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  1. Article: Another Emergent Cause of Headache.

    Wambolt, Scott R / Garza, Juan

    Cureus

    2018  Volume 10, Issue 5, Page(s) e2623

    Abstract: We present a case of a subacute headache related to leukostasis secondary to accelerated chronic myeloid leukemia (CML), which required white blood cell (WBC) reduction in the emergency department. A 28-year-old male presented to the emergency department ...

    Abstract We present a case of a subacute headache related to leukostasis secondary to accelerated chronic myeloid leukemia (CML), which required white blood cell (WBC) reduction in the emergency department. A 28-year-old male presented to the emergency department with a chronic headache found to be secondary to leukostasis from accelerated CML with a white blood cell count of 801,000 and 9% blasts. He had bilateral retinal hemorrhage and a headache associated with elevated intracranial pressure. Hydroxyurea and allopurinol were initiated in the emergency department and the patient was eventually transitioned to a tyrosine kinase inhibitor as outpatient therapy. Headaches are a frequent cause of emergency department visits, and this case illustrates another possible etiology of headache requiring emergent intervention.
    Language English
    Publishing date 2018-05-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

    Bround, Michael J / Wambolt, Rich / Cen, Haoning / Asghari, Parisa / Albu, Razvan F / Han, Jun / McAfee, Donald / Pourrier, Marc / Scott, Nichollas E / Bohunek, Lubos / Kulpa, Jerzy E / Chen, S R Wayne / Fedida, David / Brownsey, Roger W / Borchers, Christoph H / Foster, Leonard J / Mayor, Thibault / Moore, Edwin D W / Allard, Michael F /
    Johnson, James D

    The Journal of biological chemistry

    2016  Volume 291, Issue 45, Page(s) 23490–23505

    Abstract: Cardiac ryanodine receptor (Ryr2) ... ...

    Abstract Cardiac ryanodine receptor (Ryr2) Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Signaling ; Gene Deletion ; Glucose/metabolism ; Metabolome ; Mice ; Mice, Inbred C57BL ; Myocardial Contraction ; Myocardium/cytology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidation-Reduction ; Proteome ; Pyruvate Dehydrogenase Complex/metabolism ; Pyruvates/metabolism ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism
    Chemical Substances Proteome ; Pyruvate Dehydrogenase Complex ; Pyruvates ; Ryanodine Receptor Calcium Release Channel ; ryanodine receptor 2. mouse ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M116.756973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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  3. Article: Ecological Risk Assessment of Sediments in Sydney Harbour, Nova Scotia, Canada

    Walker, Tony R / Willis, Rob / Gray, Tim / MacLean, Bradley / Mcmillan, Scott / Leroy, Melissa / Appleton, Rebecca / Wambolt, Nadine / Smith, Melanie

    Soil & sediment contamination. 2015 July 4, v. 24, no. 5

    2015  

    Abstract: Contamination within sediments of Sydney Harbour (once a major industrial port) were evaluated using a multiple lines-of-evidence (LOE) ecological risk assessment (ERA) approach prior to divestiture of the harbor. The multiple LOE approach included: (1) ... ...

    Abstract Contamination within sediments of Sydney Harbour (once a major industrial port) were evaluated using a multiple lines-of-evidence (LOE) ecological risk assessment (ERA) approach prior to divestiture of the harbor. The multiple LOE approach included: (1) measurement of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), metals, metalloids, petroleum hydrocarbons(PHCs), and total organic carbon (TOC) concentrations in surface sediments from multiple Sydney Harbour locations; (2) identification and application of sediment quality guidelines (SQGs) from various jurisdictions; (3) comparisons of harbor sediment chemistry against background/reference sediment chemistry; (4) determining number and frequency of exceedances over SQGs; (5) calculating mean probable effect level-quotients (PEL-Qs); (6) PAH forensic source evaluation; (7) review of previous sediment chemistry and biota tissue data; and (8) characterizing benthic habitat at harbor stations. The ERA determined that current sediments exhibited mostly low probability of adverse effects. Furthermore, contaminated sediments exhibiting a high probability of adverse effects were localized to only a few stations within the harbor. Ongoing natural recovery of harbor sediments is likely responsible for attenuating contaminants that historically were higher than those measured in this study and were previously distributed over much wider areas of the harbor. Results suggest that legacy industrial activities and current urban sewage effluents are the major sources of contamination in Sydney Harbour sediments.
    Keywords adverse effects ; carbon ; chemistry ; effluents ; environmental assessment ; forensic sciences ; guidelines ; habitats ; metalloids ; metals ; petroleum ; polychlorinated biphenyls ; polycyclic aromatic hydrocarbons ; probability ; sediment contamination ; sediments ; sewage ; Nova Scotia
    Language English
    Dates of publication 2015-0704
    Size p. 471-493.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2017739-2
    ISSN 1549-7887 ; 1532-0383
    ISSN (online) 1549-7887
    ISSN 1532-0383
    DOI 10.1080/15320383.2015.982244
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6090: Show issues

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  4. Article: Ecological Risk Assessment of Sediments in Sydney Harbour, Nova Scotia, Canada

    Walker, Tony R. / Willis, Rob / Gray, Tim / MacLean, Bradley / McMillan, Scott / Leroy, Melissa / Appleton, Rebecca / Wambolt, Nadine / Smith, Melanie

    Soil & sediment contamination

    2015  Volume 24, Issue 5/8, Page(s) 471

    Language English
    Document type Article
    ZDB-ID 2017739-2
    ISSN 1532-0383
    DOI 10.1080/15320383.2015.982244
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Cemented versus uncemented fixation of humeral components in total shoulder arthroplasty for osteoarthritis of the shoulder: a prospective, randomized, double-blind clinical trial-A JOINTs Canada Project.

    Litchfield, Robert B / McKee, Micheal D / Balyk, Robert / Mandel, Scott / Holtby, Richard / Hollinshead, Robert / Drosdowech, Darren / Wambolt, S Elizabeth / Griffin, Sharon H / McCormack, Robert

    Journal of shoulder and elbow surgery

    2011  Volume 20, Issue 4, Page(s) 529–536

    Abstract: Background: Although cemented humeral fixation is recognized as the standard of care in total shoulder arthroplasty (TSA), uncemented fixation has the potential to provide stable fixation, decrease operative time, and simplify potential revision ... ...

    Abstract Background: Although cemented humeral fixation is recognized as the standard of care in total shoulder arthroplasty (TSA), uncemented fixation has the potential to provide stable fixation, decrease operative time, and simplify potential revision procedures. This prospective, randomized, double-blind clinical trial compared cemented and uncemented humeral fixation in TSA for primary shoulder osteoarthritis.
    Methods: Patients with primary shoulder osteoarthritis requiring replacement were screened for eligibility. After providing informed consent, subjects received baseline clinical and radiologic assessments, computed tomography scans, and standardized TSA. After glenoid component insertion, patients were randomized to either a cemented or uncemented humeral component. The primary outcome was the WOOS (Western Ontario Arthritis of the Shoulder Index) score at 2 years. Other outcomes included the Short Form 12 score, American Shoulder and Elbow Surgeons score, McMaster-Toronto Arthritis Patient Preference Disability Questionnaire, operative time, complications, and revisions. Patients were assessed by a blinded evaluator at 2 and 6 weeks and 3, 6, 12, 18, and 24 months postoperatively.
    Results: In total, 161 patients consented to be included and were randomized: 80 in the cemented group and 81 in the uncemented group. There were no significant differences in demographics or baseline evaluations between groups, except for gender. The 12-, 18-, and 24-month WOOS scores showed a significant difference in favor of the cemented group. The cemented group also had better strength and forward flexion. As expected, the operative time was significantly less for the uncemented group.
    Conclusions: These findings provide level I evidence that cemented fixation of the humeral component provides better quality of life, strength, and range of motion than uncemented fixation.
    MeSH term(s) Arthroplasty, Replacement/methods ; Canada ; Cementation ; Double-Blind Method ; Health Status ; Humans ; Joint Prosthesis ; Osteoarthritis/surgery ; Prospective Studies ; Quality of Life ; Range of Motion, Articular ; Shoulder Joint/physiopathology ; Shoulder Joint/surgery ; Treatment Outcome
    Language English
    Publishing date 2011-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2011.01.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3973: Show issues Location:
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