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  1. Article: Curcumin as an Adjuvant to Cancer Immunotherapy.

    Paul, Silpita / Sa, Gaurisankar

    Frontiers in oncology

    2021  Volume 11, Page(s) 675923

    Abstract: The components of the immune system play a very sincere and crucial role in combating tumors. However, despite their firm efforts of elimination, tumor cells cleverly escape the surveillance process by adopting several immune evasion mechanisms. The ... ...

    Abstract The components of the immune system play a very sincere and crucial role in combating tumors. However, despite their firm efforts of elimination, tumor cells cleverly escape the surveillance process by adopting several immune evasion mechanisms. The conversion of immunogenicity of tumor microenvironment into tolerogenic is considered as a prime reason for tumor immune escape. Therapeutically, different immunotherapies have been adopted to block such immune escaping routes along with better clinical outcomes. Still, the therapies are haunted by several drawbacks. Over time, curcumin has been considered as a potential anti-cancer molecule. Its potentialities have been recorded against the standard hallmarks of cancer such as continuous proliferation, escaping apoptosis, continuous angiogenesis, insensitivity to growth inhibitors, tissue invasion, and metastasis. Hence, the diversity of curcumin functioning has already been established and exploration of its application with immunotherapies might open up a new avenue for scientists and clinicians. In this review, we briefly discuss the tumor's way of immune escaping, followed by various modern immunotherapies that have been used to encounter the escaping paths and their minute flaws. Finally, the conclusion has been drawn with the application of curcumin as a potential immune-adjuvant, which fearlessly could be used with immunotherapies for best outcomes.
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.675923
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  2. Article: The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer.

    Paul, Silpita / Roy, Dia / Pati, Subhadip / Sa, Gaurisankar

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 731492

    Abstract: The conventional carcinoma treatment generally encompasses the employment of radiotherapy, chemotherapy, surgery or use of cytotoxic drugs. However, recent advances in pharmacological research have divulged the importance of traditional treatments in ... ...

    Abstract The conventional carcinoma treatment generally encompasses the employment of radiotherapy, chemotherapy, surgery or use of cytotoxic drugs. However, recent advances in pharmacological research have divulged the importance of traditional treatments in cancer. The aim of the present review is to provide an overview of the importance of one such medicinal herb of Chinese and Indian origin:
    Language English
    Publishing date 2021-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.731492
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  3. Article ; Online: Tumor-infiltrating T-regulatory cells adapt to altered metabolism to promote tumor-immune escape

    Tania Sarkar / Subhanki Dhar / Gaurisankar Sa

    Current Research in Immunology, Vol 2, Iss , Pp 132-

    2021  Volume 141

    Abstract: Tumor mass and its microenvironment alter host immune system in various ways to promote tumor growth. One of the modifications is evasion of immune surveillance by augmenting the number of Tregs in tumor vicinity. Elevated levels of Tregs are seen in ... ...

    Abstract Tumor mass and its microenvironment alter host immune system in various ways to promote tumor growth. One of the modifications is evasion of immune surveillance by augmenting the number of Tregs in tumor vicinity. Elevated levels of Tregs are seen in peripheral circulation and tumor tissue of cancer patients. Cancer cells release several chemokines to attract Tregs in tumor-site. Infiltration of Tregs has clinical significance because being immunosuppressive infiltrating Tregs suppress other immune cells making the tumor microenvironment favorable for tumor growth. On the other hand, infiltrating Tregs show metabolic alteration in tumor microenvironment which allows their selective survival over the others. Persistence of Tregs in the tumor microenvironment and subsequent immunosuppression makes Tregs a potential therapeutic obstacle and the reason behind the failure of immunotherapy. In this review, we emphasize the recent development in the metabolic adaptation of tumor-infiltrating Tregs and the therapeutic approaches to boost immunity against cancer.
    Keywords T-regulatory cell ; Metabolism ; Immune-suppression ; Anti-Tumor immunity ; Tumor microenvironment ; Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Tumor-infiltrating T-regulatory cells adapt to altered metabolism to promote tumor-immune escape.

    Sarkar, Tania / Dhar, Subhanki / Sa, Gaurisankar

    Current research in immunology

    2021  Volume 2, Page(s) 132–141

    Abstract: Tumor mass and its microenvironment alter host immune system in various ways to promote tumor growth. One of the modifications is evasion of immune surveillance by augmenting the number of Tregs in tumor vicinity. Elevated levels of Tregs are seen in ... ...

    Abstract Tumor mass and its microenvironment alter host immune system in various ways to promote tumor growth. One of the modifications is evasion of immune surveillance by augmenting the number of Tregs in tumor vicinity. Elevated levels of Tregs are seen in peripheral circulation and tumor tissue of cancer patients. Cancer cells release several chemokines to attract Tregs in tumor-site. Infiltration of Tregs has clinical significance because being immunosuppressive infiltrating Tregs suppress other immune cells making the tumor microenvironment favorable for tumor growth. On the other hand, infiltrating Tregs show metabolic alteration in tumor microenvironment which allows their selective survival over the others. Persistence of Tregs in the tumor microenvironment and subsequent immunosuppression makes Tregs a potential therapeutic obstacle and the reason behind the failure of immunotherapy. In this review, we emphasize the recent development in the metabolic adaptation of tumor-infiltrating Tregs and the therapeutic approaches to boost immunity against cancer.
    Language English
    Publishing date 2021-08-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2590-2555
    ISSN (online) 2590-2555
    DOI 10.1016/j.crimmu.2021.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adenosine dialdehyde, a methyltransferase inhibitor, induces colorectal cancer cells apoptosis by regulating PIMT:p53 interaction.

    Chatterjee, Tanaya / Guha, Deblina / Dhar, Jesmita / Saha, Taniya / Paul, Debamita / Sa, Gaurisankar / Chakrabarti, Pinak

    Biochemical and biophysical research communications

    2023  Volume 684, Page(s) 149134

    Abstract: Post-translational modification (PTM) is important in controlling many biological processes by changing the structure and function of a protein. Protein methylation is an important PTM, and the role of methyltransferases has been implicated in numerous ... ...

    Abstract Post-translational modification (PTM) is important in controlling many biological processes by changing the structure and function of a protein. Protein methylation is an important PTM, and the role of methyltransferases has been implicated in numerous cellular functions. Protein L-isoaspartyl methyltransferase (PIMT) is ubiquitously expressed in almost all organisms and govern important cellular processes including apoptosis. Among other functions, PIMT has also been identified as a potent oncogene because it destabilizes the structure of the tumor suppressor p53 via methylation at the transactivation domain. In the present study we identified that out of the three methyltransferase inhibitors tested, namely, S-adenosyl-l-homocysteine (AdoHcy), adenosine and adenosine dialdehyde (AdOx), only AdOx augments p53 expression by destabilizing PIMT structure, as evident from far-UV CD. The effect of the inhibitors, AdOx in particular, to the structure of PIMT, and the binding of PIMT to the p53 transactivation domain have been investigated by docking and molecular dynamics simulations. AdOx significantly increases p53 accumulation and nuclear translocation in colon cancer cells, triggering the p53-mediated apoptotic pathway. To better understand the molecular mechanisms underlying p53 accumulation in colon cancer cells, we observed that the level of PIMT is considerably lower in AdOx-treated cells, reducing its association with p53, which stabilized p53. p53 then transactivated BAX, increasing the BAX: BCL-2 ratio and causing colon cancer cell death.
    MeSH term(s) Humans ; Protein D-Aspartate-L-Isoaspartate Methyltransferase/metabolism ; Protein D-Aspartate-L-Isoaspartate Methyltransferase/pharmacology ; bcl-2-Associated X Protein/metabolism ; Tumor Suppressor Protein p53/metabolism ; Adenosine/pharmacology ; Apoptosis ; Methyltransferases/metabolism ; Colonic Neoplasms ; Colorectal Neoplasms
    Chemical Substances Protein D-Aspartate-L-Isoaspartate Methyltransferase (EC 2.1.1.77) ; periodate-oxidized adenosine (34240-05-6) ; bcl-2-Associated X Protein ; Tumor Suppressor Protein p53 ; Adenosine (K72T3FS567) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.149134
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    Zs.A 116: Show issues Location:
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  6. Article ; Online: Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination.

    Mukherjee, Sumon / Chakraborty, Sourio / Basak, Udit / Pati, Subhadip / Dutta, Apratim / Dutta, Saikat / Roy, Dia / Banerjee, Shruti / Ray, Arpan / Sa, Gaurisankar / Das, Tanya

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 220

    Abstract: Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting ... ...

    Abstract Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have seminal roles in evasion of immune surveillance. Tumor-promoting CD4
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00787-z
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  7. Article ; Online: Tumor-associated macrophages: an effective player of the tumor microenvironment.

    Basak, Udit / Sarkar, Tania / Mukherjee, Sumon / Chakraborty, Sourio / Dutta, Apratim / Dutta, Saikat / Nayak, Debadatta / Kaushik, Subhash / Das, Tanya / Sa, Gaurisankar

    Frontiers in immunology

    2023  Volume 14, Page(s) 1295257

    Abstract: Cancer progression is primarily caused by interactions between transformed cells and the components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up the majority of the invading immune components, which are further ... ...

    Abstract Cancer progression is primarily caused by interactions between transformed cells and the components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up the majority of the invading immune components, which are further categorized as anti-tumor M1 and pro-tumor M2 subtypes. While M1 is known to have anti-cancer properties, M2 is recognized to extend a protective role to the tumor. As a result, the tumor manipulates the TME in such a way that it induces macrophage infiltration and M1 to M2 switching bias to secure its survival. This M2-TAM bias in the TME promotes cancer cell proliferation, neoangiogenesis, lymphangiogenesis, epithelial-to-mesenchymal transition, matrix remodeling for metastatic support, and TME manipulation to an immunosuppressive state. TAMs additionally promote the emergence of cancer stem cells (CSCs), which are known for their ability to originate, metastasize, and relapse into tumors. CSCs also help M2-TAM by revealing immune escape and survival strategies during the initiation and relapse phases. This review describes the reasons for immunotherapy failure and, thereby, devises better strategies to impair the tumor-TAM crosstalk. This study will shed light on the understudied TAM-mediated tumor progression and address the much-needed holistic approach to anti-cancer therapy, which encompasses targeting cancer cells, CSCs, and TAMs all at the same time.
    MeSH term(s) Humans ; Tumor-Associated Macrophages ; Tumor Microenvironment ; Macrophages ; Neovascularization, Pathologic ; Recurrence
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1295257
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  8. Article ; Online: T-memory cells against cancer: Remembering the enemy.

    Sarkar, Irene / Pati, Subhadip / Dutta, Abhishek / Basak, Udit / Sa, Gaurisankar

    Cellular immunology

    2019  Volume 338, Page(s) 27–31

    Abstract: Background: Recently various types of immunotherapies have made immense progress in combating cancer. Adoptive cell therapy, being one of the most favorable forms of immunotherapy, is rapidly moving from bench to bed.: Main body: Different types of T- ...

    Abstract Background: Recently various types of immunotherapies have made immense progress in combating cancer. Adoptive cell therapy, being one of the most favorable forms of immunotherapy, is rapidly moving from bench to bed.
    Main body: Different types of T-memory cells are being used as promising candidates for adoptive cell therapy: T effector memory (T
    Conclusion: In this review, we briefly describe the concept and types of T-memory cells as well as their role as potential candidates for anti-cancer immunotherapy.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Self Renewal ; Cytotoxicity, Immunologic ; Humans ; Immunologic Memory ; Immunotherapy, Adoptive/methods ; Neoplasms/immunology ; Neoplasms/therapy ; Stem Cells ; T-Lymphocytes/immunology
    Language English
    Publishing date 2019-03-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2019.03.002
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    Zs.A 417: Show issues Location:
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  9. Article ; Online: Retraction Notice to: FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells.

    Sakib Hossain, Dewan Md / Panda, Abir K / Manna, Argha / Mohanty, Suchismita / Bhattacharjee, Pushpak / Bhattacharyya, Sankar / Saha, Taniya / Chakraborty, Sreeparna / Kar, Rajiv K / Das, Tanya / Chatterjee, Subhrangsu / Sa, Gaurisankar

    Immunity

    2021  Volume 54, Issue 9, Page(s) 2167

    Language English
    Publishing date 2021-10-09
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.08.008
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    Zs.A 4227: Show issues Location:
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  10. Article ; Online: Truncated G-Quadruplex Isomers Cross-Talk with the Transcription Factors To Maintain Homeostatic Equilibria in c-MYC Transcription.

    Sengupta, Pallabi / Bhattacharya, Apoorva / Sa, Gaurisankar / Das, Tanya / Chatterjee, Subhrangsu

    Biochemistry

    2019  Volume 58, Issue 15, Page(s) 1975–1991

    Abstract: The nuclease hypersensitive element ... ...

    Abstract The nuclease hypersensitive element III
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; Cell Line, Tumor ; DNA/chemistry ; DNA/genetics ; DNA/metabolism ; G-Quadruplexes ; Heterogeneous-Nuclear Ribonucleoprotein K/chemistry ; Heterogeneous-Nuclear Ribonucleoprotein K/genetics ; Heterogeneous-Nuclear Ribonucleoprotein K/metabolism ; Homeostasis ; Humans ; Isomerism ; NM23 Nucleoside Diphosphate Kinases/chemistry ; NM23 Nucleoside Diphosphate Kinases/genetics ; NM23 Nucleoside Diphosphate Kinases/metabolism ; Phosphoproteins/chemistry ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding ; Proto-Oncogene Proteins c-myc/chemistry ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA Interference ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Nucleolin
    Chemical Substances Heterogeneous-Nuclear Ribonucleoprotein K ; NM23 Nucleoside Diphosphate Kinases ; Phosphoproteins ; Proto-Oncogene Proteins c-myc ; RNA-Binding Proteins ; Transcription Factors ; HNRNPK protein, human (146410-60-8) ; DNA (9007-49-2)
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.9b00030
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    Zs.A 217: Show issues Location:
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