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  1. Article ; Online: Perceived coercion, perceived pressures and procedural justice arising from global lockdowns during the COVID-19 pandemic: A scoping review.

    Ranieri, Veronica / Kamboj, Sunjeev K / Edwards, Sarah J L

    PLOS global public health

    2023  Volume 3, Issue 3, Page(s) e0001250

    Abstract: This aim of this scoping review is to map what is known about perceived coercion, perceived pressures and procedural justice within the context of the general population's experience of 'lockdowns' imposed by governments worldwide in response to the ... ...

    Abstract This aim of this scoping review is to map what is known about perceived coercion, perceived pressures and procedural justice within the context of the general population's experience of 'lockdowns' imposed by governments worldwide in response to the increased transmission of COVID-19. Arksey & O'Malley's (2005) framework for conducting scoping reviews was chosen. A sensitive search strategy was devised and conducted using PubMed, Scopus, and Web of Science using the following search terms: (adherence OR acceptance OR agreement OR trust OR distrust OR compliance OR willing*) OR (perceived coerc* OR percept* coerc* OR pressure OR force OR influence OR control OR threat OR justice) AND (lockdown) AND (COVID OR SARS-CoV-2 OR COVID-19). The database search initially produced 41,628 articles to screen. A total of 40 articles were included in this review and the following five themes were identified from the studies: perceived acceptability and willingness to adhere to lockdown; perceived control during lockdown; perceived pressures arising from lockdown; perceived threat of sanction from others and the procedural (in)justice of lockdown. Our synthesis suggests that i) individuals experienced an initial willingness and tolerance of lockdown that lessened over time as perceptions of personal control decreased; ii) that social influences may pressure individuals to follow or break lockdown rules; and iii) that justifiability and proportionality together with individuals' perceptions of harm from COVID-19 may impact the extent to which individuals adhere to lockdown. Furthermore, the review found an absence of information regarding specific individual characteristics and circumstances that increase the likelihood of experiencing perceived coercion and its related constructs and highlights a need for a better understanding of the cultural and socioeconomic factors affecting perceptions of, and adherence to, lockdown.
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0001250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Limitations to Contingency Measures: Reflections from COVID-19 Surges in the UK.

    Gordon, Caitlin / Yardley, Sarah / Lomas, David A / Edwards, Sarah J L

    The American journal of bioethics : AJOB

    2021  Volume 21, Issue 8, Page(s) 31–34

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; United Kingdom
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2021.1940365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perceived coercion, perceived pressures and procedural justice arising from global lockdowns during the COVID-19 pandemic

    Veronica Ranieri / Sunjeev K Kamboj / Sarah J L Edwards

    PLOS Global Public Health, Vol 3, Iss 3, p e

    A scoping review.

    2023  Volume 0001250

    Abstract: This aim of this scoping review is to map what is known about perceived coercion, perceived pressures and procedural justice within the context of the general population's experience of 'lockdowns' imposed by governments worldwide in response to the ... ...

    Abstract This aim of this scoping review is to map what is known about perceived coercion, perceived pressures and procedural justice within the context of the general population's experience of 'lockdowns' imposed by governments worldwide in response to the increased transmission of COVID-19. Arksey & O'Malley's (2005) framework for conducting scoping reviews was chosen. A sensitive search strategy was devised and conducted using PubMed, Scopus, and Web of Science using the following search terms: (adherence OR acceptance OR agreement OR trust OR distrust OR compliance OR willing*) OR (perceived coerc* OR percept* coerc* OR pressure OR force OR influence OR control OR threat OR justice) AND (lockdown) AND (COVID OR SARS-CoV-2 OR COVID-19). The database search initially produced 41,628 articles to screen. A total of 40 articles were included in this review and the following five themes were identified from the studies: perceived acceptability and willingness to adhere to lockdown; perceived control during lockdown; perceived pressures arising from lockdown; perceived threat of sanction from others and the procedural (in)justice of lockdown. Our synthesis suggests that i) individuals experienced an initial willingness and tolerance of lockdown that lessened over time as perceptions of personal control decreased; ii) that social influences may pressure individuals to follow or break lockdown rules; and iii) that justifiability and proportionality together with individuals' perceptions of harm from COVID-19 may impact the extent to which individuals adhere to lockdown. Furthermore, the review found an absence of information regarding specific individual characteristics and circumstances that increase the likelihood of experiencing perceived coercion and its related constructs and highlights a need for a better understanding of the cultural and socioeconomic factors affecting perceptions of, and adherence to, lockdown.
    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Author Correction: Millennial-scale glacial climate variability in Southeastern Alaska follows Dansgaard-Oeschger cyclicity.

    Wilcox, Paul S / Dorale, Jeffrey A / Baichtal, James F / Spötl, Christoph / Fowell, Sarah J / Edwards, R Lawrence / Kovarik, Johanna L

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3033

    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29698-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Host range of SARS-CoV-2 and implications for public health.

    Santini, Joanne M / Edwards, Sarah J L

    The Lancet. Microbe

    2020  Volume 1, Issue 4, Page(s) e141–e142

    MeSH term(s) COVID-19/epidemiology ; Host Specificity ; Humans ; Public Health ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30069-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anthroponotic risk of SARS-CoV-2, precautionary mitigation, and outbreak management.

    Edwards, Sarah J L / Santini, Joanne M

    The Lancet. Microbe

    2020  Volume 1, Issue 5, Page(s) e187–e188

    MeSH term(s) COVID-19/epidemiology ; Disease Outbreaks/prevention & control ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Journal Article
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30086-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is equipoise a useful concept to justify randomised controlled trials in the cultural context of Pakistan? A survey of clinicians in relation to a trial of talking therapy for young people who self-harm.

    Memon, Rakhshi / Asif, Muqaddas / Pitman, Alexandra / Chaudhry, Nasim / Husain, Nusrat / Edwards, Sarah J L

    Trials

    2023  Volume 24, Issue 1, Page(s) 506

    Abstract: Background: Clinical equipoise, also defined as the uncertainty principle, is considered essential when recruiting subjects to a clinical trial. However, equipoise is threatened when clinicians are influenced by their own preferences. Little research ... ...

    Abstract Background: Clinical equipoise, also defined as the uncertainty principle, is considered essential when recruiting subjects to a clinical trial. However, equipoise is threatened when clinicians are influenced by their own preferences. Little research has investigated equipoise in the context of trial recruitment.
    Methods: This cross-sectional survey sought clinicians' views (operationalised as 11 statements relating to treatments offered in a trial of a psychological intervention for young people) about equipoise and individual treatment preferences in the context of moral justification for recruiting young people at risk of self-harm or suicide to a randomised controlled trial (RCT) to evaluate the Youth Culturally Adapted Manual Assisted Psychological Intervention (Y-CMAP) in Pakistan. We compared the views of clinicians involved in Y-CMAP RCT recruitment to those of a sample of clinicians not involved in trial recruitment but treating similar patients, comparing their sociodemographic characteristics and the proportions of those in each group agreeing with each statement.
    Results: There was a response rate of 96% (75/78). Findings showed that, during trial recruitment and before the RCT results were known, the majority of all responding clinicians (73.3%) considered Y-CMAP to be an effective treatment for young people at risk of self-harm or suicide. Although there was an acknowledgement of individual preferences for the intervention, there was near consensus (90%) on the need to conduct an RCT for reaching an evidence-based decision. However, there were no significant differences in the proportion of recruiting clinicians reporting a treatment preference for Y-CMAP than non-recruiting clinicians (31 (88.6%) versus 36 (90%), p = 0.566). A significantly higher proportion of non-recruiting clinicians (87.5%) as compared to (48.5%) in the trial (p = 0.000) stated that there may be other treatments that may be equally good for the patients, seemingly undermining a preference for the intervention. Those reporting a treatment preference also acknowledged that there was nothing on which this preference was based, however confident they felt about them, thus accepting clinical equipoise as ethical justification for conducting the RCT. There was a significant group difference in views that treatment overall is better as a result of young patients' participation in the Y-CMAP trial (p = 0.015) (i.e. more clinicians not involved in the trial agreed with this statement). Similarly, more clinicians not involved in the trial agreed on the perceived availability of other treatment options that were good for young people at risk of self-harm (p < 0.05).
    Conclusions: The paper highlights that clinicians in Pakistan accept the notion of clinical equipoise as an ethical justification for patient participation in RCTs. The need for conducting RCTs to generate evidence base and to reduce bias was considered important by the clinical community.
    MeSH term(s) Adolescent ; Humans ; Pakistan ; Patient Selection ; Uncertainty ; Treatment Outcome ; Self-Injurious Behavior/diagnosis ; Self-Injurious Behavior/therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07397-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia.

    Edwards, Lauren / Thomas, Kelsey R / Weigand, Alexandra J / Edmonds, Emily C / Clark, Alexandra L / Brenner, Einat K / Banks, Sarah J / Gilbert, Paul E / Nation, Daniel A / Delano-Wood, Lisa / Bondi, Mark W / Bangen, Katherine J

    Cerebral circulation - cognition and behavior

    2024  Volume 6, Page(s) 100206

    Abstract: This study assessed whether the effect of vascular risk on cerebral blood flow (CBF) varies by gene dose of apolipoprotein (APOE) ε4 alleles. 144 older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent arterial spin ... ...

    Abstract This study assessed whether the effect of vascular risk on cerebral blood flow (CBF) varies by gene dose of apolipoprotein (APOE) ε4 alleles. 144 older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent arterial spin labeling and T1-weighted MRI, APOE genotyping, fluorodeoxyglucose positron emission tomography (FDG-PET), lumbar puncture, and blood pressure (BP) assessment. Vascular risk was assessed using pulse pressure (systolic BP - diastolic BP). CBF was examined in six AD-vulnerable regions: entorhinal cortex, hippocampus, inferior temporal cortex, inferior parietal cortex, rostral middle frontal gyrus, and medial orbitofrontal cortex. Linear regressions tested the interaction between APOE ε4 dose and pulse pressure on CBF in each region, adjusting for age, sex, cognitive classification, antihypertensive medication use, FDG-PET, reference CBF region, and AD biomarker positivity. There was a significant interaction between pulse pressure and APOE ɛ4 dose on CBF in the entorhinal cortex, hippocampus, and inferior parietal cortex, such that higher pulse pressure was associated with lower CBF only among ε4 homozygous participants. These findings demonstrate that the association between pulse pressure and regional CBF differs by APOE ε4 dose, suggesting that targeting modifiable vascular risk factors may be particularly important for those genetically at risk for AD.
    Language English
    Publishing date 2024-01-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-2450
    ISSN (online) 2666-2450
    DOI 10.1016/j.cccb.2024.100206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Setting up Functional Neurological Disorder Treatment Services: Questions and Answers.

    Finkelstein, Sara A / Carson, Alan / Edwards, Mark J / Kozlowska, Kasia / Lidstone, Sarah C / Perez, David L / Polich, Ginger / Stone, Jon / Aybek, Selma

    Neurologic clinics

    2023  Volume 41, Issue 4, Page(s) 729–743

    Abstract: Functional neurologic disorder (FND) is commonly encountered across outpatient and inpatient medical settings. Given the potential for a high burden of disability in some patients and mounting evidence for the efficacy of FND-specific multidisciplinary ... ...

    Abstract Functional neurologic disorder (FND) is commonly encountered across outpatient and inpatient medical settings. Given the potential for a high burden of disability in some patients and mounting evidence for the efficacy of FND-specific multidisciplinary treatment services, expanding clinical services for this population is a necessity. In this perspective article, we discuss considerations for creating FND services, including the types of services that exist, how to start, how to identify appropriate referrals, and how to develop and monitor individualized treatment plans. In addition, we discuss how this effort can be done sustainably - balancing patient needs with limited healthcare resources.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2023.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Host range of SARS-CoV-2 and implications for public health

    Joanne M Santini / Sarah J L Edwards

    The Lancet Microbe, Vol 1, Iss 4, Pp e141-e

    2020  Volume 142

    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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