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Article ; Online: Ferroptosis: regulated cell death.

Čepelak, Ivana / Dodig, Slavica / Dodig, Daniela Čepelak

2020 Volume 71, Issue 2, Page(s) 99–109

Abstract: Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron- ... ...

Abstract	Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.
MeSH term(s)	Cell Death ; Ferroptosis ; Iron ; Lipid Peroxidation ; Reactive Oxygen Species
Chemical Substances	Reactive Oxygen Species ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-06-29
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2020-71-3366
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum to: The potential of component-resolved diagnosis in laboratory diagnostics of allergy.

Dodig, Slavica / Čepelak, Ivana

Biochemia medica

2018 Volume 28, Issue 2, Page(s) 20702

Abstract: This corrects the article DOI: 10.11613/BM.2018.020501.]. ...

Abstract	[This corrects the article DOI: 10.11613/BM.2018.020501.].
Language	English
Publishing date	2018-07-18
Publishing country	Croatia
Document type	Journal Article ; Published Erratum
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2018.021201
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Article ; Online: SARS-CoV-2 - a new challenge for laboratory medicine.

Dodig, Slavica / Čepelak, Ivana / Čepelak Dodig, Daniela / Laškaj, Renata

Biochemia medica

2020 Volume 30, Issue 3, Page(s) 30503

Abstract: The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in ...

Abstract	The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or condition. The reasons for this should be sought in the processes of aging and chronic latent inflammation,
MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Health Personnel/standards ; Humans ; Inflammation Mediators/blood ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Specimen Handling/methods ; Specimen Handling/standards
Chemical Substances	Inflammation Mediators
Keywords	covid19
Language	English
Publishing date	2020-08-05
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2020.030503
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Article: The potential of component-resolved diagnosis in laboratory diagnostics of allergy.

Dodig, Slavica / Čepelak, Ivana

Biochemia medica

2018 Volume 28, Issue 2, Page(s) 20501

Abstract: The initial laboratory approach in the diagnosis of allergies is to detect the type of allergic reaction, ...

Abstract	The initial laboratory approach in the diagnosis of allergies is to detect the type of allergic reaction,
MeSH term(s)	Allergens/blood ; Cross Reactions ; Humans ; Hypersensitivity/blood ; Hypersensitivity/diagnosis ; Hypersensitivity/immunology ; Immunoassay ; Immunoglobulin E/blood ; Sensitivity and Specificity ; Skin Tests
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2018-04-15
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2018.020501
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Article: Divergent Trends in the Prevalence of Children's Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia.

Topalušić, Iva / Stipić Marković, Asja / Artuković, Marinko / Dodig, Slavica / Bucić, Lovro / Lugović Mihić, Liborija

Children (Basel, Switzerland)

2022 Volume 9, Issue 12

Abstract: Background: Previous studies have reported that the allergy epidemic in developed countries has reached its plateau, while a rise is expected in developing ones. Our aim was to compare the prevalence of allergic diseases among schoolchildren from the ... ...

Abstract	Background: Previous studies have reported that the allergy epidemic in developed countries has reached its plateau, while a rise is expected in developing ones. Our aim was to compare the prevalence of allergic diseases among schoolchildren from the city of Zagreb, Croatia after sixteen years. Methods: Symptoms of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) and risk factors were assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. An allergic profile was determined by a skin prick test. Results: The prevalence of current, ever-in-a-lifetime and diagnosed AR of 35.7%, 42.5% and 14.9% and AD of 18.1%, 37.1% and 31.1% demonstrated a significant increase. The asthma prevalence has remained unchanged. The allergen sensitivity rate has remained similar, but pollens have become dominant. Mould and dog exposure are risks for asthma (OR 14.505, OR 2.033). Exposure to cat allergens is protective in AR (OR 0.277). Parental history of allergies is a risk factor in all conditions. Conclusion: Over sixteen years, the prevalence of AR and AD, but not of asthma, have increased. The proportion of atopy has remained high. The AR/AD symptom rise is probably a consequence of increased pollen sensitisation united with high particulate matter concentrations. The stable asthma trend could be a result of decreasing exposures to indoor allergens.
Language	English
Publishing date	2022-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9121788
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Filaggrin and atopic march.

Čepelak, Ivana / Dodig, Slavica / Pavić, Ivan

Biochemia medica

2019 Volume 29, Issue 2, Page(s) 20501

Abstract: There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis. Atopic dermatitis is a ... ...

Abstract	There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis. Atopic dermatitis is a heterogeneous, recurrent childhood disease, also present in the adult age. It is increasingly attributed to systemic features and is characterized by immunological and skin barrier integrity and function dysregulation. To maintain the protective function of the skin barrier, in particular the maintenance of pH, hydration and antimicrobial functions, the filaggrin, among others, plays a significant role. Filaggrin is a multifunctional, histidine-rich, insoluble protein. The lack of filaggrin is associated with various cutaneous (
MeSH term(s)	Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/metabolism ; Filaggrin Proteins ; Humans ; Intermediate Filament Proteins/analysis ; Intermediate Filament Proteins/genetics ; Intermediate Filament Proteins/metabolism
Chemical Substances	FLG protein, human ; Filaggrin Proteins ; Intermediate Filament Proteins
Language	English
Publishing date	2019-06-20
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2019.020501
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Article ; Online: Hallmarks of senescence and aging.

Dodig, Slavica / Čepelak, Ivana / Pavić, Ivan

Biochemia medica

2019 Volume 29, Issue 3, Page(s) 30501

Abstract: The complex process of biological aging, as an intrinsic feature of living beings, is the result of genetic and, to a greater extent, environmental factors and time. For many of the changes taking place in the body during aging, three factors are ... ...

Abstract	The complex process of biological aging, as an intrinsic feature of living beings, is the result of genetic and, to a greater extent, environmental factors and time. For many of the changes taking place in the body during aging, three factors are important: inflammation, immune aging and senescence (cellular aging, biological aging). Senescence is an irreversible form of long-term cell-cycle arrest, caused by excessive intracellular or extracellular stress or damage. The purpose of this cell-cycles arrest is to limit the proliferation of damaged cells, to eliminate accumulated harmful factors and to disable potential malignant cell transformation. As the biological age does not have to be in accordance with the chronological age, it is important to find specific hallmarks and biomarkers that could objectively determine the rate of age of a person. These biomarkers might be a valuable measure of physiological,
MeSH term(s)	Aging ; Biomarkers/metabolism ; Cellular Senescence ; DNA Damage ; Humans ; Immune System/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Telomere Homeostasis
Chemical Substances	Biomarkers ; Reactive Oxygen Species
Language	English
Publishing date	2019-08-05
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2019.030501
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Article ; Online: Current status of the lateral flow immunoassay for the detection of SARS-CoV-2 in nasopharyngeal swabs.

Somborac Bačura, Anita / Dorotić, Marija / Grošić, Leonarda / Džimbeg, Monika / Dodig, Slavica

Biochemia medica

2021 Volume 31, Issue 2, Page(s) 20601

Abstract: Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diagnosis of coronavirus disease 2019 (COVID-19) are priorities during the pandemic. Symptomatic and suspected asymptomatic individuals should be tested for COVID-19 to ... ...

Abstract	Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diagnosis of coronavirus disease 2019 (COVID-19) are priorities during the pandemic. Symptomatic and suspected asymptomatic individuals should be tested for COVID-19 to confirm infection and to be excluded from social interactions. As molecular testing capacity is overloaded during the pandemic, rapid antigen tests, such as lateral flow immunoassays (LFIAs), can be a useful tool as they allow greater test availability and obtain results in a very short time. This short review aims to present the analytical properties of LFIAs in the detection of SARS-CoV-2 in nasopharyngeal swabs. Lateral flow immunoassay is a method that combines thin-layer chromatography and indirect immunochemical sandwich method and allows the detection of a specific SARS-CoV-2 antigen in nasopharyngeal swabs. Swab specimens should be adequately collected and tested as soon as possible. Users should pay attention to quality control and possible interferences. Antigen tests for SARS-CoV-2 show high sensitivity and specificity in cases with high viral loads, and should be used up to five days after the onset of the first symptoms of COVID-19. False positive results may be obtained when screening large populations with a low prevalence of COVID-19 infection, while false negative results may happen due to improper specimen collection or insufficient amount of antigen in the specimen. So as to achieve reliable results, a diagnostic accuracy study of a specific rapid antigen test should be performed.
MeSH term(s)	Antigens, Viral/analysis ; COVID-19/diagnosis ; COVID-19/virology ; False Negative Reactions ; Humans ; Immunoassay/methods ; Immunoassay/standards ; Limit of Detection ; Nasopharynx/virology ; Point-of-Care Systems ; Quality Control ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Sensitivity and Specificity ; Viral Load
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2021-06-10
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2021.020601
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Article: SARS-CoV-2 - a new challenge for laboratory medicine

Dodig, Slavica / Cepelak, Ivana / Cepelak Dodig, Daniela / Laskaj, Renata

Biochem Med (Zagreb)

Abstract	The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or condition. The reasons for this should be sought in the processes of aging and chronic latent inflammation, i.e. immunosenescence and inflammaging. Laboratory medicine specialists are currently focused on proving the presence of the virus and defining biomarkers that would enable the prediction of disease progression. For now, it has been shown that useful biomarkers can include general biomarkers of inflammation (parameters of complete blood count, C-reactive protein, interleukin-6, procalcitonin), biomarkers of myocardial damage (high sensitivity troponin I/T, B-type natriuretic peptide, and N-terminal B type natriuretic peptide), and vascular biomarkers (D-dimer, prothrombin time, fibrinogen). Their actual diagnostic specificity, sensitivity and predictive value need to be tested on a larger number of subjects. In addition, it is important to find and evaluate specific biomarkers of immunosenescence.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #710277
Database	COVID19

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Article ; Online: SARS-CoV-2 – a new challenge for laboratory medicine

Dodig, Slavica / Čepelak, Ivana / Čepelak Dodig, Daniela / Laškaj, Renata

Biochemia Medica

2020

Abstract	The new corona virus SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus 2) causes a disease called COVID-19 (coronavirus disease 2019), that develops mostly in subjects with already impaired immune system function, primarily in the elderly and in individuals with some chronic disease or condition. The reasons for this should be sought in the processes of aging and chronic latent inflammation, i.e. immunosenescence and inflammaging. Laboratory medicine specialists are currently focused on proving the presence of the virus and defining biomarkers that would enable the prediction of disease progression. For now, it has been shown that useful biomarkers can include general biomarkers of inflammation (parameters of complete blood count, C-reactive protein, interleukin-6, procalcitonin), biomarkers of myocardial damage (high sensitivity troponin I/T, B-type natriuretic peptide, and N-terminal B type natriuretic peptide), and vascular biomarkers (D-dimer, prothrombin time, fibrinogen). Their actual diagnostic specificity, sensitivity and predictive value need to be tested on a larger number of subjects. In addition, it is important to find and evaluate specific biomarkers of immunosenescence.
Keywords	biomarkers ; COVID-19 ; SARS-CoV-2 ; laboratory medicine ; patient safety ; covid19
Subject code	610
Language	English
Publisher	Medicinska naklada
Publishing country	hr
Document type	Article ; Online
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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