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Article ; Online: Fetal Blood Sampling in Cytomegalovirus Infection: Balancing the Risks and Benefits.

Pomar, Léo / Sichitiu, Joanna / Baud, David

American journal of obstetrics and gynecology

2024

Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Letter
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2024.04.041
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Article: Examen échographique du premier trimestre : au-delà de la clarté nucale.

Contier, Agathe / Sichitiu, Joanna / Rieder, Wawrzyniec

Revue medicale suisse

2023 Volume 19, Issue 846, Page(s) 1916–1921

Abstract: Pregnancy care has gradually evolved over the last two decades, with a trend towards earlier detection and diagnosis of both maternal and fetal pathologies. At the core of this process, antenatal ultrasound allows to identify a large number of congenital ...

Title translation	First trimester ultrasound: beyond nuchal translucency.
Abstract	Pregnancy care has gradually evolved over the last two decades, with a trend towards earlier detection and diagnosis of both maternal and fetal pathologies. At the core of this process, antenatal ultrasound allows to identify a large number of congenital malformations as early as the end of the first trimester. It has also become an increasingly specialized procedure, requiring considerable material and human resources. In this article, we review the basic principles of first-trimester ultrasound, focusing on most recent screening recommendations.
MeSH term(s)	Pregnancy ; Humans ; Female ; Pregnancy Trimester, First ; Nuchal Translucency Measurement ; Down Syndrome/diagnosis ; Ultrasonography ; Ultrasonography, Prenatal
Language	French
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2023.19.846.1916
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Article ; Online: Optimizing blood conservation in caesarean sections: Intravaginal tamponade technique for abnormal placentae insertion.

Moser, Laureline / Vouga, Manon / Benkortbi, Khadidja / Boussac, Emilie / Cuenoud, Alexia / Sichitiu, Joanna / Desseauve, David

European journal of obstetrics & gynecology and reproductive biology: X

2024 Volume 21, Page(s) 100282

Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1613
ISSN (online)	2590-1613
DOI	10.1016/j.eurox.2024.100282
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Article ; Online: Intrapartum care of women with COVID-19: A practical approach.

Sichitiu, Joanna / Desseauve, David

European journal of obstetrics, gynecology, and reproductive biology

2020 Volume 249, Page(s) 94–95

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Female ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; Pregnancy ; Pregnancy Complications, Infectious/therapy ; Prenatal Care ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-06
Publishing country	Ireland
Document type	Letter
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2020.04.018
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Article ; Online: Should we offer elective induction of labor to nulliparous women at 39 weeks?

Sichitiu, Joanna / Desseauve, David

American journal of obstetrics and gynecology

2019 Volume 221, Issue 3, Page(s) 288

MeSH term(s)	Cohort Studies ; Elective Surgical Procedures ; Female ; Humans ; Labor, Induced ; Labor, Obstetric ; Pregnancy
Language	English
Publishing date	2019-06-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2019.05.048
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Article ; Online: Contribution of fetal blood sampling to determining the prognosis of congenital cytomegalovirus infections: a case-cohort study in Switzerland.

Pomar, Léo / Contier, Agathe / Stojanov, Milos / Guenot, Cécile / Sichitiu, Joanna / Truttmann, Anita C / Vial, Yvan / Baud, David

American journal of obstetrics and gynecology

2024

Abstract: Background: Cytomegalovirus is responsible for the most common congenital infection, affecting 0.5% to 1.0% of live births in Europe. Congenital cytomegalovirus infection can be diagnosed during pregnancy by viral DNA amplification in the amniotic fluid, ...

Abstract	Background: Cytomegalovirus is responsible for the most common congenital infection, affecting 0.5% to 1.0% of live births in Europe. Congenital cytomegalovirus infection can be diagnosed during pregnancy by viral DNA amplification in the amniotic fluid, but the prognosis of fetuses without severe brain abnormalities remains difficult to establish on the basis of prenatal imaging alone. Objective: To identify predictors of moderate to severe symptomatic cytomegalovirus infection among fetal blood parameters and to propose an algorithm on the basis of these parameters and on prenatal imaging that would provide the best positive and negative predictive values. Study design: Fetal blood sampling at 21-28 weeks gestation was performed in fetuses with congenital cytomegalovirus infection confirmed by amniocentesis after maternal infection in the first-trimester or periconceptional period. We compared the levels of hemoglobin, thrombocytes, γ-glutamyl transpeptidase, aspartate aminotransferase, alanine aminotransferase, β2-microglobulin, immunoglobulins G and M, and cytomegalovirus DNA viral loads in amniotic fluid and fetal blood between those with moderate to severe symptomatic infection and those with asymptomatic to mild infection (median follow-up of 36 months for live births). Results: Among 58 fetuses included, 25 (43%) had a moderate to severe symptomatic infection: 16 with severe cerebral abnormalities, 5 with multiple signs or symptoms at birth, 2 with bilateral sensorineural hearing loss, and 2 with neurodevelopmental delay. The values of thrombocytes, aspartate aminotransferase, β2 microglobulin, Immunoglobulin M, and cytomegalovirus viral loads differed significantly between fetuses with moderate to severe symptomatic infection and those with asymptomatic to mild infection. The optimal strategy to predict moderate to severe symptomatic infection was to first perform fetal brain imaging, followed by fetal blood sampling with the following cutoffs: thrombocytes <120,000/mL, viremia ≥5 log Conclusion: The combination of thrombocytes, β2-microglobulin, and cytomegalovirus viral load in fetal blood can be used for prognosis determination, particularly in cytomegalovirus-infected fetuses without severe brain abnormalities at the time of prenatal diagnosis. Future studies should evaluate whether these parameters remain useful in infected fetuses who have been treated with valacyclovir before fetal blood sampling.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2024.03.032
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Article ; Online: Assessing feasibility and maternal acceptability of a biomechanically-optimized supine birth position: A pilot study.

Bouille, Lisa / Sichitiu, Joanna / Favre, Julien / Desseauve, David

PloS one

2021 Volume 16, Issue 9, Page(s) e0257285

Abstract: Background: In order to manage a protracted second stage of labor, "eminence-based" birth positions have been suggested by some healthcare professionals. Recent biomechanical studies have promoted the use of an optimized supine birthing position in this ...

Abstract	Background: In order to manage a protracted second stage of labor, "eminence-based" birth positions have been suggested by some healthcare professionals. Recent biomechanical studies have promoted the use of an optimized supine birthing position in this setting. However, uncertainty exists regarding the feasibility of this posture, and its acceptability by women. This pilot study primarily aimed to assess these characteristics. Objective and methods: In this monocentric prospective study, 20 women with a protracted second stage of labor were asked to maintain a biomechanically-optimized position for at least 20 minutes at full dilatation. This posture is similar to the McRoberts' maneuver. Maintaining the position for 20 minutes or more was considered clinically relevant and indicative of feasibility and acceptability. Satisfaction with the position was assessed using a Visual Analogue Scale (VAS). A sub-group analysis was performed to assess eventual differences between more and less satisfied patients, according to the median of patients' satisfaction scores. Results: Seventeen patients (85%) maintained the optimized position for at least 20 minutes. The median satisfaction score of these participants was 8 (interquartile range: 1) out of 10. No significant differences were found between the two sub-groups (satisfaction score <8 vs satisfaction score ≥8) regarding general and obstetric characteristics, as well as obstetrical and fetal outcomes. Conclusion: The optimized position is acceptable and feasible for women experiencing a protracted second stage of labor. Further clinical studies are needed to assess the efficiency of such positions when women undergo an obstructed labor.
MeSH term(s)	Adult ; Analgesia, Epidural ; Analgesia, Obstetrical ; Biomechanical Phenomena ; Delivery, Obstetric ; Feasibility Studies ; Female ; Humans ; Labor Stage, Second ; Obstetrics/methods ; Parturition ; Patient Positioning ; Patient Satisfaction ; Pilot Projects ; Pregnancy ; Pregnancy Outcome ; Prospective Studies ; Visual Analog Scale
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0257285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Carbetocin for the prevention of post-partum hemorrhage after vaginal birth: a real-world application.

Sichitiu, Joanna / Baud, David / Desseauve, David

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 8114–8117

Abstract: Objective: To compare maternal outcomes using Carbetocin versus Oxytocin for the active management of the third stage of labor, given a temporary national shortage of Oxytocin.: Methods: We conducted a retrospective observational study on a cohort of ...

Abstract	Objective: To compare maternal outcomes using Carbetocin versus Oxytocin for the active management of the third stage of labor, given a temporary national shortage of Oxytocin. Methods: We conducted a retrospective observational study on a cohort of 866 women with vaginal deliveries at our center, >36 weeks of gestation, between November 2018 and March 2019. During the shortage period, each woman received a single slow intravenous injection of Carbetocin 100 µg at delivery of the anterior shoulder, rather than Oxytocin 5 UI, as postpartum hemorrhage prophylaxis. 146 (16.9%) patients received Carbetocin versus 720 (83.1%) receiving Oxytocin. The outcomes were rates of postpartum hemorrhage, severe postpartum hemorrhage, and placental retention. Results: Incidence rates of placental retention and postpartum hemorrhage were 4.9% and 9.4% respectively. Placenta retention was significantly more likely following Carbetocin administration (adjusted odds ratio 2.5; 95% confidence interval 1.2-5.0). Postpartum hemorrhage rates were not significantly different (adjusted odds ratio 1.1; 95% confidence interval 0.6-2.1), as were severe postpartum hemorrhage rates (adjusted odds ratio 0.7; 95% confidence interval 0.2-2.2). Conclusion: Carbetocin is as effective as Oxytocin for postpartum hemorrhage prevention. However, we would reserve it for use after placental delivery due to the increased retention rates.
MeSH term(s)	Female ; Humans ; Pregnancy ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/drug therapy ; Oxytocin/therapeutic use ; Oxytocics/therapeutic use ; Placenta ; Placenta, Retained/prevention & control ; Placenta, Retained/drug therapy ; Postpartum Period
Chemical Substances	carbetocin (88TWF8015Y) ; Oxytocin (50-56-6) ; Oxytocics
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1962841
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Article ; Online: Advanced Maternal Age Among Nulliparous at Term and Risk of Unscheduled Cesarean Delivery.

Braggion, Axelle / Favre, Guillaume / Lepigeon, Karine / Sichitiu, Joanna / Baud, David / Desseauve, David

American journal of obstetrics & gynecology MFM

2023 Volume 5, Issue 8, Page(s) 100972

Abstract: Background: With the rise in the number of women giving birth at an advanced age, the association between advanced maternal age and adverse obstetrical outcomes is a growing concern in developed countries. Despite the well-established link between ... ...

Abstract	Background: With the rise in the number of women giving birth at an advanced age, the association between advanced maternal age and adverse obstetrical outcomes is a growing concern in developed countries. Despite the well-established link between advanced maternal age and pregnancy-related complications, there has been limited research examining the specific risks related to unscheduled cesarean delivery in nulliparas at term. Objective: This study aimed to evaluate the risks associated with unscheduled cesarean delivery in nulliparas at ≥37 weeks of gestation, comparing the outcomes of younger patients with those aged ≥40 years. Study design: This retrospective cohort study was conducted in a tertiary maternity hospital in Switzerland (high-income country). The study included nulliparas who delivered a live-born infant at ≥37 weeks between January 2015 and December 2019. We excluded pregnant women who had a planned cesarean delivery, were aged <18 years, multiparous, delivered before 37 weeks of gestation, or had pregnancies that ended in stillbirth. Participants were divided into 2 age groups: (1) ≥40 years and (2) <40 years. The primary outcome was the incidence of unscheduled cesarean delivery. Its association with advanced maternal age was evaluated after adjusting for confounding factors by multivariate logistic regression, expressed as an adjusted odds ratio. Secondary outcomes included pregnancy outcomes and neonatal outcomes. Results: A total of 5211 patients were included: 173 in the ≥40-years (advanced maternal age) group and 5038 in the <40-years (non-advanced maternal age) group; 26.01% (95% confidence interval, 19.65-33.22; n=45) of women in the advanced maternal age group had an unscheduled cesarean delivery, whereas 15.26% (95% confidence interval, 14.28-16.29; n=769) of women in the non-advanced maternal age group underwent the procedure. Advanced maternal age was associated with unscheduled cesarean delivery, with an adjusted odds ratio of 1.51 (95% confidence interval, 1.06-2.17; P=.024). Among vaginal deliveries, assisted procedures were performed on 29.7% (95% confidence interval, 21.9-38.4; n=38) of advanced maternal age patients vs 20.1% (95% confidence interval, 18.9-21.3; n=856) of non-advanced maternal age patients. Postpartum blood loss >1000 mL occurred in 5.8% (95% confidence interval, 2.8-10.4; n=10) of advanced maternal age patients and 3.1% (95% confidence interval, 2.6-3.6; n=156) of non-advanced maternal age patients. Conclusion: Advanced maternal age is associated with increased risk of unscheduled cesarean delivery among nulliparas. This provides healthcare professionals with confirmation that advanced age may represent an individual risk factor, suggesting that nulliparous patients aged over 40 years may benefit from improved information regarding the factors contributing to this pregnancy outcome.
MeSH term(s)	Infant ; Infant, Newborn ; Pregnancy ; Female ; Humans ; Adult ; Middle Aged ; Maternal Age ; Retrospective Studies ; Cesarean Section/adverse effects ; Delivery, Obstetric ; Pregnancy Outcome ; Pregnancy Complications/epidemiology
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2023.100972
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Article: Intrapartum care of women with COVID-19: A practical approach

Sichitiu, Joanna / Desseauve, David

Eur J Obstet Gynecol Reprod Biol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #34838
Database	COVID19

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