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  1. Article: A case of idiopathic chylous ascites.

    Olaru, Adina / Venkatachalapathy, Suresh V / James, Martin / Martinez-Calle, Nicolas

    Oxford medical case reports

    2023  Volume 2023, Issue 2, Page(s) omad009

    Abstract: Chylous ascites is a rare condition found in 1 in 20 000 patients admitted to hospital with abdominal distention. It is caused by a limited number of pathologies but can, in rare situations, be idiopathic. Its management is difficult and usually involves ...

    Abstract Chylous ascites is a rare condition found in 1 in 20 000 patients admitted to hospital with abdominal distention. It is caused by a limited number of pathologies but can, in rare situations, be idiopathic. Its management is difficult and usually involves correcting the primary pathology, making idiopathic chylous ascites particularly difficult to manage. We present a case of idiopathic chylous ascites extensively investigated over a period of several years. An incidental finding of B cell lymphoma was initially suspected to have been the primary cause of the ascites; however, after successful treatment of this condition, the patient's ascites did not resolve. Diagnostic difficulties and management are discussed and an overview of the diagnostic process is outlined through this case.
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omad009
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  2. Article ; Online: Rare central nervous system lymphomas.

    Kaji, Furqaan Ahmed / Martinez-Calle, Nicolás / Sovani, Vishakha / Fox, Christopher Paul

    British journal of haematology

    2022  Volume 197, Issue 6, Page(s) 662–678

    Abstract: Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS ... ...

    Abstract Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS lymphomas are of the diffuse large B-cell lymphoma (DLBCL) subtype for which treatment strategies, particularly the use of high-dose methotrexate-based protocols and consolidation with autologous stem cell transplantation, are well established. Other histopathological subtypes of CNS lymphoma are comparatively less common with published data on these rare lymphomas dominated by smaller case series and retrospective reports. Consequently, there exists little clinical consensus on the optimal methods to diagnose and manage these clinically and biologically heterogeneous CNS lymphomas. In this review article, we focus on rarer CNS lymphomas, summarising the available clinical data on incidence, context, diagnostic features, reported management strategies, and clinical outcomes.
    MeSH term(s) Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Non-Hodgkin/epidemiology ; Meninges ; Retrospective Studies ; Transplantation, Autologous
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18128
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  3. Article: Correction: Ordoñez, et al.; DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters? Cancers 2019, 11, 1424.

    Ordoñez, Raquel / Martínez-Calle, Nicolás / Agirre, Xabier / Prosper, Felipe

    Cancers

    2020  Volume 12, Issue 7

    Abstract: The authors would like to make a correction to their published paper [ ... ]. ...

    Abstract The authors would like to make a correction to their published paper [...].
    Language English
    Publishing date 2020-07-13
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12071885
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  4. Article: DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters?

    Ordoñez, Raquel / Martínez-Calle, Nicolás / Agirre, Xabier / Prosper, Felipe

    Cancers

    2019  Volume 11, Issue 10

    Abstract: Gene regulation through DNA methylation is a well described phenomenon that has a prominent role in physiological and pathological cell-states. This epigenetic modification is usually grouped in regions denominated CpG islands, which frequently co- ... ...

    Abstract Gene regulation through DNA methylation is a well described phenomenon that has a prominent role in physiological and pathological cell-states. This epigenetic modification is usually grouped in regions denominated CpG islands, which frequently co-localize with gene promoters, silencing the transcription of those genes. Recent genome-wide DNA methylation studies have challenged this paradigm, demonstrating that DNA methylation of regulatory regions outside promoters is able to influence cell-type specific gene expression programs under physiologic or pathologic conditions. Coupling genome-wide DNA methylation assays with histone mark annotation has allowed for the identification of specific epigenomic changes that affect enhancer regulatory regions, revealing an additional layer of complexity to the epigenetic regulation of gene expression. In this review, we summarize the novel evidence for the molecular and biological regulation of DNA methylation in enhancer regions and the dynamism of these changes contributing to the fine-tuning of gene expression. We also analyze the contribution of enhancer DNA methylation on the expression of relevant genes in acute myeloid leukemia and chronic myeloproliferative neoplasms. The characterization of the aberrant enhancer DNA methylation provides not only a novel pathogenic mechanism for different tumors but also highlights novel potential therapeutic targets for myeloid derived neoplasms.
    Language English
    Publishing date 2019-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11101424
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  5. Article ; Online: Advances in treatment of elderly primary central nervous system lymphoma.

    Martinez-Calle, Nicolas / Isbell, Lisa K / Cwynarski, Kate / Schorb, Elisabeth

    British journal of haematology

    2021  Volume 196, Issue 3, Page(s) 473–487

    Abstract: The management of older individuals (≥60 years) with primary central nervous system lymphoma remains a clinical challenge. Identification of optimal therapy and delivering adequate dose intensity are two of the major issues in treating elderly patients. ... ...

    Abstract The management of older individuals (≥60 years) with primary central nervous system lymphoma remains a clinical challenge. Identification of optimal therapy and delivering adequate dose intensity are two of the major issues in treating elderly patients. Premorbid performance status and comorbidities influence individualised treatment approaches and geriatric assessment tools are increasingly utilised. Optimal induction treatment remains high-dose methotrexate-based immunochemotherapy, delivery is feasible in the majority of patients and the goal of treatment remains achieving complete remission. Consolidation strategies are also relevant in the elderly, aiming to maximise duration of response and quality of life (QoL). Potential options include high-dose therapy with haematopoietic stem cell consolidation, non-myeloablative chemotherapy and whole-brain radiotherapy. Efficacy of novel agents, such as Bruton tyrosine kinase inhibitors and lenalidomide, have been reported; these represent an alternative for elderly patients unfit for chemotherapy. Prognosis remains poor, improvement of outcomes in this age group is urgently needed.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Algorithms ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/etiology ; Central Nervous System Neoplasms/therapy ; Clinical Decision-Making ; Combined Modality Therapy/methods ; Disease Management ; Geriatric Assessment ; Humans ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/therapy ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Quality of Life ; Retreatment ; Treatment Outcome
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17799
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  6. Article ; Online: Scedosporium apiospermum

    Figueroa, Rocio / Martinez-Calle, Nicolas / Prescott, Katie / Bishton, Mark

    EJHaem

    2020  Volume 1, Issue 2, Page(s) 418–419

    Language English
    Publishing date 2020-10-26
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.121
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  7. Article ; Online: Population-based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large-cell lymphoma using Public Health England data.

    Halligan, Sarah J / Grainge, Matthew J / Martinez-Calle, Nicolas / Fox, Christopher P / Bishton, Mark J

    British journal of haematology

    2021  Volume 196, Issue 4, Page(s) 932–938

    Abstract: Systemic anaplastic large-cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immunoconjugate brentuximab vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results of a ... ...

    Abstract Systemic anaplastic large-cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immunoconjugate brentuximab vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results of a pivotal phase II study. We present a population-based study describing outcomes of relapsed sALCL in England after BV, using Public Health England data. We obtained information on all relapsed/refractory (r/r) sALCL patients ≥18 years treated with BV monotherapy in England between 1 January 2014 and 31 December 2019. The final cohort comprised 127 patients with a median age of 60 years (range 19-89). Eighteen (14·2%) had received stem cell transplant in first remission. Median two-year overall survival (OS) was 46·6%. The vast majority of deaths (59) occurred within 18 months, with very few events after this. Receipt of BV as second line compared to third or fourth line was associated with significantly improved survival (two-year OS 50·3% vs 29·7%, P = 0·03). There was no difference in OS for different subgroups, including anaplastic lymphoma kinase status, age, gender, or receipt of stem cell transplantation in first response. We report excellent survival following treatment with BV in a real-world setting, comparable with previous clinical trial data.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Brentuximab Vedotin/pharmacology ; Brentuximab Vedotin/therapeutic use ; Cohort Studies ; Databases, Factual ; England ; Female ; Humans ; Lymphoma, Large-Cell, Anaplastic/drug therapy ; Lymphoma, Large-Cell, Anaplastic/mortality ; Male ; Middle Aged ; Survival Analysis
    Chemical Substances Antineoplastic Agents, Immunological ; Brentuximab Vedotin (7XL5ISS668)
    Language English
    Publishing date 2021-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17896
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  8. Article ; Online: Allogeneic hematopoietic stem cell transplantation outcome in oldest known surviving patients with Wiskott-Aldrich syndrome.

    Anantharachagan, Ariharan / Loh, Sook Yin / Burns, Siobhan O / Laurence, Arian / Tadros, Susan / Tholouli, Eleni / Lwin, Yadanar / Martinez-Calle, Nicolas / Vaitla, P / Morris, Emma C

    The journal of allergy and clinical immunology. Global

    2023  Volume 3, Issue 1, Page(s) 100191

    Abstract: Regardless of their age, adult patients with Wiskott-Aldrich syndrome should be considered for hematopoietic stem cell transplantation if clinically indicated. ...

    Abstract Regardless of their age, adult patients with Wiskott-Aldrich syndrome should be considered for hematopoietic stem cell transplantation if clinically indicated.
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Case Reports
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100191
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  9. Article ; Online: Response to letter.

    Martínez-Calle, Nicolás / Rubio, Manuel / Yuste, José Ramón

    Journal of travel medicine

    2014  Volume 21, Issue 3, Page(s) 220–221

    MeSH term(s) Animals ; Artemisinins/adverse effects ; Eosinophilia/etiology ; Humans ; Male ; Praziquantel/administration & dosage ; Schistosoma haematobium ; Schistosomiasis ; Travel
    Chemical Substances Artemisinins ; Praziquantel (6490C9U457)
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1111/jtm.12103_2
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    Zs.A 4120: Show issues Location:
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  10. Article: Early MRI Predictors of Relapse in Primary Central Nervous System Lymphoma Treated with MATRix Immunochemotherapy.

    Cornell, Isabel / Al Busaidi, Ayisha / Wastling, Stephen / Anjari, Mustafa / Cwynarski, Kate / Fox, Christopher P / Martinez-Calle, Nicolas / Poynton, Edward / Maynard, John / Thust, Steffi C

    Journal of personalized medicine

    2023  Volume 13, Issue 7

    Abstract: Primary Central Nervous System Lymphoma (PCNSL) is a highly malignant brain tumour. We investigated dynamic changes in tumour volume and apparent diffusion coefficient (ADC) measurements for predicting outcome following treatment with MATRix chemotherapy ...

    Abstract Primary Central Nervous System Lymphoma (PCNSL) is a highly malignant brain tumour. We investigated dynamic changes in tumour volume and apparent diffusion coefficient (ADC) measurements for predicting outcome following treatment with MATRix chemotherapy in PCNSL. Patients treated with MATRix (
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13071182
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