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Article: Ovarian Causes of Pseudomyxoma Peritonei (PMP)-A Literature Review.

Ionescu, Sinziana / Marincas, Marian / Madge, Octavia Luciana / Dicu-Andreescu, Irinel Gabriel / Chitoran, Elena / Rotaru, Vlad / Cirimbei, Ciprian / Gherghe, Mirela / Ene, Adina / Rosca, Robert / Radu, Madalina / Simion, Laurentiu

Cancers

2024 Volume 16, Issue 8

Abstract: Background: Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of ... ...

Abstract	Background: Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of mucinous and gelatinous structures. Typically, the development of pseudomyxoma peritonei is associated with the rupture of appendiceal mucinous tumors and other gastrointestinal or ovarian mucinous tumors. The goal of our literature review was to identify various aspects that characterize the ovarian causes of pseudomyxoma peritonei. Materials and methods: The authors performed an extensive literature search between 1 February 2024 and 2 March 2024 on the following databases: Pubmed, Scopus, Oxford Journals, and Reaxys, and the findings were summarized into seven main clinical and paraclinical situations. Results: According to our research, the main instances in which pseudomyxoma peritonei can be triggered by an ovarian cause are the following: (1) mucinous cystadenoma; (2) mucinous ovarian cancer; (3) colon cancer with ovarian metastasis; (4) malignant transformation of an ovarian primary mature cystic teratoma; (5) appendiceal mucocele with peritoneal dissemination mimicking an ovarian tumor with peritoneal carcinomatosis; (6) mucinous borderline tumor developing inside an ovarian teratoma; and (7) the association between a mucinous bilateral ovarian cancer and a colonic tumor. Conclusions: In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration.
Language	English
Publishing date	2024-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16081446
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PET/PDT theranostics: synthesis and biological evaluation of a peptide-targeted gallium porphyrin.

Bryden, Francesca / Savoie, Huguette / Rosca, Elena V / Boyle, Ross W

Dalton transactions (Cambridge, England : 2003)

2015 Volume 44, Issue 11, Page(s) 4925–4932

Abstract: The development of novel theranostic agents is an important step in the pathway towards personalised medicine, with the combination of diagnostic and therapeutic modalities into a single treatment agent naturally lending itself to the optimisation and ... ...

Abstract	The development of novel theranostic agents is an important step in the pathway towards personalised medicine, with the combination of diagnostic and therapeutic modalities into a single treatment agent naturally lending itself to the optimisation and personalisation of treatment. In pursuit of the goal of a molecular theranostic suitable for use as a PET radiotracer and a photosensitiser for PDT, a novel radiolabelled peptide-porphyrin conjugate targeting the α6β1-integrin has been developed. (69/71)Ga and (68)Ga labelling of an azide-functionalised porphyrin has been carried out in excellent yields, with subsequent bioconjugation to an alkyne-functionalised peptide demonstrated. α6β1-integrin expression of two cell lines has been evaluated by flow cytometry, and therapeutic potential of the conjugate demonstrated. Evaluation of the phototoxicity of the porphyrin-peptide theranostic conjugate in comparison to an untargeted control porphyrin in vitro, demonstrated significantly enhanced activity for a cell line with higher α6β1-integrin expression when compared with a cell line exhibiting lower α6β1-integrin expression.
MeSH term(s)	Alkynes/chemistry ; Amino Acid Sequence ; Azides/chemistry ; Catalysis ; Copper/chemistry ; Cycloaddition Reaction ; Gallium Radioisotopes/therapeutic use ; HeLa Cells ; Humans ; Kinetics ; Metalloporphyrins/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/therapeutic use ; Photochemotherapy ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/therapeutic use ; Positron-Emission Tomography ; Temperature
Chemical Substances	Alkynes ; Azides ; Gallium Radioisotopes ; Metalloporphyrins ; Peptides ; Photosensitizing Agents ; Copper (789U1901C5)
Language	English
Publishing date	2015-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c4dt02949f
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Article: Unemployment Status Subsequent to Cancer Diagnosis and Therapies: A Systematic Review and Meta-Analysis.

Chimienti, Martina / Morlino, Giustino / Ingravalle, Fabio / Vinci, Antonio / Colarusso, Emilio / De Santo, Carolina / Formosa, Valeria / Gentile, Lavinia / Lorusso, Grazia / Mosconi, Claudia / Scaramella, Martina / Rosca, Virginia / Veneziano, Elena / Torino, Francesco / Emberti Gialloreti, Leonardo / Palombi, Leonardo

Cancers

2023 Volume 15, Issue 5

Abstract: The purpose of our study is to examine whether cancer and treatments are associated with job loss or changes in employment status. Eight prospective studies were included in the systematic review and meta-analysis, with a population aged 18-65 years, ... ...

Abstract	The purpose of our study is to examine whether cancer and treatments are associated with job loss or changes in employment status. Eight prospective studies were included in the systematic review and meta-analysis, with a population aged 18-65 years, analyzing treatment regimen and psychophysical and social status in post-cancer follow-up of at least 2 years. In the meta-analysis, a comparison was made between recovered unemployed cases and cases from a standard reference population. Results are summarized graphically using a forest plot. We showed that cancer and subsequent treatment are risk factors for unemployment with an overall relative risk of 7.24 (lnRR: 1.98, 95% CI: 1.32-2.63) or for change in employment status. Individuals undergoing chemotherapy and/or radiation treatment and those with brain and colorectal cancers are more likely to develop disabilities that negatively affect the risk of unemployment. Finally, variables such as low level education, female sex, older age, and being overweight before starting therapy are associated with higher risk of unemployment. In the future, it will be necessary for people with cancer to have access to specific health, social welfare, and employment support programs. In addition, it is desirable that they become more involved in their choice of therapeutic treatment.
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15051513
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Article ; Online: Thermosensitive, near-infrared-labeled nanoparticles for topotecan delivery to tumors.

Rosca, Elena V / Wright, Michael / Gonitel, Roman / Gedroyc, Wladyslaw / Miller, Andrew D / Thanou, Maya

Molecular pharmaceutics

2015 Volume 12, Issue 5, Page(s) 1335–1346

Abstract: Liposomal nanoparticles have proven to be versatile systems for drug delivery. However, the progress in clinic has been slower and less efficient than expected. This suggests a need for further development using carefully designed chemical components to ... ...

Abstract	Liposomal nanoparticles have proven to be versatile systems for drug delivery. However, the progress in clinic has been slower and less efficient than expected. This suggests a need for further development using carefully designed chemical components to improve usefulness under clinical conditions and maximize therapeutic effect. For cancer chemotherapy, PEGylated liposomes were the first nanomedicine to reach the market and have been used clinically for several years. Approaches toward targeted drug delivery using next generation "thermally triggered" nanoparticles are now in clinical trials. However, clinically tested thermosensitive liposomes (TSLs) lack the markers that allow tumor labeling and improved imaging for tissue specific applied hyperthermia. Here we describe the development of optically labeled TSLs for image guidance drug delivery and proof-of-concept results for their application in the treatment of murine xenograft tumors using the anticancer drug topotecan. These labeled TSLs also allow the simultaneous, real-time diagnostic imaging of nanoparticle biodistribution using a near-infrared (NIR; 750-950 nm) fluorophore coupled to a lipidic component of the lipid bilayer. When combined with multispectral fluorescence analysis, this allows for specific and high sensitivity tracking of the nanoparticles in vivo. The application of NIR fluorescence-labeled TSLs could have a transformative effect on future cancer chemotherapy.
MeSH term(s)	Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Drug Delivery Systems/methods ; Female ; Liposomes/chemistry ; Mice ; Microscopy, Fluorescence ; Nanomedicine/methods ; Nanoparticles/chemistry ; Ovarian Neoplasms/drug therapy ; Polyethylene Glycols/chemistry ; Topotecan/administration & dosage ; Topotecan/chemistry ; Topotecan/therapeutic use
Chemical Substances	Antineoplastic Agents ; Liposomes ; Polyethylene Glycols (30IQX730WE) ; Topotecan (7M7YKX2N15)
Language	English
Publishing date	2015-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/mp5002679
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Article: Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review

Ioniță-Mîndrican, Corina-Bianca / Ziani, Khaled / Mititelu, Magdalena / Oprea, Eliza / Neacșu, Sorinel Marius / Moroșan, Elena / Dumitrescu, Denisa-Elena / Roșca, Adrian Cosmin / Drăgănescu, Doina / Negrei, Carolina

Nutrients. 2022 June 26, v. 14, no. 13

2022

Abstract: Throughout history, malnutrition and deficiency diseases have been a problem for our planet’s population. A balanced diet significantly influences everyone’s health, and fiber intake appears to play a more important role than previously thought. The ... ...

Abstract	Throughout history, malnutrition and deficiency diseases have been a problem for our planet’s population. A balanced diet significantly influences everyone’s health, and fiber intake appears to play a more important role than previously thought. The natural dietary fibers are a category of carbohydrates in the constitution of plants that are not completely digested in the human intestine. High-fiber foods, such as fruits, vegetables and whole grains, have consistently been highly beneficial to health and effectively reduced the risk of disease. Although the mode of action of dietary fiber in the consumer body is not fully understood, nutritionists and health professionals unanimously recognize the therapeutic benefits. This paper presents the fiber consumption in different countries, the metabolism of fiber and the range of health benefits associated with fiber intake. In addition, the influence of fiber intake on the intestinal microbiome, metabolic diseases (obesity and diabetes), neurological aspects, cardiovascular diseases, autoimmune diseases and cancer prevention are discussed. Finally, dietary restrictions and excess fiber are addressed, which can cause episodes of diarrhea and dehydration and increase the likelihood of bloating and flatulence or even bowel obstruction. However, extensive studies are needed regarding the composition and required amount of fiber in relation to the metabolism of saprotrophic microorganisms from the enteral level and the benefits of the various pathologies with which they can be correlated.
Keywords	diabetes ; diarrhea ; dietary fiber ; flatulence ; humans ; intestinal microorganisms ; intestines ; malnutrition ; mechanism of action ; metabolism ; obesity ; risk ; saprotrophs ; therapeutics
Language	English
Dates of publication	2022-0626
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132641
Database	NAL-Catalogue (AGRICOLA)

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Article: Black Sea Mussels Qualitative and Quantitative Chemical Analysis: Nutritional Benefits and Possible Risks through Consumption

Mititelu, Magdalena / Neacșu, Sorinel Marius / Oprea, Eliza / Dumitrescu, Denisa-Elena / Nedelescu, Mirela / Drăgănescu, Doina / Nicolescu, Teodor Octavian / Roșca, Adrian Cosmin / Ghica, Manuela

Nutrients. 2022 Feb. 24, v. 14, no. 5

2022

Abstract: Mussels have a particular nutritional value, representing a highly valued food source and thus sought after worldwide. Their meat is a real culinary delicacy, rich in proteins, lipids, carbohydrates, trace elements, enzymes, and vitamins. The seasonal ... ...

Abstract	Mussels have a particular nutritional value, representing a highly valued food source and thus sought after worldwide. Their meat is a real culinary delicacy, rich in proteins, lipids, carbohydrates, trace elements, enzymes, and vitamins. The seasonal variation of mussels’ biochemical composition has been studied to determine the best harvesting period to capitalize on various biologically active fractions. In this work biochemical determinations have been performed on fresh flesh samples of Mytilus galloprovincialis specimens from the Black Sea coast to study seasonal variations in mussels’ biochemical compounds. An analysis of significant lipid classes and the fatty acid composition of lipid extracts obtained from mussel flesh has also been performed. Since mussels retain pollutants from the marine environment, in parallel, the concentration of heavy metals in the meat of mussels collected for the analysis of the chemical composition was investigated. The impact and risk of heavy metal poisoning due to food consumption of mussels contaminated due to pollution of the marine harvesting area was evaluated by the bio-concentration factor of metals and estimated daily intakes of heavy metals through mussel consumption.
Keywords	Mytilus galloprovincialis ; chemical analysis ; coasts ; fatty acid composition ; food consumption ; heavy metals ; lipids ; marine environment ; meat ; mussels ; nutritive value ; pollution ; risk ; seasonal variation ; Black Sea
Language	English
Dates of publication	2022-0224
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14050964
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Article: Insights into the Phaeozems pedogenesis using total elemental composition analysis. A case study from north-eastern Romania

Pîrnău, Radu Gabriel / Patriche, Cristian Valeriu / Roșca, Bogdan / Mirea, Dragoș Alexandru / Diaconu, Vasile / Stan, Cristina Oana / Bobric, Elena Diana / Vasiliniuc, Ionuț / Mănăilescu, Cristian / Rusu, Constantin

Geoderma. 2022 Mar. 01, v. 409

2022

Abstract: ... the relict character of the pre-Eneolithic soil. The geogenic elements like Al, Fe, K, Rb, and V are highly ...

Abstract	Phaeozems with very deep mollic topsoil overlying a cambic B horizon occur in a patchy distribution in Eastern Romania, in areas where present climatic conditions are rather favourable for forest soils development. Due to their unusual characteristics, it has been hypothesized that the main factors implied in their development could be related to the prehistoric habitation and climate changes during the Holocene, but this approach was never explored. In this context, an archaeological excavation into an Eneolithic (5000–3500 BCE) settlement located in north-eastern Romania offered the opportunity to investigate pre- and post-Eneolithic development of these soils. Fifty soil samples were collected above and below an Eneolithic dwelling floor, between adjacent dwellings and by off-site sampling. A portable X-ray fluorescence (pXRF) spectrometer was used to scan the soil samples and the total element composition of 18 elements was retained for subsequent statistical analysis. The main objective of this study was to analyse the depth functions of elemental contents in relation to the morphological characteristics of these soils in order to infer the pedogenic pathways of their formation. Results showed increased concentrations of P, Sr, Ca, Cu and Zn above the Eneolithic layer relative to the control soil profile, as a result of both prehistoric and recent anthropogenic activities, but similar trends bellow the dwelling remnants and between adjacent dwellings, which suggest the relict character of the pre-Eneolithic soil. The geogenic elements like Al, Fe, K, Rb, and V are highly correlated, have similar curve shapes in all analysed profiles and generally increase with depth, starting from the pre-Eneolithic land surface. The variability of Ti, Zr and Ti/Zr ratio shows a clear contrast in the upper part of soil profiles and a similarity below the Eneolithic level. Statistical analysis also confirms at least two major phases in the evolution of these soils. The application of the Pettitt test placed most of the elemental changes at the depth were the upper soil welded to the buried Eneolithic soil. Therefore, our study demonstrates the utility of Pettitt test in detecting pedogenic thresholds, besides its traditional use for time series analysis. The characteristics of the pre-Eneolithic soils support the hypothesis that they were already formed in the mid-Holocene, which constituted the prerequisite for the beginnings of human habitation and agriculture in this area. It can be concluded that the successive changes of climate and the land use since the mid-Holocene until present are likely the main factors that controlled the formation of the upper part of these overthickened soils, resulting in an incipient Luvic Phaeozem, which extended and welded downward to a relict Cambic Chernozem.
Keywords	B horizons ; Chernozems ; Holocene epoch ; Phaeozems ; X-radiation ; archaeology ; case studies ; elemental composition ; evolution ; fluorescence ; forests ; human settlements ; land use ; soil formation ; soil profiles ; spectrometers ; statistical analysis ; time series analysis ; topsoil ; Romania
Language	English
Dates of publication	2022-0301
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	281080-3
ISSN	1872-6259 ; 0016-7061
ISSN (online)	1872-6259
ISSN	0016-7061
DOI	10.1016/j.geoderma.2021.115604
Database	NAL-Catalogue (AGRICOLA)

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Article: Targeting drugs to combinations of receptors: a modeling analysis of potential specificity.

Caplan, Michael R / Rosca, Elena V

Annals of biomedical engineering

2005 Volume 33, Issue 8, Page(s) 1113–1124

Abstract: Targeting drugs to specific cells by conjugating the drug to an antibody or ligand for a cell surface receptor currently requires that the receptor be uniquely over-expressed by the target cell (the target cell over-expresses a particular receptor in ... ...

Abstract	Targeting drugs to specific cells by conjugating the drug to an antibody or ligand for a cell surface receptor currently requires that the receptor be uniquely over-expressed by the target cell (the target cell over-expresses a particular receptor in comparison with untargeted cells, which do display this receptor type but a lesser number of them). Here we develop a mathematical model to predict the behavior of multivalent ligand-drug constructs containing two different ligands for two different receptors, which would allow targeting cells that do not uniquely over-express any receptor. In this model, target cells express both receptors at a high level; whereas, untargeted cells express one receptor type at the high level but the other at a lower level. The model predicts that these heterovalent conjugates (containing two different types of ligands) can achieve specificity even when the target cell does not uniquely over-express any one receptor type. Using the current approach, constructs in which only one ligand type is used will bind as much to untargeted cells as to the target cells. Therefore, this combination strategy can enormously expand the number of applications for which cell surface receptor targeting of drugs is an appropriate option.
MeSH term(s)	Animals ; Drug Delivery Systems ; Humans ; Ligands ; Models, Chemical ; Receptors, Cell Surface/agonists ; Receptors, Cell Surface/chemistry
Chemical Substances	Ligands ; Receptors, Cell Surface
Language	English
Publishing date	2005-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	185984-5
ISSN	1573-9686 ; 0090-6964 ; 0191-5649
ISSN (online)	1573-9686
ISSN	0090-6964 ; 0191-5649
DOI	10.1007/s10439-005-5779-1
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Article ; Online: Glioblastoma targeting via integrins is concentration dependent.

Rosca, Elena V / Gillies, Robert J / Caplan, Michael R

Biotechnology and bioengineering

2009 Volume 104, Issue 2, Page(s) 408–417

Abstract: A novel approach to treat cancer more selectively is achieved by targeting drugs to cells via conjugating the drug or imaging agent to an antibody or ligand for a cell surface receptor that is over-expressed by the target cell population. Previous work ... ...

Abstract	A novel approach to treat cancer more selectively is achieved by targeting drugs to cells via conjugating the drug or imaging agent to an antibody or ligand for a cell surface receptor that is over-expressed by the target cell population. Previous work by us has suggested that enhanced specificity can be obtained by multivalency of binding moieties. In this study we investigated the binding specificity of a multivalent construct including three peptides segments (TWYKIAFQRNRK), which bind the alpha(6)beta(1)-integrin, linked by poly(ethylene glycol) spacers. The binding specificity of the constructs was calculated by quantifying their binding to target cells (glioma cells, SF 767) relative to non-targeted cells (normal human astrocytes, NHA). Dodecapeptide constructs (monovalent) exhibit specificity equal to the ratio of receptor expression at all concentrations. However, trivalent constructs demonstrated a sharp increase in specificity at concentrations less than the affinity of the receptor-ligand bond (4.28 microM). These experiments (conducted at 4 degrees C) were consistent with the theoretical prediction and indicate that the biophysical model captures the basic trend of the data in the absence of receptor internalization, although the concentration at which increased specificity is observed is greater than predicted. The biophysical model does not predict the results of 37 degrees C experiments, and this is shown to be due to internalization which occurs at 37 degrees C but not at 4 degrees C.
MeSH term(s)	Cell Line, Tumor ; Drug Delivery Systems/methods ; Humans ; Integrins/metabolism ; Ligands ; Peptides/metabolism ; Protein Binding ; Receptors, Cell Surface/metabolism
Chemical Substances	Integrins ; Ligands ; Peptides ; Receptors, Cell Surface
Language	English
Publishing date	2009-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.22424
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Article ; Online: Antibacterial Polysiloxane Polymers and Coatings for Cochlear Implants.

Cozma, Vlad / Rosca, Irina / Radulescu, Luminita / Martu, Cristian / Nastasa, Valentin / Varganici, Cristian-Dragos / Ursu, Elena-Laura / Doroftei, Florica / Pinteala, Mariana / Racles, Carmen

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 16

Abstract: Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios ... ...

Abstract	Within this study, new materials were synthesized and characterized based on polysiloxane modified with different ratios of
MeSH term(s)	Acetylcysteine/chemistry ; Acetylcysteine/pharmacology ; Acetylcysteine/therapeutic use ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Adhesion/drug effects ; Biofilms/drug effects ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Coated Materials, Biocompatible/therapeutic use ; Cochlear Implants/adverse effects ; Cochlear Implants/microbiology ; Otitis/drug therapy ; Polymers/chemistry ; Polymers/pharmacology ; Polymers/therapeutic use ; Rats, Wistar ; Siloxanes/chemistry ; Siloxanes/pharmacology ; Siloxanes/therapeutic use ; Streptococcus pneumoniae/drug effects ; Sulfhydryl Compounds/chemistry ; Surface Properties ; Rats
Chemical Substances	Anti-Bacterial Agents ; Coated Materials, Biocompatible ; Polymers ; Siloxanes ; Sulfhydryl Compounds ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2021-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26164892
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