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  1. Article ; Online: A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure.

    Kutyna, Monika M / Kok, Chung Hoow / Lim, Yoon / Tran, Elizabeth Ngoc Hoa / Campbell, David / Paton, Sharon / Thompson-Peach, Chloe / Lim, Kelly / Cakouros, Dimitrios / Arthur, Agnes / Hughes, Timothy / Kumar, Sharad / Thomas, Daniel / Gronthos, Stan / Hiwase, Devendra K

    Leukemia

    2022  Volume 36, Issue 11, Page(s) 2678–2689

    Abstract: Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment ... ...

    Abstract Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment remains unknown. We performed multiomic (transcriptome, DNA damage response, cytokine secretome and functional profiling) characterization of bone marrow stromal cells from tMN patients. Critically, we also compared (i) patients with myeloid neoplasm and another cancer but without cytotoxic exposure, (ii) typical primary myeloid neoplasm, and (iii) age-matched controls to decipher the microenvironmental changes induced by cytotoxics vs. neoplasia. Strikingly, tMN exhibited a profoundly senescent phenotype with induction of CDKN1A and β-Galactosidase, defective phenotype, and proliferation. Moreover, tMN stroma showed delayed DNA repair and defective adipogenesis. Despite their dormant state, tMN stromal cells were metabolically highly active with a switch toward glycolysis and secreted multiple pro-inflammatory cytokines indicative of a senescent-secretory phenotype that inhibited adipogenesis. Critically, senolytics not only eliminated dormant cells, but also restored adipogenesis. Finally, sequential patient sampling showed senescence phenotypes are induced within months of cytotoxic exposure, well prior to the onset of secondary cancer. Our data underscores a role of senescence in the pathogenesis of tMN and provide a valuable resource for future therapeutics.
    MeSH term(s) Humans ; Cellular Senescence/genetics ; Secretome ; Mesenchymal Stem Cells/metabolism ; Antineoplastic Agents/pharmacology ; Cytokines/metabolism ; Neoplasms ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents ; Cytokines
    Language English
    Publishing date 2022-08-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-022-01686-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
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  2. Article ; Online: Manipulative rehabilitation applied soon after lumbar disc surgery improves late post-operative functional disability: A preliminary 2-year follow-up study.

    Kim, Byungho J / Kim, Taeyeong / Ahn, Junghoon / Cho, Heecheol / Kim, Dongyun / Yoon, Bumchul

    Journal of back and musculoskeletal rehabilitation

    2017  Volume 30, Issue 5, Page(s) 999–1004

    Abstract: Background: Studies have shown late post-operative physical disability and residual pain in patients following lumbar disc surgery despite growing evidence of its beneficial effects. Therefore, rehabilitation is required to minimise the late post- ... ...

    Abstract Background: Studies have shown late post-operative physical disability and residual pain in patients following lumbar disc surgery despite growing evidence of its beneficial effects. Therefore, rehabilitation is required to minimise the late post-operative complications.
    Objective: To assess the feasibility of manipulative rehabilitation to improve late post-operative outcomes.
    Methods: Twenty-one patients aged 25-65 years undergoing lumbar microdiscectomy were randomly assigned to the rehabilitation group (n= 14) or active control group (n= 7) by simple randomisation. Eight rehabilitation sessions were initiated 2-3 weeks after surgery. Thirty-minute sessions were conducted twice weekly for four weeks. Post-operative physical disability and pain were assessed at baseline and at the two-year follow-up.
    Results: Post-operative physical disability improved more in patients who had undergone rehabilitation than in those who had received control care (63% vs. -23%, P< 0.05). Post-operative residual low back and leg pain were alleviated in the treatment group (26% and 57%, respectively), but intensified in the control group (-5% and -8%, respectively).
    Conclusions: This study demonstrated the potential of manipulative rehabilitation and importance of post-operative management after lumbar disc surgery. Definitive trials with larger sample sizes are required to confirm the feasibility and potential therapeutic effectiveness of this approach.
    Language English
    Publishing date 2017-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1184721-9
    ISSN 1878-6324 ; 1053-8127
    ISSN (online) 1878-6324
    ISSN 1053-8127
    DOI 10.3233/BMR-169546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4580: Show issues Location:
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  3. Book ; Online: Gender, women, and the tobacco epidemic / edited by Jonathan M. Samet and Soon-Young Yoon

    Samet, Jonathan M / Yoon, Soon-Young / World Health Organization

    2010  

    Abstract: 249 p. ...

    Abstract 249 p.
    Keywords Smoking ; Women's health ; Women ; Tobacco ; Smoking and Health ; epidemiology ; adverse effects
    Language English
    Publisher Geneva : World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Gender, women, and the tobacco epidemic / edited by Jonathan M. Samet and Soon-Young Yoon

    Samet, Jonathan M / Yoon, Soon-Young / World Health Organization

    2010  

    Abstract: 249 p. ...

    Abstract 249 p.
    Keywords Smoking ; Women's Health ; Women ; Tobacco ; Smoking and Health ; epidemiology ; adverse effects
    Language English
    Publisher World Health Organization
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Deep learning segmentation and registration-driven lung parenchymal volume and movement CT analysis in prone positioning.

    Park, Hyungin / Yoon, Soon Ho

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0299366

    Abstract: Purpose: To conduct a volumetric and movement analysis of lung parenchyma in prone positioning using deep neural networks (DNNs).: Method: We included patients with suspected interstitial lung abnormalities or disease who underwent full-inspiratory ... ...

    Abstract Purpose: To conduct a volumetric and movement analysis of lung parenchyma in prone positioning using deep neural networks (DNNs).
    Method: We included patients with suspected interstitial lung abnormalities or disease who underwent full-inspiratory supine and prone chest CT at a single institution between June 2021 and March 2022. A thoracic radiologist visually assessed the fibrosis extent in the total lung (using units of 10%) on supine CT. After preprocessing the images into 192×192×192 resolution, a DNN automatically segmented the whole lung and pulmonary lobes in prone and supine CT images. Affine registration matched the patient's center and location, and the DNN deformably registered prone and supine CT images to calculate the x-, y-, z-axis, and 3D pixel movements.
    Results: In total, 108 CT pairs had successful registration. Prone positioning significantly increased the left lower (90.2±69.5 mL, P = 0.000) and right lower lobar volumes (52.5±74.2 mL, P = 0.000). During deformable registration, the average maximum whole-lung pixel movements between the two positions were 1.5, 1.9, 1.6, and 2.8 cm in each axis and 3D plane. Compared to patients with <30% fibrosis, those with ≥30% fibrosis had smaller volume changes (P<0.001) and smaller pixel movements in all axes between the positions (P = 0.000-0.007). Forced vital capacity (FVC) correlated with the left lower lobar volume increase (Spearman correlation coefficient, 0.238) and the maximum whole-lung pixel movements in all axes (coefficients, 0.311 to 0.357).
    Conclusions: Prone positioning led to the preferential expansion of the lower lobes, correlated with FVC, and lung fibrosis limited lung expansion during prone positioning.
    MeSH term(s) Humans ; Deep Learning ; Prone Position ; Pulmonary Fibrosis ; Respiration ; Lung/diagnostic imaging
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Real-time Ray Tracing for Cardiothoracic Imaging.

    Yoon, Soon Ho / Goo, Hyun Woo

    Radiology. Cardiothoracic imaging

    2023  Volume 5, Issue 4, Page(s) e220304

    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6135
    ISSN (online) 2638-6135
    DOI 10.1148/ryct.220304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Changes in COVID-19 CT Manifestations with Vaccination and the Omicron Variant.

    Yoon, Soon Ho / Goo, Jin Mo

    Radiology

    2023  Volume 307, Issue 3, Page(s) e230454

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.230454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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  8. Article ; Online: Radiologic Abnormalities in Prolonged SARS-CoV-2 Infection: A Systematic Review.

    Beck, Kyongmin Sarah / Yoon, Jeong-Hwa / Yoon, Soon Ho

    Korean journal of radiology

    2024  Volume 25, Issue 5, Page(s) 473–480

    Abstract: We systematically reviewed radiological abnormalities in patients with prolonged SARS-CoV-2 infection, defined as persistently positive polymerase chain reaction (PCR) results for SARS-CoV-2 for > 21 days, with either persistent or relapsed symptoms. We ... ...

    Abstract We systematically reviewed radiological abnormalities in patients with prolonged SARS-CoV-2 infection, defined as persistently positive polymerase chain reaction (PCR) results for SARS-CoV-2 for > 21 days, with either persistent or relapsed symptoms. We extracted data from 24 patients (median age, 54.5 [interquartile range, 44-64 years]) reported in the literature and analyzed their representative CT images based on the timing of the CT scan relative to the initial PCR positivity. Our analysis focused on the patterns and distribution of CT findings, severity scores of lung involvement on a scale of 0-4, and the presence of migration. All patients were immunocompromised, including 62.5% (15/24) with underlying lymphoma and 83.3% (20/24) who had received anti-CD20 therapy within one year. Median duration of infection was 90 days. Most patients exhibited typical CT appearance of coronavirus disease 19 (COVID-19), including ground-glass opacities with or without consolidation, throughout the follow-up period. Notably, CT severity scores were significantly lower during ≤ 21 days than during > 21 days (
    MeSH term(s) Humans ; COVID-19/diagnostic imaging ; Tomography, X-Ray Computed/methods ; SARS-CoV-2 ; Lung/diagnostic imaging ; Middle Aged ; Adult ; Immunocompromised Host ; Female ; Male ; Severity of Illness Index
    Language English
    Publishing date 2024-04-29
    Publishing country Korea (South)
    Document type Journal Article ; Systematic Review ; Review
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2023.1149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Management of incidental anterior mediastinal lesions: summary of relevant studies.

    Yoon, Soon Ho

    Mediastinum (Hong Kong, China)

    2019  Volume 3, Page(s) 9

    Abstract: With the increasing use of chest computed tomography (CT) imaging, the detection of asymptomatic incidental lesions in the anterior mediastinum has become more frequent. The prevalence of incidental nodular lesions in the anterior mediastinum is 0.49% to ...

    Abstract With the increasing use of chest computed tomography (CT) imaging, the detection of asymptomatic incidental lesions in the anterior mediastinum has become more frequent. The prevalence of incidental nodular lesions in the anterior mediastinum is 0.49% to 0.89%. Most of these lesions manifest as soft tissue nodules measuring between 10 and 30 mm on non-contrast CT images. Thymic epithelial tumors are mainly responsible for larger lesions, while smaller lesions are primarily benign cysts. Most incidental thymic epithelial tumors are early-stage and have a favorable outcome. During follow-up, most lesions are stable, but some show indolent growth. Incidental lesions can be managed by a conservative patient-tailored approach with regular follow-up and the use of non-invasive imaging modalities such as magnetic resonance imaging.
    Language English
    Publishing date 2019-03-20
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med.2019.03.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ChatGPT Vision for Radiological Interpretation: An Investigation Using Medical School Radiology Examinations.

    Kim, Hyungjin / Kim, Paul / Joo, Ijin / Kim, Jung Hoon / Park, Chang Min / Yoon, Soon Ho

    Korean journal of radiology

    2024  Volume 25, Issue 4, Page(s) 403–406

    MeSH term(s) Humans ; Schools, Medical ; Radiography ; Radiology
    Language English
    Publishing date 2024-03-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2024.0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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