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  1. Book ; Online: Recent Developments in Annexin Biology

    Jaiswal, Jyoti K. / Gerke, Volker / Rescher, Ursula / Kim Lim, Lina Hsiu

    2021  

    Keywords Research & information: general ; inflammation ; nigericin ; pyroptosis ; mass spectrometry ; lipidomics ; anxA2 ; Birbeck granules ; Langerhans cell ; A2t ; annexin ; plasma membrane repair ; membrane curvature ; membrane curvature sensing ; membrane shaping ; interdisciplinary research ; cell rupture ; membrane damage ; bias analysis ; G protein-coupled receptor (GPCR) ; formyl peptide receptor 1 ; danger-associated molecular pattern (DAMP) ; pathogen-associated molecular pattern (PAMP) ; annexin A1 peptide Ac2-26 ; cholesterol ; AnxA6 ; chaperone-mediated autophagy ; endolysosomes ; NPC1 ; Lamp2A ; annexin A2 ; microdomain ; cross-linker ; quartz crystal microbalance with dissipation monitoring (QCM-D) ; mucin-1 ; claudin-1 ; zona occludens ; ERK1/2 pathway ; angiogenesis ; F-actin polymerization ; BeWo spheroids ; Ishikawa cells ; influenza ; RNA-sequencing ; transcriptomics ; autophagy ; Annexin-A1 ; infection ; adherens junction ; macroautophagy ; breast cancer ; estrogen receptor negative ; Annexin A2 ; metastasis ; annexin-A6 ; membrane repair ; human skeletal muscle ; cap subdomain ; fluorescence ; electron microscopy ; CLEM ; annexin A6 ; RasGRF2 ; EGFR ; cell growth ; cell motility ; acquired resistance ; tyrosine kinase inhibitors ; muscle injury ; plasma membrane ; vesicle ; muscular dystrophy ; annexinA2 egress ; exocytosis ; chromaffin cells ; thrombosis ; Annexin A1 ; formyl peptide receptors ; sickle cell disease ; sepsis ; Annexin ; membrane ; injury ; virus ; lipid ; cancer
    Size 1 electronic resource (266 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289872
    ISBN 9783036501994 ; 3036501991
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: ANO5 in membrane repair - Status: "It's complicated".

    Gerke, Volker / Rescher, Ursula

    Cell calcium

    2021  Volume 97, Page(s) 102415

    Abstract: ANO5/TMEM16E gene mutations are associated with myopathies. Two recent publications in the Journal of Cell Biology now both confirm that ANO5 deficiency results in defective plasma membrane repair and ... ...

    Abstract ANO5/TMEM16E gene mutations are associated with myopathies. Two recent publications in the Journal of Cell Biology now both confirm that ANO5 deficiency results in defective plasma membrane repair and Ca
    Language English
    Publishing date 2021-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2021.102415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Can you teach an old receptor new tricks?

    Raabe, Carsten Alexander / Rescher, Ursula

    Journal of leukocyte biology

    2020  Volume 110, Issue 2, Page(s) 217–218

    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.2CE0920-568R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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  4. Article: Repurposing Antifungals for Host-Directed Antiviral Therapy?

    Schloer, Sebastian / Goretzko, Jonas / Rescher, Ursula

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 2

    Abstract: Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that ... ...

    Abstract Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that hide from immune cell and antibody detection. Thus, other approaches than immunization are critical for the management and control of viral infections. Viruses are prone to mutations leading to the rapid emergence of resistant strains upon treatment with direct antivirals. In contrast to the direct interference with pathogen components, host-directed therapies aim to target host factors that are essential for the pathogenic replication cycle or to improve the host defense mechanisms, thus circumventing resistance. These relatively new approaches are often based on the repurposing of drugs which are already licensed for the treatment of other unrelated diseases. Here, we summarize what is known about the mechanisms and modes of action for a potential use of antifungals as repurposed host-directed anti-infectives for the therapeutic intervention to control viral infections.
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15020212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics.

    Gerke, Volker / Gavins, Felicity N E / Geisow, Michael / Grewal, Thomas / Jaiswal, Jyoti K / Nylandsted, Jesper / Rescher, Ursula

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1574

    Abstract: Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated ... ...

    Abstract Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca
    MeSH term(s) Animals ; Annexins/chemistry ; Taste ; Cell Membrane/metabolism ; Signal Transduction ; Biological Transport ; Calcium/metabolism ; Mammals/metabolism
    Chemical Substances Annexins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45954-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Repurposing Antifungals for Host-Directed Antiviral Therapy?

    Sebastian Schloer / Jonas Goretzko / Ursula Rescher

    Pharmaceuticals, Vol 15, Iss 212, p

    2022  Volume 212

    Abstract: Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that ... ...

    Abstract Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that hide from immune cell and antibody detection. Thus, other approaches than immunization are critical for the management and control of viral infections. Viruses are prone to mutations leading to the rapid emergence of resistant strains upon treatment with direct antivirals. In contrast to the direct interference with pathogen components, host-directed therapies aim to target host factors that are essential for the pathogenic replication cycle or to improve the host defense mechanisms, thus circumventing resistance. These relatively new approaches are often based on the repurposing of drugs which are already licensed for the treatment of other unrelated diseases. Here, we summarize what is known about the mechanisms and modes of action for a potential use of antifungals as repurposed host-directed anti-infectives for the therapeutic intervention to control viral infections.
    Keywords antifungals ; host-directed drug therapy ; drug repurposing ; azoles ; polyenes ; echinocandins ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 570
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Characterization of the Atl-mediated staphylococcal internalization mechanism.

    Schlesier, Tim / Siegmund, Anke / Rescher, Ursula / Heilmann, Christine

    International journal of medical microbiology : IJMM

    2020  Volume 310, Issue 8, Page(s) 151463

    Abstract: Staphylococcus aureus internalization by non-professional phagocytes is considered a main pathogenicity mechanism leading to chronic infections. The well-established mechanism of Staphylococcus aureus internalization is mediated by fibronectin (Fn)- ... ...

    Abstract Staphylococcus aureus internalization by non-professional phagocytes is considered a main pathogenicity mechanism leading to chronic infections. The well-established mechanism of Staphylococcus aureus internalization is mediated by fibronectin (Fn)-binding proteins (FnBPs), Fn as a bridging molecule and the host cell α
    MeSH term(s) Adhesins, Bacterial ; Bacterial Proteins ; HSC70 Heat-Shock Proteins ; Humans ; N-Acetylmuramoyl-L-alanine Amidase ; Phagocytes/microbiology ; Staphylococcus aureus/pathogenicity
    Chemical Substances Adhesins, Bacterial ; Bacterial Proteins ; HSC70 Heat-Shock Proteins ; fibronectin-binding proteins, bacterial ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
    Language English
    Publishing date 2020-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2020.151463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5333: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs.

    Schreiber, André / Ambrosy, Benjamin / Planz, Oliver / Schloer, Sebastian / Rescher, Ursula / Ludwig, Stephan

    Pharmaceutics

    2022  Volume 14, Issue 9

    Abstract: The coronavirus disease 2019 (COVID-19) represents a global public health burden. In addition to vaccination, safe and efficient antiviral treatment strategies to restrict the viral spread within the patient are urgently needed. An alternative approach ... ...

    Abstract The coronavirus disease 2019 (COVID-19) represents a global public health burden. In addition to vaccination, safe and efficient antiviral treatment strategies to restrict the viral spread within the patient are urgently needed. An alternative approach to a single-drug therapy is the combinatory use of virus- and host-targeted antivirals, leading to a synergistic boost of the drugs' impact. In this study, we investigated the property of the MEK1/2 inhibitor ATR-002's (zapnometinib) ability to potentiate the effect of direct-acting antivirals (DAA) against SARS-CoV-2 on viral replication. Treatment combinations of ATR-002 with nucleoside inhibitors Molnupiravir and Remdesivir or 3C-like protease inhibitors Nirmatrelvir and Ritonavir, the ingredients of the drug Paxlovid, were examined in Calu-3 cells to evaluate the advantage of their combinatory use against a SARS-CoV-2 infection. Synergistic effects could be observed for all tested combinations of ATR-002 with DAAs, as calculated by four different reference models in a concentration range that was very well-tolerated by the cells. Our results show that ATR-002 has the potential to act synergistically in combination with direct-acting antivirals, allowing for a reduction in the effective concentrations of the individual drugs and reducing side effects.
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14091776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Highlight: annexins in health and disease.

    Rescher, Ursula / Grewal, Thomas

    Biological chemistry

    2016  Volume 397, Issue 10, Page(s) 947–948

    Language English
    Publishing date 2016-10-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2016-0264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.50: Show issues Location:
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  10. Article ; Online: Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection

    Kummer, Susann / Lander, Angelika / Goretzko, Jonas / Kirchoff, Norman / Rescher, Ursula / Schloer, Sebastian

    Emerging microbes & infections

    2022  Volume 11, Issue 1, Page(s) 195–207

    Abstract: Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV). The latest occasional EVD outbreak (2013-2016) in Western African, which was accompanied by a high fatality rate, showed the great potential of epidemic and ...

    Abstract Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV). The latest occasional EVD outbreak (2013-2016) in Western African, which was accompanied by a high fatality rate, showed the great potential of epidemic and pandemic spread. Antiviral therapies against EBOV are very limited, strain-dependent (only antibody therapies are available) and mostly restricted to symptomatic treatment, illustrating the urgent need for novel antiviral strategies. Thus, we evaluated the effect of the clinically widely used antifungal itraconazole and the antidepressant fluoxetine for a repurposing against EBOV infection. While itraconazole, similar to U18666A, directly binds to and inhibits the endosomal membrane protein Niemann-Pick C1 (NPC1), fluoxetine, which belongs to the structurally unrelated group of weakly basic, amphiphile so-called "functional inhibitors of acid sphingomyelinase" (FIASMA) indirectly acts on the lysosome-residing acid sphingomyelinase via enzyme detachment leading to subsequent lysosomal degradation. Both, the drug-induced endolysosomal cholesterol accumulation and the altered endolysosomal pH, might interfere with the fusion of viral and endolysosomal membrane, preventing infection with EBOV. We further provide evidence that cholesterol imbalance is a conserved cross-species mechanism to hamper EBOV infection. Thus, exploring the endolysosomal host-pathogen interface as a suitable antiviral treatment may offer a general strategy to combat EBOV infection.
    MeSH term(s) Antiviral Agents/pharmacology ; Cholesterol/metabolism ; Ebolavirus/drug effects ; Ebolavirus/genetics ; Ebolavirus/physiology ; Endosomes/drug effects ; Endosomes/metabolism ; Fluoxetine/pharmacology ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/genetics ; Hemorrhagic Fever, Ebola/metabolism ; Hemorrhagic Fever, Ebola/virology ; Humans ; Itraconazole/pharmacology ; Niemann-Pick C1 Protein/genetics ; Niemann-Pick C1 Protein/metabolism ; Sphingomyelin Phosphodiesterase/antagonists & inhibitors ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism ; Virus Internalization/drug effects
    Chemical Substances Antiviral Agents ; Niemann-Pick C1 Protein ; Fluoxetine (01K63SUP8D) ; Itraconazole (304NUG5GF4) ; Cholesterol (97C5T2UQ7J) ; SMPD1 protein, human (EC 3.1.4.12) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2021.2020598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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