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  1. Book: Manual of biological markers of disease

    Venrooij, Walther J. van

    1996  

    Author's details ed. by W. J. van Venrooij
    Keywords Biological Markers
    Language English
    Size Getr. Zählung
    Publisher Kluwer Acad. Publ
    Publishing place Dordrecht u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007630230
    ISBN 0-7923-4242-9 ; 0-7923-4243-7 ; 978-0-7923-4242-7 ; 978-0-7923-4243-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1997 A 6445 order for loan Magazin

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  2. Book: Structure and function of eukaryotic RNP

    Venrooij, Walther J. van

    Heidelberg, Oct. 22 - 24, 1987

    (Molecular biology reports ; 12,3 : Spec. Issue)

    1987  

    Author's details [guest ed.:] W. J. van Venrooij
    Series title Molecular biology reports ; 12,3 : Spec. Issue
    Keywords Ribonucleoproteins / congresses
    Size S. 135 - 249 : Ill., graph. Darst.
    Publisher Nijhoff
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT003079215
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1140 -12- verfügbar in Königswinter Königswinter

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  3. Article ; Online: How citrullination invaded rheumatoid arthritis research.

    van Venrooij, Walther J / Pruijn, Ger J M

    Arthritis research & therapy

    2014  Volume 16, Issue 1, Page(s) 103

    Abstract: Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial ... ...

    Abstract Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. In the first years after the initial publications, the focus was on the antibodies directed to citrullinated proteins. It is now realized that citrullinating enzymes and citrullinated proteins may have important roles in the maintenance of the inflammatory processes in the joints. There is also accumulating evidence for a direct role of citrullination in tissue destruction in the rheumatoid synovium. Here we will discuss the development and importance of anti-citrullinated protein antibodies in rheumatoid arthritis as well as recent findings implicating citrullination in the pathophysiology of rheumatoid arthritis.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Autoantibodies/immunology ; Autoantigens/immunology ; Citrulline/immunology ; Citrulline/metabolism ; Humans ; Proteins/immunology ; Proteins/metabolism
    Chemical Substances Autoantibodies ; Autoantigens ; Proteins ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2014-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar4458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Citrulline is an Essential Constituent of Antigenic Determinants Recognized by Rheumatoid Arthritis-specific Autoantibodies. 1998.

    Schellekens, Gerard A / de Jong, Ben A W / van den Hoogen, Frank H J / van de Putte, Leo B A / van Venrooij, Walther J

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Volume 195, Issue 1, Page(s) 8–16

    MeSH term(s) Arthritis, Rheumatoid/history ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Autoantibodies/history ; Autoantigens/history ; Autoimmunity ; Citrulline/history ; Citrulline/immunology ; History, 20th Century ; Humans
    Chemical Substances Autoantibodies ; Autoantigens ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2015-07-01
    Publishing country United States
    Document type Classical Article ; Historical Article ; Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 28: Show issues

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  5. Article ; Online: The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis.

    Pruijn, Ger Jm / Wiik, Allan / van Venrooij, Walther J

    Arthritis research & therapy

    2010  Volume 12, Issue 1, Page(s) 203

    Abstract: The presence or absence of antibodies to citrullinated peptides/proteins (ACPA) is an important parameter that helps a clinician set a diagnosis of early rheumatoid arthritis and, hence, initiate treatment. There are several commercial tests available to ...

    Abstract The presence or absence of antibodies to citrullinated peptides/proteins (ACPA) is an important parameter that helps a clinician set a diagnosis of early rheumatoid arthritis and, hence, initiate treatment. There are several commercial tests available to measure ACPA levels, although it can be difficult to decide what the best test for a given clinical question is. We analyzed literature data in which the diagnostic and other properties of various ACPA tests are compared. The results show that for diagnostic purposes the CCP2 test has the highest specificity, the highest sensitivity in stratified studies and the highest positive predictive value. For the prediction of future joint destruction the CCP2, MCV, and CCP3 tests may be used. The ability to predict the likelihood of not achieving sustained disease-modifying antirheumatic drug-free remission was highest for the CCP2 test. Finally, the levels of anti-CCP2 and anti-CCP3 (and possibly anti-mutated citrullinated vimentin) in rheumatoid arthritis patients are not significantly influenced by TNFalpha blocking agents.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/metabolism ; Autoantibodies/analysis ; Autoantibodies/blood ; Autoantigens/immunology ; Biomarkers/analysis ; Biomarkers/metabolism ; Citrulline/metabolism ; Humans ; Immunoassay/methods ; Peptides/metabolism ; Proteins/metabolism ; Sensitivity and Specificity
    Chemical Substances Autoantibodies ; Autoantigens ; Biomarkers ; Peptides ; Proteins ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2010
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Autoimmune diseases: early diagnosis and new treatment strategies.

    Konforte, Danijela / Diamandis, Eleftherios P / van Venrooij, Walther J / Lories, Rik / Ward, Michael M

    Clinical chemistry

    2012  Volume 58, Issue 11, Page(s) 1510–1514

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Autoantibodies/blood ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Biomarkers/analysis ; Citrulline/immunology ; Genetic Markers ; Genome-Wide Association Study ; Humans
    Chemical Substances Autoantibodies ; Biomarkers ; Genetic Markers ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2012-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2012.189480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: De vicieuze cirkel die leidt tot reumatoïde artritis: experimenteel bewijs voor de stappen in deze cyclus.

    van Venrooij, Walther J / Pruijn, Ger J M

    Nederlands tijdschrift voor geneeskunde

    2009  Volume 153, Page(s) B232

    Abstract: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the joints and the presence of anti-citrullinated protein autoantibodies (ACPA). ACPA are very specific for RA and are involved in its pathophysiology. Five steps, all of which are ... ...

    Title translation The vicious circle that leads to rheumatoid arthritis; experimental evidence of the steps involved in this circle.
    Abstract Rheumatoid arthritis (RA) is characterized by chronic inflammation of the joints and the presence of anti-citrullinated protein autoantibodies (ACPA). ACPA are very specific for RA and are involved in its pathophysiology. Five steps, all of which are supported by experimental evidence, can be distinguished during the development of the chronic inflammation in RA. Step 1: During inflammation a large influx of inflammatory cells takes place. These cells will ultimately die via apoptosis. When the dying cells are not cleared efficiently, citrullinated proteins and citrullinating enzymes are released into the extracellular space. Step 2: Extracellular proteins are citrullinated by these enzymes. Step 3: Only individuals with a certain genetic background produce ACPA. Step 4: Arthritis is induced by the formation of immune complexes of ACPA and citrullinated proteins. Step 5: These immune complexes stimulate the inflammation, which leads to the recruitment of new inflammatory cells. This establishes a vicious cycle, the RA cycle.
    MeSH term(s) Apoptosis/immunology ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/physiopathology ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Citrulline/immunology ; Citrulline/metabolism ; Humans ; Peptides, Cyclic/immunology
    Chemical Substances Autoantibodies ; Peptides, Cyclic ; cyclic citrullinated peptide ; Citrulline (29VT07BGDA)
    Language Dutch
    Publishing date 2009
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An important step towards completing the rheumatoid arthritis cycle.

    van Venrooij, Walther J / Pruijn, Ger J M

    Arthritis research & therapy

    2008  Volume 10, Issue 5, Page(s) 117

    Abstract: In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients, and that ... ...

    Abstract In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients, and that such immune complexes co-localize with complement factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid arthritis cycle) for the development and chronic nature of this disease.
    MeSH term(s) Antigen-Antibody Complex/blood ; Antigen-Antibody Complex/immunology ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/physiopathology ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoantigens/blood ; Autoantigens/immunology ; Complement C3/immunology ; Fibrinogen/immunology ; Fibrinogen/metabolism ; Humans
    Chemical Substances Antigen-Antibody Complex ; Autoantibodies ; Autoantigens ; Complement C3 ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2008
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: All you wanted to know about anti-CCP but were afraid to ask.

    Wiik, Allan S / van Venrooij, Walther J / Pruijn, Ger J M

    Autoimmunity reviews

    2010  Volume 10, Issue 2, Page(s) 90–93

    Abstract: The most specific biomarker associated with the diagnosis of rheumatoid arthritis (RA) is autoantibodies to citrullinated peptides/proteins (ACPA). Though recognized as an important marker of progressive erosive disease its use has been hampered by doubt ...

    Abstract The most specific biomarker associated with the diagnosis of rheumatoid arthritis (RA) is autoantibodies to citrullinated peptides/proteins (ACPA). Though recognized as an important marker of progressive erosive disease its use has been hampered by doubt about what is a positive versus a negative reaction in the several assays that have become available commercially. This review intends to indicate that the CCP2 assay has the highest specificity and sensitivity in stratified studies that encompass sera from RA patients and non-RA inflammatory controls compared to other ACPA tests. Still, larger and strictly stratified studies are highly warranted to substantiate this conclusion.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Autoantibodies/blood ; Autoantigens/immunology ; Citrulline/immunology ; Humans ; Peptides, Cyclic/immunology ; Rats ; Sensitivity and Specificity
    Chemical Substances Autoantibodies ; Autoantigens ; Peptides, Cyclic ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2010-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2010.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anti-CCP2 antibodies: an overview and perspective of the diagnostic abilities of this serological marker for early rheumatoid arthritis.

    van Venrooij, Walther J / Zendman, Albert J W

    Clinical reviews in allergy & immunology

    2007  Volume 34, Issue 1, Page(s) 36–39

    Abstract: The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of ... ...

    Abstract The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of the rheumatoid factor (70-75%). The antibodies can be detected very early in the disease and can be used as an indicator for the progression and prognosis of RA. In this review, these interesting properties and some future possibilities of this diagnostic test are discussed.
    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Biomarkers/blood ; Disease Progression ; Humans ; Peptides, Cyclic/immunology ; Prognosis ; Sensitivity and Specificity
    Chemical Substances Autoantibodies ; Biomarkers ; Peptides, Cyclic ; cyclic citrullinated peptide
    Language English
    Publishing date 2007-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-007-8029-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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