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  1. Article ; Online: The latest achievements in biochemistry, biophysics and biotechnology-50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland.

    Jozef, Dulak

    IUBMB life

    2022  Volume 75, Issue 1, Page(s) 7

    MeSH term(s) Humans ; History, 20th Century ; Poland ; Universities ; Faculty ; Biotechnology ; Biophysics
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Historical Article ; Editorial
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2701
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    Zs.A 1611: Show issues Location:
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  2. Article ; Online: Cardioprotective Effects of Hydrogen Sulfide and Its Potential Therapeutic Implications in the Amelioration of Duchenne Muscular Dystrophy Cardiomyopathy.

    Łoboda, Agnieszka / Dulak, Józef

    Cells

    2024  Volume 13, Issue 2

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Humans ; Animals ; Mice ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/therapeutic use ; Muscular Dystrophy, Duchenne/drug therapy ; Cardiomyopathies/drug therapy ; Cardiomyopathies/etiology ; Antioxidants ; Caenorhabditis elegans
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Antioxidants
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020158
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  3. Article ; Online: Gene therapy. The legacy of Wacław Szybalski.

    Dulak, Józef

    Acta biochimica Polonica

    2021  Volume 68, Issue 3, Page(s) 359–375

    Abstract: Seminal demonstration of the possibility of stable genetic modification of mammalian cells performed by Wacław and Elisabeth Szybalski opened the doors for gene therapy, the term coined by Wacław Szybalski already in 1962. In the next 60 years, numerous ... ...

    Abstract Seminal demonstration of the possibility of stable genetic modification of mammalian cells performed by Wacław and Elisabeth Szybalski opened the doors for gene therapy, the term coined by Wacław Szybalski already in 1962. In the next 60 years, numerous tools for gene delivery have been developed and applied for clinical research, culminating in the registration of several genetic therapies in Europe and the USA. Some of these strategies, aimed to treat severe combined immunodeficiencies, inherited forms of blindness, spinal muscular atrophy, some cancers, and genetic anemias, are the real hope for patients suffering from previously incurable diseases or the ones whose treatment was not effective. On the approaching 60th anniversary of gene therapy, combined with the 100th anniversary of the birth of Professor Wacław Szybalski (September 9th, 1921), who passed away on December 16, 2020, here I present the summary of the most important aspects of clinical applications of genetic therapies.
    MeSH term(s) Animals ; Europe ; Genetic Therapy/history ; Genetic Therapy/methods ; History, 20th Century ; History, 21st Century ; Humans ; Mice ; Muscular Atrophy, Spinal/history ; Muscular Atrophy, Spinal/therapy ; Severe Combined Immunodeficiency/history ; Severe Combined Immunodeficiency/therapy ; United States ; beta-Thalassemia/history ; beta-Thalassemia/therapy
    Language English
    Publishing date 2021-08-31
    Publishing country Poland
    Document type Biography ; Historical Article ; Journal Article ; Review
    ZDB-ID 595762-x
    ISSN 1734-154X ; 0001-527X
    ISSN (online) 1734-154X
    ISSN 0001-527X
    DOI 10.18388/abp.2020_5805
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    Zs.B 232: Show issues Location:
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  4. Article ; Online: Truth in Science and Medicine

    Józef Dulak

    Relacje Międzykulturowe, Vol 4, Iss 2(10) (2021)

    The Hope and Hype of Stem Cell Therapies

    2021  

    Abstract: The article examines the practice of cell therapies, often named as stem cell therapies. For the general public this is recognized as promising treatment for many diseases, offering hope for many people to restore health to themselves or their loved ones. ...

    Abstract The article examines the practice of cell therapies, often named as stem cell therapies. For the general public this is recognized as promising treatment for many diseases, offering hope for many people to restore health to themselves or their loved ones. However, despite the enormous potential that this type of treatment holds, it has its limitations. The tension between hope, science, truth and deception can come to the fore especially when someone is fighting for their life. Moral and ethical issues play a key role in such cases, serving as guideposts obscured, however, by information noise.
    Keywords stem cell therapy ; science ; medicine ; communication ; Ethnology. Social and cultural anthropology ; GN301-674
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Ksiegarnia Akademicka Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration.

    Łoboda, Agnieszka / Dulak, Józef

    Antioxidants & redox signaling

    2023  Volume 38, Issue 7-9, Page(s) 619–642

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Signal Transduction/physiology ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/pathology ; Regeneration/physiology
    Chemical Substances NF-E2-Related Factor 2
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2022.0208
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  6. Article ; Online: Unproven cell interventions in Poland and the exploitation of European Union law on advanced therapy medicinal products.

    Dulak, Józef / Pecyna, Marlena

    Stem cell reports

    2023  Volume 18, Issue 8, Page(s) 1610–1620

    Abstract: The global threat of unproven "stem cell therapies" develops despite the repeated statements of scientific organizations and regulatory agencies warning about the improper rationale, lack of effectiveness, and potential health risks of such commercial ... ...

    Abstract The global threat of unproven "stem cell therapies" develops despite the repeated statements of scientific organizations and regulatory agencies warning about the improper rationale, lack of effectiveness, and potential health risks of such commercial activities. Here, this problem is discussed from Poland's perspective, where unjustified "stem cell medical experiments" have raised the concern of responsible scientists and physicians. The paper describes how the European Union law on advanced therapy medicinal products and the hospital exemption rule have been used improperly and unlawfully on a mass scale. The article indicates serious scientific, medical, legal, and social issues of these activities.
    MeSH term(s) European Union ; Poland ; Stem Cell Transplantation
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.05.017
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  7. Book: Angiogenesis and vascularisation

    Dulak, Józef / Józkowicz, Alicja / Łoboda, Agnieszka

    cellular and molecular mechanisms in health and diseases

    2013  

    Author's details Józef Dulak ; Alicja Józkowicz ; Agnieszka Łoboda ed
    Language English
    Size X, 416 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book
    HBZ-ID HT018188298
    ISBN 978-3-7091-1427-8 ; 3-7091-1427-6 ; 9783709114285 ; 3709114284
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 892 on loan 0 Vormerkungen

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  8. Article ; Online: Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing.

    Stępniewski, Jacek / Jeż, Mateusz / Dulak, Józef

    Stem cell research

    2023  Volume 68, Page(s) 103046

    Abstract: miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR-16- ... ...

    Abstract miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR-16-p was negatively associated with the severity of cardiac hypertrophy. Therefore, to better understand the role of these microRNAs in human cardiomyocytes in regard to their proliferative potential and hypertrophic growth, we generated hiPSC line with complete deletion of miR-15a/16-1 cluster using CRISPR/Cas9 gene editing. Obtained cells demonstrate expression of pluripotency markers, differentiation capacity into all three germ layers and normal karyotype.
    MeSH term(s) Humans ; Animals ; Mice ; Gene Editing ; Induced Pluripotent Stem Cells/metabolism ; CRISPR-Cas Systems/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cardiomegaly
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103046
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  9. Article ; Online: Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing

    Jacek Stępniewski / Mateusz Jeż / Józef Dulak

    Stem Cell Research, Vol 68, Iss , Pp 103046- (2023)

    2023  

    Abstract: miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR-16- ... ...

    Abstract miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR-16-p was negatively associated with the severity of cardiac hypertrophy. Therefore, to better understand the role of these microRNAs in human cardiomyocytes in regard to their proliferative potential and hypertrophic growth, we generated hiPSC line with complete deletion of miR-15a/16-1 cluster using CRISPR/Cas9 gene editing. Obtained cells demonstrate expression of pluripotency markers, differentiation capacity into all three germ layers and normal karyotype.
    Keywords hiPSC ; microRNA-15a ; microRNA-16-1 ; CRISPR/Cas9 ; Cardiomyocytes ; Cardiac hypertrophy ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Many roles for Pax7.

    Dulak, Józef

    Cell cycle (Georgetown, Tex.)

    2016  Volume 16, Issue 1, Page(s) 21–22

    Language English
    Publishing date 2016-10-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2016.1248729
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