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Article: Drs. Cao and Zheng reply.

Cao, Hua / Zheng, Jie

2017 Volume 44, Issue 7, Page(s) 1100

Language	English
Publishing date	2017-08-17
Publishing country	Canada
Document type	Journal Article ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.170531
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article: ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine.

Dai, Jianye / Fang, Junwei / Sun, Shujun / Chen, Qiwen / Cao, Huijuan / Zheng, Ningning / Zhang, Yongyu / Lu, Aiping

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 235969

Abstract: ... treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special ... controversy because ZHENG classification only depends on observation, knowledge, and clinical experience ... microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable ...

Abstract	With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms and signs of patients even if they have a different disease. However, it caused controversy because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. Although researchers and scientists of TCM have done some work with a lot of beneficial methods, the results could not reach satisfactory with the shortcomings of generalizing the entire state of the body or ignoring the patients' feelings. By total summary, mining, and integration of existing researches, the present paper attempts to introduce a novel macro-microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable approach for Chinese personalized medicine in an effective way. In this paper, we give the brief introduction and preliminary validation, and discuss strategies and system-oriented technologies for achieving this goal.
Language	English
Publishing date	2013-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/235969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Evidence-Based Dampness-Heat ZHENG (Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor.

Jiao, Ju-Ying / Cheng, Chien-Shan / Cao, Zhang-Qi / Chen, Lian-Yu / Chen, Zhen

Chinese journal of integrative medicine

2022 Volume 30, Issue 1, Page(s) 85–95

Abstract: ... complementary and alternative medicine. It emphasizes symptoms and ZHENG (syndrome)-based treatment combined ... advantage encourages an exploration of the essence of dampness-heat ZHENG (DHZ) in cancer and investigation ... that can be used for the establishment of a future standardized ZHENG-based cancer animal model. ...

Abstract	Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG (syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG (DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.
MeSH term(s)	Animals ; Humans ; Medicine, Chinese Traditional ; Hot Temperature ; Pancreatic Neoplasms/therapy ; Models, Animal ; Syndrome
Language	English
Publishing date	2022-06-20
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-022-3675-8
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Zs.A 5823: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: ZHENG-Omics Application in ZHENG Classification and Treatment

Jianye Dai / Junwei Fang / Shujun Sun / Qiwen Chen / Huijuan Cao / Ningning Zheng / Yongyu Zhang / Aiping Lu

Evidence-Based Complementary and Alternative Medicine, Vol

Chinese Personalized Medicine

2013 Volume 2013

Abstract	With the hope to provide an effective approach for personalized diagnosis and treatment clinically, traditional chinese medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) classification, which could be identified clinical special phenotypes by symptoms and signs of patients even if they have a different disease. However, it caused controversy because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which lacks objectivity and repeatability. Although researchers and scientists of TCM have done some work with a lot of beneficial methods, the results could not reach satisfactory with the shortcomings of generalizing the entire state of the body or ignoring the patients' feelings. By total summary, mining, and integration of existing researches, the present paper attempts to introduce a novel macro-microconcept of ZHENG-omics, with the prospect of bright future in providing an objective and repeatable approach for Chinese personalized medicine in an effective way. In this paper, we give the brief introduction and preliminary validation, and discuss strategies and system-oriented technologies for achieving this goal.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Understanding Acupuncture Based on ZHENG Classification from System Perspective.

Fang, Junwei / Zheng, Ningning / Wang, Yang / Cao, Huijuan / Sun, Shujun / Dai, Jianye / Li, Qianhua / Zhang, Yongyu

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 956967

Abstract: ... on ZHENG classification is a systematic research on understanding its complexity. The system perspective is ... the global effect of acupuncture. Secondly, the global effect of acupuncture could reflect ZHENG information ... Specificity. Furthermore, based on comprehensive ZHENG classification, omics researches could help ...

Abstract	Acupuncture is an efficient therapy method originated in ancient China, the study of which based on ZHENG classification is a systematic research on understanding its complexity. The system perspective is contributed to understand the essence of phenomena, and, as the coming of the system biology era, broader technology platforms such as omics technologies were established for the objective study of traditional chinese medicine (TCM). Omics technologies could dynamically determine molecular components of various levels, which could achieve a systematic understanding of acupuncture by finding out the relationships of various response parts. After reviewing the literature of acupuncture studied by omics approaches, the following points were found. Firstly, with the help of omics approaches, acupuncture was found to be able to treat diseases by regulating the neuroendocrine immune (NEI) network and the change of which could reflect the global effect of acupuncture. Secondly, the global effect of acupuncture could reflect ZHENG information at certain structure and function levels, which might reveal the mechanism of Meridian and Acupoint Specificity. Furthermore, based on comprehensive ZHENG classification, omics researches could help us understand the action characteristics of acupoints and the molecular mechanisms of their synergistic effect.
Language	English
Publishing date	2013-11-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/956967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Applications of New Technologies and New Methods in ZHENG Differentiation.

Dai, Jianye / Sun, Shujun / Cao, Huijuan / Zheng, Ningning / Wang, Wenyu / Gou, Xiaojun / Su, Shibing / Zhang, Yongyu

Evidence-based complementary and alternative medicine : eCAM

2012 Volume 2012, Page(s) 298014

Abstract: ... treatment based on ZHENG (TCM syndrome) differentiation, which could be identified as clinical special ... phenotypes by symptoms and signs of patients. However, it caused skepticism and criticism because ZHENG ... touching), in this paper, the applications of new technologies and new methods on the ZHENG differentiation ...

Abstract	With the hope to provide an effective approach for personalized diagnosis and treatment clinically, Traditional Chinese Medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) differentiation, which could be identified as clinical special phenotypes by symptoms and signs of patients. However, it caused skepticism and criticism because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which is lack of objectivity and repeatability. Scientists have done fruitful researches for its objectivity and standardization. Compared with traditional four diagnostic methods (looking, listening and smelling, asking, and touching), in this paper, the applications of new technologies and new methods on the ZHENG differentiation were systemically reviewed, including acquisition, analysis, and integration of clinical data or information. Furthermore, the characteristics and application range of these technologies and methods were summarized. It will provide reference for further researches.
Language	English
Publishing date	2012-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2012/298014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Understanding Acupuncture Based on ZHENG Classification from System Perspective

Junwei Fang / Ningning Zheng / Yang Wang / Huijuan Cao / Shujun Sun / Jianye Dai / Qianhua Li / Yongyu Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2013 Volume 2013

Abstract	Acupuncture is an efficient therapy method originated in ancient China, the study of which based on ZHENG classification is a systematic research on understanding its complexity. The system perspective is contributed to understand the essence of phenomena, and, as the coming of the system biology era, broader technology platforms such as omics technologies were established for the objective study of traditional chinese medicine (TCM). Omics technologies could dynamically determine molecular components of various levels, which could achieve a systematic understanding of acupuncture by finding out the relationships of various response parts. After reviewing the literature of acupuncture studied by omics approaches, the following points were found. Firstly, with the help of omics approaches, acupuncture was found to be able to treat diseases by regulating the neuroendocrine immune (NEI) network and the change of which could reflect the global effect of acupuncture. Secondly, the global effect of acupuncture could reflect ZHENG information at certain structure and function levels, which might reveal the mechanism of Meridian and Acupoint Specificity. Furthermore, based on comprehensive ZHENG classification, omics researches could help us understand the action characteristics of acupoints and the molecular mechanisms of their synergistic effect.
Keywords	Medicine (General) ; R5-920 ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Differences of excess and deficiency zheng in patients with chronic hepatitis B by urinary metabonomics.

Sun, Shujun / Dai, Jianye / Fang, Junwei / Gou, Xiaojun / Cao, Huijuan / Zheng, Ningning / Wang, Yang / Zhang, Wei / Zhang, Yongyu / Jia, Wei / Hu, Yiyang

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 738245

Abstract: ... into different subtypes in order to guide the appropriate treatment, which is called Zheng (TCM syndrome ... classification. Excess and deficiency ZHENG is a couple of basic ZHENGs of maladjusted body nature, reflecting ... the struggling state of human body and pathogenic factor and is important and prevalently exists in the ZHENG ...

Abstract	Traditional Chinese medicine (TCM) physicians stratify patients with the same disease into different subtypes in order to guide the appropriate treatment, which is called Zheng (TCM syndrome) classification. Excess and deficiency ZHENG is a couple of basic ZHENGs of maladjusted body nature, reflecting the struggling state of human body and pathogenic factor and is important and prevalently exists in the ZHENG classification of many diseases. The present work using chronic hepatitis B (CHB) as an entry point explored the substance connotation of excess and deficiency ZHENG with the metabonomic technology based on gas chromatography-mass spectrometry (GC-MS). The different substantial basis of two ZHENGs suggested that CHB patients could be categorized into two groups with diverse pathogenesis. The differential metabolites and disturbed pathways compared to not-obvious ZHENG characters patients (without ZHENG group/WZ) were selected in both of the two ZHENGs. The ROC analysis demonstrated that five metabolites had a greater potential to be the clinic biomarkers of EZ or DZ. And excess ZHENG revealed a higher level of immune function than deficiency ZHENG. We are eager to transform the concept of traditional excess and deficiency ZHENGs to modern therapeutic approaches, with the prospect to help to promote personalized medicine.
Language	English
Publishing date	2013-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/738245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Effect of Zhen Qi Fu Zheng granules on the bone marrow depression model induced by Zidorf.

Miao, Mingsan / Cao, Lihua / Bai, Ming / Chen, Gangling

Saudi journal of biological sciences

2017 Volume 25, Issue 2, Page(s) 220–225

Abstract: ... bone marrow depression. Therefore, we investigated the effects of Zhen Qi Fu Zheng (AQFZ) granules ...

Abstract	Zidorf is a commonly used drug for the treatment of AIDS, the most common side effects of AZT was bone marrow depression. Therefore, we investigated the effects of Zhen Qi Fu Zheng (AQFZ) granules on the model of bone marrow depression induced by AZT. We showed that the high, medium and low doses of AQFZ granules could increase the number of WBC in the mice model induced by AZT, and the difference was significant (
Language	English
Publishing date	2017-10-03
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2017.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Applications of New Technologies and New Methods in ZHENG Differentiation

Jianye Dai / Shujun Sun / Huijuan Cao / Ningning Zheng / Wenyu Wang / Xiaojun Gou / Shibing Su / Yongyu Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2012 Volume 2012

Abstract	With the hope to provide an effective approach for personalized diagnosis and treatment clinically, Traditional Chinese Medicine (TCM) is being paid increasing attention as a complementary and alternative medicine. It performs treatment based on ZHENG (TCM syndrome) differentiation, which could be identified as clinical special phenotypes by symptoms and signs of patients. However, it caused skepticism and criticism because ZHENG classification only depends on observation, knowledge, and clinical experience of TCM practitioners, which is lack of objectivity and repeatability. Scientists have done fruitful researches for its objectivity and standardization. Compared with traditional four diagnostic methods (looking, listening and smelling, asking, and touching), in this paper, the applications of new technologies and new methods on the ZHENG differentiation were systemically reviewed, including acquisition, analysis, and integration of clinical data or information. Furthermore, the characteristics and application range of these technologies and methods were summarized. It will provide reference for further researches.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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