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  1. Article ; Online: Extracellular matrix remodeling in the tumor immunity.

    Du, Wei / Xia, Xueming / Hu, Fan / Yu, Jiayun

    Frontiers in immunology

    2024  Volume 14, Page(s) 1340634

    Abstract: The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving as a reservoir for signaling molecules. The abundance and ... ...

    Abstract The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving as a reservoir for signaling molecules. The abundance and degree of cross-linking of ECM components are critical determinants of tissue stiffness. In the process of tumorigenesis, the interaction between ECM and immune cells within the tumor microenvironment (TME) frequently leads to ECM stiffness, thereby disrupting normal mechanotransduction and promoting malignant progression. Therefore, acquiring a thorough comprehension of the dysregulation of ECM within the TME would significantly aid in the identification of potential therapeutic targets for cancer treatment. In this regard, we have compiled a comprehensive summary encompassing the following aspects: (1) the principal components of ECM and their roles in malignant conditions; (2) the intricate interaction between ECM and immune cells within the TME; and (3) the pivotal regulators governing the onco-immune response in ECM.
    MeSH term(s) Humans ; Mechanotransduction, Cellular ; Extracellular Matrix ; Neoplasms ; Carcinogenesis ; Cell Transformation, Neoplastic ; Tumor Microenvironment/physiology
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1340634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Histopathological characteristics of peri-implant soft tissue in reconstructed jaws with vascularized bone flaps].

    Dong, Jiayun / Li, Xuefen / Lu, Ruifang / Hu, Wenjie / Meng, Huanxin

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2024  Volume 56, Issue 1, Page(s) 25–31

    Abstract: Objective: To analyze the histopathological characteristics of peri-implant soft tissue in reconstructed jaws and the changes after keratinized mucosa augmentation (KMA) with free gingival graft (FGG).: Methods: Twenty patients were enrolled in this ... ...

    Abstract Objective: To analyze the histopathological characteristics of peri-implant soft tissue in reconstructed jaws and the changes after keratinized mucosa augmentation (KMA) with free gingival graft (FGG).
    Methods: Twenty patients were enrolled in this study. Five patients of them, who were periodontal and systemic healthy and referred for crown lengthening before restoration with healthy keratinized gingiva collected were enrolled as healthy controls. 15 patients of them were with fibula or iliac bone flaps jaw reconstruction (10 with fibula flap and 5 with iliac flap), who were referred to FGG and implant exposures before restoration. Soft tissue was collected before FGG in reconstructed jaws, and in 5 patients (3 with fibula flap and 2 with iliac flap) 8 weeks after FGG if a second surgery was conducted. Histological analysis with hematoxylin-eosin stain and immunological analysis to interlukin-1 (IL-1), interlukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were performed.
    Results: Thickness from the bottom of stratum basale to the top of stratum granulosum and thickness of keratinized layer in reconstructed jaws were significantly lower compared with that of natural healthy keratinized gingiva [0.27 (0.20, 0.30) mm
    Conclusion: The lack of rete pegs and inflammatory factors were common in soft tissue with jaw reconstruction. FGG can improve the quality of the epithelium and may improve the stability of the mucosa around implants.
    MeSH term(s) Humans ; Gingiva ; Gingivoplasty ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Jaw ; Interleukin-1 ; Dental Implants
    Chemical Substances Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-1 ; Dental Implants
    Language Chinese
    Publishing date 2024-02-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2452593-5
    ISSN 1671-167X
    ISSN 1671-167X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MED15::TFE3 fusion renal cell carcinoma with extensive cystic change: A clinicopathologic and molecular genetic study of 2 cases, with an emphasis on differential diagnosis.

    Yin, Xiaona / Hu, Xingen / Xu, Jiayun / Xiong, Danting / Zhao, Ming

    American journal of clinical pathology

    2024  

    Abstract: Objectives: TFE3-rearranged renal cell carcinomas (RCCs) harbor gene fusions between TFE3 and 1 of many partner genes. MED15::TFE3 fusion RCC is rare, often cystic, and easily misdiagnosed.: Methods: This study aimed to characterize 2 cases of MED15:: ...

    Abstract Objectives: TFE3-rearranged renal cell carcinomas (RCCs) harbor gene fusions between TFE3 and 1 of many partner genes. MED15::TFE3 fusion RCC is rare, often cystic, and easily misdiagnosed.
    Methods: This study aimed to characterize 2 cases of MED15::TFE3 fusion RCC with extensive cystic change using fluorescence in situ hybridization and targeted RNA sequencing.
    Results: Both patients were young adult women aged 29 and 35 years. Radiologically, both presented with a cystic Bosniak category II renal lesion. The cysts measured 9.3 cm and 4.8 cm in greatest dimension. Both patients underwent cyst enucleation, and neither had tumor recurrence or metastasis at 26 and 6 months of follow-up, respectively. Microscopically, both tumors were entirely cystic, with thick, fibrous cystic walls lined by small clusters of cells with clear to eosinophilic cytoplasm and uniform, round nuclei with inconspicuous nucleoli. There were also small aggregations of similar clear cells within the cystic walls. Foci of basement membrane-like material depositions were noted in 1 case; calcifications were observed in both cases. Both cases demonstrated nuclear positivity for PAX8 and TFE3 and cytoplasmic staining for Melan-A; HMB45, CAIX, and CK7 were negative. Fluorescence in situ hybridization revealed that both tumors were positive for TFE3 rearrangements. RNA sequencing identified MED15::TFE3 gene fusions in both cases.
    Conclusions: The main differential diagnosis of MED15::TFE3 fusion RCC includes multilocular cystic renal neoplasm of low malignant potential and atypical renal cysts. Molecular confirmation of TFE3 fusion is essential for establishing the correct diagnosis.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqae011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter to the Editor: Statins as potential confounding factors to investigate the association between the use of GLP-1 receptor agonists and risk of HCC.

    Li, Zheng / Zhang, Yi / Li, Ying / Lan, Jie / Hu, Yuzhu / Yu, Jiayun / Meng, Qianqian / Zou, Bingwen

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Hydrolysis reactivity reveals significant seasonal variation in the composition of organic peroxides in ambient PM

    Dai, Yishuang / Chen, Zhongming / Qin, Xuan / Dong, Ping / Xu, Jiayun / Hu, Jingcheng / Gu, Linghao / Chen, Shiyi

    The Science of the total environment

    2024  Volume 927, Page(s) 172143

    Abstract: Atmospheric organic peroxides (POs) play a key role in the formation of ... ...

    Abstract Atmospheric organic peroxides (POs) play a key role in the formation of O
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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  6. Article ; Online: Nomogram for predicting pathologic complete response to neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma.

    Liu, Guihong / Chen, Tao / Zhang, Xin / Hu, Binbin / Yu, Jiayun

    Cancer medicine

    2024  Volume 13, Issue 5, Page(s) e7075

    Abstract: Purpose: A pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) is seen in up to 40% of the patients with esophageal squamous cell carcinoma (ESCC). No nomogram has been constructed for the prediction of pCR for patients whose ... ...

    Abstract Purpose: A pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) is seen in up to 40% of the patients with esophageal squamous cell carcinoma (ESCC). No nomogram has been constructed for the prediction of pCR for patients whose primary chemotherapy was a taxane-based regimen. The aim is to identify characteristics associated with a pCR through analyzing multiple pre- and post-nCRT variables and to develop a nomogram for the prediction of pCR for these patients by integrating clinicopathological characteristics and hematological biomarkers.
    Materials and methods: We analyzed 293 patients with ESCC who underwent nCRT followed by esophagectomy. Clinicopathological factors, hematological parameters before nCRT, and hematotoxicity during nCRT were collected. Univariate and multivariate logistic regression analyses were performed to identify predictive factors for pCR. A nomogram model was built and evaluated for both discrimination and calibration.
    Results: After surgery, 37.88% of the study patients achieved pCR. Six variables were included in the nomogram: sex, cN stage, chemotherapy regimen, duration of nCRT, pre-nCRT neutrophil-to-lymphocyte ratio (NLR), and pre-nCRT platelet-to-lymphocyte ratio (PLR). The nomogram indicated good accuracy and consistency in predicting pCR, with a C-index of 0.743 (95% confidence interval: 0.686, 0.800) and a p value of 0.600 (>0.05) in the Hosmer-Lemeshow goodness-of-fit test.
    Conclusions: Female, earlier cN stage, duration of nCRT (< 62 days), chemotherapy regimen of taxane plus platinum, pre-nCRT NLR (≥2.199), and pre-nCRT PLR (≥99.302) were significantly associated with a higher pCR in ESCC patients whose primary chemotherapy was a taxane-based regimen for nCRT. A nomogram was developed and internally validated, showing good accuracy and consistency.
    MeSH term(s) Humans ; Female ; Esophageal Squamous Cell Carcinoma ; Nomograms ; Esophageal Neoplasms/pathology ; Neoadjuvant Therapy ; Pathologic Complete Response ; Chemoradiotherapy ; Taxoids ; Retrospective Studies
    Chemical Substances Taxoids
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter to the Editor: Is the evidence convincing for the expansion of CHB treatment criteria to reduce the risk of HCC?

    Li, Zheng / Zhang, Yi / Li, Ying / Chen, Xi / Hu, Jie / Yu, Jiayun / Hu, Yuzhu / Nie, Shihong / Li, Nanjing / Wen, Qinglian / Zou, Bingwen

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  8. Article ; Online: Impact of City Forests on Haze Reduction—Implementation of the National Forest City Policy in China

    Hu, Zhao / Chen, Jian / Dong, Jiayun

    Forests. 2023 Mar. 29, v. 14, no. 4

    2023  

    Abstract: ... in the eastern region, and cities east of the Hu Huanyong line; (3) the NFCP will improve urban green space ...

    Abstract The construction and development of China’s forest cities revolves around the goal of building an environmentally friendly society and achieving harmonious development between human beings and nature, which is essentially the implementation of the concept of green development and helps promote the sustainable development of sustainable cities. Based on the panel data of 263 prefecture-level cities in China from 2001 to 2020, the National Forest City Policy (NFCP) is used as a quasi-natural experiment to assess the effect of NFCP on haze pollution management and their heterogeneity using a time-varying DID (difference-in-differences) model, and a mediating effect model is used to analyze the mechanism of the effect of NFCP on haze pollution. The research found that (1) the NFCP can reduce urban haze pollution, and this finding remained robust after placebo tests and the replacement of explanatory variables; (2) the NFCP is more conducive to reducing haze pollution in the Pearl River Delta urban agglomeration, Type II large cities, cities in the eastern region, and cities east of the Hu Huanyong line; (3) the NFCP will improve urban green space coverage, raise residents’ awareness of environmental protection, and promote the development of tertiary industries, thereby promoting urban haze reduction.
    Keywords environmental protection ; forests ; green infrastructure ; humans ; issues and policy ; models ; national forests ; placebos ; pollution ; river deltas ; rivers ; sustainable development ; China
    Language English
    Dates of publication 2023-0329
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f14040703
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Preparation and characterization of flexible laminated composites impregnated with TPU/SiO

    Hu, Jiayun / Liang, Chunling / Zhang, Yan / Li, Yuanyuan / Wang, Ping

    International journal of occupational safety and ergonomics : JOSE

    2022  Volume 29, Issue 3, Page(s) 998–1006

    Abstract: At present, people face the danger of various occupational exposures, resulting in the rapid development of protective composites among which puncture-resistant materials are an essential component. In this article, composites impregnated with polyester ... ...

    Abstract At present, people face the danger of various occupational exposures, resulting in the rapid development of protective composites among which puncture-resistant materials are an essential component. In this article, composites impregnated with polyester polyurethane (TPU)/SiO
    MeSH term(s) Humans ; Silicon Dioxide ; Occupational Exposure ; Polyesters ; Polyurethanes ; Punctures
    Chemical Substances Silicon Dioxide (7631-86-9) ; Polyesters ; Polyurethanes
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1335568-5
    ISSN 2376-9130 ; 1080-3548
    ISSN (online) 2376-9130
    ISSN 1080-3548
    DOI 10.1080/10803548.2022.2108634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4764: Show issues Location:
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  10. Article ; Online: Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective activities.

    Wen, Wen / Hu, Jiadong / Wang, Chenxi / Yang, Rui / Zhang, Yabo / Huang, Baibei / Qiao, Tingting / Wang, Jiayun / Chen, Xin

    Bioorganic & medicinal chemistry letters

    2024  Volume 102, Page(s) 129670

    Abstract: Histone deacetylase 6 (HDAC6) has drawn more and more attention for its potential application in Alzheimer's disease (AD) therapy. A series of tetrahydro-β-carboline (THβC) hydroxamic acids with aryl linker were synthesized. In enzymatic assay, all ... ...

    Abstract Histone deacetylase 6 (HDAC6) has drawn more and more attention for its potential application in Alzheimer's disease (AD) therapy. A series of tetrahydro-β-carboline (THβC) hydroxamic acids with aryl linker were synthesized. In enzymatic assay, all compounds exhibited nanomolar IC
    MeSH term(s) Rats ; Animals ; Histone Deacetylase 6 ; Histone Deacetylase Inhibitors/pharmacology ; Hydrogen Peroxide/pharmacology ; Hydroxamic Acids/pharmacology ; Neuronal Outgrowth ; Histone Deacetylase 1/metabolism ; Structure-Activity Relationship ; Carbolines
    Chemical Substances Histone Deacetylase 6 (EC 3.5.1.98) ; tryptoline (65027TMI0H) ; Histone Deacetylase Inhibitors ; Hydrogen Peroxide (BBX060AN9V) ; Hydroxamic Acids ; Histone Deacetylase 1 (EC 3.5.1.98) ; Carbolines
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2024.129670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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