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Article ; Online: The Clinical Efficacy of High-Voltage Long-Duration Pulsed Radiofrequency Treatment in Pudendal Neuralgia: A Retrospective Study.

Wang, Cheng-Long / Song, Tao

Neuromodulation : journal of the International Neuromodulation Society

2022 Volume 25, Issue 8, Page(s) 1372–1377

Abstract: Background: Patients with pudendal neuralgia (PN) experience long-lasting chronic pain ... To determine the safety and clinical efficacy of high-voltage, long-duration PRF application ... Results: VAS, SF-36, and PHQ-9 scores at 1, 4, and 12 weeks after high-voltage long-duration PRF ...

Abstract	Background: Patients with pudendal neuralgia (PN) experience long-lasting chronic pain, hyperalgesia, and comorbid emotional disorders, such as depression and anxiety. Treatment via conventional pulsed radiofrequency (PRF) current carries a significantly high rate of failure. Objective: To determine the safety and clinical efficacy of high-voltage, long-duration PRF application to the pudendal nerve in patients with PN. Study design: Observational retrospective design, self before-after controlled clinical trial. Materials and methods: We analyzed the records of 70 patients of our hospital with diagnosed PN. Treatment consisted of PRF application to the pudendal nerve, using computed tomography guidance to target the pudendal nerve at the level of the ischial spine or ischial tuberosity of the affected side. PRF was applied with the following parameters: temperature 42 °C, frequency 2 Hz, pulse width 20 ms, field intensity ramped gradually from 40 to 90 V, duration 900 sec. The therapeutic effect was evaluated by collecting patient scores for the visual analog scale (VAS), SF-36 health survey questionnaire (SF-36), and patient health questionnaire (PHQ-9) before treatment and at 1-, 4-, and 12-week follow-ups after PRF treatment. Data were analyzed by paired t-test with p < 0.05 considered to be statistically significant. Results: VAS, SF-36, and PHQ-9 scores at 1, 4, and 12 weeks after high-voltage long-duration PRF treatment were significantly improved relative to their respective pretreatment baseline scores (p < 0.05 for all). The effective rate at 12 weeks after high-voltage long-duration PRF was up to 88.6%. Limitations: A small sample size and lack of a control group. Conclusions: High-voltage long-duration PRF provided significant short-term (at least 12 weeks) pain relief to most patients with PN; it also improved subjective measures of depression and quality of life over the same duration of time.
Language	English
Publishing date	2022-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500372-3
ISSN	1525-1403 ; 1094-7159
ISSN (online)	1525-1403
ISSN	1094-7159
DOI	10.1111/ner.13401
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Article ; Online: Surgical intervention of a femoral shaft fracture in a patient with intraosseous arteriovenous malformation: A case report.

Wang, Cheng-Long / Chen, Cheng-Wei

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2021 Volume 28, Issue 5, Page(s) 1202–1205

MeSH term(s)	Humans ; Arteriovenous Malformations/complications ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/surgery ; Femoral Fractures/complications ; Femoral Fractures/diagnostic imaging
Language	English
Publishing date	2021-02-25
Publishing country	Japan
Document type	Case Reports
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2020.12.030
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Article: [Plant Diversity Changes and Its Driving Factors of Abandoned Land at Different Restoration Stages in the Middle of the Qinling Mountains].

Yan, Cheng-Long / Xue, Yue / Wang, Yi-Fei / Kang, Hai-Bin / Wang, De-Xiang

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 2, Page(s) 992–1003

Abstract: The process of vegetation restoration is often accompanied by significant changes in aboveground plant diversity. To explore the driving mechanism of litter nutrient-soil nutrient-enzyme activity stoichiometry on aboveground vegetation change is of great ...

Abstract	The process of vegetation restoration is often accompanied by significant changes in aboveground plant diversity. To explore the driving mechanism of litter nutrient-soil nutrient-enzyme activity stoichiometry on aboveground vegetation change is of great importance for maintaining regional biodiversity conservation and ecological stability. Taking typical abandoned farmland of different restoration years （1， 8， 16， 31， and 50 a） in the Qinling Mountains as the research object， the variation characteristics of plant community diversity during vegetation restoration were analyzed through field investigation. Litter nutrients， soil nutrients， and the activities of five extracellular enzymes， including
MeSH term(s)	Plants ; Biodiversity ; Soil ; Soil Microbiology ; Nutrients ; Ecosystem ; China
Chemical Substances	Soil
Language	Chinese
Publishing date	2024-03-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202303002
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Article ; Online: Skimmianine attenuates liver ischemia/reperfusion injury by regulating PI3K–AKT signaling pathway-mediated inflammation, apoptosis and oxidative stress

Cheng-long Huo / Bing Wang / Xuewen Zhang / Zhen-Gang Sun

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Liver ischemia/reperfusion (I/R) injury is a common injury after liver transplantation and hepatectomy. Skimmianine (Ski) has antibacterial, antiviral pharmacological effects. However, it is not clear whether Ski has a protective effect against ... ...

Abstract	Abstract Liver ischemia/reperfusion (I/R) injury is a common injury after liver transplantation and hepatectomy. Skimmianine (Ski) has antibacterial, antiviral pharmacological effects. However, it is not clear whether Ski has a protective effect against liver I/R injury. In the present study, we established a mouse liver I/R model and an AML12 cell hypoxia-reoxygenation (H/R) model, both pretreated with different concentrations of Ski. Serum transaminase levels, necrotic liver area, cell viability, inflammatory factors, oxidative stress and apoptosis-related levels were measured to assess the protective effect of Ski against liver I/R injury. Western blotting was used to detect apoptosis-related proteins and PI3K–AKT pathway-related proteins. Mice and cells were also treated with PI3K inhibitor LY294002 to assess changes in indicators of liver injury. The results showed that Ski significantly reduced transaminase levels, liver necrosis area, oxidative stress, and apoptosis levels in mice with I/R. Ski also inhibited cell injury and apoptosis after H/R. Moreover, Ski activated phosphorylation of PI3K–AKT pathway-related proteins after liver I/R and cell H/R. Importantly, the PI3K inhibitor LY294002 effectively reversed the alleviation of I/R injury caused by Ski. These results confirm that Ski exerts a protective effect against liver I/R injury through activation of the PI3K–AKT pathway.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Modeling Syphilis and HIV Coinfection: A Case Study in the USA.

Wang, Cheng-Long / Gao, Shasha / Li, Xue-Zhi / Martcheva, Maia

Bulletin of mathematical biology

2023 Volume 85, Issue 3, Page(s) 20

Abstract: Syphilis and HIV infections form a dangerous combination. In this paper, we propose an epidemic model of HIV-syphilis coinfection. The model always has a unique disease-free equilibrium, which is stable when both reproduction numbers of syphilis and HIV ... ...

Abstract	Syphilis and HIV infections form a dangerous combination. In this paper, we propose an epidemic model of HIV-syphilis coinfection. The model always has a unique disease-free equilibrium, which is stable when both reproduction numbers of syphilis and HIV are less than 1. If the reproduction number of syphilis (HIV) is greater than 1, there exists a unique boundary equilibrium of syphilis (HIV), which is locally stable if the invasion number of HIV (syphilis) is less than 1. Coexistence equilibrium exists and is stable when all reproduction numbers and invasion numbers are greater than 1. Using data of syphilis cases and HIV cases from the US, we estimated that both reproduction numbers for syphilis and HIV are slightly greater than 1, and the boundary equilibrium of syphilis is stable. In addition, we observed competition between the two diseases. Treatment for primary syphilis is more important in mitigating the transmission of syphilis. However, it might lead to increase of HIV cases. The results derived here could be adapted to other multi-disease scenarios in other regions.
MeSH term(s)	Humans ; HIV Infections/complications ; HIV Infections/epidemiology ; Syphilis/complications ; Syphilis/epidemiology ; Models, Biological ; Coinfection/epidemiology ; Mathematical Concepts
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184905-0
ISSN	1522-9602 ; 0007-4985 ; 0092-8240
ISSN (online)	1522-9602
ISSN	0007-4985 ; 0092-8240
DOI	10.1007/s11538-023-01123-w
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Zs.B 754: Show issues

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Article ; Online: Bisphosphonates-related tendinopathies and ligament disorders: Cases analysis from the U.S. Food and Drug Administration adverse event reporting system.

Ji, Lian-Hua / Zhao, Cheng-Long / Wang, Ya-Qin / Fu, Zhong-Hua

Bone

2023 Volume 177, Page(s) 116919

Abstract: Fluoroquinolone antibiotics are known to induce serious tendinopathies and ligament disorders (TPLDs) on rare occasion, but it is less well-appreciated whether such adverse reactions result from the use of bisphosphonates (BPs). In this study, we ... ...

Abstract	Fluoroquinolone antibiotics are known to induce serious tendinopathies and ligament disorders (TPLDs) on rare occasion, but it is less well-appreciated whether such adverse reactions result from the use of bisphosphonates (BPs). In this study, we assessed the correlation between TPLDs and the use of BPs via U.S. FDA Adverse Event Reporting System (FAERS) database. Bayesian and nonproportional analyses were applied to data retrieved from the FAERS database from the first quarter of 2004 to the third quarter of 2022. A total of 3202 reported cases of TPLDs were associated with five BPs (alendronate, pamidronate, ibandronate, risedronate, zoledronate), with statistically significant reporting odds ratio (ROR), proportional reporting ratio (PRR), and information component (IC). Alendronate showed the highest association with tendinopathies and ligament disorders (ROR = 16.30, PRR = 15.47, IC = 3.88), while zoledronate had the lowest association (ROR = 2.13, PRR = 2.12, IC = 1.08), which was consistent with the results of top 10 preferred terms (PTs) under the narrow standardized MedDRA queries (SMQs) sorted by frequency of reports. Excluding zoledronate, over half of patients who reported BP-related TPLDs were hospitalized, either briefly or extendedly. This was especially true for alendronate, which showed the highest rate of hospitalization (83.25 %), however, the mortality rate reported by those taking alendronate were significantly lower than those of zoledronate and pamidronate. In addition, the clinical characteristics of BP-related TPLDs was analyzed. It is more common to reported in middle-aged and elderly females, the highest proportion was in 50-69 years old. Except for osteoporosis, osteopenia, and osteoporosis prophylaxis, cancer bone metastasis was also the indication of some BPs. The most often reported concomitant/prior medicines were calcium supplements, another BPs, antitumor agents, and nonsteroidal anti-inflammatory drugs. In conclusion, we provide a comprehensive overview of the correlation and clinical characteristics, and prognosis of BP-related TPLDs deserving continued surveillance and appropriate management.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2023.116919
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Skimmianine attenuates liver ischemia/reperfusion injury by regulating PI3K-AKT signaling pathway-mediated inflammation, apoptosis and oxidative stress.

Huo, Cheng-Long / Wang, Bing / Zhang, Xuewen / Sun, Zhen-Gang

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18232

Abstract: Liver ischemia/reperfusion (I/R) injury is a common injury after liver transplantation and hepatectomy. Skimmianine (Ski) has antibacterial, antiviral pharmacological effects. However, it is not clear whether Ski has a protective effect against liver I/R ...

Abstract	Liver ischemia/reperfusion (I/R) injury is a common injury after liver transplantation and hepatectomy. Skimmianine (Ski) has antibacterial, antiviral pharmacological effects. However, it is not clear whether Ski has a protective effect against liver I/R injury. In the present study, we established a mouse liver I/R model and an AML12 cell hypoxia-reoxygenation (H/R) model, both pretreated with different concentrations of Ski. Serum transaminase levels, necrotic liver area, cell viability, inflammatory factors, oxidative stress and apoptosis-related levels were measured to assess the protective effect of Ski against liver I/R injury. Western blotting was used to detect apoptosis-related proteins and PI3K-AKT pathway-related proteins. Mice and cells were also treated with PI3K inhibitor LY294002 to assess changes in indicators of liver injury. The results showed that Ski significantly reduced transaminase levels, liver necrosis area, oxidative stress, and apoptosis levels in mice with I/R. Ski also inhibited cell injury and apoptosis after H/R. Moreover, Ski activated phosphorylation of PI3K-AKT pathway-related proteins after liver I/R and cell H/R. Importantly, the PI3K inhibitor LY294002 effectively reversed the alleviation of I/R injury caused by Ski. These results confirm that Ski exerts a protective effect against liver I/R injury through activation of the PI3K-AKT pathway.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Oxidative Stress ; Liver/metabolism ; Inflammation/metabolism ; Apoptosis ; Transaminases/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; skimmianine (4E1KLC380B) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45354-2
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Article ; Online: The efficacy of Modified Major Bupleurum Decoction in postoperative management of intrahepatic cholelithiasis.

Long, Kui / Zhang, Cheng / Wang, Luyao / Xu, Ning

Asian journal of surgery

2024

Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.067
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Book ; Online: Inductive Graph Unlearning

Wang, Cheng-Long / Huai, Mengdi / Wang, Di

2023

Abstract: As a way to implement the "right to be forgotten" in machine learning, \textit{machine unlearning} aims to completely remove the contributions and information of the samples to be deleted from a trained model without affecting the contributions of other ... ...

Abstract	As a way to implement the "right to be forgotten" in machine learning, \textit{machine unlearning} aims to completely remove the contributions and information of the samples to be deleted from a trained model without affecting the contributions of other samples. Recently, many frameworks for machine unlearning have been proposed, and most of them focus on image and text data. To extend machine unlearning to graph data, \textit{GraphEraser} has been proposed. However, a critical issue is that \textit{GraphEraser} is specifically designed for the transductive graph setting, where the graph is static and attributes and edges of test nodes are visible during training. It is unsuitable for the inductive setting, where the graph could be dynamic and the test graph information is invisible in advance. Such inductive capability is essential for production machine learning systems with evolving graphs like social media and transaction networks. To fill this gap, we propose the \underline{{\bf G}}\underline{{\bf U}}ided \underline{{\bf I}}n\underline{{\bf D}}uctiv\underline{{\bf E}} Graph Unlearning framework (GUIDE). GUIDE consists of three components: guided graph partitioning with fairness and balance, efficient subgraph repair, and similarity-based aggregation. Empirically, we evaluate our method on several inductive benchmarks and evolving transaction graphs. Generally speaking, GUIDE can be efficiently implemented on the inductive graph learning tasks for its low graph partition cost, no matter on computation or structure information. The code will be available here: https://github.com/Happy2Git/GUIDE. Comment: To appear in the 32nd USENIX Security Symposium, August 2023, Anaheim, CA, USA
Keywords	Computer Science - Machine Learning ; Computer Science - Cryptography and Security ; Computer Science - Social and Information Networks
Subject code	006
Publishing date	2023-04-06
Publishing country	us
Document type	Book ; Online
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Article ; Online: New Glycerolipids from the Traditional Chinese Medicine of Syngnathus acus (Hai-Long).

Gao, Zhen / Wang, Meng-Xue / Gao, Cheng-Long / Chen, Sha / Li, Xu-Wen

Chemistry & biodiversity

2023 Volume 20, Issue 6, Page(s) e202300616

Abstract: ... Long). Their structures were elucidated by comprehensive spectral analyses involving UV, IR, MS, 1D and ...

Abstract	Two new glycerolipids, syngaculipids A and B (1 and 2), one first naturally occurring metabolite (8), together with five known compounds (3-7) were isolated from the AcOEt fraction of Syngnathus acus L. (Hai-Long). Their structures were elucidated by comprehensive spectral analyses involving UV, IR, MS, 1D and 2D NMR spectra and ECD calculations. All the isolated compounds were evaluated for their cytotoxicity against A549 and HCT-116 cell lines. Compound 8 exhibited moderate cytotoxicity with IC
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Molecular Structure ; HCT116 Cells
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300616
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