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  1. Article ; Online: NETosis creates a link between diabetes and Long COVID.

    Thierry, Alain R

    Physiological reviews

    2023  Volume 104, Issue 2, Page(s) 651–654

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Diabetes Mellitus ; Neutrophils ; Extracellular Traps
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00032.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A New Paradigm of the Origins of Circulating DNA in Patients with Cancer.

    Thierry, Alain R / Pisareva, Ekaterina

    Cancer discovery

    2023  Volume 13, Issue 10, Page(s) 2122–2124

    Abstract: Summary: By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not ... ...

    Abstract Summary: By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying a systemic impact of cancer on cell turnover or DNA clearance. See related article by Mattox et al., p. 2166 (1).
    MeSH term(s) Female ; Humans ; Cell-Free Nucleic Acids ; DNA/genetics ; Ovarian Neoplasms ; Lung ; Colorectal Neoplasms
    Chemical Substances Cell-Free Nucleic Acids ; DNA (9007-49-2)
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-0824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Does the newly observed inflammatory syndrome in children demonstrate a link between uncontrolled neutrophil extracellular traps formation and COVID-19?

    Thierry, Alain R

    Pediatric research

    2020  Volume 89, Issue 4, Page(s) 716–717

    MeSH term(s) COVID-19 ; Child ; Extracellular Traps ; Humans ; Mucocutaneous Lymph Node Syndrome ; Neutrophils ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-020-0996-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19.

    Thierry, Alain R

    Physiological reviews

    2020  Volume 100, Issue 4, Page(s) 1597–1598

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Estrone/analogs & derivatives ; Fibrinolysin ; Humans ; Leukocyte Elastase ; Pandemics ; Pneumonia, Viral ; Risk Factors ; SARS-CoV-2
    Chemical Substances Estrone (2DI9HA706A) ; Leukocyte Elastase (EC 3.4.21.37) ; Fibrinolysin (EC 3.4.21.7) ; estropipate (SVI38UY019)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00019.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Corrigendum: What is the role of the neutrophil extracellular traps in the cardiovascular disease burden associated with hemodialysis bioincompatibility?

    Cristol, Jean-Paul / Thierry, Alain R / Bargnoux, Anne-Sophie / Morena-Carrere, Marion / Canaud, Bernard

    Frontiers in medicine

    2024  Volume 11, Page(s) 1393023

    Abstract: This corrects the article DOI: 10.3389/fmed.2023.1268748.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2023.1268748.].
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1393023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Host/genetic factors associated with COVID-19 call for precision medicine.

    Thierry, Alain R

    Precision clinical medicine

    2020  Volume 3, Issue 3, Page(s) 228–234

    Abstract: If the current rate of infection are to be better managed, and future waves of infection kept at bay, it is absolutely necessary that the conditions and mechanisms of exposure to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) be better ... ...

    Abstract If the current rate of infection are to be better managed, and future waves of infection kept at bay, it is absolutely necessary that the conditions and mechanisms of exposure to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) be better understood, as well as the downstream severe or lethal clinical complications. While the identification of notable comorbidities has now helped to define broad risk groups, the idiosyncratic responses of individual patients can generate unexpected clinical deterioration that is difficult to predict from initial clinical features. Thus, physicians caring for patients with COVID-19 face clinical dilemmas on a daily basis. The ability to decipher individual predispositions to SARS-CoV-2 infection or severe illness, in light of variations in host immunological and inflammatory responses, in particular as a result of genetic variations, would be of great benefit in infection management. To this end, this work associates the description of COVID-19 clinical complications, comorbidities, sequelae, and environmental and genetic factors. We also give examples of underlying genomic susceptibility to COVID-19, especially with regard to the newly reported link between the disease and the unbalanced formation of neutrophil extracellular traps. As a consequence, we propose that the host/genetic factors associated with COVID-19 call for precision medicine in its treatment. This is to our knowledge the first article describing elements towards precision medicine for patients with COVID-19.
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2948341-4
    ISSN 2516-1571 ; 2096-5303
    ISSN (online) 2516-1571
    ISSN 2096-5303
    DOI 10.1093/pcmedi/pbaa026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mitochondria-derived cell-to-cell communication.

    Al Amir Dache, Zahra / Thierry, Alain R

    Cell reports

    2023  Volume 42, Issue 7, Page(s) 112728

    Abstract: In addition to their intracellular mobility, mitochondria and their components can exist outside the cells from which they originate. As a result, they are capable of acting on non-parental distant cells and mediate intercellular communication in ... ...

    Abstract In addition to their intracellular mobility, mitochondria and their components can exist outside the cells from which they originate. As a result, they are capable of acting on non-parental distant cells and mediate intercellular communication in physiological conditions and in a variety of pathologies. It has recently been demonstrated that this horizontal transfer governs a wide range of biological processes, such as tissue homeostasis, the rescue of injured recipient cells, and tumorigenesis. In addition, due to mitochondria's bacterial ancestry, they and their components can be recognized as damage-associated molecular patterns (DAMPs) by the immune cells, leading to inflammation. Here, we provide an overview of the most current and significant findings concerning the different structures of extracellular mitochondria and their by-products and their functions in the physiological and pathological context. This account illustrates the ongoing expansion of our understanding of mitochondria's biological role and functions in mammalian organisms.
    MeSH term(s) Animals ; Cell Communication ; Inflammation ; Mammals ; Mitochondria
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Does the newly observed inflammatory syndrome in children demonstrate a link between uncontrolled neutrophil extracellular traps formation and COVID-19?

    Thierry, Alain R

    Pediatr. res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32492695
    Database COVID19

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  9. Article ; Online: Mitochondria-derived cell-to-cell communication

    Zahra Al Amir Dache / Alain R. Thierry

    Cell Reports, Vol 42, Iss 7, Pp 112728- (2023)

    2023  

    Abstract: Summary: In addition to their intracellular mobility, mitochondria and their components can exist outside the cells from which they originate. As a result, they are capable of acting on non-parental distant cells and mediate intercellular communication ... ...

    Abstract Summary: In addition to their intracellular mobility, mitochondria and their components can exist outside the cells from which they originate. As a result, they are capable of acting on non-parental distant cells and mediate intercellular communication in physiological conditions and in a variety of pathologies. It has recently been demonstrated that this horizontal transfer governs a wide range of biological processes, such as tissue homeostasis, the rescue of injured recipient cells, and tumorigenesis. In addition, due to mitochondria’s bacterial ancestry, they and their components can be recognized as damage-associated molecular patterns (DAMPs) by the immune cells, leading to inflammation. Here, we provide an overview of the most current and significant findings concerning the different structures of extracellular mitochondria and their by-products and their functions in the physiological and pathological context. This account illustrates the ongoing expansion of our understanding of mitochondria’s biological role and functions in mammalian organisms.
    Keywords CP: Cell biology ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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