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Article ; Online: Special Issue on Synthesis of Novel Heterocyclic Compounds and Evaluation of Their Antimicrobial Activity

Anna Pawełczyk / Lucjusz Zaprutko

Applied Sciences, Vol 13, Iss 21, p

2023 Volume 11755

Abstract: Since their discovery or, to be exact, their definition, the chemistry of heterocyclic compounds has rapidly developed, and the range of their application has grown wider [.] ...

Abstract	Since their discovery or, to be exact, their definition, the chemistry of heterocyclic compounds has rapidly developed, and the range of their application has grown wider [.]
Keywords	n/a ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Kumquat Fruits as an Important Source of Food Ingredients and Utility Compounds

Pawełczyk, Anna / Żwawiak, Justyna / Zaprutko, Lucjusz

Food Reviews International. 2023 Feb. 17, v. 39, no. 2 p.875-895

2023

Abstract: The kumquat tree occurs in practically all countries of the subtropical zone. Kumquat fruits with a characteristic shape, size, colour and taste are the smallest of edible citrus and the only ones that can be eaten as a whole with the peel. Those fruits ... ...

Abstract	The kumquat tree occurs in practically all countries of the subtropical zone. Kumquat fruits with a characteristic shape, size, colour and taste are the smallest of edible citrus and the only ones that can be eaten as a whole with the peel. Those fruits are rich in fiber, carotenoids, vitamins and minerals. The most important components are polyphenols showing antioxidant properties, in particular flavonoids of which the one characteristic is phloretin. The essential oils extracted from them are rich in numerous terpenoids, responsible for fragrance and aroma. An extensive literature review was carried out to collect data on the chemical composition of kumquat fruit and other selected parts of the plant. These data, depending on the variety, origin, part of the plant and method of obtaining were compiled and presented in the appropriate tables and figures. The structures of the most important components were also presented. Due to their nutritional properties and biological activity (antioxidant, antimicrobial, antitumor etc.) these components are potential sources of ingredients for foods, phytopharmaceuticals and cosmetics.
Keywords	Citrus ; antioxidants ; bioactive properties ; carotenoids ; chemical composition ; color ; cosmetics ; flavonoids ; fruits ; kumquats ; odors ; phytopharmaceuticals ; polyphenols ; subtropics ; taste ; trees ; Kumquat fruits ; kumquat tree ; chemical composition of kumquat ; biological effects ; cosmetic potential ; nutritional potential
Language	English
Dates of publication	2023-0217
Size	p. 875-895.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	53834-6
ISSN	1525-6103 ; 8755-9129
ISSN (online)	1525-6103
ISSN	8755-9129
DOI	10.1080/87559129.2021.1928179
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Mediating Role of Organisational Identification between Psychological Contract and Work Results: An Individual Level Investigation.

Rogozińska-Pawełczyk, Anna / Gadomska-Lila, Katarzyna

International journal of environmental research and public health

2022 Volume 19, Issue 9

Abstract: The aim of this article is to identify the relationship between the fulfilment of relational and transactional psychological contracts and work results, taking into account the mediation effect expressed in organisational identification. The empirical ... ...

Abstract	The aim of this article is to identify the relationship between the fulfilment of relational and transactional psychological contracts and work results, taking into account the mediation effect expressed in organisational identification. The empirical research was conducted on a group of 402 HR professionals responsible for designing and implementing HR practices in one of the leading companies of the Polish energy sector. Hypotheses were tested using the partial least squares structural equation modelling technique (PLS-SEM). Based on our research, we found that the implementation of both relational and transactional psychological contracts positively influenced the results achieved by HR professionals, both directly and indirectly, through the mediating role of organisational identification. The results indicate that the relationship between the psychological contract and work results is stronger when mediated by organisational identification. It plays an important role, especially in relation to the transactional contract. The collected results lead to the conclusion that organisations, wishing to increase the level of work results achieved by HR professionals, should as much as possible fulfil the expectations of employees and meet the commitments made to them within the framework of the established psychological contract. The study makes an important contribution to the understanding of the "priority" importance of organisational identification in enhancing the efforts of HR professionals to deliver work results that benefit both employees and the organisation.
MeSH term(s)	Contracts ; Organizations ; Personal Satisfaction
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19095404
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Article: Novel Molecular Consortia of Cannabidiol with Nonsteroidal Anti-Inflammatory Drugs Inhibit Emerging Coronaviruses' Entry.

Pawełczyk, Anna / Nowak, Rafał / Gazecka, Monika / Jelińska, Anna / Zaprutko, Lucjusz / Zmora, Paweł

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: The COVID-19 pandemic provoked a global health crisis and highlighted the need for new therapeutic strategies. In this study, we explore the potential of the molecular consortia of cannabidiol (CBD) and non-steroidal anti-inflammatory drugs (NSAIDs) as ... ...

Abstract	The COVID-19 pandemic provoked a global health crisis and highlighted the need for new therapeutic strategies. In this study, we explore the potential of the molecular consortia of cannabidiol (CBD) and non-steroidal anti-inflammatory drugs (NSAIDs) as novel antiviral dual-target agents against SARS-CoV-2/COVID-19. CBD is a natural compound with a wide range of therapeutic activities, including antiviral and anti-inflammatory properties, while NSAIDs are commonly used to mitigate the symptoms of viral infections. Chemical modifications of CBD with NSAIDs were performed to obtain dual-target agents with enhanced activity against SARS-CoV-2. The synthesised compounds were characterised using spectroscopic techniques. The biological activity of three molecular consortia (CBD-ibuprofen, CBD-ketoprofen, and CBD-naproxen) was evaluated in cell lines transduced with vesicular stomatitis virus-based pseudotypes bearing the SARS-CoV-1 or SARS-CoV-2 spike proteins or infected with influenza virus A/Puerto Rico/8/34. The results showed that some CBD-NSAID molecular consortia have superior antiviral activity against SARS-CoV-1 and SARS-CoV-2, but not against the influenza A virus. This may suggest a potential therapeutic role for these compounds in the treatment of emerging coronavirus infections. Further studies are needed to investigate the efficacy of these compounds in vivo, and their potential use in clinical settings. Our findings provide a promising new approach to combatting current and future viral emergencies.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12070951
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Article ; Online: Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives.

Pawełczyk, Anna / Zaprutko, Lucjusz

Future medicinal chemistry

2020 Volume 12, Issue 19, Page(s) 1743–1757

Abstract: At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based on the analysis of numerous references and selected methods of computational ...

Abstract	At the end of 2019, a novel virus causing severe acute respiratory syndrome to spread globally. There are currently no effective drugs targeting SARS-CoV-2. In this study, based on the analysis of numerous references and selected methods of computational chemistry, the strategy of integrative structural modification of small molecules with antiviral activity into potential active complex molecules has been presented. Proposed molecules have been designed based on the structure of triterpene oleanolic acid and complemented by structures characteristic of selected anti-COVID therapy assisted drugs. Their pharmaceutical molecular parameters and the preliminary bioactivity were calculated and predicted. The results of the above analyses show that among the designed complex substances there are potential antiviral agents directed mainly on SARS-CoV-2.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; COVID-19 ; Cardiovascular Agents/chemistry ; Cardiovascular Agents/pharmacology ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Humans ; Oleanolic Acid/chemistry ; Oleanolic Acid/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Cardiovascular Agents ; Drugs, Chinese Herbal ; Oleanolic Acid (6SMK8R7TGJ)
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	England
Document type	Journal Article
ISSN	1756-8927
ISSN (online)	1756-8927
DOI	10.4155/fmc-2020-0204
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Satysfakcja z pracy a stres zawodowy – wyniki badań ilościowych w 3 jednostkach organizacyjnych urzędu.

Rogozińska-Pawełczyk, Anna

Medycyna pracy

2018 Volume 69, Issue 3, Page(s) 301–315

Abstract: Background: The influence of subjective perception of occupational stress and its individual factors on the overall level of job satisfaction was analyzed. The respondents were also asked to answer the question of the potential differences in terms of ... ...

Title translation	Job satisfaction vs. occupational stress - Quantitative analysis of 3 organizational units of a public sector institution.
Abstract	Background: The influence of subjective perception of occupational stress and its individual factors on the overall level of job satisfaction was analyzed. The respondents were also asked to answer the question of the potential differences in terms of variables in managers and non-managers, and in various demographic factors. Material and methods: This article presents the results of a study conducted among 5930 people employed in 3 units of the examined public sector institution. The research was conducted using computer-assisted web interview method. The parameters of the polynomial model of ordered categories were estimated. Results: The results showed a statistically significant effect between the variables and the differences between the groups of subjects. Analyzes showed slight differences between men and women. Employees with a low level of stress and high job satisfaction were noted in the oldest group, aged over 55 years, and in managers. Low levels of stress and job satisfaction were observed in young employees with the shortest period of employment. Among those least satisfied with the work and experiencing high levels of stress there were respondents with 6-15 years of employment in non-managerial positions. While the highest levels of stress and high satisfaction were found in people aged 46-55 years, with more than 20 years of work experience. Conclusions: The results of the estimation of the polynomial model parameters of ordered categories indicate that the level of perceived stress is related to the level of job satisfaction. The lower the level of stress and stressors in the workplace, the greater the job satisfaction in the surveyed unit. Med Pr 2018;69(3):301-315.
MeSH term(s)	Adult ; Age Factors ; Employment/psychology ; Employment/statistics & numerical data ; Female ; Humans ; Interpersonal Relations ; Job Satisfaction ; Male ; Middle Aged ; Occupational Stress/epidemiology ; Occupational Stress/psychology ; Personal Satisfaction ; Poland ; Public Sector ; Social Support ; Workplace/psychology ; Workplace/statistics & numerical data ; Young Adult
Language	Polish
Publishing date	2018-03-30
Publishing country	Poland
Document type	Journal Article
ZDB-ID	128739-4
ISSN	0465-5893
ISSN	0465-5893
DOI	10.13075/mp.5893.00695
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Article: Curcumin-Triterpene Type Hybrid as Effective Sonosensitizers for Sonodynamic Therapy in Oral Squamous Cell Carcinoma.

Sowa-Kasprzak, Katarzyna / Józkowiak, Małgorzata / Olender, Dorota / Pawełczyk, Anna / Piotrowska-Kempisty, Hanna / Zaprutko, Lucjusz

Pharmaceutics

2023 Volume 15, Issue 7

Abstract: Sonodynamic therapy (SDT) is a non-invasive therapeutic modality in cancer treatment that combines low-intensity ultrasound (US) and sonosensitizers. Tumor cells are destroyed through the synergistic effects of ultrasound and a chemical sonosensitizer. ... ...

Abstract	Sonodynamic therapy (SDT) is a non-invasive therapeutic modality in cancer treatment that combines low-intensity ultrasound (US) and sonosensitizers. Tumor cells are destroyed through the synergistic effects of ultrasound and a chemical sonosensitizer. This study focused on the synthesis and in vitro evaluation of the sonodynamic effect of natural curcumin, triterpene oleanolic acid, and their semi-synthetic derivatives on tongue cancer SCC-25 and hypopharyngeal FaDu cell lines. The combination of the tested compounds with sonication showed a synergistic increase in cytotoxicity. In the group of oleanolic acid derivatives, oleanoyl hydrogen succinate (
Language	English
Publishing date	2023-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15072008
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Article ; Online: Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review.

Żwawiak, Justyna / Pawełczyk, Anna / Olender, Dorota / Zaprutko, Lucjusz

Mini reviews in medicinal chemistry

2021 Volume 21, Issue 12, Page(s) 1509–1526

Abstract: Triterpenes are a wide and important group of compounds that have several promising pharmacological properties, such as hepatoprotective, anti-inflammatory, anti-HIV, antioxidant, or anticancer activities. Such potent substances can be successfully ... ...

Abstract	Triterpenes are a wide and important group of compounds that have several promising pharmacological properties, such as hepatoprotective, anti-inflammatory, anti-HIV, antioxidant, or anticancer activities. Such potent substances can be successfully incorporated in more complex chemical systems e.g. codrugs or pro-drugs that have a better pharmacological profile. The codrug is connected with a drug formation pathway to chemically cohere at least two drug molecules to improve positive therapeutic efficiency or decrease side effects. The codrug can be cleaved in the organism to generate effective compounds previously used as substrates. This article presents an overview of codrugs that consist of pentacyclic triterpene moiety that is chosen as a basic codrug moiety due to their wide range of vital activities and another drug molecule fragment. It was found that triterpenoid codrugs are characterized by a wide range of biological activities. However, most of them have anticancer potency.
MeSH term(s)	Animals ; Humans ; Pentacyclic Triterpenes/metabolism ; Pentacyclic Triterpenes/pharmacology ; Prodrugs/metabolism
Chemical Substances	Pentacyclic Triterpenes ; Prodrugs
Language	English
Publishing date	2021-01-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557521666210105110848
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Article ; Online: Curcuminoid Chalcones: Synthesis and Biological Activity against the Human Colon Carcinoma (Caco-2) Cell Line.

Olender, Dorota / Sowa-Kasprzak, Katarzyna / Pawełczyk, Anna / Skóra, Bartosz / Zaprutko, Lucjusz / Szychowski, Konrad A

Current medicinal chemistry

2023

Abstract: Background: There are many current scientific reports on the synthesis of various derivatives modelled on the structure of known small-molecular and natural bioactive compounds. Curcuminoid chalcones are an innovative class of compounds with significant ...

Abstract	Background: There are many current scientific reports on the synthesis of various derivatives modelled on the structure of known small-molecular and natural bioactive compounds. Curcuminoid chalcones are an innovative class of compounds with significant therapeutic potential against various diseases and they perfectly fit into the current trends in the search for new biologically active substances. Aim: The aim of this study was to design and synthesise a series of curcuminoid chalcones. Objective: The objective of this scientific paper was to synthesise twelve curcuminoid chalcones and confirm their structures using spectral methods. Additionally, the biological activity of three of the synthesised compounds was evaluated using various assays, and their anticancer properties and toxicity were studied. Methods: The proposed derivatives were obtained via the Claisen-Schmidt reaction of selected acetophenones and aldehydes in various conditions using both classical methods: the solutions and solvent-free microwave (MW) or ultrasound (US) variants. The most optimal synthetic method for the selected curcuminoid chalcones was the classical Claisen-Schmidt condensation in an alkaline (NaOH) medium. Spectral methods were used to confirm the structures of the compounds. The resazurin reduction assay, caspase-3 activity assay, and RT-qPCR method were performed, followed by measurements of the intracellular reactive oxygen species (ROS) level and the lactate dehydrogenase (LDH) release level. Results: Twelve designed curcuminoid chalcones were successfully synthesized and structurally confirmed by NMR, MS, and IR spectroscopy. Examination of the anticancer activity was carried out for the three most interesting chalcone products. Conclusion: The results suggested that compound 3a increased the metabolism and/or proliferation of the human colon carcinoma (Caco-2) cell line, while compounds 3b and 3f showed significant toxicity against the Caco-2 cell line. Overall, the preliminary results suggested that compound 3b exhibited the most favorable anticancer activity.
Language	English
Publishing date	2023-09-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673257972230919055832
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Article ; Online: The Mediating Role of Organisational Identification between Psychological Contract and Work Results

Anna Rogozińska-Pawełczyk / Katarzyna Gadomska-Lila

International Journal of Environmental Research and Public Health, Vol 19, Iss 5404, p

An Individual Level Investigation

2022 Volume 5404

Abstract	The aim of this article is to identify the relationship between the fulfilment of relational and transactional psychological contracts and work results, taking into account the mediation effect expressed in organisational identification. The empirical research was conducted on a group of 402 HR professionals responsible for designing and implementing HR practices in one of the leading companies of the Polish energy sector. Hypotheses were tested using the partial least squares structural equation modelling technique (PLS-SEM). Based on our research, we found that the implementation of both relational and transactional psychological contracts positively influenced the results achieved by HR professionals, both directly and indirectly, through the mediating role of organisational identification. The results indicate that the relationship between the psychological contract and work results is stronger when mediated by organisational identification. It plays an important role, especially in relation to the transactional contract. The collected results lead to the conclusion that organisations, wishing to increase the level of work results achieved by HR professionals, should as much as possible fulfil the expectations of employees and meet the commitments made to them within the framework of the established psychological contract. The study makes an important contribution to the understanding of the “priority” importance of organisational identification in enhancing the efforts of HR professionals to deliver work results that benefit both employees and the organisation.
Keywords	psychological contract ; relational psychological contract ; transactional psychological contract ; organisational identification ; work results ; HR professionals ; Medicine ; R
Subject code	690
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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