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Artikel ; Online: Desmopressin Acetate in Percutaneous Ultrasound-Guided Native Kidney Biopsy in Patients with Reduced Kidney Function: A Double-Blind Randomized Controlled Trial.

Sattari, Shahab Aldin / Shahoori, Azita / Shahbazian, Heshmatollah / Sabetnia, Leila / Aref, Asieh / Sattari, Ali Reza / Ghorbani, Ali

Iranian journal of kidney diseases

2022 Band 16, Heft 4, Seite(n) 238–245

Abstract: Introduction: Bleeding events are the most common complications after kidney biopsy. This study aims to evaluate the effect of desmopressin administration on bleeding complication, in native kidney biopsy candidates with reduced kidney function.: ... ...

Abstract	Introduction: Bleeding events are the most common complications after kidney biopsy. This study aims to evaluate the effect of desmopressin administration on bleeding complication, in native kidney biopsy candidates with reduced kidney function. Methods: This double-blind randomized clinical trial enrolled 18 to 80 years old patients with 15 < eGFR < 90 mL/min/ 1.73m² from July 2017 to August 2020. Patients were randomly assigned to receive either 3 µg/kg of intranasal desmopressin acetate or 1 mL/kg of intranasal sodium chloride 0.65%, one hour before ultrasound-guided, percutaneous native kidney biopsy. The primary outcome was the post-biopsy bleeding complications, and secondary outcomes were the volume of perirenal hematoma, and changes of post-biopsy hemoglobin and hematocrit level, plasma sodium and blood pressure (Clinical Trial Registration ID: IRCT20090701002112N3). Results: A total of 120 patients (58 men and 62 women), 60 patients in each group, were analyzed. The mean age and eGFR of the patients were 45.29 ± 15.95 years and 51.77 ± 18.02 ml/min/ 1.73m², respectively. Desmopressin administration significantly decreased post-biopsy perirenal hematoma compared to placebo (7/60 [11.6%]) vs. 33/60 [40%]; P < .05), and the hematoma volume was significantly smaller in the desmopressin group, in case of hematoma formation (2.31 ± 1.17 vs. 7.72 ± 5.45 mm³, P < .05). Conclusion: Desmopressin administration before kidney biopsy is a safe and effective strategy to prevent bleeding complications. Considering absolute risk reduction of about 28%, the number needed to treat is about 4 procedures. We recommend considering desmopressin administration before percutaneous native kidney biopsy. DOI: 10.52547/ijkd.6966.
Mesh-Begriff(e)	Adult ; Biopsy/adverse effects ; Biopsy/methods ; Deamino Arginine Vasopressin/adverse effects ; Double-Blind Method ; Female ; Hematoma/drug therapy ; Hematoma/pathology ; Humans ; Kidney ; Kidney Diseases/pathology ; Male ; Middle Aged ; Ultrasonography, Interventional/adverse effects ; Young Adult
Chemische Substanzen	Deamino Arginine Vasopressin (ENR1LLB0FP)
Sprache	Englisch
Erscheinungsdatum	2022-09-02
Erscheinungsland	Iran
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Ambulatory monitoring of blood pressure and pregnancy outcome in pregnant women with white coat hypertension in the third trimester of pregnancy.

Shahbazian, Nahid / Shahbazian, Heshmatollah / Mohammadjafari, Razieh / Mousavi, Mahsan

Journal of nephropharmacology

2013 Band 2, Heft 1, Seite(n) 5–9

Abstract: Introduction: ...

Abstract	Introduction:
Sprache	Englisch
Erscheinungsdatum	2013-01-01
Erscheinungsland	Iran
Dokumenttyp	Journal Article
ZDB-ID	2756100-8
ISSN	2345-4202
ISSN	2345-4202
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients

Heshmatollah Shahbazian / Shokouh Shayanpour / Ali Ghorbani

Saudi Journal of Kidney Diseases and Transplantation, Vol 27, Iss 1, Pp 88-

A double-blind, randomized, controlled clinical trial

2016 Band 93

Abstract: This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled ... ...

Abstract	This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled clinical trial, the efficacy and safety of NAC in reduction of oxidative stress was evaluated in 40 chronic HD patients. The study was conducted at the HD Department of the Golestan Hospital, Ahvaz, Iran. Data were analyzed using SPSS version 19. Paired samples test showed that the mean score of the serum level of total anti-oxidant capacity (TAC) increased from 26.39 ± 17.03 to 33.26 ± 18.8 (Pvalue = 0.01) and from 24.02 ± 16.47 to 25.38 ± 17.04 (P = 0.1) in the NAC and placebo groups, respectively. Difference in the mean TAC changes between groups was statistically significant (P= 0.042). In our study, NAC administration could reduce oxidative stress in chronic HD patients. No major side-effects were observed.
Schlagwörter	Medicine ; R
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2016-01-01T00:00:00Z
Verlag	Wolters Kluwer Medknow Publications
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Diabetic kidney disease; review of the current knowledge.

Shahbazian, Heshmatollah / Rezaii, Isa

Journal of renal injury prevention

2013 Band 2, Heft 2, Seite(n) 73–80

Abstract: Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy ... ...

Abstract	Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has some role. Some metabolites of arachidonic acid, hemodynamic derangements and genetic factors have also some role. Although diabetic nephropathy is most common cause of nephropathy in these patients, but diabetic patients are also prone to other urinary tract and renal parenchymal disease and should not be confused with renal failure due to diabetic nephropathy. The principle of treatment of diabetic nephropathy is based on tight control of hyperglycemia, tight control of blood pressure and glomerular pressure, control of dyslipidemia, restriction of protein intake and smoking withdrawal.
Sprache	Englisch
Erscheinungsdatum	2013-06-01
Erscheinungsland	Iran
Dokumenttyp	Journal Article ; Review
ZDB-ID	2747305-3
ISSN	2345-2781
ISSN	2345-2781
DOI	10.12861/jrip.2013.24
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Diabetic kidney disease; review of the current knowledge

Shahbazian Heshmatollah / Rezaii Isa

Journal of Renal Injury Prevention, Vol 2, Iss 2, Pp 73-

2013 Band 80

Abstract	Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has some role. Some metabolites of arachidonic acid, hemodynamic derangements and genetic factors have also some role. Although diabetic nephropathy is most common cause of nephropathy in these patients, but diabetic patients are also prone to other urinary tract and renal parenchymal disease and should not be confused with renal failure due to diabetic nephropathy. The principle of treatment of diabetic nephropathy is based on tight control of hyperglycemia, tight control of blood pressure and glomerular pressure, control of dyslipidemia, restriction of protein intake and smoking withdrawal.
Schlagwörter	Diabetic kidney disease ; Chronic kidney disease ; End-stage renal disease ; Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2013-06-01T00:00:00Z
Verlag	Society of Diabetic Nephropathy Prevention
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Evaluation of administration of oral N-acetylcysteine to reduce oxidative stress in chronic hemodialysis patients: A double-blind, randomized, controlled clinical trial.

Shahbazian, Heshmatollah / Shayanpour, Shokouh / Ghorbani, Ali

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2016 Band 27, Heft 1, Seite(n) 88–93

Abstract	This study was designed to assess the efficacy of N-acetylcysteine (NAC) on the reduction of oxidative stress in chronic hemodialysis (HD) patients through measurement of total serum anti-oxidant capacity. In this randomized, double-blind, controlled clinical trial, the efficacy and safety of NAC in reduction of oxidative stress was evaluated in 40 chronic HD patients. The study was conducted at the HD Department of the Golestan Hospital, Ahvaz, Iran. Data were analyzed using SPSS version 19. Paired samples test showed that the mean score of the serum level of total anti-oxidant capacity (TAC) increased from 26.39±17.03 to 33.26±18.8 (Pvalue=0.01) and from 24.02±16.47 to 25.38±17.04 (P=0.1) in the NAC and placebo groups, respectively. Difference in the mean TAC changes between groups was statistically significant (P=0.042). In our study, NAC administration could reduce oxidative stress in chronic HD patients. No major side-effects were observed.
Mesh-Begriff(e)	Acetylcysteine/administration & dosage ; Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Free Radical Scavengers/administration & dosage ; Humans ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/therapy ; Male ; Oxidative Stress/drug effects ; Prospective Studies ; Renal Dialysis ; Time Factors ; Treatment Outcome
Chemische Substanzen	Free Radical Scavengers ; Acetylcysteine (WYQ7N0BPYC)
Sprache	Englisch
Erscheinungsdatum	2016-01
Erscheinungsland	Saudi Arabia
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.174084
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Kaposi Sarcoma in Kidney Transplanted Patients

Heshmatollah Shahbazian

Urology Journal, Vol 1, Iss 2, Pp 111-

2004 Band 114

Abstract: Purpose: Newly developed malignancies in kidney transplanted patients are one of the complications attributed to immunosuppression. Kaposi sarcoma is an unusual malignancy in general population, but may develop in kidney transplanted patients with highly ...

Abstract	Purpose: Newly developed malignancies in kidney transplanted patients are one of the complications attributed to immunosuppression. Kaposi sarcoma is an unusual malignancy in general population, but may develop in kidney transplanted patients with highly varying prevalence. Our aim is to evaluate the prevalence, clinical manifestations, and outcome of Kaposi sacoma in kidney transplanted patients. Materials and Methods: Five hundred and eighty cases (330 male, 250 female) with a mean age of 38.2 were followed for 36 months (range 9 months to 10 years), visiting every two months. History taking and physical examination with emphasis on skin and mucosa were taken. Biopsy of suspicious sin, mucosal, and visceral lesions assigned by other paraclinical methods was performed. Except 7 cases which were HLA identical to donors, all patients were managed with cyclosporine, Azathioprine and Prednisolone. Results: Fourteen patients (2.2%) developed Kaposi sarcoma (biopsy documented which constituted 60% of all post-transplantation malignancies. They were 11 males and 3 females with a mean age of 41 years. Sarcoma developed 8 to 31 months after transplantation with an average of 18 months. Of these patients, 13 had skin involvement that one of them had pulmonary involvement too. Another patient had only abdominal involvement. Azathioprine was discontinued all patients, and cyclosporine was reduced in skin affected patients. In patients with visceral involvement cyclosporine was discontinued and then chemotherapy was initiated. All 3 patients with visceral involvement didn't respond to chemotherapy and expired after 6 months. Of 11 patients with skin involvement, one had complete and 2 had incomplete remission of whom, one expired due to acute rejection. Renal function in 8 patients was acceptable, but 2 had impaired renal function, yet didn't need dialysis. Conclusion: Prevalence of Kaposi sarcoma in our patients is more than western countries. Visceral involvement is uncommon. But has poor prognosis. Reducing immunosuppression with discontinuation of azathioprine and significant reducing cyclosporine dosage can cease skin evolvement, with preserving renal function in most of the patients.
Schlagwörter	Diseases of the genitourinary system. Urology ; RC870-923 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Urology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Thema/Rubrik (Code)	610 ; 616
Sprache	Englisch
Erscheinungsdatum	2004-06-01T00:00:00Z
Verlag	Shaheed Beheshti University of Medical Sciences
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: The complete genome sequence BK polyomavirus study in kidney transplanted patients

Manoochehr Makvandi / Gholam Abbas Kaydani / Heshmatollah Shahbazian / Alireza Teimoori / Fakher Rahim / Sajjad Aslani

Journal of Nephropathology, Vol 8, Iss 2, Pp e15-e

2019 Band 15

Abstract: Background: BK polyomavirus is a member of the Polyomaviridae. This virus has spread worldwide and up to 82% of the world populations are serologically positive. BK polyomavirus usually transmits through inhalation or fecal-oral way in childhood, as well ...

Abstract	Background: BK polyomavirus is a member of the Polyomaviridae. This virus has spread worldwide and up to 82% of the world populations are serologically positive. BK polyomavirus usually transmits through inhalation or fecal-oral way in childhood, as well as is likely to cause an asymptomatic disease. The virus can be reactivated in people who are immunocompromised. Objectives: In this study we aimed to determine the complete genome sequence of BK polyomavirus in 5 patients receiving kidney transplantation in Golestan hospital, Ahvaz, south west of Iran. Materials and Methods: The study was performed on urine and blood samples from kidney transplant ward, Golestan hospital, Ahvaz, Iran. To amplify the whole genome of BK polyomavirus AccuPower ProFi Taq PCR PreMix kit (Bioneer, South Korea) was used. Then, purified fragments were cloned into the vector. Sequences derived from the sequencing process were assembled by MEGA7 software. Data were analyzed using MEGA7 software and a phylogenetic tree was built based on the maximum likelihood ratio method. Results: Overall, 40 urine samples (40%) and two plasma samples (12%) were positive for BK virus DNA. For the selected samples, W.G. Long PCR was performed and 5.1 kbp fragment was observed in all five samples. These fragments were cloned and sequenced. Genomic sequence analysis of the 5 strains studied showed 97.6% homology and all our study samples were of the same clade, which could be a reason for our patients to be infected with the same strain. Comparing the 5 isolates in our study with reference strains, showed more than 98% of homology, and variation was observed in less than 2% of nucleotides. Conclusion: These five isolates showed more than 98% homology compared to the reference sequences, which can be attributed to the fact that these patients are infected with a common strain or that the genomic stability in the strain exists in our geographic area. We can conclude that in our geographic region there is a genomic stability and this strain can also be used ...
Schlagwörter	bk polyomavirus ; full genome ; kidney transplantation ; polyomaviridae ; Pathology ; RB1-214 ; Internal medicine ; RC31-1245 ; Other systems of medicine ; RZ201-999
Thema/Rubrik (Code)	630
Sprache	Englisch
Erscheinungsdatum	2019-04-01T00:00:00Z
Verlag	Society of Diabetic Nephropathy Prevention
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Prevalence, awareness and risk factors of hypertension in southwest of Iran.

Yazdanpanah, Leila / Shahbazian, Hajieh / Shahbazian, Heshmatollah / Latifi, Seyed-Mahmuod

Journal of renal injury prevention

2015 Band 4, Heft 2, Seite(n) 51–56

Abstract: Introduction: Hypertension is an important cause of stroke, heart and kidney disease and these diseases are the cause for about two-thirds of all mortalities around the world.: Objectives: The aim of this study was to assess the prevalence, awareness ...

Abstract	Introduction: Hypertension is an important cause of stroke, heart and kidney disease and these diseases are the cause for about two-thirds of all mortalities around the world. Objectives: The aim of this study was to assess the prevalence, awareness and risk factors of hypertension in Ahvaz, southwest of Iran. Patients and methods: In this descriptive-analytical study, 944 participants older than 20 years were enrolled. Systolic blood pressure (BP) ≥140 mm Hg, diastolic BP ≥90 mm Hg or the use of antihypertensive medication was considered as hypertension. Systolic BP = 140-159 mm Hg or diastolic BP = 90-99 mm Hg were defined as stage 1, and systolic BP ≥160 mm Hg or diastolic BP ≥100 mm Hg were considered as stage 2 of hypertension. Systolic BP = 120-139 mm Hg and diastolic BP= 80-89 mm Hg were considered as prehypertensive state. Results: The prevalence of hypertension in Ahvaz was 17.58% (95% CI: 15.28-20.14) (males; 45.8%, females; 54.2%). Age-adjusted prevalence of hypertension was 8.6%; age- and sex-adjusted prevalence of hypertension was 3.7%. Seventy-two cases (7.7%) were prehypertensive. The frequency of stage 1 hypertension was 10.8% and stage 2 was 5.7%. Among them, 53.6% were not aware of their disease and 22% of hypertensive cases were controlled. Logistic regression analysis showed that age, metabolic syndrome and family history of hypertension had significant relationship with hypertension. Conclusion: This study showed that, age, metabolic syndrome and family history of disease are risk factors of hypertension in Ahvaz population. About half of patients were unaware of their disease and about 20% had controlled BP.
Sprache	Englisch
Erscheinungsdatum	2015-06-01
Erscheinungsland	Iran
Dokumenttyp	Journal Article
ZDB-ID	2747305-3
ISSN	2345-2781
ISSN	2345-2781
DOI	10.12861/jrip.2015.11
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Changes in body mass index after pediatric renal transplantation.

Beladi Mousavi, Seyed Seifollah / Valavi, Ehsan / Aminzadeh, Majid / Shahbazian, Heshmatollah / Otukesh, Hasan / Hoseini, Rozita / Cheraghian, Bahman

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2020 Band 31, Heft 2, Seite(n) 448–453

Abstract: Significant weight gain following renal transplantation is common in adult and pediatric recipients and mostly depends on receiving higher doses of steroids, changes in mood and feelings, as well as their level of physical activities. This study was ... ...

Abstract	Significant weight gain following renal transplantation is common in adult and pediatric recipients and mostly depends on receiving higher doses of steroids, changes in mood and feelings, as well as their level of physical activities. This study was performed to evaluate body weight and body mass index (BMI) before and after kidney transplantation in children and adolescents. In this cross-sectional study, 71 pediatric renal transplant recipients (42 boys and 29 girls) were included. World Health Organization criteria were used for comparing Z-score BMI for age in our cases. Overweight was defined as Z-score BMI >+1 SD (standard deviation) and obesity as >+2 SD. At the time of transplantation, the mean age was 10.8 ± 3 years (5-16 years) and based on BMIZ-score, the patients were found to be thin (BMIZs <-2 SD) in 16.9%, normal (BMIZs = -2 to +1 SD) in 67.6%, overweight (>+1 SD to +2 SD) in 9.9%, and obese (BMIZs >+2 SD) in 5.6%.The mean follow-up duration after transplantation was 3.57 ± 1.68 years (1-7 years) and at the time of reevaluation after transplant, their mean age was 14.4 years (6-18 years). The mean BMI was 22 ± 5.3 kg/m
Mesh-Begriff(e)	Adolescent ; Age Factors ; Body Mass Index ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Incidence ; Iran/epidemiology ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Pediatric Obesity/diagnosis ; Pediatric Obesity/epidemiology ; Pediatric Obesity/physiopathology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Thinness/diagnosis ; Thinness/epidemiology ; Thinness/physiopathology ; Time Factors ; Treatment Outcome ; Weight Gain
Sprache	Englisch
Erscheinungsdatum	2020-06-12
Erscheinungsland	Saudi Arabia
Dokumenttyp	Journal Article
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.284020
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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