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  1. Article ; Online: Contribution of immunology: immune response to vaccination and limits

    Brochot, Étienne

    Nephrologie & therapeutique

    2023  Volume 19, Issue S1, Page(s) 15–20

    Abstract: Advances over the past 50 years in the field of vaccination and the exploration of the immune response offer positive prospects for the prevention of infectious diseases. However, there is still a long way to go to improve the efficacy and safety of ... ...

    Title translation Apport de l’immunologie : réponse immunitaire à la vaccination et limites
    Abstract Advances over the past 50 years in the field of vaccination and the exploration of the immune response offer positive prospects for the prevention of infectious diseases. However, there is still a long way to go to improve the efficacy and safety of vaccination for transplant recipients or immunocompromised patients in the broad sense. In these populations, the benefit/risk balance of vaccination is even more pronounced in favor than that of the general population. Thus, consistently generating data in these populations is of great importance but can be disrupted by various human, technical and financial factors. In this text, we will attempt to describe some of these limitations for the immune response to vaccination and its exploration, especially in transplant recipients.
    MeSH term(s) Humans ; Vaccination ; Immunocompromised Host ; Transplant Recipients ; Immunity
    Language French
    Publishing date 2023-06-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1684/ndt.2023.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6298: Show issues Location:
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  2. Article ; Online: Commentary on: Lack of predictive capacity of pre-transplant anti-BK virus antibodies for post-transplant reactivation.

    Brochot, Etienne

    Journal of nephrology

    2023  Volume 36, Issue 4, Page(s) 953–954

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Risk Factors ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-01-30
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01579-y
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    Zs.A 3369: Show issues Location:
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  3. Article ; Online: Is there a role for SARS-CoV-2 antigen testing in the post-containment strategy?

    Brochot, Etienne

    Journal of clinical virology plus

    2021  Volume 1, Issue 1, Page(s) 100009

    Abstract: Background: With the availability and widespread deployment of antigenic tests for SARS-CoV-2 during the second epidemic wave in Europe, the performance of such tests in real-life situations is beginning to become available.: Objectives: The question ...

    Abstract Background: With the availability and widespread deployment of antigenic tests for SARS-CoV-2 during the second epidemic wave in Europe, the performance of such tests in real-life situations is beginning to become available.
    Objectives: The question of the role of these tests during periods of low circulation of the virus has been legitimately raised.
    Study design: We addressed this question by analyzing the results of more than 16,000 SARS-CoV-2 PCRs during the first half of 2020 in a French region heavily affected by COVID-19. We were thus able to calculate and extrapolate the theoretical sensitivity of the antigenic tests for various periods during and after the first epidemic wave.
    Results: As the PCR-positivity rate of nasopharyngeal swabs declined over time, the proportion of samples with low Ct levels also decreased. Thus, the calculation of the analytical sensitivity of the antigenic tests ranged from 70 to 80% when the percentage of PCR positivity was > 1%, but fell below this score when it was lower.
    Conclusions: The performance and relevance of antigenic tests appears to be more limited during phases of low circulation of the virus. This may have a negative impact on the effectiveness of isolation, testing, and contact tracing strategies.
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2667-0380
    ISSN (online) 2667-0380
    DOI 10.1016/j.jcvp.2021.100009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The value and complexity of studying cellular immunity against BK Polyomavirus in kidney transplant recipients.

    Aubry, Aurélien / Demey, Baptiste / Castelain, Sandrine / Helle, François / Brochot, Etienne

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2024  Volume 171, Page(s) 105656

    Abstract: BK Polyomavirus is of particular concern for kidney transplant recipients, due to their immunosuppression. This problem is exacerbated by the high effectiveness of antirejection therapies, which also compromise the organism's ability to fight viral ... ...

    Abstract BK Polyomavirus is of particular concern for kidney transplant recipients, due to their immunosuppression. This problem is exacerbated by the high effectiveness of antirejection therapies, which also compromise the organism's ability to fight viral infections. The long-term risk is loss of graft function through BKPyV-associated nephropathy (BKPyVAN). The assessment of host immunity and its link to the control of viral infections is a major challenge. In terms of humoral immunity, researchers have highlighted the prognostic value of the pre-transplantation anti-BKPyV immunoglobulin G titer. However, humoral immunity alone does not guarantee viral clearance, and the correlation between the humoral response and the time course of the infection remains weak. In contrast, cellular immunity variables appear to be more closely associated with viral clearance, given that the cellular immune response to the kidney transplant is the main target of immunosuppressive treatments in recipients. However, the assessment of the cellular immune response to BK Polyomavirus is complex, and many details still need to be characterized. Here, we review the current state of knowledge about BKPyV cellular immunity, as well as the difficulties that may be encountered in studying it in kidney transplant recipient. This is an essential area of research for optimizing the management of transplant recipients and minimizing the risks associated with insidious BKPyV disease.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; BK Virus/physiology ; Transplant Recipients ; Polyomavirus Infections ; Kidney Diseases ; Tumor Virus Infections
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2024.105656
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    Zs.A 3790: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Epidemiology and Dynamics of BK Polyomavirus Replication after Kidney Transplantation.

    Brochot, Etienne / Demey, Baptiste / Aubry, Aurélien / Descamps, Véronique / Morel, Virginie / Presne, Claire / Brazier, François / Helle, François

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Background/objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus's impact on ... ...

    Abstract Background/objectives: In the absence of an effective antiviral treatment for BK polyomavirus (BKPyV), a better understanding of the epidemiology and time course of BKPyV replication after kidney transplantation is needed to limit the virus's impact on the graft outcome.
    Methods: In a 7-year study, we screened more than 430 kidney transplant recipients and analyzed the time course and virological characteristics of BKPyV replication.
    Results: Urinary viral replication was observed in 116 (27%) of the 430 patients, and 90 of the 116 (78%) had viral DNAemia. Thirty-eight patients (8.8%) were presumed to have nephropathy (DNAemia > 4 log10 copies/mL). Of the patients with BKPyV replication, 48%, 60%, 71%, and 80% were first found to be positive one, two, three, and four months post-transplantation. The initial viral load in the urine was below 7 log10 copies/mL in 100% of the patients with viral replication first detected before the first month, and this proportion was 57% when viral replication was first detected after the first month. When the BKPyV replication was first detected in a urine sample at month 3 or later, 81.5% of patients had concomitant BKPyV DNAemia. The predominant viral subtype was Ib2 (60%), and there was no apparent relationship between the subtype and the time course of BKPyV replication.
    Conclusions: Urinary BKPyV replication occurs early after renal transplantation and in most patients will increase to a level requiring therapeutic intervention. Close monitoring for BKPyV in the early post-transplantation period would enable the pre-emptive adjustment of the immunosuppression regimen.
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040315
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  6. Article: Evaluation of the ABL NGS assay for HIV-1 drug resistance testing.

    Lhossein, Thomas / Sylvain, Karine / Descamps, Véronique / Morel, Virginie / Demey, Baptiste / Brochot, Etienne

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e22210

    Abstract: HIV evolution and variability around the world requires special monitoring of the viral strains in infected people. High-throughput HIV sequencing and drug resistance testing techniques have become routinely available over the last few years. We ... ...

    Abstract HIV evolution and variability around the world requires special monitoring of the viral strains in infected people. High-throughput HIV sequencing and drug resistance testing techniques have become routinely available over the last few years. We conducted a study to assess the new CE-marked ABL NGS HIV genotyping assay on an Illumina® platform, to compare the results (the detection of resistance associated mutations (RAMs) detected in the three main targets: reverse transcriptase, protease, and integrase) with those produced by three Sanger-based assays, and to compare the assays' respective costs. For the 10 samples and a 20 % sensitivity threshold for the NGS technology, the percent agreement between the four assays ranged from 99.5 % to 100 %. We detected 4 more and 10 more RAMs of interest when we lowered the NGS assay's threshold to 10 % and 3 %, respectively. At a threshold of 3 %, the antiretroviral sensitivity interpretation algorithm (for protease inhibitors) was modified for only two patients. The NGS assay's unit cost fell rapidly as the number of samples per run increased. Compared with Sanger sequencing, the ABL NGS HIV genotyping assay is just as robust and somewhat more expensive but opens up interesting multiplexing perspectives for virology laboratories.
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22210
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  7. Article ; Online: Seroconversion of Immunoglobulins to SARS-CoV2 in Patients With Inflammatory Bowel Disease Patients Treated by Biologics.

    Fumery, Mathurin / Matias, Clement / Brochot, Etienne

    Journal of Crohn's & colitis

    2020  Volume 14, Issue 12, Page(s) 1792–1793

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/blood ; COVID-19/complications ; Female ; Gastrointestinal Agents/therapeutic use ; Humans ; Immunoglobulins/blood ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Infliximab/therapeutic use ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Seroconversion ; Young Adult
    Chemical Substances Antibodies, Monoclonal, Humanized ; Gastrointestinal Agents ; Immunoglobulins ; vedolizumab (9RV78Q2002) ; Infliximab (B72HH48FLU)
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjaa154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6634: Show issues Location:
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  8. Article: Comparison of two RT-qPCR methods targeting BK polyomavirus microRNAs in kidney transplant recipients.

    Zoubir, Kenza / Descamps, Véronique / Aubry, Aurélien / Helle, Francois / Francois, Catherine / Castelain, Sandrine / Brochot, Etienne / Demey, Baptiste

    Frontiers in medicine

    2023  Volume 10, Page(s) 1281625

    Abstract: Background: BK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new ... ...

    Abstract Background: BK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new tools are required to enhance the biological monitoring of the infection. Viral microRNAs are promising new biomarkers, but the performance of RT-qPCR methods limits the clinical application and the validation of a standard method for quantification.
    Methods: We compared
    Results: Cycle threshold values were constantly higher with
    Conclusion: Overall,
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1281625
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  9. Article ; Online: Neutralizing antibodies directed against SARS-CoV-2 in a population residing in a nursing home and a long-term care unit.

    Moyet, Julien / Helle, Francois / Bourdenet, Gwladys / Joseph, Cédric / Gubler, Brigitte / Brochot, Etienne / Bloch, Frédéric

    Geriatrics & gerontology international

    2021  Volume 21, Issue 11, Page(s) 1066–1068

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; Long-Term Care ; Nursing Homes ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-10-01
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14289
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    Zs.A 5801: Show issues Location:
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  10. Article ; Online: Intercellular Transmission of Naked Viruses through Extracellular Vesicles: Focus on Polyomaviruses.

    Helle, Francois / Handala, Lynda / Bentz, Marine / Duverlie, Gilles / Brochot, Etienne

    Viruses

    2020  Volume 12, Issue 10

    Abstract: Extracellular vesicles have recently emerged as a novel mode of viral transmission exploited by naked viruses to exit host cells through a nonlytic pathway. Extracellular vesicles can allow multiple viral particles to collectively traffic in and out of ... ...

    Abstract Extracellular vesicles have recently emerged as a novel mode of viral transmission exploited by naked viruses to exit host cells through a nonlytic pathway. Extracellular vesicles can allow multiple viral particles to collectively traffic in and out of cells, thus enhancing the viral fitness and diversifying the transmission routes while evading the immune system. This has been shown for several RNA viruses that belong to the Picornaviridae, Hepeviridae, Reoviridae, and Caliciviridae families; however, recent studies also demonstrated that the BK and JC viruses, two DNA viruses that belong to the Polyomaviridae family, use a similar strategy. In this review, we provide an update on recent advances in understanding the mechanisms used by naked viruses to hijack extracellular vesicles, and we discuss the implications for the biology of polyomaviruses.
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Endocytosis/physiology ; Extracellular Vesicles/virology ; Humans ; Immune Evasion/physiology ; Polyomavirus/immunology ; Polyomavirus/metabolism ; Polyomavirus Infections/transmission ; Tumor Virus Infections/transmission ; Tumor Virus Infections/virology ; Virus Internalization ; Virus Replication/physiology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2020-09-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12101086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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