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  1. Article: The Malarial Question-Letter from Dr. Denman.

    Denman, A M

    Texas medical journal (Austin, Tex.)

    2023  Volume 13, Issue 1, Page(s) 25–27

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8495
    ISSN 0892-8495
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  2. Article: That Resection: Letter from Dr. A. N. Denman.

    Denman, A M

    Texas medical journal (Austin, Tex.)

    2023  Volume 11, Issue 3, Page(s) 113–118

    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 0892-8495
    ISSN 0892-8495
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  3. Article ; Online: Consecutive Experience with Left Bundle Branch Area Pacing in a High-Volume Australian Centre.

    Puchalski, Robert J / Denman, Russell A / Haqqani, Haris M / Deen, Vincent R

    Heart, lung & circulation

    2023  Volume 32, Issue 8, Page(s) 993–999

    Abstract: Introduction: Left-bundle branch area pacing (LBBAP) is a relatively new technique for conduction system pacing. Australian safety and efficacy data is currently lacking. We aim to evaluate the learning curve, medium-term safety, and lead performance in ...

    Abstract Introduction: Left-bundle branch area pacing (LBBAP) is a relatively new technique for conduction system pacing. Australian safety and efficacy data is currently lacking. We aim to evaluate the learning curve, medium-term safety, and lead performance in a high-volume Australian setting.
    Methods: We performed a retrospective cohort study of 200 consecutive LBBAP procedures performed by a single operator at two centres between January 2019 and May 2020. Left bundle branch area pacing was performed predominantly via left subclavian access using a 69 cm Medtronic SelectSecure 3830 pacing lead and a preformed non-steerable C315-His sheath. Procedural success was defined as evidence of left septal or left bundle branch area capture as evidenced by a right bundle branch block-like paced morphology. Procedural characteristics, and follow-up (including lead performance) data were collected. Procedural efficiency over time, as well as safety data, were collected.
    Results: Median age was 78.26 years (interquartile range [IQR] 71-85), 37% were female. Atrial fibrillation was present in 22%. The left ventricular ejection fraction <50% in 24%, atrioventricular (AV) block was present in 43.5%, left bundle branch block in 22.5% and right bundle branch block in 24.5%. Acute procedural success was 91.5%. Implant threshold was 0.6V @ 0.5 ms, and 0.75V @ 0.5 ms at 11.9 months of follow-up. The QRS was significant reduced (baseline 134 ms vs implant 114 ms, p<0.001) There was a reduction in procedural time and X-ray dose over the course of the study. There were no complications specific to LBBAP.
    Conclusion: LBBAP appears to be a safe and effective pacing strategy. The QRS duration was significantly reduced compared to baseline. There appears to be an early learning curve with LBBAP.
    MeSH term(s) Female ; Humans ; Aged ; Male ; Bundle-Branch Block/epidemiology ; Bundle-Branch Block/therapy ; Retrospective Studies ; Stroke Volume ; Australia/epidemiology ; Ventricular Function, Left ; Atrioventricular Block ; Electrocardiography ; Cardiac Pacing, Artificial ; Treatment Outcome
    Language English
    Publishing date 2023-05-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.04.293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4988: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Corrigendum to "Effects of feed additives on rumen function and bacterial and archaeal communities during a starch and fructose challenge" (J. Dairy Sci. 106:8787-8808).

    Golder, H M / Denman, S E / McSweeney, C / Celi, P / Lean, I J

    Journal of dairy science

    2024  Volume 107, Issue 5, Page(s) 3336–3346

    Abstract: Heifers (n = 40) were randomly allocated to 5 treatment groups: (1) control (no additives); (2) virginiamycin (VM; 200 mg/d); (3) monensin (MT; 200 mg/d) + tylosin (110 mg/d); (4) monensin (MLY; 220 mg/d) + live yeast (5.0 × ... ...

    Abstract Heifers (n = 40) were randomly allocated to 5 treatment groups: (1) control (no additives); (2) virginiamycin (VM; 200 mg/d); (3) monensin (MT; 200 mg/d) + tylosin (110 mg/d); (4) monensin (MLY; 220 mg/d) + live yeast (5.0 × 10
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2024-107-5-3336
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    Zs.B 810: Show issues Location:
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  5. Article: Jaundice during treatment of myelomatosis with M & B 938.

    DENMAN, A M / WARD, H W

    British medical journal

    1960  Volume 1, Issue 5171, Page(s) 482

    MeSH term(s) Antineoplastic Agents/toxicity ; Diphenylamine ; Humans ; Jaundice/etiology ; Multiple Myeloma/therapy ; Plasma Cells
    Chemical Substances Antineoplastic Agents ; 4,4'-diamidinodiphenylamine (15535-96-3) ; Diphenylamine (9N3CBB0BIQ)
    Language English
    Publishing date 1960-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    DOI 10.1136/bmj.1.5171.482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pulsed Field Ablation of Atrial Fibrillation: An Initial Australian Single-Centre Experience.

    Lee, Xiang Wen / Freeman, Blake M / Gunthorpe, Nicole G / Eagle, Liam M / Webster, Meghan A / Betts, John R / Denman, Russell A / Haqqani, Haris M

    Heart, lung & circulation

    2023  Volume 33, Issue 1, Page(s) 46–54

    Abstract: Background: Pulsed field ablation (PFA) is a newer ablation energy source with the potential to reduce complications and improve efficacy compared to conventional thermal atrial fibrillation (AF) ablation. This study aimed to present an initial single- ... ...

    Abstract Background: Pulsed field ablation (PFA) is a newer ablation energy source with the potential to reduce complications and improve efficacy compared to conventional thermal atrial fibrillation (AF) ablation. This study aimed to present an initial single-centre Australian experience of PFA for AF ablation.
    Methods: Initial consecutive patients undergoing PFA for paroxysmal or persistent AF at a single centre were included. Baseline patient characteristics, procedural data and clinical outcomes were collected prospectively at the time of the procedure. Patients were followed up at 3 months and 6-monthly thereafter.
    Results: In total, 100 PFA procedures were performed in 97 patients under general anaesthesia. All pulmonary veins (403 of 403) were successfully isolated acutely. Median follow-up was 218 days (range, 16-343 days), and the Kaplan-Meier estimate for freedom from atrial arrhythmias at 180 days was 87% (95% confidence interval 79%-95%). Median procedure time was 74 minutes (range, 48-134 minutes). Median fluoroscopy dose-area product was 345 μGym
    Conclusions: Pulsed field ablation can be performed safely and efficiently, with encouraging efficacy in early follow-up. Further data and clinical trials will be required to assess the comparative utility of PFA in contemporary AF ablation practice.
    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Australia/epidemiology ; Pulmonary Veins/surgery ; Catheter Ablation/methods ; Treatment Outcome ; Recurrence
    Language English
    Publishing date 2023-12-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.10.012
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    Zs.A 4988: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Challenges and the Evolving Landscape of Assessing Blood-Based PD-L1 Expression as a Biomarker for Anti-PD-(L)1 Immunotherapy.

    Wang, Tao / Denman, Desirée / Bacot, Silvia M / Feldman, Gerald M

    Biomedicines

    2022  Volume 10, Issue 5

    Abstract: While promising, PD-L1 expression on tumor tissues as assessed by immunohistochemistry has been shown to be an imperfect biomarker that only applies to a limited number of cancers, whereas many patients with PD-L1-negative tumors still respond to anti-PD- ...

    Abstract While promising, PD-L1 expression on tumor tissues as assessed by immunohistochemistry has been shown to be an imperfect biomarker that only applies to a limited number of cancers, whereas many patients with PD-L1-negative tumors still respond to anti-PD-(L)1 immunotherapy. Recent studies using patient blood samples to assess immunotherapeutic responsiveness suggests a promising approach to the identification of novel and/or improved biomarkers for anti-PD-(L)1 immunotherapy. In this review, we discuss the advances in our evolving understanding of the regulation and function of PD-L1 expression, which is the foundation for developing blood-based PD-L1 as a biomarker for anti-PD-(L)1 immunotherapy. We further discuss current knowledge and clinical study results for biomarker identification using PD-L1 expression on tumor and immune cells, exosomes, and soluble forms of PD-L1 in the peripheral blood. Finally, we discuss key challenges for the successful development of the potential use of blood-based PD-L1 as a biomarker for anti-PD-(L)1 immunotherapy.
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10051181
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  8. Article ; Online: Effects of feed additives on rumen function and bacterial and archaeal communities during a starch and fructose challenge.

    Golder, H M / Denman, S E / McSweeney, C / Celi, P / Lean, I J

    Journal of dairy science

    2023  Volume 106, Issue 12, Page(s) 8787–8808

    Abstract: The objective of this study was to improve understandings of the rumen microbial ecosystem during ruminal acidosis and responses to feed additives to improve prudent use strategies for ruminal acidosis control. Rumen bacterial and archaeal community ... ...

    Abstract The objective of this study was to improve understandings of the rumen microbial ecosystem during ruminal acidosis and responses to feed additives to improve prudent use strategies for ruminal acidosis control. Rumen bacterial and archaeal community composition (BCC) and its associations with rumen fermentation measures were examined in Holstein heifers fed feed additives and challenged with starch and fructose. Heifers (n = 40) were randomly allocated to 5 treatment groups: (1) control (no additives); (2) virginiamycin (VM; 200 mg/d); (3) monensin (MT; 200 mg/d) + tylosin (110 mg/d); (4) monensin (MLY; 220 mg/d) + live yeast (5.0 × 10
    MeSH term(s) Animals ; Cattle ; Female ; Acidosis/veterinary ; Animal Feed/analysis ; Archaea ; Bacteria ; Diet/veterinary ; Fermentation ; Fructose/metabolism ; Histamine/analysis ; Histamine/metabolism ; Hydrogen-Ion Concentration ; Lactates/analysis ; Monensin/metabolism ; RNA, Ribosomal, 16S/genetics ; Rumen/metabolism ; Saccharomyces cerevisiae ; Starch/metabolism
    Chemical Substances Fructose (30237-26-4) ; Histamine (820484N8I3) ; Lactates ; Monensin (906O0YJ6ZP) ; RNA, Ribosomal, 16S ; Starch (9005-25-8)
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2023-23486
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    Zs.B 810: Show issues Location:
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  9. Book: Immunology of the rheumatic diseases

    Denman, A. M.

    (Annals of the rheumatic diseases ; 52, Suppl. 1 ; Heberden papers)

    1993  

    Author's details scientific ed. A. M. Denman
    Series title Annals of the rheumatic diseases ; 52, Suppl. 1
    Heberden papers
    Collection
    Keywords Rheumatic Diseases / immunology
    Size S54 S. : Ill., graph. Darst.
    Publisher BMJ Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004493273
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 114 -52,Suppl.1- verfügbar in Königswinter Königswinter

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  10. Article ; Online: Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis.

    Ngo, Linh / Lee, Xiang Wen / Elwashahy, Mohamed / Arumugam, Pooja / Yang, Ian A / Denman, Russell / Haqqani, Haris / Ranasinghe, Isuru

    European heart journal. Quality of care & clinical outcomes

    2023  Volume 9, Issue 5, Page(s) 447–458

    Abstract: Aims: Catheter ablation of atrial fibrillation (AF) is now a mainstream procedure although long-term outcomes are uncertain. We performed a systematic review and meta-analysis of procedural outcomes at 5 years and beyond.: Methods and results: We ... ...

    Abstract Aims: Catheter ablation of atrial fibrillation (AF) is now a mainstream procedure although long-term outcomes are uncertain. We performed a systematic review and meta-analysis of procedural outcomes at 5 years and beyond.
    Methods and results: We searched PubMed and Embase and after the screening, identified 73 studies (67 159 patients) reporting freedom from atrial arrhythmia, all-cause death, stroke, and major bleeding at ≥5 years after AF ablation. The pooled mean age was 59.7y, 71.5% male, 62.2% paroxysmal AF, and radiofrequency was used in 78.1% of studies. Pooled incidence of freedom from atrial arrhythmia at 5 years was 50.6% (95%CI 45.5-55.7%) after a single ablation and 69.7% [95%CI (confidence interval) 63.8-75.3%) after multiple procedures. The incidence was higher among patients with paroxysmal compared with non-paroxysmal AF after single (59.7% vs. 33.3%, p = 0.002) and multiple (80.8% vs. 60.6%, p < 0.001) ablations but was comparable between radiofrequency and cryoablation. Pooled incidences of other outcomes were 6.0% (95%CI 3.2-9.7%) for death, 2.4% (95%CI 1.4-3.7%) for stroke, and 1.2% (95%CI 0.8-2.0%) for major bleeding at 5 years. Beyond 5 years, freedom from arrhythmia recurrence remained largely stable (52.3% and 64.7% after single and multiple procedures at 10 years), while the risk of stroke and bleeding increased over time.
    Conclusion: Nearly 70% of patients having multiple ablations remained free from atrial arrhythmia at 5 years, with the incidence slightly decreasing beyond this period. Risk of death, stroke, and major bleeding at 5 years were low but increased over time, emphasizing the importance of long-term thromboembolism prevention and bleeding risk management.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Atrial Fibrillation/drug therapy ; Treatment Outcome ; Anti-Arrhythmia Agents/therapeutic use ; Hemorrhage ; Stroke/complications ; Catheter Ablation/adverse effects ; Catheter Ablation/methods
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2823451-0
    ISSN 2058-1742 ; 2058-5225
    ISSN (online) 2058-1742
    ISSN 2058-5225
    DOI 10.1093/ehjqcco/qcad037
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