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Article ; Online: Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.

Bertin, Daniel / Bongrand, Pierre / Bardin, Nathalie

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: The success of artificial intelligence and machine learning is an incentive to develop new algorithms to increase the rapidity and reliability of medical diagnosis. Here we compared different strategies aimed at processing microscope images used to ... ...

Abstract	The success of artificial intelligence and machine learning is an incentive to develop new algorithms to increase the rapidity and reliability of medical diagnosis. Here we compared different strategies aimed at processing microscope images used to detect anti-neutrophil cytoplasmic antibodies, an important vasculitis marker: (i) basic classifier methods (logistic regression, k-nearest neighbors and decision tree) were used to process custom-made indices derived from immunofluorescence images yielded by 137 sera. (ii) These methods were combined with dimensional reduction to analyze 1733 individual cell images. (iii) More complex models based on neural networks were used to analyze the same dataset. The efficiency of discriminating between positive and negative samples and different fluorescence patterns was quantified with Rand-type accuracy index, kappa index and ROC curve. It is concluded that basic models trained on a limited dataset allowed for positive/negative discrimination with an efficiency comparable to that obtained by conventional analysis performed by humans (0.84 kappa score). More extensive datasets and more sophisticated models may be required for efficient discrimination between fluorescence patterns generated by different auto-antibody species.
MeSH term(s)	Humans ; Antibodies, Antineutrophil Cytoplasmic ; Artificial Intelligence ; Reproducibility of Results ; Fluorescent Antibody Technique ; Machine Learning
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063270
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: 3‐D ballistic transport of ellipsoidal volcanic projectiles considering horizontal wind field and variable shape‐dependent drag coefficients

Bertin, Daniel

Journal of geophysical research. 2017 Feb., v. 122, no. 2

2017

Abstract: An innovative 3‐D numerical model for the dynamics of volcanic ballistic projectiles is presented here. The model focuses on ellipsoidal particles and improves previous approaches by considering horizontal wind field, virtual mass forces, and drag forces ...

Abstract	An innovative 3‐D numerical model for the dynamics of volcanic ballistic projectiles is presented here. The model focuses on ellipsoidal particles and improves previous approaches by considering horizontal wind field, virtual mass forces, and drag forces subjected to variable shape‐dependent drag coefficients. Modeling suggests that the projectile's launch velocity and ejection angle are first‐order parameters influencing ballistic trajectories. The projectile's density and minor radius are second‐order factors, whereas both intermediate and major radii of the projectile are of third order. Comparing output parameters, assuming different input data, highlights the importance of considering a horizontal wind field and variable shape‐dependent drag coefficients in ballistic modeling, which suggests that they should be included in every ballistic model. On the other hand, virtual mass forces should be discarded since they almost do not contribute to ballistic trajectories. Simulation results were used to constrain some crucial input parameters (launch velocity, ejection angle, wind speed, and wind azimuth) of the block that formed the biggest and most distal ballistic impact crater during the 1984–1993 eruptive cycle of Lascar volcano, Northern Chile. Subsequently, up to 10⁶ simulations were performed, whereas nine ejection parameters were defined by a Latin‐hypercube sampling approach. Simulation results were summarized as a quantitative probabilistic hazard map for ballistic projectiles. Transects were also done in order to depict aerial hazard zones based on the same probabilistic procedure. Both maps combined can be used as a hazard prevention tool for ground and aerial transits nearby unresting volcanoes.
Keywords	geophysics ; mathematical models ; research ; wind speed ; Chile
Language	English
Dates of publication	2017-02
Size	p. 1126-1151.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1002/2016JB013320
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: La cryo-microscopie électronique révèle une nouvelle vision de la cellule et de ses composants.

Lévy, Daniel / Di Cicco, Aurélie / Bertin, Aurélie / Dezi, Manuela

Medecine sciences : M/S

2021 Volume 37, Issue 4, Page(s) 379–385

Abstract: Cryo-electron microscopy (cryo-EM) is a technique for imaging biological samples that plays a central role in structural biology, with high impact on research fields such as cell and developmental biology, bioinformatics, cell physics and applied ... ...

Title translation	Cryo-electron microcopy for a new vision of the cell and its components.
Abstract	Cryo-electron microscopy (cryo-EM) is a technique for imaging biological samples that plays a central role in structural biology, with high impact on research fields such as cell and developmental biology, bioinformatics, cell physics and applied mathematics. It allows the determination of structures of purified proteins within cells. This review describes the main recent advances in cryo-EM, illustrated by examples of proteins of biomedical interest, and the avenues for future development.
MeSH term(s)	Cells/ultrastructure ; Cryoelectron Microscopy/methods ; Myosin Type I/ultrastructure ; Protein Conformation ; Spike Glycoprotein, Coronavirus/ultrastructure
Chemical Substances	Spike Glycoprotein, Coronavirus ; Myosin Type I (EC 3.6.1.-)
Language	French
Publishing date	2021-04-28
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2021034
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Article ; Online: Patient control preferences for medical decision making before and after evaluation for left ventricular assist device.

Krishnan, Vishal / Bertin, Kaitlyn B / McIlvennan, Colleen K / Thompson, Jocelyn S / Matlock, Daniel D / Allen, Larry A

American heart journal plus : cardiology research and practice

2023 Volume 26, Page(s) 100245

Abstract: Understanding patients' preferred roles in medical decision making (i.e., passive, collaborative, active) is important to personalized care and patient engagement. Patient control preferences have been described for many treatment decisions, but their ... ...

Abstract	Understanding patients' preferred roles in medical decision making (i.e., passive, collaborative, active) is important to personalized care and patient engagement. Patient control preferences have been described for many treatment decisions, but their stability over time has not been characterized, particularly for major medical events with long-term implications. We prospectively surveyed 233 patients at the initiation of evaluation for a left ventricular assist device, and 1 and 6 months later, including collection of the Control Preferences Scale. Collaborative and active preferences were most common initially, followed by a shift towards more active. Approximately half of patients reported a different control preference in follow up. Patients with higher income and education levels were more likely to prefer an active role. These findings suggest that most patients want to be engaged in shared decision making, but to what degree is varied, can change over time, and is influenced by social determinants of health.
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2022.100245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply.

Bertin, Daniel / Brodovitch, Alexandre / Beziane, Abdelouahab / Mege, Jean Louis / Heim, Xavier / Bardin, Nathalie

Arthritis & rheumatology (Hoboken, N.J.)

2021 Volume 73, Issue 5, Page(s) 899–900

MeSH term(s)	COVID-19 ; Humans ; Immunoglobulin G ; Risk Factors ; SARS-CoV-2
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41633
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Article ; Online: Drivers of 'voluntary' recruitment and challenges for families with adolescents engaged with armed groups

Alexandra H Blackwell / Yvonne Agengo / Daniel Ozoukou / Julia Ulrike Wendt / Alice Nigane / Paradis Goana / Bertin Kanani / Kathryn Falb

PLOS Global Public Health, Vol 3, Iss 5, p e

Qualitative insights from Central African Republic and Democratic Republic of the Congo.

2023 Volume 0001265

Abstract: Globally, armed conflicts have increased threefold since 2010. The number of children voluntarily engaging with armed groups is also rising, despite increasing efforts to prevent this grave human rights violation. However, traditional approaches focusing ...

Abstract	Globally, armed conflicts have increased threefold since 2010. The number of children voluntarily engaging with armed groups is also rising, despite increasing efforts to prevent this grave human rights violation. However, traditional approaches focusing on the prevention, release, and reintegration of children through forced recruitment do not adequately address the complex and interlinking push and pull factors of voluntary recruitment. This qualitative study sought to deepen understanding of the drivers and consequences of voluntary recruitment from the perspectives of adolescents and their caregivers, as well as to explore how to better support families living in conflict settings. In-depth interviews were conducted with 74 adolescents (44 boys and 30 girls) ages 14 to 20 years and 39 caregivers (18 men and 21 women) ages 32 to 66 years in two distinct conflict settings: North Kivu, Democratic Republic of Congo and Ouham-Pendé, Central African Republic. Interviews with adolescents utilized a visual narrative technique. The findings examine the unique perspectives of adolescents engaged with armed groups and their caregivers to understand how conflict experiences, economic insecurity, and social insecurity influence adolescent's engagement with armed groups and reintegration with their families. The study found that families living in conflict settings are subject to traumatic experiences and economic hardship that erode protective family relationships, leaving adolescent boys and girls particularly vulnerable to the systemic and overlapping factors that influence them to engage with and return to armed groups. The findings illustrate how these factors can disrupt protective social structures, and inversely how familial support can act as a potential protective factor against recruitment and break the cycle of reengagement. By better understanding the experiences of adolescents enduring recruitment and how to support caregivers of those adolescents, more comprehensive programming models can be developed to ...
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mandibular bone effects of botulinum toxin injections in masticatory muscles in adult.

Kahn, Alexis / Kün-Darbois, Jean-Daniel / Bertin, Helios / Corre, Pierre / Chappard, Daniel

Oral surgery, oral medicine, oral pathology and oral radiology

2019 Volume 129, Issue 2, Page(s) 100–108

Abstract: Objective: Botulinum toxin (BTX) is injected into masticatory muscles to treat various conditions. Animal studies have demonstrated bone loss at the condylar and alveolar regions of the mandible after BTX injection into masticatory muscles. The aim of ... ...

Abstract	Objective: Botulinum toxin (BTX) is injected into masticatory muscles to treat various conditions. Animal studies have demonstrated bone loss at the condylar and alveolar regions of the mandible after BTX injection into masticatory muscles. The aim of the present study was to investigate mandibular bone changes in patients who received BTX injections in masticatory muscles. Study design: Twelve adult patients who received BTX injections into masticatory muscles were included in this study. Cone beam computed tomography (CBCT) was performed before and 12 months after the injection. The condylar and alveolar regions of the mandible were analyzed by using texture analysis of the CBCT images with the run length method. Condylar cortical thickness was measured, and 3-dimensional analysis of the mandible was also performed. Six patients who did not receive BTX injections were used as controls. Results: A run length parameter (gray level nonuniformity) was found to be increased in condylar and alveolar bones. A significant cortical thinning was found at the anterior portion of the right condyle. Three-dimensional analysis showed significant changes in the condylar bone and at the digastric fossa. No changes in mandibular angles were found. Conclusions: This study identified mandibular bone changes in adult patients who received BTX injection into masticatory muscles.
MeSH term(s)	Adult ; Animals ; Bone Diseases, Metabolic ; Botulinum Toxins ; Botulinum Toxins, Type A ; Cone-Beam Computed Tomography ; Humans ; Mandible ; Mandibular Condyle ; Masticatory Muscles
Chemical Substances	Botulinum Toxins (EC 3.4.24.69) ; Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2019-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2019.03.007
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Article ; Online: Anti-Jo-1 autoantibodies: biomarkers of severity and evolution of the disease in antisynthetase syndrome.

Arcani, Robin / Rey, Louise / Mazziotto, Alice / Bertin, Daniel / Kaplanski, Gilles / Jarrot, Pierre-André / Lafforgue, Pierre / Venton, Geoffroy / Heim, Xavier / Villani, Patrick / Mège, Jean-Louis / Brodovitch, Alexandre / Bardin, Nathalie

Arthritis research & therapy

2023 Volume 25, Issue 1, Page(s) 125

Abstract: Background: Anti-Jo-1 autoantibodies represent essential markers in the diagnosis of antisynthetase syndrome (ASS). In this retrospective study, we aimed to investigate whether their concentrations and fluctuations could both respectively reflect the ... ...

Abstract	Background: Anti-Jo-1 autoantibodies represent essential markers in the diagnosis of antisynthetase syndrome (ASS). In this retrospective study, we aimed to investigate whether their concentrations and fluctuations could both respectively reflect the severity and evolution of ASS. Methods: Between 2015 and 2020, clinical and biological features of ASS patients with at least one positive measure of anti-Jo-1 autoantibody were collected. At each serum sampling, we assessed myositis activity by using the Myositis Intention to Treat Activities Index (MITAX) and compared anti-Jo-1 concentrations with ASS severity, anti-Jo-1 concentrations between patients with and without active disease, and changes in anti-Jo-1 concentrations with disease activity. Results: Forty-eight patients with ASS had at least one positive determination of anti-Jo-1 concentration. Among them, twenty-nine patients had at least two determinations of anti-Jo-1 autoantibody in their follow-up. We showed that these autoantibody concentrations were significantly correlated with MITAX (r = 0.4, p = 0.03) and creatine kinase concentration (r = 0.34, p = 0.002) and that they were significantly higher in patients with active disease than in those with inactive disease (91.7 IU/L vs 44.4 IU/L, p = 0.016). During follow-up, we found a significant correlation between fluctuations of anti-Jo-1 autoantibody concentrations and MITAX score (r = 0.7, p < 0.0001). Conclusion: Our results suggest that anti-Jo-1 autoantibody concentration could be a predictive marker of the severity and evolution of ASS and show that their quantification could represent a precious tool for disease monitoring and for improving the therapeutic management of ASS patients.
MeSH term(s)	Humans ; Autoantibodies ; Biomarkers ; Myositis ; Retrospective Studies
Chemical Substances	Autoantibodies ; Biomarkers
Language	English
Publishing date	2023-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-023-03116-5
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Article: Agroforestry Management Systems Drive the Composition, Diversity, and Function of Fungal and Bacterial Endophyte Communities in Theobroma Cacao Leaves.

Wemheuer, Franziska / Berkelmann, Dirk / Wemheuer, Bernd / Daniel, Rolf / Vidal, Stefan / Bisseleua Daghela, Hervé Bertin

Microorganisms

2020 Volume 8, Issue 3

Abstract: Cacao ( ...

Abstract	Cacao (
Language	English
Publishing date	2020-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8030405
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Article ; Online: Drivers of 'voluntary' recruitment and challenges for families with adolescents engaged with armed groups: Qualitative insights from Central African Republic and Democratic Republic of the Congo.

Blackwell, Alexandra H / Agengo, Yvonne / Ozoukou, Daniel / Wendt, Julia Ulrike / Nigane, Alice / Goana, Paradis / Kanani, Bertin / Falb, Kathryn

PLOS global public health

2023 Volume 3, Issue 5, Page(s) e0001265

Abstract	Globally, armed conflicts have increased threefold since 2010. The number of children voluntarily engaging with armed groups is also rising, despite increasing efforts to prevent this grave human rights violation. However, traditional approaches focusing on the prevention, release, and reintegration of children through forced recruitment do not adequately address the complex and interlinking push and pull factors of voluntary recruitment. This qualitative study sought to deepen understanding of the drivers and consequences of voluntary recruitment from the perspectives of adolescents and their caregivers, as well as to explore how to better support families living in conflict settings. In-depth interviews were conducted with 74 adolescents (44 boys and 30 girls) ages 14 to 20 years and 39 caregivers (18 men and 21 women) ages 32 to 66 years in two distinct conflict settings: North Kivu, Democratic Republic of Congo and Ouham-Pendé, Central African Republic. Interviews with adolescents utilized a visual narrative technique. The findings examine the unique perspectives of adolescents engaged with armed groups and their caregivers to understand how conflict experiences, economic insecurity, and social insecurity influence adolescent's engagement with armed groups and reintegration with their families. The study found that families living in conflict settings are subject to traumatic experiences and economic hardship that erode protective family relationships, leaving adolescent boys and girls particularly vulnerable to the systemic and overlapping factors that influence them to engage with and return to armed groups. The findings illustrate how these factors can disrupt protective social structures, and inversely how familial support can act as a potential protective factor against recruitment and break the cycle of reengagement. By better understanding the experiences of adolescents enduring recruitment and how to support caregivers of those adolescents, more comprehensive programming models can be developed to adequately prevent voluntary recruitment and promote successful reintegration, enabling children to reach their full potential.
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0001265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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