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  1. Article ; Online: Giving alloHSCT a needed LIF(t).

    Murphy, William J

    Blood

    2022  Volume 140, Issue 19, Page(s) 2008–2009

    MeSH term(s) Humans ; Graft vs Host Disease ; Leukemia Inhibitory Factor ; Transplantation, Homologous ; Hematopoietic Stem Cell Transplantation ; Leukemia
    Chemical Substances Leukemia Inhibitory Factor
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022018006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  2. Article ; Online: Drilling down interferon in GVHD/GVL.

    Murphy, William J

    Blood

    2022  Volume 141, Issue 8, Page(s) 821–823

    MeSH term(s) Mice ; Animals ; Interferons ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Calgranulin B
    Chemical Substances Interferons (9008-11-1) ; S100A9 protein, mouse ; Calgranulin B
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022019232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Show issues

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  3. Article ; Online: The quest for a damage risk criterion for hazardous noise exposure.

    Murphy, William J / Flamme, Gregory A

    The Journal of the Acoustical Society of America

    2023  Volume 154, Issue 1, Page(s) R1–R2

    Abstract: The Reflections series takes a look back on historical articles from The Journal of the Acoustical Society of America that have had a significant impact on the science and practice of acoustics. ...

    Abstract The Reflections series takes a look back on historical articles from The Journal of the Acoustical Society of America that have had a significant impact on the science and practice of acoustics.
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0019934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 591: Show issues Location:
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  4. Article ; Online: The urgent need for more basic research on SARS-Cov2 infection and vaccines in assessing potential psychoneurological effects using maternal immune activation (MIA) and other preclinical modeling.

    Murphy, William J

    Brain, behavior, and immunity

    2021  Volume 97, Page(s) 1–3

    Abstract: The rapid development and application of different SARS-Cov2 vaccines world-wide has resulted in impressive efficacy and protection from this deadly pandemic. However, the existence of different and continuously developing vaccine candidates coupled with ...

    Abstract The rapid development and application of different SARS-Cov2 vaccines world-wide has resulted in impressive efficacy and protection from this deadly pandemic. However, the existence of different and continuously developing vaccine candidates coupled with the likelihood of continued application due to both waning immune responses and emergence of viral mutants, means that more basic research regarding their efficacy and continued application are needed. This is particularly true with use of preclinical models involving effects when given during pregnancy. The substantial body of data on the impact of maternal immune activation (MIA) on neurologic development and behavior in the progeny necessitates the need to have all vaccine candidates, particularly when inducing strong toll receptor (TLR) responses, involving these models. Use of other preclinical models involving autoimmunity and allergy coupled with incorporation of human modifying variables of aging and obesity should also be applied to better reflect the heterogeneity of the general population and potential off-target effects that may arise. Additionally, the use of human ACE2 receptor transgenic mouse models can shed insights given the differential tissues expression at different stages in development. However, to foster these types of basic research studies involving different vaccine products, initiatives must first be implemented and supported at the governmental level even while clinical data still accumulates.
    MeSH term(s) Animals ; COVID-19 ; Female ; Humans ; Mice ; Pandemics ; Pregnancy ; RNA, Viral ; SARS-CoV-2 ; Vaccines
    Chemical Substances RNA, Viral ; Vaccines
    Language English
    Publishing date 2021-07-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2276: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 327: Show issues

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  5. Article ; Online: The immunobiology of SARS-CoV-2 infection and vaccine responses: potential influences of cross-reactive memory responses and aging on efficacy and off-target effects.

    Collins, Craig P / Longo, Dan L / Murphy, William J

    Frontiers in immunology

    2024  Volume 15, Page(s) 1345499

    Abstract: Immune responses to both SARS-CoV-2 infection and its associated vaccines have been highly variable within the general population. The increasing evidence of long-lasting symptoms after resolution of infection, called post-acute sequelae of COVID-19 ( ... ...

    Abstract Immune responses to both SARS-CoV-2 infection and its associated vaccines have been highly variable within the general population. The increasing evidence of long-lasting symptoms after resolution of infection, called post-acute sequelae of COVID-19 (PASC) or "Long COVID," suggests that immune-mediated mechanisms are at play. Closely related endemic common human coronaviruses (hCoV) can induce pre-existing and potentially cross-reactive immunity, which can then affect primary SARS-CoV-2 infection, as well as vaccination responses. The influence of pre-existing immunity from these hCoVs, as well as responses generated from original CoV2 strains or vaccines on the development of new high-affinity responses to CoV2 antigenic viral variants, needs to be better understood given the need for continuous vaccine adaptation and application in the population. Due in part to thymic involution, normal aging is associated with reduced naïve T cell compartments and impaired primary antigen responsiveness, resulting in a reliance on the pre-existing cross-reactive memory cell pool which may be of lower affinity, restricted in diversity, or of shorter duration. These effects can also be mediated by the presence of down-regulatory anti-idiotype responses which also increase in aging. Given the tremendous heterogeneity of clinical data, utilization of preclinical models offers the greatest ability to assess immune responses under a controlled setting. These models should now involve prior antigen/viral exposure combined with incorporation of modifying factors such as age on immune responses and effects. This will also allow for mechanistic dissection and understanding of the different immune pathways involved in both SARS-CoV-2 pathogen and potential vaccine responses over time and how pre-existing memory responses, including potential anti-idiotype responses, can affect efficacy as well as potential off-target effects in different tissues as well as modeling PASC.
    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Vaccines ; Aging ; Immunoglobulin Idiotypes
    Chemical Substances Vaccines ; Immunoglobulin Idiotypes
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1345499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Potential role of anti-Idiotype responses on the neurological effects of post-acute sequelae of COVID-19 (PASC).

    Murphy, William J / Collins, Craig P / Ashwood, Paul

    Brain, behavior, and immunity

    2023  Volume 116, Page(s) 317–320

    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Disease Progression
    Language English
    Publishing date 2023-12-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  7. Article ; Online: Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination. Reply.

    Murphy, William J / Longo, Dan L

    The New England journal of medicine

    2022  Volume 386, Issue 9, Page(s) 898–899

    MeSH term(s) Antibodies, Anti-Idiotypic ; Antibodies, Neutralizing/immunology ; COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Anti-Idiotypic ; Antibodies, Neutralizing
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2119443
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Suppressive effects of obesity on NK cells: is it time to incorporate obesity as a clinical variable for NK cell-based cancer immunotherapy regimens?

    Canter, Robert J / Judge, Sean J / Collins, Craig P / Yoon, Daniel Jaeho / Murphy, William J

    Journal for immunotherapy of cancer

    2024  Volume 12, Issue 3

    MeSH term(s) Humans ; Killer Cells, Natural ; Immunotherapy ; Neoplasms/therapy ; Obesity/therapy
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-008443
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  9. Book: Handbook of cell and organ culture /by Donald J. Merchant; Raymond H. Kahn; William H. Murphy

    Merchant, Donald J / Kahn, Raymond H / Murphy, William H

    1965  

    Language English
    Size VIII, 263 S
    Edition 2. ed., 2. print
    Document type Book
    Note Literaturangaben
    Database Leibniz Institute of Plant Biochemistry

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  10. Article ; Online: Erratum: Personal attenuation ratings versus derated noise reduction ratings for hearing protection devices [J. Acoust. Soc. Am. 152(2), 1074-1089 (2022)].

    Murphy, William J / Gong, Wei / Karch, Stephanie J / Federman, Jeremy / Schulz, Theresa Y

    The Journal of the Acoustical Society of America

    2023  Volume 153, Issue 1, Page(s) 50

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0016818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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