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Article ; Online: Marine natural products.

Carroll, Anthony R / Copp, Brent R / Grkovic, Tanja / Keyzers, Robert A / Prinsep, Michèle R

2024 Volume 41, Issue 2, Page(s) 162–207

Abstract: Covering: January to the end of December 2022This review covers the literature published in 2022 for marine natural products (MNPs), with 645 citations (633 for the period January to December 2022) referring to compounds isolated from marine ... ...

Abstract	Covering: January to the end of December 2022This review covers the literature published in 2022 for marine natural products (MNPs), with 645 citations (633 for the period January to December 2022) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, the submerged parts of mangroves and other intertidal plants. The emphasis is on new compounds (1417 in 384 papers for 2022), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. An analysis of NP structure class diversity in relation to biota source and biome is discussed.
MeSH term(s)	Animals ; Biological Products/chemistry ; Marine Biology ; Molecular Structure ; Cnidaria/chemistry ; Echinodermata/chemistry ; Aquatic Organisms
Chemical Substances	Biological Products
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d3np00061c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Marine-derived Polyaromatic Butenolides - Isolation, Synthesis and Biological Evaluations.

Bracegirdle, Joe / Keyzers, Robert A

Current pharmaceutical design

2020 Volume 26, Issue 35, Page(s) 4351–4361

Abstract: Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of ... ...

Abstract	Marine invertebrates, especially tunicates, are a lucrative resource for the discovery of new lead compounds for the development of clinically utilized drugs. This review describes the isolation, synthesis and biological activities of several classes of marine-derived butenolide natural products, namely rubrolides and related cadiolides and prunolides. All relevant studies pertaining to these compounds up to the end of 2019 are included.
MeSH term(s)	4-Butyrolactone/analogs & derivatives ; Aquatic Organisms ; Biological Products/pharmacology ; Humans
Chemical Substances	Biological Products ; butenolide (8KXK25H388) ; 4-Butyrolactone (OL659KIY4X)
Language	English
Publishing date	2020-04-18
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666200518110617
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Zs.A 4714: Show issues

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Article: In silico

Singh, Harpreet / Almaazmi, Shaikha Y / Dutta, Tanima / Keyzers, Robert A / Blatch, Gregory L

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1158912

Abstract: Plasmodium ... ...

Abstract	Plasmodium falciparum
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1158912
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Article ; Online: Stictamycin, an Aromatic Polyketide Antibiotic Isolated from a New Zealand Lichen-Sourced

Hou, Peng / Woolner, V Helen / Bracegirdle, Joe / Hunt, Patricia / Keyzers, Robert A / Owen, Jeremy G

Journal of natural products

2023 Volume 86, Issue 3, Page(s) 526–532

Abstract: Here we describe the isolation and characterization of stictamycin, a new aromatic polyketide with activity ... ...

Abstract	Here we describe the isolation and characterization of stictamycin, a new aromatic polyketide with activity against
MeSH term(s)	Streptomyces/chemistry ; Polyketides/chemistry ; Lichens/genetics ; Anti-Bacterial Agents/chemistry ; New Zealand ; Multigene Family
Chemical Substances	Polyketides ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.2c00801
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Zs.A 1144: Show issues

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Article ; Online: Marine natural products.

Carroll, Anthony R / Copp, Brent R / Davis, Rohan A / Keyzers, Robert A / Prinsep, Michèle R

Natural product reports

2023 Volume 40, Issue 2, Page(s) 275–325

Abstract: Covering: January to December 2021This review covers the literature published in 2021 for marine natural products (MNPs), with 736 citations (724 for the period January to December 2021) referring to compounds isolated from marine microorganisms and ... ...

Abstract	Covering: January to December 2021This review covers the literature published in 2021 for marine natural products (MNPs), with 736 citations (724 for the period January to December 2021) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1425 in 416 papers for 2021), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. An analysis of the number of authors, their affiliations, domestic and international collection locations, focus of MNP studies, citation metrics and journal choices is discussed.
MeSH term(s)	Animals ; Biological Products/chemistry ; Marine Biology ; Molecular Structure ; Cnidaria/chemistry ; Echinodermata/chemistry ; Aquatic Organisms
Chemical Substances	Biological Products
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d2np00083k
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Article ; Online: Characterization of marine-derived halogenated indoles as ligands of the aryl hydrocarbon receptor.

King, Jessie / Woolner, Victoria H / Keyzers, Robert A / Rosengren, Rhonda J

Toxicology reports

2022 Volume 9, Page(s) 1198–1203

Abstract: The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor thought to mediate a number of physiological roles in the body, is becoming a target of interest for the development of new therapeutics. However, previous research has ... ...

Abstract	The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor thought to mediate a number of physiological roles in the body, is becoming a target of interest for the development of new therapeutics. However, previous research has demonstrated that the downstream effects of AhR ligands cannot be predicted based simply on whether a ligand acts as an agonist or antagonist and the persistence of AhR signaling is thought to be a key determining feature. The current study investigated the AhR activity of four halogenated indoles isolated from the New Zealand red alga,
Language	English
Publishing date	2022-05-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.05.016
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Article ; Online: Marine natural products.

Carroll, Anthony R / Copp, Brent R / Davis, Rohan A / Keyzers, Robert A / Prinsep, Michèle R

Natural product reports

2022 Volume 39, Issue 6, Page(s) 1122–1171

Abstract: Covering: 2020This review covers the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated from marine microorganisms and phytoplankton, green, ... ...

Abstract	Covering: 2020This review covers the literature published in 2020 for marine natural products (MNPs), with 757 citations (747 for the period January to December 2020) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1407 in 420 papers for 2020), together with the relevant biological activities, source organisms and country of origin. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included. A meta analysis of bioactivity data relating to new MNPs reported over the last five years is also presented.
MeSH term(s)	Animals ; Aquatic Organisms ; Biological Products/chemistry ; Bryozoa/chemistry ; Cnidaria/chemistry ; Marine Biology ; Molecular Structure
Chemical Substances	Biological Products
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/d1np00076d
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Article ; Online: Natural Products from Tongan Marine Organisms.

Taufa, Taitusi / Subramani, Ramesh / Northcote, Peter T / Keyzers, Robert A

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 15

Abstract: The islands of the South Pacific Ocean have been in the limelight for natural product biodiscovery, due to their unique and pristine tropical waters and environment. The Kingdom of Tonga is an archipelago in the central Indo-Pacific Ocean, consisting of ... ...

Abstract	The islands of the South Pacific Ocean have been in the limelight for natural product biodiscovery, due to their unique and pristine tropical waters and environment. The Kingdom of Tonga is an archipelago in the central Indo-Pacific Ocean, consisting of 176 islands, 36 of which are inhabited, flourishing with a rich diversity of flora and fauna. Many unique natural products with interesting bioactivities have been reported from Indo-Pacific marine sponges and other invertebrate phyla; however, there have not been any reviews published to date specifically regarding natural products from Tongan marine organisms. This review covers both known and new/novel Marine Natural Products (MNPs) and their biological activities reported from organisms collected within Tongan territorial waters up to December 2020, and includes 109 MNPs in total, the majority from the phylum Porifera. The significant biological activity of these metabolites was dominated by cytotoxicity and, by reviewing these natural products, it is apparent that the bulk of the new and interesting biologically active compounds were from organisms collected from one particular island, emphasizing the geographic variability in the chemistry between these organisms collected at different locations.
MeSH term(s)	Animals ; Aquatic Organisms/chemistry ; Aquatic Organisms/metabolism ; Biodiversity ; Biological Products/analysis ; Drug Discovery/methods ; Pacific Ocean ; Porifera/chemistry ; Porifera/metabolism ; Secondary Metabolism/physiology ; Tonga ; Tropical Climate
Chemical Substances	Biological Products
Language	English
Publishing date	2021-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26154534
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Article ; Online: Behavioral metabolomics: how behavioral data can guide metabolomics research on neuropsychiatric disorders.

van de Wetering, Ross / Vorster, Jan A / Geyrhofer, Sophie / Harvey, Joanne E / Keyzers, Robert A / Schenk, Susan

Metabolomics : Official journal of the Metabolomic Society

2023 Volume 19, Issue 8, Page(s) 69

Abstract: Introduction: Metabolomics produces vast quantities of data but determining which metabolites are the most relevant to the disease or disorder of interest can be challenging.: Objectives: This study sought to demonstrate how behavioral models of ... ...

Abstract	Introduction: Metabolomics produces vast quantities of data but determining which metabolites are the most relevant to the disease or disorder of interest can be challenging. Objectives: This study sought to demonstrate how behavioral models of psychiatric disorders can be combined with metabolomics research to overcome this limitation. Methods: We designed a preclinical, untargeted metabolomics procedure, that focuses on the determination of central metabolites relevant to substance use disorders that are (a) associated with changes in behavior produced by acute drug exposure and (b) impacted by repeated drug exposure. Untargeted metabolomics analysis was carried out on liquid chromatography-mass spectrometry data obtained from 336 microdialysis samples. Samples were collected from the medial striatum of male Sprague-Dawley (N = 21) rats whilst behavioral data were simultaneously collected as part of a (±)-3,4-methylenedioxymethamphetamine (MDMA)-induced behavioral sensitization experiment. Analysis was conducted by orthogonal partial least squares, where the Y variable was the behavioral data, and the X variables were the relative concentrations of the 737 detected features. Results: MDMA and its derivatives, serotonin, and several dopamine/norepinephrine metabolites were the greatest predictors of acute MDMA-produced behavior. Subsequent univariate analyses showed that repeated MDMA exposure produced significant changes in MDMA metabolism, which may contribute to the increased abuse liability of the drug as a function of repeated exposure. Conclusion: These findings highlight how the inclusion of behavioral data can guide metabolomics data analysis and increase the relevance of the results to the phenotype of interest.
MeSH term(s)	Rats ; Male ; Animals ; N-Methyl-3,4-methylenedioxyamphetamine/metabolism ; N-Methyl-3,4-methylenedioxyamphetamine/pharmacology ; Metabolomics/methods ; Rats, Sprague-Dawley ; Serotonin ; Dopamine/metabolism
Chemical Substances	N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM) ; Serotonin (333DO1RDJY) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2250617-2
ISSN	1573-3890 ; 1573-3882
ISSN (online)	1573-3890
ISSN	1573-3882
DOI	10.1007/s11306-023-02034-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum

Harpreet Singh / Shaikha Y. Almaazmi / Tanima Dutta / Robert A. Keyzers / Gregory L. Blatch

Frontiers in Molecular Biosciences, Vol

a drug repurposing strategy against malaria

2023 Volume 10

Abstract: Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative agent of malaria in humans, a deadly vector borne infectious disease. A key phase of malaria pathology, is the invasion of human erythrocytes, resulting in ... ...

Abstract	Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative agent of malaria in humans, a deadly vector borne infectious disease. A key phase of malaria pathology, is the invasion of human erythrocytes, resulting in drastic remodeling by exported parasite proteins, including molecular chaperones and co-chaperones. The survival of the parasite within the human host is mediated by P. falciparum heat shock protein 70s (PfHsp70s) and J domain proteins (PfJDPs), functioning as chaperones-co-chaperones partnerships. Two complexes have been shown to be important for survival and pathology of the malaria parasite: PfHsp70-x-PFE0055c (exported); and PfHsp70-2-PfSec63 (endoplasmic reticulum). Virtual screening was conducted on the drug repurposing library, the Pandemic Response Box, to identify small-molecules that could specifically disrupt these chaperone complexes. Five top ranked compounds possessing preferential binding affinity for the malarial chaperone system compared to the human system, were identified; three top PfHsp70-PfJDP binders, MBX 1641, zoliflodacin and itraconazole; and two top J domain binders, ezetimibe and a benzo-diazepinone. These compounds were validated by repeat molecular dockings and molecular dynamics simulation, resulting in all the compounds, except for MBX 1461, being confirmed to bind preferentially to the malarial chaperone system. A detailed contact analysis of the PfHsp70-PfJDP binders identified two different types of modulators, those that potentially inhibit complex formation (MBX 1461), and those that potentially stabilize the complex (zoliflodacin and itraconazole). These data suggested that zoliflodacin and itraconazole are potential novel modulators specific to the malarial system. A detailed contact analysis of the J domain binders (ezetimibe and the benzo-diazepinone), revealed that they bound with not only greater affinity but also a better pose to the malarial J domain compared to that of the human system. These data suggested that ezetimibe ...
Keywords	Hsp70 ; J domain protein ; pandemic response box ; virtual screening ; drug repurposing ; Biology (General) ; QH301-705.5
Subject code	572
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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