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  1. Article: Editorial: Role of complement activation in kidney diseases.

    Oda, Takashi / Sawai, Toshihiro

    Frontiers in medicine

    2023  Volume 10, Page(s) 1297938

    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1297938
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  2. Article ; Online: Editorial

    Takashi Oda / Toshihiro Sawai

    Frontiers in Medicine, Vol

    Role of complement activation in kidney diseases

    2023  Volume 10

    Keywords complement activation ; alternative pathway ; classical pathway ; lectin pathway ; kidney diseases ; eculizumab ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: CD14+ Dendritic-Shaped Cells Functioning as Dendritic Cells in Rheumatoid Arthritis Synovial Tissues.

    Kurose, Rie / Satoh, Takashi / Kurose, Akira / Ishibashi, Yasuyuki / Uzuki, Miwa / Wakai, Yuji / Sasaki, Tomoyuki / Ishida, Kinji / Ogasawara, Katsutoshi / Sawai, Takashi

    ACR open rheumatology

    2024  

    Abstract: Objective: We previously reported that CD14+ dendritic-shaped cells exhibit a dendritic morphology, engage in pseudo-emperipolesis with lymphocytes, and express CD90 in the perivascular areas of rheumatoid arthritis (RA) synovial tissues. However, it ... ...

    Abstract Objective: We previously reported that CD14+ dendritic-shaped cells exhibit a dendritic morphology, engage in pseudo-emperipolesis with lymphocytes, and express CD90 in the perivascular areas of rheumatoid arthritis (RA) synovial tissues. However, it remains unclear whether these CD14
    Methods: The localization and number of CD14
    Results: CD14
    Conclusion: CD14+ cells migrate and spread from the circulating blood to RA synovial tissues while expressing CD90, and CD14
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Case of a Patient with Cancer of Unknown Primary in the Poor Prognosis Group Who Had a Experienced a Beneficial Treatment Course].

    Jin, Takashi / Takayama, Toshizo / Tomita, Yusuke / Sawai, Koya / Honma, Rio / Takeda, Hiroko / Tsuji, Yasushi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 51, Issue 2, Page(s) 167–169

    Abstract: A 47-year-old woman with general malaise and abdominal pain presented with multiple liver tumors and lymph node metastasis. She was diagnosed with small cell carcinoma on the basis of a lymph node biopsy; however, the primary lesion was not identified. ... ...

    Abstract A 47-year-old woman with general malaise and abdominal pain presented with multiple liver tumors and lymph node metastasis. She was diagnosed with small cell carcinoma on the basis of a lymph node biopsy; however, the primary lesion was not identified. Finally, we diagnosed her with cancer of unknown primary lesion and placed her in the poor prognosis group. Although her general condition was poor, she experienced a relatively good response to treatment for small cell carcinoma.
    MeSH term(s) Humans ; Female ; Middle Aged ; Carcinoma, Small Cell ; Neoplasms, Unknown Primary/drug therapy ; Small Cell Lung Carcinoma ; Lung Neoplasms ; Prognosis
    Language Japanese
    Publishing date 2024-03-07
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of acute moderate-intensity cycling on cfDNA levels considering menstrual cycle phases.

    Sawai, Akemi / Shida, Takashi / Hoshikawa, Yoshihiro / Hatanaka, Sho / Ueda, Mashiro / Kato, Yuri / Tokinoya, Katsuyuki / Natsui, Hiroaki / Kawakami, Yasushi / Takekoshi, Kazuhiro

    Frontiers in sports and active living

    2024  Volume 6, Page(s) 1322295

    Abstract: Introduction: We aimed to determine the effects of exercise on cell-free DNA (cfDNA) levels and concentration changes during the menstrual cycle in participants with regular menstrual cycles and no exercise habits.: Methods: Eleven sedentary female ... ...

    Abstract Introduction: We aimed to determine the effects of exercise on cell-free DNA (cfDNA) levels and concentration changes during the menstrual cycle in participants with regular menstrual cycles and no exercise habits.
    Methods: Eleven sedentary female students with regular menstrual cycles and ovulation performed bicycle exercises at 60% VO
    Results: Based on the concentration of ovarian hormones, seven individuals were finally analyzed. No significant phase difference was observed in cfDNA across all time points. cfDNA (menstrual phase:
    Discussion: The results indicate that while resting cfDNA levels are unlikely to be affected by a woman's menstrual cycle, the increase in cfDNA after exercise is higher in the ovulatory phase (when only E2 increases) and lower in the luteal phase (when E2 and P4 increase with exercise) compared to that in the menstrual phase (when E2 and P4 are in low levels), suggesting the contribution of increased ovarian hormone levels after exercise.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2024.1322295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case of pancreaticoduodenal artery bleeding after laparoscopic right colectomy requiring open hemostasis.

    Ono, Rika / Tominaga, Tetsuro / Nonaka, Takashi / Takamura, Yuma / Oishi, Kaido / Shiraishi, Toshio / Hashimoto, Shintaro / Noda, Keisuke / Sawai, Terumitsu / Nagayasu, Takeshi

    Surgical case reports

    2024  Volume 10, Issue 1, Page(s) 18

    Abstract: Background: Pancreatic and duodenal-related complications after right colectomy carry a higher risk of mortality.: Case presentation: A 64-year-old woman underwent laparoscopic right colectomy for a laterally spreading tumor in the cecum. On ... ...

    Abstract Background: Pancreatic and duodenal-related complications after right colectomy carry a higher risk of mortality.
    Case presentation: A 64-year-old woman underwent laparoscopic right colectomy for a laterally spreading tumor in the cecum. On postoperative day 10, she experienced sudden hematemesis. Contrast-enhanced computed tomography (CT) of the abdomen showed a large amount of hemorrhage in the stomach, but no obvious extravasation. In addition, free air was observed near the duodenal bulb. Despite blood transfusion, vital signs remained unstable and emergency surgery was performed. The abdomen was opened through midline incisions in the upper and lower abdomen. A fragile wall and perforation were observed at the border of the left side of the duodenal bulb and pancreas, with active bleeding observed from inside. As visualization of the bleeding point proved difficult, the duodenum was divided circumferentially to confirm the bleeding point and hemostasis was performed using 4-0 PDS. The left posterior wall of the duodenum was missing, exposing the pancreatic head. For reconstruction, the jejunum was elevated via the posterior colonic route and the duodenal segment and elevated jejunum were anastomosed in an end-to-side manner. Subsequently, gastrojejunal and Brown anastomoses were added. Drains were placed before and after the duodenojejunal anastomosis. Postoperative vital signs were stable and the patient was extubated on postoperative day 1. Follow-up contrast-enhanced CT of the abdomen showed no active bleeding, and the patient was discharged home on postoperative day 21. As of 6 months postoperatively, the course of recovery has been uneventful.
    Conclusions: We encountered a case of pancreaticoduodenal artery hemorrhage after laparoscopic right colectomy. Bleeding at this site can prove fatal, so treatment plans should be formulated according to the urgency of the situation.
    Language English
    Publishing date 2024-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-024-01816-x
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  7. Article ; Online: Short-term outcomes after laparoscopic colorectal cancer surgery in patients over 90 years old: a Japanese multicenter study.

    Yamashita, Mariko / Tominaga, Tetsuro / Nonaka, Takashi / Hisanaga, Makoto / Takeshita, Hiroaki / Fukuoka, Hidetoshi / To, Kazuo / Tanaka, Kenji / Sawai, Terumitsu / Nagayasu, Takeshi

    BMC surgery

    2024  Volume 24, Issue 1, Page(s) 2

    Abstract: Background: The effect of laparoscopic surgery on short-term outcomes in colorectal cancer patients over 90 years old has remained unclear.: Methods: We reviewed 87 colorectal cancer patients aged over 90 years who underwent surgery between 2016 and ... ...

    Abstract Background: The effect of laparoscopic surgery on short-term outcomes in colorectal cancer patients over 90 years old has remained unclear.
    Methods: We reviewed 87 colorectal cancer patients aged over 90 years who underwent surgery between 2016 and 2022. Patients were divided into an open surgery group (n = 22) and a laparoscopic surgery group (n = 65). The aim of this study was to investigate the effect of laparoscopic surgery on postoperative outcome in elderly colorectal cancer patients, as compared to open surgery.
    Results: Seventy-eight patients (89.7%) had comorbidities. Frequency of advanced T stage was lower with laparoscopic surgery (p = 0.021). Operation time was longer (open surgery 146 min vs. laparoscopic surgery 203 min; p = 0.002) and blood loss was less (105 mL vs. 20 mL, respectively; p < 0.001) with laparoscopic surgery. Length of hospitalization was longer with open surgery (22 days vs. 18 days, respectively; p = 0.007). Frequency of infectious complications was lower with laparoscopic surgery (18.5%) than with open surgery (45.5%; p = 0.021). Multivariate analysis revealed open surgery (p = 0.026; odds ratio, 3.535; 95% confidence interval, 1.159-10.781) as an independent predictor of postoperative infectious complications.
    Conclusions: Laparoscopic colorectal resection for patients over 90 years old is a useful procedure that reduces postoperative infectious complications.
    MeSH term(s) Aged, 80 and over ; Humans ; Colectomy/adverse effects ; Colectomy/methods ; Colorectal Neoplasms/surgery ; Japan/epidemiology ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Postoperative Complications/epidemiology ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-023-02298-8
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  8. Article: Spatial Resolution of Suprachoroidal-Transretinal Stimulation Estimated by Recording Single-Unit Activity From the Cat Lateral Geniculate Nucleus.

    Miyoshi, Tomomitsu / Morimoto, Takeshi / Sawai, Hajime / Fujikado, Takashi

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 717429

    Abstract: Retinal prostheses are devices used to restore visual sensation in patients suffering from photoreceptor degeneration, such as retinitis pigmentosa. Suprachoroidal-transretinal stimulation (STS) is a prosthesis with retinal electrodes located in the ... ...

    Abstract Retinal prostheses are devices used to restore visual sensation in patients suffering from photoreceptor degeneration, such as retinitis pigmentosa. Suprachoroidal-transretinal stimulation (STS) is a prosthesis with retinal electrodes located in the sclera. STS has the advantage that it is safer than epiretinal or subretinal prostheses, as the implant is not directly attached to the retinal tissue. We have previously reported feasibility of STS with animal experiments and clinical trials. However, functional evaluation with neurophysiological experiments is still largely missing. To estimate the spatial resolution of STS, single-unit activities in response to STS were recorded from relay cells in the dorsal lateral geniculate nucleus of cats, and the response probability of the units was analyzed in relation to the distance between the stimulus location and the receptive field of each recorded unit. A platinum electrode was attached to the sclera after lamellar resection, and the return electrode was placed in the vitreous. The stimulating current, which ranged from 50 to 500 μA, was applied between these electrodes, and the probability of spike responses occurring just after retinal stimulation was measured. The distance at half-maximum of response was determined from the collected response probabilities as a function of stimulus intensity for all units characterized by their distances from the receptive field center to the stimulation point. As the stimulation became weaker, this distance decreased to 1.8° at 150 and 100 μA. As another estimation, the radius of 25% response probability was 1.4° at 100 μA. The diameter of the stimulated cat retinal area, 3.6° or 2.8°, corresponds to human visual acuity of 0.005 or 0.007, or finger counting. Considering the lower hazard to the retina of STS and its potentially large visual field coverage, STS is an attractive method for retinal prosthetic device development.
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.717429
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  9. Article ; Online: Usefulness of internal organ retractors in making sutureless delta-shaped intracorporeal anastomosis during laparoscopic colectomy.

    Nonaka, Takashi / Tominaga, Tetsuro / Akazawa, Yuko / Sawai, Terumitsu / Nagayasu, Takeshi

    Techniques in coloproctology

    2021  Volume 25, Issue 11, Page(s) 1255–1256

    MeSH term(s) Anastomosis, Surgical ; Colectomy ; Humans ; Laparoscopy
    Language English
    Publishing date 2021-06-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-021-02470-3
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  10. Article ; Online: Successful Laparoscopic Resection of Rectal Cancer With Uterine Invasion Using a Combined Endoscopic Transanal and Transvaginal Approach.

    Nonaka, Takashi / Tominaga, Tetsuro / Akazawa, Yuko / Sawai, Terumitsu / Nagayasu, Takeshi

    Diseases of the colon and rectum

    2021  Volume 64, Issue 8, Page(s) e464

    MeSH term(s) Female ; Humans ; Laparoscopy/methods ; Middle Aged ; Natural Orifice Endoscopic Surgery ; Neoplasm Invasiveness ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Transanal Endoscopic Surgery ; Uterus/pathology ; Uterus/surgery ; Vagina
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002055
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