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Article ; Online: KNOCKDOWN OF CIRC_0001379 ATTENUATES HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE APOPTOSIS AND INFLAMMATORY RESPONSE BY MIR-98-5P/SOX6 AXIS.

Wang, Kun / Wang, Huifeng / Zhang, Qiang / Liu, Feijun

2023 Volume 60, Issue 3, Page(s) 410–418

Abstract: Abstract: Background: Aberrant expression of circular RNAs (circRNAs) has been revealed to have crucial roles in the pathological processes of cardiovascular disease. Here, this study aimed to investigate the role and mechanism of circ_0001379 in ... ...

Abstract	Abstract: Background: Aberrant expression of circular RNAs (circRNAs) has been revealed to have crucial roles in the pathological processes of cardiovascular disease. Here, this study aimed to investigate the role and mechanism of circ_0001379 in hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury to explore the potential action of circ_0001379 in acute myocardial infarction (AMI). Methods: Levels of genes and proteins were examined by quantitative real-time polymerase chain reaction and western blot. Cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, and flow cytometry were used to detect cardiomyocyte proliferation and apoptosis, respectively. The activity of IL-1β, IL-6, and TNF-α was determined by ELISA analysis. The target relationship between miR-98-5p and circ_0001379 or SOX6 (SRY-Box Transcription Factor 6) was verified by dual-luciferase reporter and RNA immunoprecipitation assays. Results: Circ_0001379 was highly expressed in AMI mouse model and H/R-induced cardiomyocytes. Functionally, circ_0001379 silencing attenuated H/R-evoked cardiomyocyte apoptosis and inflammatory response. Mechanistically, circ_0001379 functioned as a sponge for miR-98-5p, which directly targeted SOX6. Moreover, circ_0001379 could regulate SOX6 expression via sponging miR-98-5p. Further rescue experiments showed that inhibition of miR-98-5p reversed the protective effects of circ_0001379 silencing on H/R-induced cardiomyocytes. Besides that, miR-98-5p overexpression abolished H/R-evoked cardiomyocyte apoptosis and inflammatory response, while this condition was abated by SOX6. Conclusion: Circ_0001379 silencing protects cardiomyocytes from H/R-induced apoptosis and inflammatory response by miR-98-5p/SOX6 axis, suggesting a novel therapeutic strategy for AMI prevention.
MeSH term(s)	Animals ; Mice ; Apoptosis/genetics ; Cell Proliferation ; Hypoxia ; MicroRNAs/genetics ; Myocytes, Cardiac ; Tumor Necrosis Factor-alpha ; RNA, Circular/genetics
Chemical Substances	MicroRNAs ; Tumor Necrosis Factor-alpha ; Sox6 protein, mouse ; RNA, Circular
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000002178
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endothelial dysfunction of syphilis: Pathogenesis.

Liu, Zhaoping / Zhang, Xiaohong / Xiong, Shun / Huang, Shaobin / Ding, Xuan / Xu, Man / Yao, Jiangchen / Liu, Shuangquan / Zhao, Feijun

Journal of the European Academy of Dermatology and Venereology : JEADV

2024

Abstract: Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining ...

Abstract	Treponema pallidum is the causative factor of syphilis, a sexually transmitted disease (STD) characterized by perivascular infiltration of inflammatory cells, vascular leakage, swelling and proliferation of endothelial cells (ECs). The endothelium lining blood and lymphatic vessels is a key barrier separating body fluids from host tissues and is a major target of T. pallidum. In this review, we focus on how T. pallidum establish intimate interactions with ECs, triggering endothelial dysfunction such as endothelial inflammation, abnormal repairment and damage of ECs. In addition, we summarize that migration and invasion of T. pallidum across vascular ECs may occur through two pathways. These two mechanisms of transendothelial migration are paracellular and cholesterol-dependent, respectively. Herein, clarifying the relationship between T. pallidum and endothelial dysfunction is of great significance to provide novel strategies for diagnosis and prevention of syphilis, and has a great potential prospect of clinical application.
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19899
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Hydrophobic modification of cellulose nanofibers by gallic acid and the application in pressure sensing.

Li, Zhimao / Yan, Chunxia / Xu, Wenjing / Shang, Yanlong / Wu, Qian / Mehmood, Saqib / Wang, Feijun / Cheng, Chunzu / Liu, Qiong / Shao, Ziqiang

International journal of biological macromolecules

2024 Volume 261, Issue Pt 2, Page(s) 129770

Abstract: Via rational molecular structure design and using gallic acid (GA) for hydrophobic modification of cellulose nanofibers (CNF), the "polymer dipole" CNF-GA with hydrophilic main chains and hydrophobic side chains was prepared, which improved the poor ... ...

Abstract	Via rational molecular structure design and using gallic acid (GA) for hydrophobic modification of cellulose nanofibers (CNF), the "polymer dipole" CNF-GA with hydrophilic main chains and hydrophobic side chains was prepared, which improved the poor piezoelectric properties of CNF used for preparing pressure sensors. Due to the appearance of the side chains, the elongation at break of the CNF-GA-2, compared with CNF, was enhanced by 186 %, and the excellent tensile strength, puncture load, and tearing strength were displayed. Moreover, the significant glass transition temperature (T
MeSH term(s)	Humans ; Cellulose/chemistry ; Nanofibers/chemistry ; Polymers ; Tensile Strength ; Hydrophobic and Hydrophilic Interactions ; Nitrites ; Transition Elements
Chemical Substances	Cellulose (9004-34-6) ; MXene ; Polymers ; Nitrites ; Transition Elements
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.129770
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Article ; Online: Advances in embedding techniques of anthocyanins: Improving stability, bioactivity and bioavailability.

Cheng, Yingying / Liu, Jiayi / Li, Ling / Ren, Jiali / Lu, Jun / Luo, Feijun

Food chemistry: X

2023 Volume 20, Page(s) 100983

Abstract: The health benefits of anthocyanins have attracted extensive research interest. However, anthocyanins are sensitive to certain environmental and gastrointestinal conditions and have low oral bioavailability. It has been reported that delivery systems ... ...

Abstract	The health benefits of anthocyanins have attracted extensive research interest. However, anthocyanins are sensitive to certain environmental and gastrointestinal conditions and have low oral bioavailability. It has been reported that delivery systems made in different ways could improve the stability, bioavailability and bioactivity of anthocyanins. This present review summarizes the factors affecting the stability of anthocyanins and the reasons for poor bioavailability, and various technologies for encapsulation of anthocyanins including microcapsules, nanoemulsions, microemulsions, Pickering emulsions, nanoliposomes, nanoparticles, hydrogels and co-assembly with amphiphilic peptides were discussed. In particular, the effects of these encapsulation technologies on the stability, bioavailability and bioactivities of anthocyanins
Language	English
Publishing date	2023-11-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2023.100983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insight into the invasion process and immune-protective evaluation of Tp0971, a membrane lipoprotein from

Zhang, Xiaohong / Duan, Junxia / Wang, Yali / Xie, Bibo / Zhou, Jie / Zhao, Sisi / Yin, Weiguo / Liu, Peng / Zhao, Feijun

Microbiology spectrum

2023 Volume 11, Issue 6, Page(s) e0004723

Abstract: Importance: The past two decades have seen a worldwide resurgence in infections caused ... ...

Abstract	Importance: The past two decades have seen a worldwide resurgence in infections caused by
MeSH term(s)	Animals ; Humans ; Treponema pallidum/genetics ; Syphilis/prevention & control ; Spirochaetales ; Lipoproteins ; Vaccines
Chemical Substances	Lipoproteins ; Vaccines
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00047-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions.

Qin, Dandan / Han, Shuai / Liu, Menglin / Guo, Tianyi / Hu, Zuomin / Zhou, Yaping / Luo, Feijun

International journal of biological macromolecules

2023 Volume 230, Page(s) 123163

Abstract: Phellinus linteus (P. linteus) is a famous Chinese medicine and has a long history in China. In recent years, P. linteus polysaccharides (PLPs) have attracted extensive attention because of their biological activities such as anti-bacteria, anti-aging, ... ...

Abstract	Phellinus linteus (P. linteus) is a famous Chinese medicine and has a long history in China. In recent years, P. linteus polysaccharides (PLPs) have attracted extensive attention because of their biological activities such as anti-bacteria, anti-aging, anti-oxidation, anti-inflammation, anti-tumor, hepatoprotective effect and hypoglycemic effect. In this review, we systemically summarized the advances in extractions, purifications and structural characterizations of PLPs, and also analyzed their biological functions and molecular mechanisms. Meanwhile, the structure-activity relationships of PLPs are closely related to their anti-oxidation and anti-tumor activities. So far, the applications of PLPs are still very limited, further exploring structure-activity relationships, biological functions and their mechanisms of PLPs will promote to develop functional foods.
MeSH term(s)	Basidiomycota/chemistry ; Polysaccharides/pharmacology ; Polysaccharides/chemistry ; Anti-Inflammatory Agents ; China
Chemical Substances	Polysaccharides ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-01-06
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123163
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Article: Identification and Verification of Potential Hub Genes in Amphetamine-Type Stimulant (ATS) and Opioid Dependence by Bioinformatic Analysis.

Zhang, Wei / Deng, Xiaodong / Liu, Huan / Ke, Jianlin / Xiang, Mingliang / Ma, Ying / Zhang, Lixia / Yang, Ming / Liu, Yun / Huang, Feijun

Frontiers in genetics

2022 Volume 13, Page(s) 837123

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.837123
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Article ; Online: A Comprehensive Review of Health-Benefiting Components in Rapeseed Oil.

Shen, Junjun / Liu, Yejia / Wang, Xiaoling / Bai, Jie / Lin, Lizhong / Luo, Feijun / Zhong, Haiyan

Nutrients

2023 Volume 15, Issue 4

Abstract: Rapeseed oil is the third most consumed culinary oil in the world. It is well-known for its high content of unsaturated fatty acids, especially polyunsaturated fatty acids, which make it of great nutritional value. There is increasing evidence that a ... ...

Abstract	Rapeseed oil is the third most consumed culinary oil in the world. It is well-known for its high content of unsaturated fatty acids, especially polyunsaturated fatty acids, which make it of great nutritional value. There is increasing evidence that a diet rich in unsaturated fatty acids offers health benefits. Although the consumption of rapeseed oil cuts across many areas around the world, the nutritional elements of rapeseed oil and the exact efficacy of the nutrients remain unclear. In this review, we systematically summarized the latest studies on functional rapeseed components to ascertain which component of canola oil contributes to its function. Apart from unsaturated fatty acids, there are nine functional components in rapeseed oil that contribute to its anti-microbial, anti-inflammatory, anti-obesity, anti-diabetic, anti-cancer, neuroprotective, and cardioprotective, among others. These nine functional components are vitamin E, flavonoids, squalene, carotenoids, glucoraphanin, indole-3-Carbinol, sterols, phospholipids, and ferulic acid, which themselves or their derivatives have health-benefiting properties. This review sheds light on the health-benefiting effects of rapeseed oil in the hope of further development of functional foods from rapeseed.
MeSH term(s)	Rapeseed Oil ; Plant Oils/pharmacology ; Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated ; Phospholipids ; Brassica napus ; Fatty Acids
Chemical Substances	Rapeseed Oil ; Plant Oils ; Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated ; Phospholipids ; Fatty Acids
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040999
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dietary flavonoids prevent diabetes through epigenetic regulation: advance and challenge

Han, Shuai / Luo, Yi / Liu, Bo / Guo, Tianyi / Qin, Dandan / Luo, Feijun

Critical Reviews in Food Science and Nutrition. 2023 Dec. 20, v. 63, no. 33 p.11925-11941

2023

Abstract: The pathophysiology of diabetes has been studied extensively in various countries, but effective prevention and treatment methods are still insufficient. In recent years, epigenetics has received increasing attention from researchers in exploring the ... ...

Abstract	The pathophysiology of diabetes has been studied extensively in various countries, but effective prevention and treatment methods are still insufficient. In recent years, epigenetics has received increasing attention from researchers in exploring the etiology and treatment of diabetes. DNA methylation, histone modifications, and non-coding RNAs play critical roles in the occurrence, maintenance, and progression of diabetes and its complications. Therefore, preventing or reversing the epigenetic alterations that occur during the development of diabetes may reduce the individual and societal burden of the disease. Dietary flavonoids serve as natural epigenetic modulators for the discovery of biomarkers for diabetes prevention and the development of alternative therapies. However, there is limited knowledge about the potential beneficial effects of flavonoids on the epigenetics of diabetes. In this review, the multidimensional epigenetic effects of different flavonoid subtypes in diabetes were summarized. Furthermore, it was discussed that parental flavonoid diets might reduce diabetes incidence in offspring, which represent a promising opportunity to prevent diabetes in the future. Future work will depend on exploring anti-diabetic effects of different flavonoids with different epigenetic regulation mechanisms and clinical trials.Highlights• “Epigenetic therapy” could reduce the burden of diabetic patients • “Epigenetic diet” ameliorates diabetes • Targeting epigenetic regulations by dietary flavonoids in the diabetes prevention • Dietary flavonoids prevent diabetes via transgenerational epigenetic inheritance
Keywords	DNA methylation ; biomarkers ; diabetes ; epigenetics ; etiology ; flavonoids ; food science ; histones ; nutrition ; pathophysiology ; progeny ; dietary flavonoids ; transgenerational epigenetic inheritance
Language	English
Dates of publication	2023-1220
Size	p. 11925-11941.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2097637
Database	NAL-Catalogue (AGRICOLA)

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Z 2732: Show issues

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Article ; Online: Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions

Qin, Dandan / Han, Shuai / Liu, Menglin / Guo, Tianyi / Hu, Zuomin / Zhou, Yaping / Luo, Feijun

International Journal of Biological Macromolecules. 2023 Mar., v. 230 p.123163-

2023

Abstract	Phellinus linteus (P. linteus) is a famous Chinese medicine and has a long history in China. In recent years, P. linteus polysaccharides (PLPs) have attracted extensive attention because of their biological activities such as anti-bacteria, anti-aging, anti-oxidation, anti-inflammation, anti-tumor, hepatoprotective effect and hypoglycemic effect. In this review, we systemically summarized the advances in extractions, purifications and structural characterizations of PLPs, and also analyzed their biological functions and molecular mechanisms. Meanwhile, the structure-activity relationships of PLPs are closely related to their anti-oxidation and anti-tumor activities. So far, the applications of PLPs are still very limited, further exploring structure-activity relationships, biological functions and their mechanisms of PLPs will promote to develop functional foods.
Keywords	Oriental traditional medicine ; Phellinus linteus ; glycemic effect ; hepatoprotective effect ; polysaccharides ; systematic review ; China ; Phellinus linteus polysaccharides ; Extraction methods ; Structural characterization ; Biological activities ; Structure-activity relationship ; P. linteus ; PLPs ; TCA ; FT-IR ; HPGPC ; NMR ; GC–MS ; GC ; SEC-MALLS-RI-VISC ; AFM ; HPAEC ; HPSEC-MALLS ; DLS ; SEM ; ROS ; DPPH ; ABTS ; TEAC ; FRAP ; SOD ; CAT ; GSH-Px ; TAA ; GSTA4 ; PCR ; BHMT1 ; APAP ; ALT ; AST ; MDA ; H2O2 ; CYP ; UGTs ; SULTs ; STZ ; DM ; IRS1 ; FOXO ; PC ; PE ; FBPase ; G6Pase ; GLUT2 ; GCK ; CPT1A ; ACOX1 ; LDLR ; HMGCR ; Bcl-2 ; Akt ; PGE2 ; Reg IV ; EGFR ; LPS ; CRP ; TNF-α ; IL-6 ; TLR4 ; JNK ; NF-κB ; Cldn1 ; ZO1 ; Ocln ; PCoA ; IR ; HK ; PK ; NOD ; IFN-γ ; IL-2 ; IL-4 ; MAPK ; AP-1 ; NO ; IL-1β ; IL-12 ; PPAR ; DSS ; AMPK ; PTK ; PKC ; Ara ; Fuc ; Fru ; Gal ; Gal A ; Glc ; GlcN ; Glu A ; Man ; Rha ; Xyl ; ARTP
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123163
Database	NAL-Catalogue (AGRICOLA)

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