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  1. Article ; Online: Synergistic anti-malarial effects of Ocimum sanctum leaf extract and artemisinin.

    Ulhaq, Zulvikar Syambani

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2023  Volume 41, Issue 4, Page(s) 250–251

    MeSH term(s) Antimalarials ; Ocimum sanctum ; Plant Extracts/pharmacology ; Artemisinins
    Chemical Substances holy basil leaf extract (SCJ765569P) ; Antimalarials ; Plant Extracts ; artemisinin (9RMU91N5K2) ; Artemisinins
    Language English
    Publishing date 2023-01-25
    Publishing country Spain
    Document type Letter ; Comment
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2022.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An urgent call to identify the probable cause of severe acute hepatitis outbreak in children.

    Ulhaq, Zulvikar Syambani / Soraya, Gita Vita

    Medicine in microecology

    2022  Volume 14, Page(s) 100056

    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-0978
    ISSN (online) 2590-0978
    DOI 10.1016/j.medmic.2022.100056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is relying on RNFL specific enough to identify any changes in the CNS?

    Faridwazdi, Dzakky Avecienna Nur / Hasan, Yuliono Trika Nur / Milliana, Alvi / Ulhaq, Zulvikar Syambani

    Advances in ophthalmology practice and research

    2024  Volume 4, Issue 1, Page(s) 14

    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2667-3762
    ISSN (online) 2667-3762
    DOI 10.1016/j.aopr.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transcriptomic analysis reveals mitochondrial dysfunction in the pathogenesis of Nager syndrome in sf3b4-depleted zebrafish.

    Ulhaq, Zulvikar Syambani / Tse, William Ka Fai

    Biochimica et biophysica acta. Molecular basis of disease

    2024  Volume 1870, Issue 4, Page(s) 167128

    Abstract: Nager syndrome (NS) is a rare acrofacial dysostosis caused by heterozygous loss-of-function variants in the splicing factor 3B subunit 4 (SF3B4). The main clinical features of patients with NS are characterized by facial-mandibular and preaxial limb ... ...

    Abstract Nager syndrome (NS) is a rare acrofacial dysostosis caused by heterozygous loss-of-function variants in the splicing factor 3B subunit 4 (SF3B4). The main clinical features of patients with NS are characterized by facial-mandibular and preaxial limb malformations. The migration and specification of neural crest cells are crucial for craniofacial development, and mitochondrial fitness appears to play a role in such processes. Here, by analyzing our previously published transcriptome dataset, we aim to investigate the potential involvement of mitochondrial components in the pathogenesis of craniofacial malformations, especially in sf3b4 mutant zebrafish. We identified that oxidative phosphorylation (OXPHOS) defects and overproduction of reactive oxygen species (ROS) due to decreased antioxidants defense activity, which leads to oxidative damage and mitochondrial dysfunction. Furthermore, our results highlight that fish lacking sf3b4 gene, primarily display defects in mitochondrial complex I. Altogether, our findings suggest that mitochondrial dysfunction may contribute to the development of the craniofacial anomalies observed in sf3b4-depleted zebrafish.
    MeSH term(s) Animals ; Gene Expression Profiling ; Mandibulofacial Dysostosis ; Mitochondrial Diseases ; Mutation ; RNA Splicing Factors/genetics ; Zebrafish/genetics ; Disease Models, Animal
    Chemical Substances RNA Splicing Factors
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2024.167128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Comment on the assessment of "Association of interleukin-6 gene polymorphisms and glaucoma: systematic review and meta-analysis".

    Ulhaq, Zulvikar Syambani

    European journal of ophthalmology

    2020  Volume 31, Issue 4, Page(s) 2171–2172

    MeSH term(s) Glaucoma/genetics ; Humans ; Interleukin-6/genetics ; Polymorphism, Genetic
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/1120672120962049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3342: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease.

    Ulhaq, Zulvikar Syambani / Tse, William Ka Fai

    Genes

    2024  Volume 15, Issue 1

    Abstract: Perfluorohexanesulfonic acid (PFHxS) is a highly prevalent environmental pollutant, often considered to be less toxic than other poly- and perfluoroalkyl substances (PFASs). Despite its relatively lower environmental impact compared to other PFASs, ... ...

    Abstract Perfluorohexanesulfonic acid (PFHxS) is a highly prevalent environmental pollutant, often considered to be less toxic than other poly- and perfluoroalkyl substances (PFASs). Despite its relatively lower environmental impact compared to other PFASs, several studies have suggested that exposure to PFHxS may be associated with disruptions of liver function in humans. Nevertheless, the precise pathomechanisms underlying PFHxS-induced non-alcoholic fatty liver disease (NAFLD) remain relatively unclear. Therefore, this study applied our previously published transcriptome dataset to explore the effects of PFHxS exposure on the susceptibility to NAFLD and to identify potential mechanisms responsible for PFHxS-induced NAFLD through transcriptomic analysis conducted on zebrafish embryos. Results showed that exposure to PFHxS markedly aggravated hepatic symptoms resembling NAFLD and other metabolic syndromes (MetS) in fish. Transcriptomic analysis unveiled 17 genes consistently observed in both NAFLD and insulin resistance (IR), along with an additional 28 genes identified in both the adipocytokine signaling pathway and IR. These shared genes were also found within the NAFLD dataset, suggesting that hepatic IR may play a prominent role in the development of PFHxS-induced NAFLD. In conclusion, our study suggests that environmental exposure to PFHxS could be a potential risk factor for the development of NAFLD, challenging the earlier notion of PFHxS being safer as previously claimed.
    MeSH term(s) Animals ; Humans ; Non-alcoholic Fatty Liver Disease/genetics ; Zebrafish/genetics ; Risk Factors ; Fluorocarbons ; Insulin Resistance/genetics ; Sulfonic Acids
    Chemical Substances perfluorohexanesulfonic acid (355-46-4) ; Fluorocarbons ; Sulfonic Acids
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15010093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transcriptome alterations in sf3b4-depleted zebrafish: Insights into cataract formation in retinitis pigmentosa model.

    Ulhaq, Zulvikar Syambani / Ogino, Yukiko / Tse, William Ka Fai

    Experimental eye research

    2024  Volume 240, Page(s) 109819

    Abstract: Posterior subcapsular cataract (PSC) frequently develops as a complication in patients with retinitis pigmentosa (RP). Despite numerous scientific investigations, the intricate pathomechanisms underlying cataract formation in individuals affected by RP ... ...

    Abstract Posterior subcapsular cataract (PSC) frequently develops as a complication in patients with retinitis pigmentosa (RP). Despite numerous scientific investigations, the intricate pathomechanisms underlying cataract formation in individuals affected by RP remain elusive. Therefore, our study aims to elucidate the potential pathogenesis of cataracts in an RP model using splicing factor subunit 3b (sf3b4) mutant zebrafish. By analyzing our previously published transcriptome dataset, we identified that, in addition to RP, cataract was listed as the second condition in our transcriptomic analysis. Furthermore, we confirmed the presence of nucleus retention in the lens fiber cells, along with abnormal cytoskeleton expression in both the lens fiber cells and lens epithelial cells in sf3b4-depleted fish. Upon closer examination, we identified 20 differentially expressed genes (DEGs) that played a role in cataract formation, with 95 % of them related to the downregulation of structural lens proteins. Additionally, we also identified that among all the DEGs, 13 % were associated with fibrotic processes. It seems that the significant upregulation of inflammatory mediators, in conjunction with TGF-β signaling, plays a central role in the cellular biology of PSC and posterior capsular opacification (PCO) in sf3b4 mutant fish. In summary, our study provides valuable insights into cataract formation in the RP model of sf3b4 mutants, highlighting its complexity driven by changes in structural lens proteins and increased cytokines/growth factors.
    MeSH term(s) Humans ; Animals ; Zebrafish/genetics ; Transcriptome ; Cataract/etiology ; Capsule Opacification/etiology ; Lens, Crystalline ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/diagnosis ; Crystallins/genetics
    Chemical Substances Crystallins
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2024.109819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Update on "Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis".

    Ulhaq, Zulvikar Syambani

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2020  Volume 52, Issue 1, Page(s) 67–70

    MeSH term(s) Diabetes Mellitus, Type 2/genetics ; Estrogen Receptor alpha/genetics ; Humans ; Metabolic Syndrome/genetics ; Polymorphism, Genetic
    Chemical Substances Estrogen Receptor alpha
    Language English
    Publishing date 2020-01-16
    Publishing country Germany
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1063-6377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Brain aromatase modulates cardiac functions in embryonic zebrafish.

    Ulhaq, Zulvikar Syambani

    International journal of veterinary science and medicine

    2019  Volume 7, Issue 1, Page(s) 31–34

    Abstract: Oestradiol ( ... ...

    Abstract Oestradiol (E
    Language English
    Publishing date 2019-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720504-6
    ISSN 2314-4599 ; 2314-4599
    ISSN (online) 2314-4599
    ISSN 2314-4599
    DOI 10.1080/23144599.2019.1675287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Association Between Genetic Polymorphisms in Estrogen Receptor Genes and the Risk of Ocular Disease: A Meta-Analysis

    Ulhaq, Zulvikar Syambani

    Turkish journal of ophthalmology

    2020  Volume 50, Issue 4, Page(s) 216–220

    Abstract: Objectives: To evaluate the association between estrogen receptor : Materials and methods: A meta-analysis was performed of all available studies that investigated the association between : Results: Studies that were selected based on inclusion ... ...

    Abstract Objectives: To evaluate the association between estrogen receptor
    Materials and methods: A meta-analysis was performed of all available studies that investigated the association between
    Results: Studies that were selected based on inclusion criteria reported 5 and 4 single-nucleotide polymorphisms (SNPs) identified in the
    Conclusion: The recessive genotype of
    MeSH term(s) DNA/genetics ; Estrogen Receptor beta/genetics ; Eye Diseases/genetics ; Eye Diseases/metabolism ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Risk Factors
    Chemical Substances ESR2 protein, human ; Estrogen Receptor beta ; Receptors, Estrogen ; DNA (9007-49-2)
    Language English
    Publishing date 2020-08-27
    Publishing country Turkey
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2586160-8
    ISSN 2149-8709 ; 2147-2661 ; 1300-0659 ; 1300-0659 ; 2149-8695
    ISSN (online) 2149-8709 ; 2147-2661 ; 1300-0659
    ISSN 1300-0659 ; 2149-8695
    DOI 10.4274/tjo.galenos.2020.91298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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