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  1. Article ; Online: Anti-tumor necrosis factor agents and COVID-19: A word of caution.

    Hajjar, Roy / Chan, Gabriel

    Journal of clinical and translational research

    2020  Volume 6, Issue 3, Page(s) 94–96

    Language English
    Publishing date 2020-08-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 3019815-X
    ISSN 2424-810X ; 2382-6533
    ISSN (online) 2424-810X
    ISSN 2382-6533
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  2. Article: Inulin impacts tumorigenesis promotion by colibactin-producing

    Oliero, Manon / Hajjar, Roy / Cuisiniere, Thibault / Fragoso, Gabriela / Calvé, Annie / Santos, Manuela M

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1067505

    Abstract: Introduction: The prebiotic inulin has previously shown both protective and tumor-promoting effects in colorectal cancer (CRC). These inconsistencies may be due to the gut microbial composition as several bacteria have been associated with CRC. ... ...

    Abstract Introduction: The prebiotic inulin has previously shown both protective and tumor-promoting effects in colorectal cancer (CRC). These inconsistencies may be due to the gut microbial composition as several bacteria have been associated with CRC. Specifically, polyketide synthase-positive (
    Methods: Mice received a 2% dextran sodium sulfate (DSS) solution followed by oral gavage with the murine
    Results: Inulin supplementation led to increase EcNC101 colonization compared to mice receiving the control diet. The increased colonization of EcNC101 resulted in more DSBs, tumor burden, and tumor progression in
    Discussion: Our results suggest that the presence of
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1067505
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  3. Article ; Online: Conservative Management of Obesity in Kidney Transplant Candidates.

    Hajjar, Roy / Marcotte, Cynthia / Chan, Gabriel

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2021  Volume 32, Issue 3, Page(s) 347–353

    Abstract: Objective: Obesity is prevalent in patients with chronic kidney disease and is associated with increased complications after kidney transplantation (KT). A body mass index limit is used in most transplant programs, though few studies have focused on ... ...

    Abstract Objective: Obesity is prevalent in patients with chronic kidney disease and is associated with increased complications after kidney transplantation (KT). A body mass index limit is used in most transplant programs, though few studies have focused on conservative weight loss in KT candidates. The objective of this retrospective study is to evaluate the efficacy of a basic conservative weight management program in morbidly obese KT candidates and to perform a comprehensive nutritional evaluation.
    Methods: This retrospective study included patients with a body mass index (BMI) >35 kg/m
    Results: Eighty patients were observed for a mean of 24 months. Successful weight loss (BMI < 35 kg/m
    Conclusion: The conservative weight loss program can have limited but non-negligible, success. Future successful nutritional interventions should take into consideration this surprising comprehensive profile of morbidly obese KT candidates.
    MeSH term(s) Body Mass Index ; Conservative Treatment ; Female ; Humans ; Kidney Transplantation ; Male ; Obesity, Morbid/complications ; Obesity, Morbid/therapy ; Renal Insufficiency, Chronic/complications ; Retrospective Studies ; Weight Loss
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2021.03.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3273: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran.

    Gerkins, Claire / Hajjar, Roy / Oliero, Manon / Santos, Manuela M

    Journal of visualized experiments : JoVE

    2022  , Issue 189

    Abstract: Gut barrier integrity is a hallmark of intestinal health. While gut barrier integrity can be assessed using indirect markers such as the measurement of plasma inflammatory markers and bacterial translocation to the spleen and lymph nodes, the gold ... ...

    Abstract Gut barrier integrity is a hallmark of intestinal health. While gut barrier integrity can be assessed using indirect markers such as the measurement of plasma inflammatory markers and bacterial translocation to the spleen and lymph nodes, the gold standard directly quantifies the ability of selected molecules to traverse the gut mucosal layer toward systemic circulation. This article uses a non-invasive, cost-effective, and low-burden technique to quantify and follow in real time the intestinal permeability in mice using fluorescein-isothiocyanate-labeled dextran (FITC-dextran). Prior to oral supplementation with FITC-dextran, the mice are fasted. They are then gavaged with FITC-dextran diluted in phosphate-buffered saline (PBS). One hour after the gavage, the mice are subjected to general anesthesia using isoflurane, and the in vivo fluorescence is visualized in an imaging chamber. This technique aims to assess residual fluorescence in the abdominal cavity and the hepatic uptake, which is suggestive of portal migration of the fluorescent probe. Blood and stool samples are collected 4 h after oral gavage, and the mice are sacrificed. Plasma and fecal samples diluted in PBS are then plated, and the fluorescence is recorded. The concentration of FITC-dextran is then calculated using a standard curve. In previous research, in vivo imaging has shown that fluorescence rapidly spreads to the liver in mice with a weaker gut barrier induced by a low-fiber diet, while in mice supplemented with fiber to strengthen the gut barrier, the fluorescent signal is retained mostly in the gastrointestinal tract. In addition, in this study, control mice had elevated plasma fluorescence and reduced fluorescence in the stool, while inversely, inulin-supplemented mice had higher levels of fluorescence signals in the gut and low levels in the plasma. In summary, this protocol provides qualitative and quantitative measurements of intestinal permeability as a marker for gut health.
    MeSH term(s) Mice ; Animals ; Dextrans ; Fluorescein-5-isothiocyanate ; Fluorescence ; Fluorescent Dyes
    Chemical Substances fluorescein isothiocyanate dextran ; Dextrans ; Fluorescein-5-isothiocyanate (I223NX31W9) ; Fluorescent Dyes
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/64710
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  5. Article ; Online: The role of butyrate in surgical and oncological outcomes in colorectal cancer.

    Hajjar, Roy / Richard, Carole S / Santos, Manuela M

    American journal of physiology. Gastrointestinal and liver physiology

    2021  Volume 320, Issue 4, Page(s) G601–G608

    Abstract: Butyrate is a short-chain fatty acid produced by colonic gut bacteria as a result of fermentation of dietary fibers. In the colon, butyrate is a major energy substrate and contributes to the nutritional support and proliferation of a healthy mucosa. It ... ...

    Abstract Butyrate is a short-chain fatty acid produced by colonic gut bacteria as a result of fermentation of dietary fibers. In the colon, butyrate is a major energy substrate and contributes to the nutritional support and proliferation of a healthy mucosa. It also promotes the intestinal barrier function by enhancing mucus production and tight junctions. In addition to its pro-proliferative effect in healthy colonocytes, butyrate inhibits the proliferation of cancer cells. The antineoplastic effect of butyrate is associated with the inhibitory effect of butyrate on histone deacetylase (HDAC) enzymes, which promote carcinogenesis. Due to the metabolic shift of cancer cells toward glycolysis, unused butyrate accumulates and inhibits procarcinogenic HDACs. In addition, recent studies suggest that butyrate may improve the healing of colonic tissue after surgery in animal models, specifically at the site of reconnection of colonic ends, anastomosis, after surgical resection. Here, we review current evidence on the impact of butyrate on epithelial integrity and colorectal cancer and present current knowledge on data that support its potential applications in surgical practice.
    MeSH term(s) Bacteria/metabolism ; Butyrates/metabolism ; Cell Movement ; Cell Proliferation ; Colon/metabolism ; Colon/microbiology ; Colon/pathology ; Colon/surgery ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Energy Metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Epithelial Cells/pathology ; Gastrointestinal Microbiome ; Humans ; Neoplasm Invasiveness ; Permeability ; Wound Healing
    Chemical Substances Butyrates
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00316.2020
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Spontaneous Small Bowel Perforation during Preoperative Progressive Pneumoperitoneum for Incisional Hernia Repair: Risk Zero Does Not Exist.

    Hajjar, Roy / Badrudin, David / Bendavid, Yves

    The American surgeon

    2020  Volume 85, Issue 12, Page(s) e599–e601

    MeSH term(s) Female ; Hernia, Ventral/surgery ; Herniorrhaphy/methods ; Humans ; Incisional Hernia/surgery ; Intestinal Perforation/etiology ; Middle Aged ; Pneumoperitoneum, Artificial/adverse effects ; Postoperative Complications/etiology ; Risk Assessment
    Language English
    Publishing date 2020-01-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Are Cancer Patients at Higher Risk of Death With COVID-19?

    Adashek, Jacob J / Hajjar, Joud / Chemaly, Roy F / Kurzrock, Razelle

    Journal of immunotherapy and precision oncology

    2020  Volume 3, Issue 2, Page(s) 49–51

    Language English
    Publishing date 2020-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3032799-4
    ISSN 2590-017X ; 2666-2345
    ISSN (online) 2590-017X
    ISSN 2666-2345
    DOI 10.4103/2666-2345.280883
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  8. Article: Minimally invasive management of a paraduodenal hernia with intestinal malrotation.

    Misheva, Bojana / Hajjar, Roy / Sebajang, Herawaty / Schwenter, Frank

    Journal of surgical case reports

    2020  Volume 2020, Issue 9, Page(s) rjaa326

    Abstract: Paraduodenal hernias (PDHs) are rare entities that may present with acute or subacute symptoms, and which pose challenges to prompt diagnosis and treatment. The minimally invasive management of these hernias is emerging as a new compelling approach to ... ...

    Abstract Paraduodenal hernias (PDHs) are rare entities that may present with acute or subacute symptoms, and which pose challenges to prompt diagnosis and treatment. The minimally invasive management of these hernias is emerging as a new compelling approach to optimize surgical recovery. We present the case of a 42-year-old female patient who presented with acute abdominal pain and symptoms of bowel obstruction. Abdominal imaging suggested the presence of a left PDH. Laparoscopic exploration was performed. Intestinal malrotation was noted with incarceration of a small bowel loop in the Landzert fossa. The incarcerated bowel loop was freed and primary repair of the hernial defect was performed. PDHs are usually congenital and involve a herniation of abdominal content into the left mesocolon, between the mesocolon and the posterior abdominal wall. Minimally invasive treatment, consisting of adhesiolysis and repair of the hernial defect, seems to be a valid and safe option.
    Language English
    Publishing date 2020-09-22
    Publishing country England
    Document type Case Reports
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjaa326
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  9. Article ; Online: Long-term follow-up of a cohort with post sleeve gastrectomy leaks: results of endoscopic treatment and salvage surgery.

    Deffain, Alexis / Alfaris, Heba / Hajjar, Roy / Thibeault, Felix / Dimassi, Wael / Denis, Ronald / Garneau, Pierre Y / Studer, Anne-Sophie / Pescarus, Radu

    Surgical endoscopy

    2023  Volume 37, Issue 12, Page(s) 9358–9365

    Abstract: Introduction: Laparoscopic sleeve gastrectomy (LSG) is the most performed bariatric procedure worldwide. The most challenging postoperative complication is gastric leak. The objectives of this study are to examine the efficacy and morbidity of different ...

    Abstract Introduction: Laparoscopic sleeve gastrectomy (LSG) is the most performed bariatric procedure worldwide. The most challenging postoperative complication is gastric leak. The objectives of this study are to examine the efficacy and morbidity of different therapeutic strategies addressing leakage, and the long-term outcomes of a cohort of LSG leaks.
    Methods: A retrospective review of patients treated for LSG leaks between September 2014 and January 2023 at our high-volume bariatric surgery center was performed.
    Results: The charts of 37 patients (29 women and 8 men) were reviewed, with a mean age of 43 years and a median follow-up of 24 months. The mean preoperative body mass index was 45.1 kg/m
    Conclusions: Purely endoscopic management was successful in 81% of cases; with 97% success rate if diagnosis earlier than 6 weeks. After four failed endoscopic procedures, a surgical approach should be considered. Delayed diagnosis appears to be a significant risk factor for failure of endoscopic treatment.
    MeSH term(s) Male ; Humans ; Female ; Adult ; Follow-Up Studies ; Obesity, Morbid/surgery ; Obesity, Morbid/complications ; Laparoscopy/methods ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Stomach ; Retrospective Studies ; Treatment Outcome ; Anastomotic Leak/etiology ; Anastomotic Leak/surgery
    Language English
    Publishing date 2023-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10386-2
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    Zs.A 2214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Combined Mucinous and Neuroendocrine Tumours of the Appendix Managed with Surgical Cytoreduction and Oxaliplatin-based Hyperthermic Intraperitoneal Chemotherapy.

    Hajjar, Roy / Dubé, Pierre / Mitchell, Andrew / Sidéris, Lucas

    Cureus

    2019  Volume 11, Issue 1, Page(s) e3894

    Abstract: Appendiceal neoplasms account for 1% of appendectomy specimens. Common subtypes include mucinous cystadenoma, adenocarcinoma, and neuroendocrine tumors (NETs). The simultaneous presence of appendicular mucinous and NETs is a rare event. Depending on the ... ...

    Abstract Appendiceal neoplasms account for 1% of appendectomy specimens. Common subtypes include mucinous cystadenoma, adenocarcinoma, and neuroendocrine tumors (NETs). The simultaneous presence of appendicular mucinous and NETs is a rare event. Depending on the tumors' morphological distribution in the affected organ, they are qualified as either "collision" or "combined" tumours. We herein present the case of a 50-year-old male who presented with acute appendicitis and who was subsequently found to have pseudomyxoma peritonei (PMP) due to a perforated combined mucinous and neuroendocrine tumours. The patient was treated by right hemicolectomy and cytoreductive surgery (CRS) with oxaliplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC). He was cancer free 20 months later. Due to the limited clinical experience with this presentation, no formal recommendations exist as to its management other than those applicable to each cancer alone. The efficacity of treatment on the long-term prognosis on these combined tumors is yet to be elucidated.
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3894
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