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  1. Article: Symblepharon Formation in the Setting of Steven-Johnson Syndrome.

    Cheung, Eric / Zhang, Xiao Chi

    The Journal of emergency medicine

    2023  Volume 65, Issue 2, Page(s) e146–e148

    MeSH term(s) Humans ; Conjunctival Diseases ; Stevens-Johnson Syndrome/diagnosis ; Cicatrix ; Vision Disorders
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.04.022
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    Zs.A 1895: Show issues Location:
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  2. Article ; Online: ChatGPT and the Law of the Horse.

    Cheung, Alexander T M / Nasir-Moin, Mustafa / Oermann, Eric K

    The American journal of bioethics : AJOB

    2023  Volume 23, Issue 10, Page(s) 55–57

    MeSH term(s) Horses ; Animals ; Bioethics
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2023.2250279
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    Zs.A 6814: Show issues Location:
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  3. Article ; Online: The role of ROS in tumour development and progression.

    Cheung, Eric C / Vousden, Karen H

    Nature reviews. Cancer

    2022  Volume 22, Issue 5, Page(s) 280–297

    Abstract: Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS ... ...

    Abstract Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS limitation pathways are common features of cancer cells. ROS also function to modulate the tumour environment, affecting the various stromal cells that provide metabolic support, a blood supply and immune responses to the tumour. Although it is clear that ROS play important roles during tumorigenesis, it has been difficult to reliably predict the effect of ROS modulating therapies. We now understand that the responses to ROS are highly complex and dependent on multiple factors, including the types, levels, localization and persistence of ROS, as well as the origin, environment and stage of the tumours themselves. This increasing understanding of the complexity of ROS in malignancies will be key to unlocking the potential of ROS-targeting therapies for cancer treatment.
    MeSH term(s) Carcinogenesis ; Cell Transformation, Neoplastic ; Humans ; Neoplasms/pathology ; Reactive Oxygen Species/metabolism ; Signal Transduction
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-021-00435-0
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  4. Article ; Online: Catheter Versus Hybrid Ablation for Persistent Atrial Fibrillation: The Lesion Set Matters.

    Braunstein, Eric D / Gabriels, James K / Cheung, Jim W / Markowitz, Steven M

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 7 Pt 2, Page(s) 1193–1194

    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Treatment Outcome ; Catheter Ablation ; Catheters
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.03.019
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  5. Article ; Online: Global Mental Health Security-Time for Action.

    Ip, Eric C / Cheung, Daisy

    JAMA health forum

    2020  Volume 1, Issue 6, Page(s) e200622

    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2020.0622
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  6. Article ; Online: Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence Variability.

    Dehipawala, Sunil / Cheung, Eric / Tremberger, George / Cheung, Tak

    Entropy (Basel, Switzerland)

    2021  Volume 23, Issue 8

    Abstract: The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence ... ...

    Abstract The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence with intra-LCD structural information based on cryo-EM data was published recently. An application of entropy and Higuchi fractal dimension calculations was described using the Znf521 and HAR1 sequences. A computational analysis of the intra-LCD sequence entropy and Higuchi fractal dimension values at the amino acid level and at the ATCG nucleotide level were conducted without the sliding window requirement. The computational results were consistent in predicting the intermediate entropy/fractal dimension value produced when two subsequences at two different entropy/fractal dimension values were combined. The computational method without the application of a sliding-window was extended to an analysis of the recently reported virulent genes-Orf6, Nsp6, and Orf7a-in SARS-CoV-2. The relationship between the virulence functionality and entropy values was found to have correlation coefficients between 0.84 and 0.99, using a 5% uncertainty on the cell viability data. The analysis found that the most virulent Orf6 gene sequence had the lowest nucleotide entropy and the highest protein fractal dimension, in line with extreme value theory. The Orf6 codon usage bias in relation to vaccine design was discussed.
    Language English
    Publishing date 2021-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e23081038
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  7. Article ; Online: The age-based digital divide in an increasingly digital world: A focus group investigation during the COVID-19 pandemic.

    Cheung, Ken / Chau, Anson Kai Chun / Woo, Jean / Lai, Eric Tc

    Archives of gerontology and geriatrics

    2023  Volume 115, Page(s) 105225

    Abstract: Background and objectives: Previous research has identified numerous benefits of information and communication technology (ICT) on the well-being of older adults. However, it has been increasingly recognized that older adults do not necessarily catch up ...

    Abstract Background and objectives: Previous research has identified numerous benefits of information and communication technology (ICT) on the well-being of older adults. However, it has been increasingly recognized that older adults do not necessarily catch up with the rapidly digitalized society, known as the 'age-based digital divide'. The progress of digitalization has been accelerated during the COVID-19 pandemic, which may have widened the digital divide. This study aimed to gain a better understanding of their living experience and concerns about digital exclusion during the pandemic. The perceptions of older adults in Hong Kong, a highly digitalized, metropolitan city, towards the digital age and its impact on their daily living during the COVID-19 pandemic were explored.
    Research design and methods: We conducted 12 focus group interviews with 77 community-dwelling older adults during the COVID-19 pandemic. Data were analyzed using thematic analysis, applying both organization, reduction, and refinement.
    Results: Four themes were identified: 1) Diversified means to access community information; 2) Facilitated daily living through the usage of ICTs; 3) Concerns about age-related decline in function; and 4) Fear of digital exclusion and accelerated digitalization during the pandemic. The results indicate that ICT provided numerous benefits to the daily life of older adults, but our participants also expressed concerns about age-related losses and the fear of digital exclusion due to the ongoing digitalization of society.
    Discussion and implications: Our findings indicated that older adults do not necessarily benefit from technological innovations, which are becoming more pervasive during the pandemic. To create age-friendly environments that cater to the needs of all members of society in the digital age, policymakers and service providers should provide diverse choices for older adults, rather than relying solely on one-size-fits-all technological solutions.
    MeSH term(s) Humans ; Aged ; COVID-19/epidemiology ; Pandemics ; Digital Divide ; Focus Groups ; Communication
    Language English
    Publishing date 2023-10-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2023.105225
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    Zs.A 1729: Show issues Location:
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  8. Article ; Online: COVID-19 Lockdowns: a Public Mental Health Ethics Perspective.

    Cheung, Daisy / Ip, Eric C

    Asian bioethics review

    2020  Volume 12, Issue 4, Page(s) 503–510

    Abstract: States all over the world have reacted to COVID-19 with quarantines of entire cities, provinces, and even nations. Previous studies and preliminary evidence from current lockdowns suggest that emergency measures protecting the public's physical health by ...

    Abstract States all over the world have reacted to COVID-19 with quarantines of entire cities, provinces, and even nations. Previous studies and preliminary evidence from current lockdowns suggest that emergency measures protecting the public's physical health by dislocating individuals, families, and social networks could well be causing a devastating public health crisis of mental ill-health in the months and years to come. This article is the first to take a public mental health ethics perspective in examining these lockdowns, the lodestar of which is the right to mental health, rooted in the concept of human dignity. Even the strictest lockdowns are not necessarily unethical but are prone to damage mental health disproportionately, with vulnerable and disadvantaged populations being at particular risk.
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2602378-7
    ISSN 1793-9453 ; 1793-8759
    ISSN (online) 1793-9453
    ISSN 1793-8759
    DOI 10.1007/s41649-020-00144-0
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  9. Article ; Online: Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence Variability

    Sunil Dehipawala / Eric Cheung / George Tremberger / Tak Cheung

    Entropy, Vol 23, Iss 1038, p

    2021  Volume 1038

    Abstract: The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence ... ...

    Abstract The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence with intra-LCD structural information based on cryo-EM data was published recently. An application of entropy and Higuchi fractal dimension calculations was described using the Znf521 and HAR1 sequences. A computational analysis of the intra-LCD sequence entropy and Higuchi fractal dimension values at the amino acid level and at the ATCG nucleotide level were conducted without the sliding window requirement. The computational results were consistent in predicting the intermediate entropy/fractal dimension value produced when two subsequences at two different entropy/fractal dimension values were combined. The computational method without the application of a sliding-window was extended to an analysis of the recently reported virulent genes—Orf6, Nsp6, and Orf7a—in SARS-CoV-2. The relationship between the virulence functionality and entropy values was found to have correlation coefficients between 0.84 and 0.99, using a 5% uncertainty on the cell viability data. The analysis found that the most virulent Orf6 gene sequence had the lowest nucleotide entropy and the highest protein fractal dimension, in line with extreme value theory. The Orf6 codon usage bias in relation to vaccine design was discussed.
    Keywords entropy ; fractal dimension ; TDP-43 ; low complexity domain sequence ; SARS-CoV-2 ; HAR1 ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Subject code 612
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Pathologic Femur Fracture in an Immunocompetent Healthy Young Adult due to Acute Osteomyelitis.

    Goyette, Evan R J / Georgantzoglou, Natalia / Kerr, Darcy A / Cheung, Yvonne / Henderson, Eric R / Linos, Konstantinos

    Case reports in pathology

    2023  Volume 2023, Page(s) 6279174

    Abstract: An immunocompetent 33-year-old woman presented with a pathologic femur fracture after one month of progressively worsening right thigh pain. Open biopsy demonstrated acute suppurative osteomyelitis despite the lack of clinical risk factors. The ... ...

    Abstract An immunocompetent 33-year-old woman presented with a pathologic femur fracture after one month of progressively worsening right thigh pain. Open biopsy demonstrated acute suppurative osteomyelitis despite the lack of clinical risk factors. The polymicrobial infection was successfully treated with three operative procedures and culture-specific antibiotic agents. Acute osteomyelitis, while an uncommon cause of pathologic fracture, must always be on the differential diagnosis, even when no obvious predisposing factors are present. When investigating for an infectious etiology in cases such as our own, considering immunodeficiency syndromes alongside the more typical causes of osteomyelitis is encouraged.
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648758-5
    ISSN 2090-679X ; 2090-6781
    ISSN (online) 2090-679X
    ISSN 2090-6781
    DOI 10.1155/2023/6279174
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