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Article ; Online: Biochemical and histopathological evaluation of systemic and ocular toxicity of favipiravir in rats.

Özcan, Delil / Özçelik, Fatih / Mammadov, Renad / Aktaş, Mehmet / Altındağ, Fikret / Alkan, Abdurrahman Alpaslan / Karapapak, Murat / Altuner, Durdu / Süleyman, Halis

Cutaneous and ocular toxicology

2024 , Page(s) 1–8

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.1080/15569527.2023.2300788
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Article ; Online: Effect of felodipine on indomethacin-induced gastric ulcers in rats.

Akbaş, Nergis / Süleyman, Bahadır / Mammadov, Renad / Gülaboğlu, Mine / Akbaş, Emin Murat / Süleyman, Halis

Experimental animals

2023 Volume 72, Issue 4, Page(s) 505–512

Abstract: Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory ... ...

Abstract	Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically in animals treated with felodipine (5 mg/kg) and famotidine in combination with indomethacin. The results were compared with those of the healthy control group and the group administered indomethacin alone. It was observed that felodipine suppressed the indomethacin-induced malondialdehyde increase (P<0.001); reduced the decrease in total glutathione amount (P<0.001), reduced the decrease superoxide dismutase (P<0.001), and catalase activities (P<0.001); and significantly inhibited ulcers (P<0.001) at the tested dose compared with indomethacin alone. Felodipine at a dose of 5 mg/kg reduced the indomethacin-induced decrease in cyclooxygenase-1 activity (P<0.001) but did not cause a significant reduction in the decrease in cyclooxygenase-2 activity. The antiulcer efficacy of felodipine was demonstrated in this experimental model. These data suggest that felodipine may be useful in the treatment of nonsteroidal anti-inflammatory drug-induced gastric injury.
MeSH term(s)	Rats ; Animals ; Indomethacin/adverse effects ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Famotidine/adverse effects ; Felodipine/adverse effects ; Rats, Wistar ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antioxidants/pharmacology
Chemical Substances	Indomethacin (XXE1CET956) ; Famotidine (5QZO15J2Z8) ; Felodipine (OL961R6O2C) ; Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants
Language	English
Publishing date	2023-06-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.23-0052
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Article ; Online: The Role of Adrenaline, Noradrenaline, and Cortisol in the Pathogenesis of the Analgesic Potency, Duration, and Neurotoxic Effect of Meperidine.

Yilmaz, Mehmet / Suleyman, Bahadir / Mammadov, Renad / Altuner, Durdu / Bulut, Seval / Suleyman, Halis

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 10

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Rats ; Animals ; Meperidine/adverse effects ; Epinephrine/therapeutic use ; Norepinephrine ; Hydrocortisone ; Metyrapone ; Caffeine/adverse effects ; Analgesics ; Epilepsy ; Seizures
Chemical Substances	Meperidine (9E338QE28F) ; Epinephrine (YKH834O4BH) ; Norepinephrine (X4W3ENH1CV) ; Hydrocortisone (WI4X0X7BPJ) ; Metyrapone (ZS9KD92H6V) ; Caffeine (3G6A5W338E) ; Analgesics
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59101793
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Article: Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats.

Cerrah, Serkan / Ozcicek, Fatih / Gundogdu, Betul / Cicek, Betul / Coban, Taha Abdulkadir / Suleyman, Bahadir / Altuner, Durdu / Bulut, Seval / Suleyman, Halis

Frontiers in pharmacology

2023 Volume 14, Page(s) 1161448

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1161448
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Article: Effects of benidipine, paracetamol, and their combination on postoperative and normal tissue pain thresholds.

Bedir, Zehra / Ozkaloglu Erdem, Kezban Tuna / Doymus, Omer / Suleyman, Halis / Yavuzer, Bulent / Cicek, Betul / Altuner, Durdu / Mammadov, Renad / Yilmaz, Mehmet / Coban, Taha Abdulkadir / Suleyman, Bahadir / Bulut, Seval

Frontiers in pharmacology

2024 Volume 14, Page(s) 1326128

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1326128
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Article ; Online: Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats.

Akbaş, Nergis / Akbaş, Emin Murat / Süleyman, Zeynep / Çiçek, Betül / Ağgül, Ahmet Gökhan / Mokhtare, Behzad / Süleyman, Halis

Cutaneous and ocular toxicology

2023 Volume 42, Issue 1, Page(s) 32–37

Abstract: Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been ... ...

Abstract	Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage. Materials and methods: Using a rat model, ATP 25 mg/kg was injected intraperitoneally in the ATP + Ribociclib (ATR) group ( Results: In the histopathological evaluation of the RCB group, dermal necrosis, degeneration in hair follicles, and pycnosis in keratinocytes were observed. Only mild degeneration was observed in the ATR group; the HC group had a normal histological appearance. The malondialdehyde (MDA) values were significantly higher and the superoxide dismutase (SOD), catalase (CAT), and total glutathione (tGSH) levels were significantly lower in the RCB group in comparison to the HC group ( Conclusion: ATP may be useful in the treatment of ribociclib-induced skin damage.
MeSH term(s)	Rats ; Animals ; Rats, Wistar ; Glutathione/metabolism ; Superoxide Dismutase ; Solvents ; Water
Chemical Substances	ribociclib (TK8ERE8P56) ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1) ; Solvents ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	605635-0
ISSN	1556-9535 ; 1556-9527 ; 0731-3829
ISSN (online)	1556-9535
ISSN	1556-9527 ; 0731-3829
DOI	10.1080/15569527.2023.2166524
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Article: The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity.

Suleyman, Halis

The Eurasian journal of medicine

2015 Volume 44, Issue 1, Page(s) 43–45

Abstract: Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of ...

Abstract	Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of gastric ulcer formation have been reported to act by blocking alpha-2 adrenergic receptors, whereas drugs possessing anti-ulcer activity have been shown to ensure gastric protection by stimulating the alpha-2 adrenergic receptors. The data derived from the literature indicate the likelihood that any drug or substance selectively stimulating the alpha-2 adrenergic receptors may possess anti-ulcer activity.
Language	English
Publishing date	2015-01-06
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	2577670-8
ISSN	1308-8742 ; 1308-8734
ISSN (online)	1308-8742
ISSN	1308-8734
DOI	10.5152/eajm.2012.09
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Article ; Online: Effects of taxifolin on aspirin-induced gastric damage in rats: macroscopic and biochemical evaluation.

Cerrah, Serkan / Akbas, Nergis / Ozcicek, Fatih / Mammadov, Renad / Altuner, Durdu / Suleyman, Halis / Bulut, Seval

Experimental animals

2023 Volume 72, Issue 4, Page(s) 513–519

Abstract: Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats ... ...

Abstract	Taxifolin (dihydroquercetin) is a flavanonol isolated from various plants and has antioxidant effects. The aim of our study was to macroscopically and biochemically investigate the effects of taxifolin on aspirin-induced oxidative gastric damage in rats and to evaluate them by comparison with those of famotidine. Rats were divided into four drug administration groups: a healthy control group, an aspirin-only group (ASG), a taxifolin + aspirin group (TASG), and a famotidine + aspirin group (FASG). The results revealed that in light of the results that we obtained, 50 mg/kg taxifolin had anti-ulcer effects. At this dose, taxifolin was able to bring COX-1 activities to a level close to those seen in healthy rats with appropriate macroscopic, oxidant/antioxidant, and biochemical parameters. Based on these results, it can be said that taxifolin may be successfully used as a more potent alternative to famotidine, which is the currently accepted treatment for aspirin-induced ulcers.
MeSH term(s)	Rats ; Animals ; Aspirin/adverse effects ; Famotidine/pharmacology ; Famotidine/therapeutic use ; Quercetin/pharmacology ; Antioxidants/pharmacology
Chemical Substances	Aspirin (R16CO5Y76E) ; taxifolin (9SOB9E3987) ; Famotidine (5QZO15J2Z8) ; Quercetin (9IKM0I5T1E) ; Antioxidants
Language	English
Publishing date	2023-06-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.22-0065
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Article: The role of Hippophae rhamnoides L. on 5-fluorouracil-ınduced oral mucositis in rats.

Dilber, Muhammet / Suleyman, Bahadir / Mammadov, Renad / Suleyman, Zeynep / Yavuzer, Bulent / Gulaboglu, Mine / Erhan, Ertugrul / Salcan, Ismail / Suleyman, Halis

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 5, Page(s) 1443–1449

Abstract: Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). ...

Abstract	Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). The 5-FU was injected in the FUG group intraperitoneally. The HRFU was injected 5-FU at 100mg/kg IP one hour after the 50mg/kg HRE was given orally. Olive oil was used as a solvent for the HG. HRE was given to the rats three times a day for ten days. 5-FU was given one dose on the 1st, 3rd and 5th days. On the 10th day, the tissues removed from the animals were euthanized with high-dose anaesthesia and were macroscopically examined. The levels of the oxidant, antioxidant and proinflammatory cytokines were investigated.It was seen that HRE alleviated the symptoms of severe mucositis by antagonizing the effects of 5-FU on oxidant, antioxidant and proinflammatory cytokines such as malondialdehyde, total glutathione, superoxide dismutase, catalase, nuclear factor kappa-B and interleukin-6 in inner cheek and tongue tissue. These results recommend that HRE may be benefical in the cure of 5-FU-associated oral mucositis.
MeSH term(s)	Rats ; Animals ; Fluorouracil/toxicity ; Antioxidants/pharmacology ; Hippophae ; Stomatitis/chemically induced ; Stomatitis/drug therapy ; Interleukin-6 ; Oxidants/pharmacology ; Intestinal Mucosa
Chemical Substances	Fluorouracil (U3P01618RT) ; Antioxidants ; Interleukin-6 ; Oxidants
Language	English
Publishing date	2023-10-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats.

Akbaş, Nergis / Suleyman, Bahadır / Mammadov, Renad / Yazıcı, Gülce Naz / Bulut, Seval / Süleyman, Halis

Experimental animals

2022 Volume 71, Issue 4, Page(s) 460–467

Abstract: The role of oxidative stress and inflammation in the pathogenesis of cyclophosphamide-related side effects has been demonstrated in previous studies. This study aimed to investigate the effect of taxifolin, due to its antioxidant and anti-inflammatory ... ...

Abstract	The role of oxidative stress and inflammation in the pathogenesis of cyclophosphamide-related side effects has been demonstrated in previous studies. This study aimed to investigate the effect of taxifolin, due to its antioxidant and anti-inflammatory properties, on cyclophosphamide-induced oxidative and inflammatory bladder injury in albino Wistar rats. The taxifolin+cyclophosphamide (TCYC) group was given 50 mg/kg of taxifolin orally by gavage. Normal saline was used as a solvent for the cyclophosphamide (CYC) group and the healthy control (HC) group. One hour after taxifolin administration, 75 mg/kg of cyclophosphamide was intraperitoneally injected in the TCYC and CYC groups. This procedure was repeated once a day for 30 days. At the end of this period, biochemical markers were studied in the excised bladder tissues and histopathological evaluations were conducted. In the histopathological evaluation of the CYC group, severe epithelial irregularity, dilatation, congestion, and polymorphonuclear leukocyte accumulation in the vascular structures were observed. Additionally, the malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels, the total oxidant status (TOS), and the oxidative stress index (OSI) values were significantly higher, and the total glutathione (tGSH) levels and total antioxidant status (TAS) were significantly lower in the CYC group in comparison to the HC group (P<0.001). Taxifolin reduced the cyclophosphamide-induced increases in the MDA, TNF-α, IL-1β, and IL-6 levels and the TOS and OSI values; it decreased the tGSH and TAS levels and reduced histopathological damage (P<0.001). Taxifolin may be useful in the treatment of cyclophosphamide-induced bladder damage.
MeSH term(s)	Rats ; Animals ; Antioxidants/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Urinary Bladder/metabolism ; Interleukin-6 ; Malondialdehyde ; Oxidative Stress ; Glutathione/metabolism ; Cyclophosphamide/adverse effects ; Rats, Wistar
Chemical Substances	taxifolin (9SOB9E3987) ; Antioxidants ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Malondialdehyde (4Y8F71G49Q) ; Glutathione (GAN16C9B8O) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2022-05-25
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.22-0030
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