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  1. Article: Clinical efficacy of two different samples of Shirishavaleha in Tamaka Shwasa (Bronchial Asthma).

    Yadav, Shyamlal Singh / Galib / Patgiri, Biswajyoti / Prajapati, Pradeep Kumar

    Ayu

    2013  Volume 33, Issue 2, Page(s) 255–260

    Abstract: Incidences of Bronchial Asthma have been raised in recent decades due to increased industrialization and pollution. This miserable condition can be compared with Tamaka Shwasa in Ayurveda. Modern synthetic drugs will provide instant relief in these cases, ...

    Abstract Incidences of Bronchial Asthma have been raised in recent decades due to increased industrialization and pollution. This miserable condition can be compared with Tamaka Shwasa in Ayurveda. Modern synthetic drugs will provide instant relief in these cases, but are tend to develop a number of adverse drug reactions. Knowing this, the current suffering population is looking towards few remedies from other systems of medicines, that are comparatively safe and provide better relief. Shirisha [Albizzia lebbeck Benth] is a drug with multi-dimensional activities emphasized in Ayurveda for different disease conditions. Considering this, two types of Shirishavaleha (confection of Shirisha) were prepared by Kwatha (decoction) of Twak (bark) and Sara (heartwood) of Shirisha to evaluate its comparative efficacy in Tamaka Shwasa (bronchial asthma). The results were assessed in terms of clinical recovery, symptomatic relief and pulmonary function improvement. A significant increase in Hb and considerable decrease in total eosinophil count, AEC and ESR were observed. The study revealed that Shirishavaleha can be used as an effective drug in bronchial asthma.
    Language English
    Publishing date 2013-03-19
    Publishing country India
    Document type Journal Article
    ISSN 0974-8520
    ISSN 0974-8520
    DOI 10.4103/0974-8520.105247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic Potentials of Shirisha (Albizia lebbeck Benth) – A Review

    Yadav Singh Shyamlal / Jaiswal M / Galib Dr / Prajapati P K

    International Journal of Ayurvedic Medicine, Vol 2, Iss

    2012  Volume 4

    Abstract: Albizia lebbeck Benth. is a large, erect, unarmed, deciduous, spreading tree belonging to the family Fabaceae (Formerly Leguminosae), member of the subfamily Mimosaceae. It is found throughout India, ascending to 900m in the Himalayas and also in the ... ...

    Abstract Albizia lebbeck Benth. is a large, erect, unarmed, deciduous, spreading tree belonging to the family Fabaceae (Formerly Leguminosae), member of the subfamily Mimosaceae. It is found throughout India, ascending to 900m in the Himalayas and also in the islands of Andaman. It contains saponins, macrocyclic alkaloids, phenolic glycosides and flavonoids. In Ayurveda, Albizia lebbeck Benth. is familiar as Shirisha and it has been attributed with properties like Vishaghna (anti-poisonous) and emphasized its efficacy in Visarpa (Erysipelas), Hicca (Hiccup), Shwasa (Breathlessness), Kasa (Cough) etc. Researches of recent past have also reported anti-inflammatory, anti-histaminic, anti-anaphylactic, anti-asthmatic, anti-microbial properties of the plant. Saponins isolated from the methanolic extract of bark and pod of Albizia lebbeck Benth. have found to possess anti-spermatogenic effect. The current review revealed that, the plant Shirisha has a number of potentials in therapeutic field.
    Keywords Albizia lebbeck Benth. ; Anti-poisonous ; Antispermatogenic ; Ayurveda. ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2012-03-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Standardization of Shirishavaleha with reference to physico-chemical characteristics.

    Yadav, Shyamlal Singh / Galib / Patgiri, B J / Shukla, V J / Prajapati, P K

    Ayu

    2012  Volume 32, Issue 4, Page(s) 560–565

    Abstract: Ten batches of Shirishavaleha were prepared by using Twak (Bark) and Sara (Heartwood) of Shirisha [Albizzia lebbeck Benth]. The adopted formulation was based on Shirisharishta of Bhaishajya Ratnavali. Though Shirisharishta has significant therapeutic ... ...

    Abstract Ten batches of Shirishavaleha were prepared by using Twak (Bark) and Sara (Heartwood) of Shirisha [Albizzia lebbeck Benth]. The adopted formulation was based on Shirisharishta of Bhaishajya Ratnavali. Though Shirisharishta has significant therapeutic effect in cases of Tamaka swasa, etc.; it has few difficulties during the pharmaceutical procedure like consuming long time, climatic influences etc. Considering these inconveniencies, the formulation composition has been converted in to Shirishavaleha. Avaleha has been prepared by using Twak and Sara of Shirisha. No significant differences were found in pharmaceutical aspects of both the samples of Shirishavaleha and the current method of preparation can be considered as standard. Attempts were also made to develop analytical profile of avaleha, which were almost similar in both the samples, except showing more Rf values in High Performance Thin Layer Chromatography profile of Sara group.
    Language English
    Publishing date 2012-01-03
    Publishing country India
    Document type Journal Article
    ISSN 0976-9382
    ISSN (online) 0976-9382
    DOI 10.4103/0974-8520.96134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of immunomodulatory activity of " Shirishavaleha"-An Ayurvedic compound formulation in albino rats

    Shyamlal Singh Yadav / Galib / P K Prajapati / B K Ashok / B Ravishankar

    Journal of Ayurveda and Integrative Medicine, Vol 2, Iss 4, Pp 192-

    2011  Volume 196

    Abstract: The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in ... ...

    Abstract The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in established experimental models. The study used Wistar rats of either sex weighing 200 ± 40 g, while the test drug was administered orally at a dose of 1.8 g/kg. Hemagglutination titer and body weight were recorded to assess effects on humoral immunity; immunological paw edema was assessed for cell-mediated immunity. Shirishavaleha prepared from heartwood shows significant enhancement in antibody formation, attenuation of body weight changes, and suppression of immunological paw edema, while Shirishavaleha prepared from bark shows weak immunomodulatory activity. The study therefore concludes that Shirishavaleha prepared from heartwood has significant immunomodulatory activity.
    Keywords Albizia lebbeck ; avaleha ; hemagglutination titer ; immunomodulatory activity ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Medknow Publications Pvt Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Anti-inflammatory activity of Shirishavaleha: An Ayurvedic compound formulation.

    Yadav, Shyamlal Singh / Galib / Ravishankar, B / Prajapati, P K / Ashok, B K / Varun, B

    International journal of Ayurveda research

    2011  Volume 1, Issue 4, Page(s) 205–207

    Abstract: The purpose of the present study was to evaluate the anti-inflammatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth.), viz. the bark (Twak) and the heartwood (Sara). The activity was screened in the ... ...

    Abstract The purpose of the present study was to evaluate the anti-inflammatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth.), viz. the bark (Twak) and the heartwood (Sara). The activity was screened in the carrageenan-induced rat paw edema model in albino rats. The raw materials were collected and authenticated in the university and the trial formulations were prepared by following standard classical guidelines. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 1.8 g/kg for 5 days. Phenylbutazone was used as the standard anti-inflammatory drug for comparison. Between the two different test samples studied, the formulation made from heartwood showed a weak anti-inflammatory activity in this model while that made from the bark produced a considerable suppression of edema after 6 h. It appears that the bark sample would be preferable for clinical use.
    Language English
    Publishing date 2011-03-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2562172-5
    ISSN 0974-925X ; 0974-7788
    ISSN (online) 0974-925X
    ISSN 0974-7788
    DOI 10.4103/0974-7788.76781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of immunomodulatory activity of "Shirishavaleha"-An Ayurvedic compound formulation in albino rats.

    Yadav, Shyamlal Singh / Galib / Prajapati, P K / Ashok, B K / Ravishankar, B

    Journal of Ayurveda and integrative medicine

    2006  Volume 2, Issue 4, Page(s) 192–196

    Abstract: The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in ... ...

    Abstract The immunomodulatory activity of Shirishavaleha prepared from two different parts of Shirisha (Albizia lebbeck Benth), i.e., Twak (Bark) and Sara (Heartwood) as main ingredients was evaluated for humoral antibody formation and cell-mediated immunity in established experimental models. The study used Wistar rats of either sex weighing 200 ± 40 g, while the test drug was administered orally at a dose of 1.8 g/kg. Hemagglutination titer and body weight were recorded to assess effects on humoral immunity; immunological paw edema was assessed for cell-mediated immunity. Shirishavaleha prepared from heartwood shows significant enhancement in antibody formation, attenuation of body weight changes, and suppression of immunological paw edema, while Shirishavaleha prepared from bark shows weak immunomodulatory activity. The study therefore concludes that Shirishavaleha prepared from heartwood has significant immunomodulatory activity.
    Language English
    Publishing date 2006-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2553425-7
    ISSN 0976-2809 ; 0976-2809
    ISSN (online) 0976-2809
    ISSN 0976-2809
    DOI 10.4103/0975-9476.90775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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