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  1. Article: Identification of Region-Specific Cytoskeletal and Molecular Alterations in Astrocytes of

    Albizzati, Elena / Florio, Elena / Miramondi, Federica / Sormonta, Irene / Landsberger, Nicoletta / Frasca, Angelisa

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 823060

    Abstract: Rett syndrome (RTT) is a neurodevelopmental disorder that represents the most common genetic cause of severe intellectual disability in females. Most patients carry mutations in the X- ... ...

    Abstract Rett syndrome (RTT) is a neurodevelopmental disorder that represents the most common genetic cause of severe intellectual disability in females. Most patients carry mutations in the X-linked
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.823060
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  2. Article: Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study.

    Ceccanti, Marco / Libonati, Laura / Ruffolo, Gabriele / Cifelli, Pierangelo / Moret, Federica / Frasca, Vittorio / Palma, Eleonora / Inghilleri, Maurizio / Cambieri, Chiara

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 982434

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.982434
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  3. Article: Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis.

    Piticchio, Tommaso / Frasca, Francesco / Malandrino, Pasqualino / Trimboli, Pierpaolo / Carrubba, Nunzia / Tumminia, Andrea / Vinciguerra, Federica / Frittitta, Lucia

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1200372

    Abstract: Background: Hashimoto's thyroiditis (HT) is the most common autoimmune disease. HT may be associated with nonthyroidal autoimmune diseases, including celiac disease (CD) or other gluten-related conditions (GRC). In the last years, interest about gluten- ... ...

    Abstract Background: Hashimoto's thyroiditis (HT) is the most common autoimmune disease. HT may be associated with nonthyroidal autoimmune diseases, including celiac disease (CD) or other gluten-related conditions (GRC). In the last years, interest about gluten-free diet (GFD) has increased for its supposed extraintestinal anti-inflammatory effect; thus, many patients with HT initiate GFD on their own.
    Objectives: The aim of this meta-analysis is to examine all available data in literature about the effect of a GFD on TgAb, TPOAb, TSH, FT4, and FT3 levels in patients with HT and no symptoms or histology of CD.
    Methods: The study was conducted according to MOOSE (Meta-analysis Of Observational Studies in Epidemiology). The search was performed on databases PubMed and Scopus. The last search was performed on 7 February 2023. Quality assessment was performed. Meta-analyses were performed using the random-effect model. Hedges'
    Results: The online search retrieved 409 articles, and 4 studies with a total of 87 patients were finally included for quantitative analysis. The risk of bias was generally low. The mean period of GFD was almost 6 months. The meta-analyses showed reduction in antibody levels with ES: -0.39 for TgAb (95% CI: -0.81 to +0.02;
    Conclusion: This is the first meta-analysis investigating the effect of GFD on HT. Our results seem to indicate a positive effect of the gluten deprivation on thyroid function and its inflammation, particularly in patients with HT and GRC. However, current lines of evidence are not yet sufficient to recommend this dietary approach to all patients with a diagnosis of HT.
    MeSH term(s) Humans ; Thyroiditis, Autoimmune ; Diet, Gluten-Free ; Celiac Disease ; Autoantibodies ; Hashimoto Disease/diagnosis ; Thyrotropin
    Chemical Substances Autoantibodies ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1200372
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  4. Book ; Online: Individual based SIS models on (not so) dense large random networks

    Delmas, Jean-François / Frasca, Paolo / Velleret, Aurélien / Garin, Federica / Tran, Viet Chi / Zitt, Pierre-André

    2023  

    Abstract: Starting from a stochastic individual based description of an SIS epidemic spreading on a random network, we study the dynamics when the size of the network tends to infinity. We recover in the limit an infinite-dimensional integro-differential equation ... ...

    Abstract Starting from a stochastic individual based description of an SIS epidemic spreading on a random network, we study the dynamics when the size of the network tends to infinity. We recover in the limit an infinite-dimensional integro-differential equation studied by Delmas, Dronnier and Zitt (2022) for an SIS epidemic propagating on a graphon. Our work covers the case of dense and sparse graphs, when the number of edges is of order $\Theta(n^a)$ with $a>1$, but not the case of very sparse graphs with $a=1$. In order to establish our limit theorem, we have to deal with both the convergence of the graph to the graphon and the convergence of the stochastic process spreading on top of these random structures: in particular, we propose a coupling between the process of interest and an epidemic that spreads on the complete graph but with a modified infectivity.

    Comment: Keywords: random graph, mathematical model for epidemiology, measure-valued process, large network limit, limit theorem, dense graph, sparse graph. Acknowledgments: This work was financed by the Labex B\'ezout (ANR-10-LABX-58) and the platform MODCOV19 of the National Institute of Mathematical Sciences and their Interactions of CNRS. 30 pages, including an appendix of 5 pages
    Keywords Mathematics - Probability ; Quantitative Biology - Populations and Evolution ; 05C80 ; 92D30 ; 60F99
    Subject code 519
    Publishing date 2023-02-26
    Publishing country us
    Document type Book ; Online
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  5. Article: The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy).

    Fracella, Matteo / Oliveto, Giuseppe / Roberto, Piergiorgio / Cinti, Lilia / Gentile, Massimo / Coratti, Eleonora / D'Ettorre, Gabriella / Cavallari, Eugenio Nelson / Romano, Francesco / Santinelli, Letizia / Maddaloni, Luca / Frasca, Federica / Scagnolari, Carolina / Antonelli, Guido / Pierangeli, Alessandra

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal infections in ... ...

    Abstract Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal infections in groups at different risk for anal cancer has not been well described in Italy. This retrospective study reports the results of HPV DNA testing and complete genotyping performed on anal swabs from 691 female and male patients attending proctology clinics in Rome during 2012-2021; one-third had repeated testing. Cumulative HPV positivity in 1212 anal swabs was approximately 60%, was not age related, and showed an increasing trend over the study period. HPV rates differed significantly by sex and HIV status: HIV-negative women had the lowest (43.6%) and HIV-positive men the highest (83.5%) HPV prevalence. HIV-positive men had more oncogenic HPV genotypes detected, more multiple infections, and the highest frequency of persistent infections. Two-thirds of all infections were vaccine-preventable. This study found that anal HPV infection rates are still elevated and even increasing in groups at low and high risk of developing anal cancer. Prevention programs need to be improved to reduce rates of anal infection in young women and men.
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020163
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  6. Article: Working wellbeing between new employees and expert nurses.

    Gagliano, Carmelo / Putzu, Federica / Cataldo, Alessandro / Ottonello, Arianna / De Muti, Federica / Robello, Giacomo / Calabro', Marina / Frasca, Martina / De Ferrari, Mauro / Ricciu, Sonia

    Professioni infermieristiche

    2022  Volume 74, Issue 4, Page(s) 267

    Abstract: Introduction: The human factor represents a fundamental element in health care processes and influences the result; never as between 2019 and 2020 has such a large number of new hires been introduced in the various public and private companies for ... ...

    Abstract Introduction: The human factor represents a fundamental element in health care processes and influences the result; never as between 2019 and 2020 has such a large number of new hires been introduced in the various public and private companies for social and health assistance. In this context, a fact-finding survey was conducted by the Decentralization Commission of Opi Genova in the months of June and July. The aim was to measure organizational health in terms of variables depending on the relationship between colleagues with different professional experience.
    Methods: To conduct the survey, a structured interview was conducted with the nursing staff on work well-being and the relationship between professionals with a sample of nurses operating in different types of health organizations in Genoa.
    Results: The results of the survey generally show the presence of stress and fatigue in all structures considered mainly due to the emotional burden of the months of the pandemic. Professional integration and general satisfaction were found in all types of structures considered. Some dimensions such as climate essentially depend on each individual case and on the personal character component of each individual. The quantitative results were represented by graphs and the qualitative results by word clouds.
    Conclusions: To fulfill their role it is necessary that operators are satisfied and motivated within the organization in which they operate. It is therefore necessary that all operators are satisfied and satisfied by the emotional context in which they are inserted.
    MeSH term(s) Emotions ; Humans ; Nursing Staff ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-01
    Publishing country Italy
    Document type Congress
    ZDB-ID 1217777-5
    ISSN 0033-0205
    ISSN 0033-0205
    DOI 10.7429/pi.2021.744267b
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4189: Show issues Location:
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  7. Book ; Online: The Laplacian Spectrum of Large Graphs Sampled from Graphons

    Vizuete, Renato / Garin, Federica / Frasca, Paolo

    2020  

    Abstract: This paper studies the Laplacian spectrum and the average effective resistance of (large) graphs that are sampled from graphons. Broadly speaking, our main finding is that the Laplacian eigenvalues of a large dense graph can be effectively approximated ... ...

    Abstract This paper studies the Laplacian spectrum and the average effective resistance of (large) graphs that are sampled from graphons. Broadly speaking, our main finding is that the Laplacian eigenvalues of a large dense graph can be effectively approximated by using the degree function of the corresponding graphon. More specifically, we show how to approximate the distribution of the Laplacian eigenvalues and the average effective resistance (Kirchhoff index) of the graph. For all cases, we provide explicit bounds on the approximation errors and derive the asymptotic rates at which the errors go to zero when the number of nodes goes to infinity. Our main results are proved under the conditions that the graphon is piecewise Lipschitz and bounded away from zero.

    Comment: 10 pages, 6 figures, submitted on April 20, 2020
    Keywords Mathematics - Probability ; Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
    Subject code 519
    Publishing date 2020-04-20
    Publishing country us
    Document type Book ; Online
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  8. Article ; Online: Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID.

    Fracella, Matteo / Mancino, Enrica / Nenna, Raffaella / Virgillito, Chiara / Frasca, Federica / D'Auria, Alessandra / Sorrentino, Leonardo / Petrarca, Laura / La Regina, Domenico / Matera, Luigi / Di Mattia, Greta / Caputo, Beniamino / Antonelli, Guido / Pierangeli, Alessandra / Viscidi, Raphael P / Midulla, Fabio / Scagnolari, Carolina

    European journal of immunology

    2024  , Page(s) e2350682

    Abstract: SARS-CoV-2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon (IFN-I) ... ...

    Abstract SARS-CoV-2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon (IFN-I) response in children and adolescents with LC symptoms (LC; n = 28). This was compared with age-matched SARS-CoV-2 recovered participants without LC symptoms (MC; n = 28) and healthy controls (HC; n = 18). We measured the mRNA expression of IFN-I (IFN-α/β/ε/ω), IFN-I receptor (IFNAR1/2), and ISGs (ISG15, ISG56, MxA, IFI27, BST2, LY6E, OAS1, OAS2, OAS3, and MDA5) in PBMCs collected 3-6 months after COVID-19. LC adolescents (12-17 years) had higher transcript levels of IFN-β, IFN-ε, and IFN-ω than HC, whereas LC children (6-11 years) had lower levels than HC. In adolescents, increased levels of IFN-α, IFN-β, and IFN-ω mRNAs were found in the LC group compared with MC, while lower levels were observed in LC children than MC. Adolescents with neurological symptoms had higher IFN-α/β mRNA levels than MC. LC and MC participants showed decreased expression of ISGs and IFNAR1, but increased expression of IFNAR2, than HC. Our results show age-related changes in the expression of transcripts involved in the IFN-I signaling pathway in children and adolescents with LC.
    Language English
    Publishing date 2024-03-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350682
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  9. Article ; Online: SARS-CoV-2-specific mucosal immune response in vaccinated versus infected children.

    Conti, Maria Giulia / Piano Mortari, Eva / Nenna, Raffaella / Pierangeli, Alessandra / Sorrentino, Leonardo / Frasca, Federica / Petrarca, Laura / Mancino, Enrica / Di Mattia, Greta / Matera, Luigi / Fracella, Matteo / Albano, Christian / Scagnolari, Carolina / Capponi, Martina / Cinicola, Bianca / Carsetti, Rita / Midulla, Fabio

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1231697

    Abstract: The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% of children had ...

    Abstract The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% of children had detectable salivary IgA against SARS-CoV-2 even before vaccination, suggesting that, in children, SARS-CoV-2 infection may be undiagnosed. After vaccination, only receptor-binding domain (RBD)-specific IgA1 significantly increased in the saliva. Conversely, infected children had significantly higher salivary RBD-IgA2 compared to IgA1, indicating that infection more than vaccination induces a specific mucosal immune response in children. Future efforts should focus on development of vaccine technologies that also activate mucosal immunity.
    MeSH term(s) Adult ; Child ; Humans ; Immunity, Mucosal ; SARS-CoV-2 ; COVID-19 ; Immunoglobulin A ; Mucous Membrane ; Vaccination ; Antibodies, Viral
    Chemical Substances Immunoglobulin A ; Antibodies, Viral
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1231697
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  10. Article: Potential IFNγ Modulation of Inflammasome Pathway in

    Filardo, Simone / Di Pietro, Marisa / Frasca, Federica / Diaco, Fabiana / Scordio, Mirko / Antonelli, Guido / Scagnolari, Carolina / Sessa, Rosa

    Life (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: Following ... ...

    Abstract Following a
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life11121359
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