej--w zarysie.

Zabłocki, Krzysztof / Bandorowicz-Pikuła, Joanna

Postepy biochemii

2012 Volume 58, Issue 4, Page(s) 387–392

Abstract: Calcium ions are universal and versatile intracellular signalling molecule which is involved in regulation of many cellular functions in all living cells throughout all animal species. It results from unique properties of Ca2+ in comparison to other two- ...

Title translation	Calcium homeostasis in the animal cell--an outline.
Abstract	Calcium ions are universal and versatile intracellular signalling molecule which is involved in regulation of many cellular functions in all living cells throughout all animal species. It results from unique properties of Ca2+ in comparison to other two- and monovalent cations commonly present inside and outside cells. On the other hand an excessive increase of intracellular Ca2+ accumulation may exert toxic effect leading to cell death. Therefore calcium content in particular cellular compartment must be precisely regulated. All cells have a complex set of proteins which allow them to remove, store or take up Ca2+ in very controlled manner. This article gives a concise survey of mechanisms involved cellular calcium homeostasis and signalling.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Homeostasis
Chemical Substances	Calcium (SY7Q814VUP)
Language	Polish
Publishing date	2012
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article: Pojemnościowy napływ jonów wapnia--czy wszystkie elementy maszynerii zostały zidentyfikowane?

Bandorowicz-Pikuła, Joanna / Zabłocki, Krzysztof

Postepy biochemii

2012 Volume 58, Issue 4, Page(s) 452–464

Abstract: Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism leading to a transient increase of Ca2+ concentration in the cytoplasm ([Ca2+]c) of a leaving cell followed by refill of the internal stores with calcium. Discovery of STIM1 and STIM2 proteins ... ...

Title translation	Store-operated calcium entry--are all elements of the system already identified?.
Abstract	Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism leading to a transient increase of Ca2+ concentration in the cytoplasm ([Ca2+]c) of a leaving cell followed by refill of the internal stores with calcium. Discovery of STIM1 and STIM2 proteins located in the endoplasmic reticulum (ER) and playing a role of sensors of calcium, led to our understanding how the calcium signal from ER is propagated to calcium release-activated calcium channels (CRAC) located in the plasma membrane, resulting in their activation, flow of calcium into a cytoplasm and activation of calcium-dependent signaling. In light of controversies existing in identification of CRAC channels (such as Oral, TRPC and others), as well as identification of mechanisms of calcium entry that are independent of the presence of calcium in the internal calcium stores, in this review we discuss the newest theories about SOCE, proteins that are engaged in this mechanism as well as pathologies related to impaired SOCE.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Cell Adhesion Molecules/metabolism ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Endoplasmic Reticulum/metabolism ; Humans ; Ion Transport ; Membrane Proteins/metabolism ; Neoplasm Proteins/metabolism ; Stromal Interaction Molecule 1 ; Stromal Interaction Molecule 2
Chemical Substances	Calcium Channels ; Cell Adhesion Molecules ; Membrane Proteins ; Neoplasm Proteins ; STIM1 protein, human ; STIM2 protein, human ; Stromal Interaction Molecule 1 ; Stromal Interaction Molecule 2 ; Calcium (SY7Q814VUP)
Language	Polish
Publishing date	2012
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article ; Online: Activation of mammalian terget of rapamycin kinase and glycogen synthase kinase-3β accompanies abnormal accumulation of cholesterol in fibroblasts from Niemann-Pick type C patients.

Wos, Marcin / Komiażyk, Magdalena / Pikula, Slawomir / Tylki-Szymanska, Anna / Bandorowicz-Pikula, Joanna

Journal of cellular biochemistry

2018 Volume 120, Issue 4, Page(s) 6580–6588

Abstract: Background: Niemann Pick type C (NPC) lysosomal disorder is linked to the disruption of cholesterol transport. Recent data suggest that the molecular background of this disease is more complex. It was found that accumulation of cholesterol and ... ...

Abstract	Background: Niemann Pick type C (NPC) lysosomal disorder is linked to the disruption of cholesterol transport. Recent data suggest that the molecular background of this disease is more complex. It was found that accumulation of cholesterol and glycolipids in the late endosomal/lysosomal compartment of NPC1 cells may affect mitochondrial functions. Materials and methods: In this study, primary skin fibroblasts derived from skin biopsies of two anonymous patients with NPC-carrying mutations in the NPC1 gene, characterized by a high total cholesterol content, as well as two healthy donors were used. The presence of signaling proteins in the whole cell lysates and mitochondrial fractions were examined by Western blotting assay. Results: In this report, we provide experimental evidence that in NPC1 cells, dysfunction of mitochondria and cellular metabolism, as reported by Wos et al in 2016, coexist with alterations in signal transduction pathways, such as the mammalian target of rapamycin, AKT, phosphoinositide-dependent protein kinase-1, glycogen synthase kinase-3 β, and Jun amino-terminal kinase, leading to abnormal cholesterol accumulation and distribution. Conclusion: Differences in signal transduction between control and NPC1 cells may suggest that the latter cells experienced significant alterations in the complex molecular mechanisms that control cellular energy metabolism and vesicular transport.
MeSH term(s)	Biological Transport ; Case-Control Studies ; Cholesterol/metabolism ; Energy Metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mitochondria/metabolism ; Mitochondria/pathology ; Mutation ; Niemann-Pick Disease, Type C/genetics ; Niemann-Pick Disease, Type C/metabolism ; Niemann-Pick Disease, Type C/pathology ; Skin/metabolism ; Skin/pathology ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Intracellular Signaling Peptides and Proteins ; NPC1 protein, human ; Cholesterol (97C5T2UQ7J) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2018-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.27951
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Article: Aneksyny, białka uczestniczace w organizacji i prawidłowym funkcjonowaniu błon biologicznych--od Arabidopsis thaliana do Homo sapiens.

Bandorowicz-Pikuła, Joanna

Postepy biochemii

2007 Volume 53, Issue 2, Page(s) 143–153

Abstract: The mini-review series presented in this issue of Postepy Biochemii is focussed on some aspects of biology of calcium- and membrane-binding proteins, annexins, ubiquitous in all eucaryotic organisms (excluding yeasts), from Arabidopsis thaliana to Homo ... ...

Title translation	Annexins--proteins involved in organization and function of biological membranes--from Arabidopsis thaliana to Homo sapiens.
Abstract	The mini-review series presented in this issue of Postepy Biochemii is focussed on some aspects of biology of calcium- and membrane-binding proteins, annexins, ubiquitous in all eucaryotic organisms (excluding yeasts), from Arabidopsis thaliana to Homo sapiens. Annexins are encoded by twelve genes in verterbrates and by eight in higher plants. Their physiological significance is underlined by two facts: the numer of the annexin genes seems to grow during evolution and in some cell types they comprise up to 2% of total protein. In the present review the hypothesis is discussed suggesting that multiplication of annexin genes in evolution represents mechanism of organism adaptation to changes in environment. In addition, the experimental data are presented suggestive of annexins playing a crucial role in functioning of plasma membrane, such as signal transduction, ion and vesicular transport and membrane repair. The review is then followed by articlesdealing in details with participation of annexins in plant response to abiotic stress (Arabidopsis thaliana), in tissue mineralization (Gallus gallus), in exocytosis of catecholamines by PC12 cells (mammals) and in Niemann-Pick type C disease related to abnormal transport and intracellular storage of cholesterol (Homo sapiens).
MeSH term(s)	Animals ; Annexins/genetics ; Annexins/metabolism ; Arabidopsis/genetics ; Arabidopsis/physiology ; Biological Transport/physiology ; Calcium/metabolism ; Cell Membrane/physiology ; Cell Membrane Permeability/physiology ; Evolution, Molecular ; Humans ; Plant Proteins/genetics ; Plant Proteins/physiology ; Protein Structure, Tertiary/physiology ; Sequence Homology, Amino Acid ; Species Specificity ; Vertebrates ; Vesicular Transport Proteins/physiology
Chemical Substances	Annexins ; Plant Proteins ; Vesicular Transport Proteins ; Calcium (SY7Q814VUP)
Language	Polish
Publishing date	2007
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article: Aneksyny mitochondriów.

Bandorowicz-Pikuła, Joanna / Woś, Marcin / Sekrecka-Belniak, Anna / Pikuła, Sławomir

Postepy biochemii

2016 Volume 62, Issue 2, Page(s) 216–223

Abstract: Annexins form a family of membrane- and calcium-binding proteins, widely distributed in vertebrates. Their interactions with membranes are regulated by changes of intracellular concentration of calcium ([ ... ...

Title translation	Annexins in mitochondria.
Abstract	Annexins form a family of membrane- and calcium-binding proteins, widely distributed in vertebrates. Their interactions with membranes are regulated by changes of intracellular concentration of calcium ([Ca
Language	Polish
Publishing date	2016
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
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Article ; Online: Src and ROCK Kinases Differentially Regulate Mineralization of Human Osteosarcoma Saos-2 Cells.

Strzelecka-Kiliszek, Agnieszka / Romiszewska, Marta / Bozycki, Lukasz / Mebarek, Saida / Bandorowicz-Pikula, Joanna / Buchet, Rene / Pikula, Slawomir

International journal of molecular sciences

2019 Volume 20, Issue 12

Abstract: Osteoblasts initiate bone mineralization by releasing matrix vesicles (MVs) into the extracellular matrix (ECM). MVs promote the nucleation process of apatite formation from ... ...

Abstract	Osteoblasts initiate bone mineralization by releasing matrix vesicles (MVs) into the extracellular matrix (ECM). MVs promote the nucleation process of apatite formation from Ca
MeSH term(s)	Annexins/metabolism ; Biomarkers ; Bone Neoplasms/metabolism ; Calcification, Physiologic ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Extracellular Matrix/metabolism ; Fluorescent Antibody Technique ; Humans ; Osteosarcoma/metabolism ; rho-Associated Kinases/metabolism ; src-Family Kinases/metabolism
Chemical Substances	Annexins ; Biomarkers ; src-Family Kinases (EC 2.7.10.2) ; rho-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2019-06-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20122872
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