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Article ; Online: Ultrastructural and Morphological Effects in T-Lymphoblastic Leukemia CEM-SS Cells Following Treatment with Nordamnacanthal and Damnacanthal from Roots of

Latifah, Saiful Yazan / Gopalsamy, Banulata / Abdul Rahim, Raha / Manaf Ali, Abdul / Haji Lajis, Nordin

2022 Volume 27, Issue 13

Abstract: Background: Morinda elliptica: Aim: This study analyzed the morphological and ultrastructural effects of damnacanthal and nordamnacanthal on T-lymphoblastic leukemia CEM-SS cells.: Method: Light microscopy, Giemsa staining, Wright's staining, ... ...

Abstract	Background: Morinda elliptica Aim: This study analyzed the morphological and ultrastructural effects of damnacanthal and nordamnacanthal on T-lymphoblastic leukemia CEM-SS cells. Method: Light microscopy, Giemsa staining, Wright's staining, scanning electron microscopy, and transmission electron microscopy were carried out to determine apoptosis, necrosis, and ultrastructural changes that occurred within the cells. Results: The outcomes showed that these compounds induced cell death by apoptosis and necrosis, specifically at higher doses of 10 and 30 μg/mL. Condensation and fragmentation of the nuclear chromatin, which further separated into small, membrane-bound vesicles known as apoptotic bodies, were observed in the nuclei and cytoplasm. The plasma membranes and cytoskeletons also showed marked morphological changes upon treatment with damnacanthal and nordamnacanthal, indicating apoptosis. Conclusion: Therefore, we report that damnacanthal and nordamnacanthal exhibit anticancer properties by inducing apoptosis and necrosis in CEM-SS cells, and they have potential as a drug for the treatment of T-lymphoblastic leukemia.
MeSH term(s)	Aldehydes ; Anthraquinones/chemistry ; Apoptosis ; Humans ; Leukemia, T-Cell/drug therapy ; Morinda/chemistry ; Necrosis/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Chemical Substances	Aldehydes ; Anthraquinones ; nordamnacanthal ; damnacanthal (477-84-9)
Language	English
Publishing date	2022-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27134136
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Article ; Online: Ultrastructural and Morphological Effects in T-Lymphoblastic Leukemia CEM-SS Cells Following Treatment with Nordamnacanthal and Damnacanthal from Roots of Morinda elliptica

Saiful Yazan Latifah / Banulata Gopalsamy / Raha Abdul Rahim / Abdul Manaf Ali / Nordin Haji Lajis

Molecules, Vol 27, Iss 4136, p

2022 Volume 4136

Abstract: Background: Morinda elliptica (family Rubiaceae), locally known as ‘mengkudu kecil’, has been used by the Malays for medicinal purposes. Anthraquinones isolated from the roots of Morinda elliptica , namely nordamnacanthal and damnacanthal, have been ... ...

Abstract	Background: Morinda elliptica (family Rubiaceae), locally known as ‘mengkudu kecil’, has been used by the Malays for medicinal purposes. Anthraquinones isolated from the roots of Morinda elliptica , namely nordamnacanthal and damnacanthal, have been widely reported to exhibit anticancer and antioxidant properties in various cancer models in vitro and in vivo. Aim: This study analyzed the morphological and ultrastructural effects of damnacanthal and nordamnacanthal on T-lymphoblastic leukemia CEM-SS cells. Method: Light microscopy, Giemsa staining, Wright’s staining, scanning electron microscopy, and transmission electron microscopy were carried out to determine apoptosis, necrosis, and ultrastructural changes that occurred within the cells. Results: The outcomes showed that these compounds induced cell death by apoptosis and necrosis, specifically at higher doses of 10 and 30 μg/mL. Condensation and fragmentation of the nuclear chromatin, which further separated into small, membrane-bound vesicles known as apoptotic bodies, were observed in the nuclei and cytoplasm. The plasma membranes and cytoskeletons also showed marked morphological changes upon treatment with damnacanthal and nordamnacanthal, indicating apoptosis. Conclusion: Therefore, we report that damnacanthal and nordamnacanthal exhibit anticancer properties by inducing apoptosis and necrosis in CEM-SS cells, and they have potential as a drug for the treatment of T-lymphoblastic leukemia.
Keywords	damnacanthal ; nordamnacanthal ; CEM-SS ; T-lymphoblastic leukemia ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anticancer Potential of Damnacanthal and Nordamnacanthal from

Latifah, Saiful Yazan / Gopalsamy, Banulata / Abdul Rahim, Raha / Manaf Ali, Abdul / Haji Lajis, Nordin

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 6

Abstract: Background: This study reports on the cytotoxic properties of nordamnacanthal and damnacanthal, isolated from roots of : Methods: MTT assay, DNA fragmentation, ELISA and cell cycle analysis were carried out.: Results: Nordamnacanthal and ... ...

Abstract	Background: This study reports on the cytotoxic properties of nordamnacanthal and damnacanthal, isolated from roots of Methods: MTT assay, DNA fragmentation, ELISA and cell cycle analysis were carried out. Results: Nordamnacanthal and damnacanthal at IC Conclusion: Damnacanthal and nordamnacanthal have anticancer properties, and could act as potential treatment for T-lymphoblastic leukemia.
MeSH term(s)	Aldehydes/isolation & purification ; Aldehydes/pharmacology ; Anthraquinones/isolation & purification ; Anthraquinones/pharmacology ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Fragmentation ; Endodeoxyribonucleases/metabolism ; Humans ; Morinda/chemistry ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
Chemical Substances	Aldehydes ; Anthraquinones ; Antineoplastic Agents, Phytogenic ; nordamnacanthal ; damnacanthal (477-84-9) ; Endodeoxyribonucleases (EC 3.1.-) ; calcium magnesium dependent endodeoxyribonuclease (EC 3.1.21.-)
Language	English
Publishing date	2021-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26061554
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Article ; Online: Anticancer Potential of Damnacanthal and Nordamnacanthal from Morinda elliptica Roots on T-lymphoblastic Leukemia Cells

Saiful Yazan Latifah / Banulata Gopalsamy / Raha Abdul Rahim / Abdul Manaf Ali / Nordin Haji Lajis

Molecules, Vol 26, Iss 1554, p

2021 Volume 1554

Abstract: Background: This study reports on the cytotoxic properties of nordamnacanthal and damnacanthal, isolated from roots of Morinda elliptica on T-lymphoblastic leukaemia (CEM-SS) cell lines. Methods: MTT assay, DNA fragmentation, ELISA and cell cycle ... ...

Abstract	Background: This study reports on the cytotoxic properties of nordamnacanthal and damnacanthal, isolated from roots of Morinda elliptica on T-lymphoblastic leukaemia (CEM-SS) cell lines. Methods: MTT assay, DNA fragmentation, ELISA and cell cycle analysis were carried out. Results: Nordamnacanthal and damnacanthal at IC 50 values of 1.7 μg/mL and10 μg/mL, respectively. At the molecular level, these compounds caused internucleosomal DNA cleavage producing multiple 180–200 bp fragments that are visible as a “ladder” on the agarose gel. This was due to the activation of the Mg 2+ /Ca 2+ -dependent endonuclease. The induction of apoptosis by nordamnacanthal was different from the one induced by damnacanthal, in a way that it occurs independently of ongoing transcription process. Nevertheless, in both cases, the process of dephosphorylation of protein phosphates 1 and 2A, the ongoing protein synthesis and the elevations of the cytosolic Ca 2+ concentration were not needed for apoptosis to take place. Nordamnacanthal was found to have a cytotoxic effect by inducing apoptosis, while damnacanthal caused arrest at the G0/G1 phase of the cell cycle. Conclusion: Damnacanthal and nordamnacanthal have anticancer properties, and could act as potential treatment for T-lymphoblastic leukemia.
Keywords	damnacanthal ; nordamnacanthal ; anticancer ; CEM-SS ; apoptosis ; Mg 2+ /Ca 2+ -dependent endonuclease ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain.

Gopalsamy, Banulata / Chia, Jasmine Siew Min / Farouk, Ahmad Akira Omar / Sulaiman, Mohd Roslan / Perimal, Enoch Kumar

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 17

Abstract: Zerumbone, a monocyclic sesquiterpene from the wild ginger ... ...

Abstract	Zerumbone, a monocyclic sesquiterpene from the wild ginger plant
MeSH term(s)	Analgesia ; Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred ICR ; Narcotic Antagonists/chemistry ; Narcotic Antagonists/pharmacology ; Neuralgia/drug therapy ; Neuralgia/metabolism ; Neuralgia/pathology ; Potassium Channel Blockers/chemistry ; Potassium Channel Blockers/pharmacology ; Potassium Channels/metabolism ; Receptors, Opioid/metabolism ; Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology
Chemical Substances	Narcotic Antagonists ; Potassium Channel Blockers ; Potassium Channels ; Receptors, Opioid ; Sesquiterpenes ; zerumbone (471-05-6)
Language	English
Publishing date	2020-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25173880
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Article ; Online: Correlation between Levels of Vitamins D

Razip, Nurliyana Najwa Md / Gopalsamy, Banulata / Abdul Mutalib, Mohd Sokhini / Chang, Sui Kiat / Abdullah, Muhammad Mikhail Joseph Anthony / Azlan, Azrina / Rejali, Zulida / Khaza'ai, Huzwah

Nutrients

2021 Volume 13, Issue 7

Abstract: An overview of vitamins ... ...

Abstract	An overview of vitamins D
MeSH term(s)	Adult ; Aged ; Blood Glucose/analysis ; Case-Control Studies ; Cholecalciferol/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Female ; Glycated Hemoglobin/analysis ; Humans ; Lipids/blood ; Malaysia/epidemiology ; Male ; Middle Aged ; Nutritional Status ; Statistics, Nonparametric ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin E/blood
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Lipids ; hemoglobin A1c protein, human ; Vitamin E (1406-18-4) ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072288
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Article ; Online: Ampelopsin E Reduces the Invasiveness of the Triple Negative Breast Cancer Cell Line, MDA-MB-231.

Tieng, Francis Yew Fu / Latifah, Saiful Yazan / Md Hashim, Nur Fariesha / Khaza'ai, Huzwah / Ahmat, Norizan / Gopalsamy, Banulata / Wibowo, Agustono

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 14

Abstract: Breast cancer is the most common and the second leading cause of cancer-related deaths in women. It has two distinctive hallmarks: rapid abnormal growth and the ability to invade and metastasize. During metastasis, cancer cells are thought to form actin- ... ...

Abstract	Breast cancer is the most common and the second leading cause of cancer-related deaths in women. It has two distinctive hallmarks: rapid abnormal growth and the ability to invade and metastasize. During metastasis, cancer cells are thought to form actin-rich protrusions, called invadopodia, which degrade the extracellular matrix. Current breast cancer treatments, particularly chemotherapy, comes with adverse effects like immunosuppression, resistance development and secondary tumour formation. Hence, naturally-occurring molecules claimed to be less toxic are being studied as new drug candidates. Ampelopsin E, a natural oligostilbene extracted from
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Dipterocarpaceae/chemistry ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Humans ; Molecular Structure ; Podosomes/drug effects ; Triple Negative Breast Neoplasms
Chemical Substances	Antineoplastic Agents, Phytogenic ; Flavonoids ; ampelopsin (27200-12-0)
Language	English
Publishing date	2019-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24142619
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Article: Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

Razip, Nurliyana Najwa Md / Gopalsamy, Banulata / Abdul Mutalib, Mohd Sokhini / Chang, Sui Kiat / Abdullah, Muhammad Mikhail Joseph Anthony / Azlan, Azrina / Rejali, Zulida / Khaza’ai, Huzwah

Nutrients. 2021 July 01, v. 13, no. 7

2021

Abstract: An overview of vitamins D₃ and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D₃ and E isomers amongst diabetic Malaysians. Two groups were ...

Abstract	An overview of vitamins D₃ and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D₃ and E isomers amongst diabetic Malaysians. Two groups were recruited for participation, one comprising fifty diabetic subjects (DM) and one comprising fifty non-diabetic (non-DM) subjects, in order to assess their plasma vitamin D₃, calcium and vitamin E status. Glycaemic status (haemoglobin A1c, HbA1c; fasting blood glucose, FBG; C-Peptide) and lipid profiles (total cholesterol, TC; triglycerides, TG; low-density lipoprotein-cholesterol, LDL-C; high-density lipoprotein-cholesterol, HDL-C) were assessed, followed by anthropometric measurements. The Mann–Whitney U-test, Kruskal–Wallis and Spearman’s correlation coefficient were used to elucidate the association between levels of plasma vitamins D₃ and E and T2DM. The vitamin D₃ deficiency group (<20 ng/mL) showed a significant correlation (p < 0.05) with glycaemic status (HbA1c and FBG) and lipid profiles (HDL-C, LDL and TC). Spearman’s correlation demonstrated that vitamin D₃ status is strongly correlated with HDL levels (p < 0.05). Similarly, plasma total vitamin E levels >4.9 μg/mL revealed significantly different FBG, HbA1c, C-Peptide, LDL, HDL and TC levels across both groups. Moreover, family history, smoking, waist circumference and HbA1c levels demonstrated a significant association (p < 0.05) with levels of vitamins D and E but not FBG and lipid profiles. This could be because the pre-diabetic status among the non-DM group influenced the outcomes of this study.
Keywords	blood glucose ; c-peptide ; calcium ; case-control studies ; hemoglobin ; noninsulin-dependent diabetes mellitus ; nutrient deficiencies ; vitamin E ; waist circumference ; Malaysia
Language	English
Dates of publication	2021-0701
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13072288
Database	NAL-Catalogue (AGRICOLA)

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Article: Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain.

Gopalsamy, Banulata / Farouk, Ahmad Akira Omar / Tengku Mohamad, Tengku Azam Shah / Sulaiman, Mohd Roslan / Perimal, Enoch Kumar

Journal of pain research

2017 Volume 10, Page(s) 2605–2619

Abstract: Background: Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerumbone (Zer), a sesquiterpene compound isolated from the ... ...

Abstract	Background: Neuropathic pain is a debilitating condition that severely affects the quality of life for those with this pain condition, and treatment for pain relief is greatly sought-after. Zerumbone (Zer), a sesquiterpene compound isolated from the rhizomes of a Southeast Asian ginger plant, Objective: This study investigated the effects of prophylactic administration of zerumbone on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain. Methods: Intraperitoneal administration of Zer (5-50 mg/kg) from day 1 post-surgery was carried out to identify the onset and progression of the pain condition. Responses toward mechanical and cold allodynia, and mechanical and thermal hyperalgesia were assessed on days 3, 5, 7, 9, 11, and 14 post-surgery. Blood plasma and spinal cord levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and IL-10 were screened using enzyme-linked immunosorbent assay on day 15. Results: Zer (10 and 50 mg/kg) attenuated pain symptoms on all days of behavioral testing without any signs of sedation in the rotarod test. ED Discussion and conclusion: Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators. Zer may prove to be a novel and beneficial alternative for the management of neuropathic pain.
Language	English
Publishing date	2017-11-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S143024
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Article ; Online: Ampelopsin E Reduces the Invasiveness of the Triple Negative Breast Cancer Cell Line, MDA-MB-231

Francis Yew Fu Tieng / Saiful Yazan Latifah / Nur Fariesha Md Hashim / Huzwah Khaza’ai / Norizan Ahmat / Banulata Gopalsamy / Agustono Wibowo

Molecules, Vol 24, Iss 14, p

2019 Volume 2619

Abstract	Breast cancer is the most common and the second leading cause of cancer-related deaths in women. It has two distinctive hallmarks: rapid abnormal growth and the ability to invade and metastasize. During metastasis, cancer cells are thought to form actin-rich protrusions, called invadopodia, which degrade the extracellular matrix. Current breast cancer treatments, particularly chemotherapy, comes with adverse effects like immunosuppression, resistance development and secondary tumour formation. Hence, naturally-occurring molecules claimed to be less toxic are being studied as new drug candidates. Ampelopsin E, a natural oligostilbene extracted from Dryobalanops species, has exhibited various pharmacological properties, including anticancer and anti-inflammatory activities. However, there is yet no scientific evidence of the effects of ampelopsin E towards metastasis. Scratch assay, transwell migration and invasion assays, invadopodia and gelatin degradation assays, and ELISA were used to determine the effects of ampelopsin E towards the invasiveness of MDA-MB-231 cells. Strikingly in this study, ampelopsin E was able to halt migration, transmigration and invasion in MDA-MB-231 cells by reducing formation of invadopodia and its degradation capability through significant reduction ( p < 0.05) in expression levels of PDGF, MMP2, MMP9 and MMP14. In conclusion, ampelopsin E reduced the invasiveness of MDA-MB-231 cells and was proven to be a potential alternative in treating TNBC.
Keywords	ampelopsin E ; triple negative breast cancer ; metastasis ; invadopodia ; Organic chemistry ; QD241-441
Subject code	616 ; 610
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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