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Article: Trends in incidence of atopic disorders in children and adolescents - Analysis of German claims data.

Kohring, Claudia / Akmatov, Manas K / Dammertz, Lotte / Heuer, Joachim / Bätzing, Jörg / Holstiege, Jakob

2023 Volume 16, Issue 7, Page(s) 100797

Abstract: Background: This claims-based study aimed to assess recent nationwide trends in pediatric incidence of atopic diseases in Germany.: Methods: Incidence of atopic dermatitis, asthma, and hay fever was assessed from 2013 to 2021 in annual cohorts of 0- ... ...

Abstract	Background: This claims-based study aimed to assess recent nationwide trends in pediatric incidence of atopic diseases in Germany. Methods: Incidence of atopic dermatitis, asthma, and hay fever was assessed from 2013 to 2021 in annual cohorts of 0- to 17-year-old children and adolescents with statutory health insurance (N = 11,828,525 in 2021). Results: Incidence of atopic dermatitis remained largely unchanged (15.2 cases per 1000 children in 2021) while hay fever incidence exhibited a fluctuating trend over the study period and amounted to 8.8 cases per 1000 in 2021. Asthma incidence decreased gradually between 2013 (12.4/1000) and 2019 (8.9/1000). This downward trend was followed by a further disproportionate reduction from 2019 to 2020 (6.3/1000) and a re-increase in 2021 (7.2/1000). Conclusion: The findings complement nationwide prevalence surveys of atopic diseases in children and adolescents in Germany. Knowledge about temporal variations in risk of atopic diseases are crucial for future investigations of explanatory factors to enhance the development of preventive measures. While asthma incidence followed a declining trend throughout the study period, an unprecedentedly strong reduction in pediatric asthma risk was observed in 2020, the first year of the COVID-19-pandemic.
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2023.100797
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Article ; Online: Secular trends and regional variations in pharmacotherapy of attention-deficit/hyperactivity disorder (ADHD) among children and adolescents in Germany.

Akmatov, Manas K / Holstiege, Jakob / Bätzing, Jörg

BMC psychiatry

2021 Volume 21, Issue 1, Page(s) 405

Abstract: Background: The study aim was to examine the secular trends and regional variations in pharmacotherapy of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) in Germany.: Methods: We used nationwide drug prescription data of ...

Abstract	Background: The study aim was to examine the secular trends and regional variations in pharmacotherapy of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) in Germany. Methods: We used nationwide drug prescription data of outpatient care (2009 to 2016). The study population comprised patients aged between 5 and 14 years with the diagnoses "hyperkinetic disorders" (ICD-10 code F90) (e.g. n = 262,766 in 2016). The examined drugs were methylphenidate, amphetamines, atomoxetine and guanfacine. Results: Overall, the proportion of patients received any prescription showed a decreasing trend over years (2010, 51%; 2016, 44%). The proportion of methylphenidate prescription was higher in Western than Eastern federal states. However, atomoxetine was more often prescribed in Eastern than Western federal states. The proportion of methylphenidate prescriptions issued by pediatric psychiatrists increased from 28% (2009) to 41% (2016). Conclusion: A decreasing trend in use of pharmacotherapy may be explained by prescription restrictions issued by the Federal Joint Committee in recent years.
MeSH term(s)	Adolescent ; Atomoxetine Hydrochloride/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/therapeutic use ; Child ; Child, Preschool ; Germany ; Humans ; Methylphenidate/therapeutic use
Chemical Substances	Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49) ; Atomoxetine Hydrochloride (57WVB6I2W0)
Language	English
Publishing date	2021-08-14
Publishing country	England
Document type	Journal Article
ISSN	1471-244X
ISSN (online)	1471-244X
DOI	10.1186/s12888-021-03409-6
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Article: Secular Trends and Rural-Urban Differences in Diagnostic Prevalence of Hay Fever: A Claims-Based Study in Germany.

Akmatov, Manas K / Holstiege, Jakob / Dammertz, Lotte / Heuer, Joachim / Kohring, Claudia / Bätzing, Jörg

Journal of asthma and allergy

2022 Volume 15, Page(s) 1205–1215

Abstract: Purpose: We aimed to examine possible variations in diagnostic prevalence of hay fever between urban and rural regions as well as in age-specific temporal developments.: Patients and methods: We used nationwide outpatient claims data from the years ... ...

Abstract	Purpose: We aimed to examine possible variations in diagnostic prevalence of hay fever between urban and rural regions as well as in age-specific temporal developments. Patients and methods: We used nationwide outpatient claims data from the years 2010 to 2019. The data contain information for all individuals with statutory health insurance (SHI) in Germany who were treated at least once in respective years (n = 71,410,121 in 2019). Individuals with a confirmed diagnosis of hay fever were defined as prevalent cases. We examined the association between the degree of urbanization and age- and sex-standardized prevalence of hay fever. We used the age- and sex-structure of SHI insurees in the year 2010 as a reference population for direct standardization. Results: The standardized prevalence of hay fever increased from 6.2% in 2010 to 7.2% in 2019, corresponding to a relative increase of 16%. However, we observed a clear decrease in prevalence among children, with the strongest relative reduction in young children (0-2 years: -53%). The standardized prevalence in the total population in 2019 was lowest in rural areas with a low population density (6.6%) and highest in big urban municipalities (7.8%). In stark contrast, prevalence in 0-14-year-olds was lowest in big urban municipalities (4.3%). Conclusion: We observed a decrease in the prevalence of hay fever in children and increase in the older age groups. A clear urban-rural association observed over years may be explained by environmental factors. Deviations from this general regional pattern in children of the age group 0-14 years may be explained by differing age-specific risk factors of hay fever.
Language	English
Publishing date	2022-08-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S371791
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Article ; Online: Utilization of influenza vaccination among chronically ill individuals in Germany: A nationwide claims-based analysis.

Akmatov, Manas K / Holstiege, Jakob / Steffen, Annika / Bätzing, Jörg

Vaccine

2021 Volume 39, Issue 6, Page(s) 952–960

Abstract: ... than males, except for HIV/AIDS patients. Among HIV-patients vaccination coverage was higher by 7 percent ... points among males (43%) than females (37%). The coverage was higher nearly for all patient groups ...

Abstract	Background: Individuals with chronic diseases have a higher risk of serious complications or even death in case of influenza infection. The European Union (EU) set a goal to reach a vaccination coverage of 75% in seniors and chronically ill individuals. The aim of this study was to assess influenza vaccination uptake among individuals with a wide spectrum of chronic diseases and examine its regional variations and temporal trends over a period of the last ten years. Methods: We used nationwide SHI-physician outpatient claims data from the years 2009 to 2018 covering 87% of the total German population to assess influenza vaccination uptake among individuals over 1 year of age with at least one of the following chronic diseases: pulmonary, cardiovascular, liver, kidney, metabolic, neurological and musculoskeletal diseases, as well as immune deficiency disorders, including HIV infection. Results: Influenza vaccination coverage varied across patient populations between 19% (multiple sclerosis) and 44% (chronic kidney disease) in the influenza season 2017/18. Vaccination coverage was slightly higher among females than males, except for HIV/AIDS patients. Among HIV-patients vaccination coverage was higher by 7 percent points among males (43%) than females (37%). The coverage was higher nearly for all patient groups in the eastern than western federal states. Over the observation period vaccination uptake showed decreasing trends in most of the target groups. Among patients with HIV/AIDS and immune deficiency disorders a stagnating trend was observed. Conclusions: Vaccination uptake among chronically ill individuals is suboptimal and far from the EU-defined target of 75%. There were substantial variations in coverage by disease groups, individual factors and regions. The disease-specific evaluation of the current study allows identification of populations at higher risk with considerable vaccination gaps. Further efforts are needed to improve vaccination uptake in these vulnerable population groups.
MeSH term(s)	Chronic Disease ; Female ; Germany/epidemiology ; HIV Infections ; Humans ; Influenza Vaccines ; Influenza, Human/prevention & control ; Male ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2021-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.12.081
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Falling incidence of Parkinson's disease in Germany.

Dammertz, Lotte / Schrag, Anette / Bohlken, Jens / Heuer, Joachim / Kohring, Claudia / Schorlemmer, Julia / Akmatov, Manas K / Bätzing, Jörg / Holstiege, Jakob

European journal of neurology

2023 Volume 30, Issue 10, Page(s) 3124–3131

Abstract: Background and purpose: Idiopathic Parkinson's disease (IPD) is a progressive neurodegenerative disorder that is strongly associated with age. The aim of the present study was to describe current sex- and age-specific trends and regional differences in ... ...

Abstract	Background and purpose: Idiopathic Parkinson's disease (IPD) is a progressive neurodegenerative disorder that is strongly associated with age. The aim of the present study was to describe current sex- and age-specific trends and regional differences in the incidence of IPD diagnosed in older people in Germany. Methods: This study was based on nationwide outpatient claims and drug prescription data from the German Statutory Health Insurance, covering approximately 87% of the general population. We conducted a cohort study in patients aged 50 years or older with observation time of at least 4 years. To assess the robustness of nationwide annual IPD incidence trends from 2013 to 2019, three case definitions with varying levels of stringency regarding coded outpatient diagnoses and drug prescriptions were applied. Results: In 2019, the population at risk comprised 30,575,726 persons. Using the primary and most specific case definition, annual age- and sex-standardized cumulative IPD incidence decreased stepwise from 137 (2013) to 106 (2019) new cases per 100,000 persons. The decline in incidence was seen in both sexes, in all age groups and in the majority of German regions. The relative decrease (2013-2019) in the annual age- and sex-standardized IPD incidence varied from 23% to 28% among case definitions. Conclusion: Our findings indicate a nationwide decline in the age- and sex-standardized incidence of IPD from 2013 to 2019 in Germany. This trend was consistent using different case definitions. Further research is needed to elucidate the factors underlying this trend.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Cohort Studies ; Germany/epidemiology ; Incidence ; Parkinson Disease/epidemiology
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.16000
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Psychiatric and Nonpsychiatric Comorbidities Among Children With ADHD: An Exploratory Analysis of Nationwide Claims Data in Germany.

Akmatov, Manas K / Ermakova, Tatiana / Bätzing, Jörg

Journal of attention disorders

2019 Volume 25, Issue 6, Page(s) 874–884

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adolescent ; Asthma/epidemiology ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Diabetes Mellitus, Type 2 ; Germany/epidemiology ; Humans
Language	English
Publishing date	2019-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/1087054719865779
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Article: The Effect of the COVID-19 Pandemic on Outpatient Antibiotic Prescription Rates in Children and Adolescents-A Claims-Based Study in Germany.

Akmatov, Manas K / Kohring, Claudia / Dammertz, Lotte / Heuer, Joachim / Below, Maike / Bätzing, Jörg / Holstiege, Jakob

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: The aim of the study was to examine whether the COVID-19 pandemic had any effect on antibiotic prescription rates in children in Germany. Using the nationwide outpatient prescription data from the Statutory Health Insurance from 2010 to 2021, changes in ... ...

Abstract	The aim of the study was to examine whether the COVID-19 pandemic had any effect on antibiotic prescription rates in children in Germany. Using the nationwide outpatient prescription data from the Statutory Health Insurance from 2010 to 2021, changes in the monthly prescriptions of systemic antibiotics dispensed to children aged 0-14 years were examined (
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11101433
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Article: The Changing Epidemiology of Viral Hepatitis in a Post-Soviet Country-The Case of Kyrgyzstan.

Akmatov, Manas K / Beisheeva, Nurgul J / Nurmatov, Asylbek Z / Gulsunai, Sattarova J / Saikal, Kylychbekova N / Derkenbaeva, Aisuluu A / Abdrahmanova, Zamira O / Prokein, Jana / Klopp, Norman / Illig, Thomas / Kasymov, Omor T / Nurmatov, Zuridin S / Pessler, Frank

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Historically, viral hepatitis has been a considerable public health problem in Central Asian countries, which may have worsened after the dissolution of the Soviet Union. However, up-to-date seroepidemiological studies are lacking. The aim of the present ...

Abstract	Historically, viral hepatitis has been a considerable public health problem in Central Asian countries, which may have worsened after the dissolution of the Soviet Union. However, up-to-date seroepidemiological studies are lacking. The aim of the present study was, therefore, to provide current estimates of the seroprevalence of viral hepatitis in Kyrgyzstan, one of the economically least developed countries in the region. We conducted a population-based cross-sectional study in 2018 in the capital of Kyrgyzstan, Bishkek (
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12080989
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Article ; Online: Child abuse in 28 developing and transitional countries--results from the Multiple Indicator Cluster Surveys.

Akmatov, Manas K

International journal of epidemiology

2011 Volume 40, Issue 1, Page(s) 219–227

Abstract: ... of all forms of child abuse was also higher for male children, those living with many household members and ...

Abstract	Background: Child abuse is a recognized public health and social problem worldwide. Using data from the Multiple Indicator Cluster Surveys (MICS) we aimed to (i) compare different forms of child abuse across countries and regions, and (ii) examine factors associated with different forms of child abuse. Methods: Information on child abuse was available in 28 developing and transitional countries from the third round of the MICS conducted in 2005 and 2006 (n = 124 916 children aged between 2 and 14 years). We determined the prevalence of psychological, and moderate and severe physical abuse for the preceding month and examined correlates of different forms of child abuse with multilevel logistic regression analysis. Results: A median of 83, 64 and 43% of children in the African region experienced psychological, and moderate and severe physical abuse, respectively. A considerably lower percentage of children in transitional countries experienced these forms of abuse (56, 46 and 9%, respectively). Parental attitudes towards corporal punishment were the strongest variable associated with all forms of child abuse. The risk of all forms of child abuse was also higher for male children, those living with many household members and in poorer families. Conclusions: Child abuse is a very common phenomenon in many of the countries examined. We found substantial variations in prevalence across countries and regions, with the highest prevalence in African countries. Population-based interventions (e.g. educational programmes) should be undertaken to increase public awareness of this problem. Actions on changing parental attitudes towards corporal punishment of children may help to prevent child abuse. The specific local situation in each country should be considered when selecting intervention strategies.
MeSH term(s)	Adolescent ; Chi-Square Distribution ; Child ; Child Abuse/statistics & numerical data ; Child, Preschool ; Cluster Analysis ; Cross-Sectional Studies ; Cultural Characteristics ; Developed Countries ; Developing Countries ; Female ; Humans ; Infant ; Logistic Models ; Male ; Parents/psychology ; Prevalence ; Punishment ; Risk Factors ; Surveys and Questionnaires
Language	English
Publishing date	2011-02
Publishing country	England
Document type	Journal Article
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyq168
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Journal ; Article ; Online: Trends and regional distribution of outpatient claims for asthma, 2009–2016, Germany

Akmatov, Manas K / Holstiege, Jakob / Steffen, Annika / Bätzing, Jörg

2020

Abstract: ... 40 ... ...

Abstract	40 51
Keywords	Research
Language	English
Publisher	World Health Organization
Document type	Journal ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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