Result 1 - 10 of total 181
Humanitas (07172168)
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #829893 |
| Database | COVID19 |
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Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
2021 Volume 43, Issue 1, Page(s) 110–111
| MeSH term(s) | Anxiety Disorders/epidemiology ; COVID-19 ; Comorbidity ; Humans ; Mental Disorders/epidemiology ; Panic Disorder ; SARS-CoV-2 |
|---|---|
| Keywords | covid19 |
| Language | English |
| Publishing date | 2021-02-01 |
| Publishing country | Brazil |
| Document type | Letter |
| ISSN | 1809-452X |
| ISSN (online) | 1809-452X |
| DOI | 10.1590/1516-4446-2020-1235 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
2021 Volume 44, Issue 2, Page(s) 121–123
| MeSH term(s) | Humans ; Mental Disorders/therapy ; Mental Health ; Precision Medicine |
|---|---|
| Language | English |
| Publishing date | 2021-10-15 |
| Publishing country | Brazil |
| Document type | Editorial |
| ZDB-ID | 2024119-7 |
| ISSN | 1809-452X ; 1809-452X |
| ISSN (online) | 1809-452X |
| ISSN | 1809-452X |
| DOI | 10.1590/1516-4446-2021-0032 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Brazilian Journal of Psychiatry n.ahead 2020
clinical considerations for the most physical of mental disorders
2020
| Keywords | covid19 |
|---|---|
| Language | English |
| Publishing date | 2020-01-01 |
| Publisher | Associação Brasileira de Psiquiatria |
| Publishing country | br |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Journal of personalized medicine
2022 Volume 12, Issue 8
Abstract: The polygenic and multifactorial nature of many psychiatric disorders has hampered implementation of the personalized medicine approach in clinical practice. However, induced pluripotent stem cell (iPSC) technology has emerged as an innovative tool for ... ...
| Abstract | The polygenic and multifactorial nature of many psychiatric disorders has hampered implementation of the personalized medicine approach in clinical practice. However, induced pluripotent stem cell (iPSC) technology has emerged as an innovative tool for patient-specific disease modeling to expand the pathophysiology knowledge and treatment perspectives in the last decade. Current technologies enable adult human somatic cell reprogramming into iPSCs to generate neural cells and direct neural cell conversion to model organisms that exhibit phenotypes close to human diseases, thereby effectively representing relevant aspects of neuropsychiatric disorders. In this regard, iPSCs reflect patient pathophysiology and pharmacological responsiveness, particularly when cultured under conditions that emulate spatial tissue organization in brain organoids. Recently, the application of iPSCs has been frequently associated with gene editing that targets the disease-causing gene to deepen the illness pathophysiology and to conduct drug screening. Moreover, gene editing has provided a unique opportunity to repair the putative causative genetic lesions in patient-derived cells. Here, we review the use of iPSC technology to model and potentially treat neuropsychiatric disorders by illustrating the key studies on a series of mental disorders, including schizophrenia, major depressive disorder, bipolar disorder, and autism spectrum disorder. Future perspectives will involve the development of organ-on-a-chip platforms that control the microenvironmental conditions so as to reflect individual pathophysiological by adjusting physiochemical parameters according to personal health data. This strategy could open new ways by which to build a disease model that considers individual variability and tailors personalized treatments. |
|---|---|
| Language | English |
| Publishing date | 2022-08-20 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2662248-8 |
| ISSN | 2075-4426 |
| ISSN | 2075-4426 |
| DOI | 10.3390/jpm12081340 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 13, Issue 6
Abstract: The aim of the present study is to perform a systematic review and meta-analysis on depression, stress and anxiety in women who experienced recurrent pregnancy loss (RPL) compared to controls and to men who experienced RPL. The pooled results showed a ... ...
| Abstract | The aim of the present study is to perform a systematic review and meta-analysis on depression, stress and anxiety in women who experienced recurrent pregnancy loss (RPL) compared to controls and to men who experienced RPL. The pooled results showed a higher level of moderate/severe depression among women who experienced RPL compared to controls (5359 women, random effects model, odds ratio (OR) 3.77, 95% Confidence Interval (CI) 2.71-5.23, |
|---|---|
| Language | English |
| Publishing date | 2023-05-27 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2662250-6 |
| ISSN | 2075-1729 |
| ISSN | 2075-1729 |
| DOI | 10.3390/life13061268 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 19, Issue 4, Page(s) 835–836
Abstract: ... for both depression and sleep-wake disorders.: Citation: Daccò S, Caldirola D, Grassi M, Alciati A, Perna G ...
| Abstract | Depression screening is not part of routine clinical practice in US sleep clinics. Our study aimed to report the prevalence of depression among individuals referred to US sleep clinics. According to our findings, approximately 21% of patients had depression, with about 4% reporting severe symptoms, 9% had frequent death and/or self-harming thoughts, and 61% were taking antidepressants. Our results highlighted a considerable risk of prevalent depression in sleep clinics and supported the limited existing data on this topic. Our study advocates for the need for routine depression screening in sleep services to reduce the detrimental consequences of a delayed depression diagnosis and the risk of a worse prognosis for both depression and sleep-wake disorders. Citation: Daccò S, Caldirola D, Grassi M, Alciati A, Perna G, Defillo A. High prevalence of major depression in US sleep clinics: the need for routine depression screening in sleep services. |
|---|---|
| MeSH term(s) | Humans ; Depressive Disorder, Major ; Depression/epidemiology ; Prevalence ; Sleep ; Sleep Wake Disorders/epidemiology |
| Language | English |
| Publishing date | 2023-01-15 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2397213-0 |
| ISSN | 1550-9397 ; 1550-9389 |
| ISSN (online) | 1550-9397 |
| ISSN | 1550-9389 |
| DOI | 10.5664/jcsm.10398 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6590: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Audiology research
2023 Volume 13, Issue 3, Page(s) 314–325
Abstract: Given the involvement of balance system abnormalities in the pathophysiology of panic disorder and agoraphobia (PD-AG), we evaluated initial evidence for feasibility, acceptability, and potential clinical usefulness of 10 sessions of balance ... ...
| Abstract | Given the involvement of balance system abnormalities in the pathophysiology of panic disorder and agoraphobia (PD-AG), we evaluated initial evidence for feasibility, acceptability, and potential clinical usefulness of 10 sessions of balance rehabilitation with peripheral visual stimulation (BR-PVS) in an open-pilot 5-week intervention study including six outpatients with PD-AG who presented residual agoraphobia after selective serotonin reuptake inhibitor (SSRI) treatment and cognitive-behavioral therapy, dizziness in daily life, and peripheral visual hypersensitivity measured by posturography. Before and after BR-PVS, patients underwent posturography, otovestibular examination (no patients presented peripheral vestibular abnormalities), and panic-agoraphobic symptom and dizziness evaluation with psychometric tools. After BR-PVS, four patients achieved postural control normalization measured by posturography, and one patient exhibited a favorable trend of improvement. Overall, panic-agoraphobic symptoms and dizziness decreased, even though to a lesser extent in one patient who had not completed the rehabilitation sessions. The study presented reasonable levels of feasibility and acceptability. These findings suggest that balance evaluation should be considered in patients with PD-AGO presenting residual agoraphobia and that BR-PVS might be an adjunctive therapeutic option worth being tested in larger randomized controlled studies. |
|---|---|
| Language | English |
| Publishing date | 2023-04-28 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ISSN | 2039-4330 |
| ISSN | 2039-4330 |
| DOI | 10.3390/audiolres13030027 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Frontiers in artificial intelligence
2023 Volume 6, Page(s) 1278593
Abstract: Manual sleep staging (MSS) using polysomnography is a time-consuming task, requires significant training, and can lead to significant variability among scorers. STAGER is a software program based on machine learning algorithms that has been developed by ... ...
| Abstract | Manual sleep staging (MSS) using polysomnography is a time-consuming task, requires significant training, and can lead to significant variability among scorers. STAGER is a software program based on machine learning algorithms that has been developed by Medibio Limited (Savage, MN, USA) to perform automatic sleep staging using only EEG signals from polysomnography. This study aimed to extensively investigate its agreement with MSS performed during clinical practice and by three additional expert sleep technicians. Forty consecutive polysomnographic recordings of patients referred to three US sleep clinics for sleep evaluation were retrospectively collected and analyzed. Three experienced technicians independently staged the recording using the electroencephalography, electromyography, and electrooculography signals according to the American Academy of Sleep Medicine guidelines. The staging initially performed during clinical practice was also considered. Several agreement statistics between the automatic sleep staging (ASS) and MSS, among the different MSSs, and their differences were calculated. Bootstrap resampling was used to calculate 95% confidence intervals and the statistical significance of the differences. STAGER's ASS was most comparable with, or statistically significantly better than the MSS, except for a partial reduction in the positive percent agreement in the wake stage. These promising results indicate that STAGER software can perform ASS of inpatient polysomnographic recordings accurately in comparison with MSS. |
|---|---|
| Language | English |
| Publishing date | 2023-12-05 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ISSN | 2624-8212 |
| ISSN (online) | 2624-8212 |
| DOI | 10.3389/frai.2023.1278593 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Expert review of neurotherapeutics
2023 Volume 23, Issue 11, Page(s) 1013–1029
Abstract: Introduction: Recommendations for treating panic disorder (PD) in older patients are scarce. The authors have systematically reviewed whether several recommended medications are superior to others and their optimal doses in this age group.: Methods: ... ...
| Abstract | Introduction: Recommendations for treating panic disorder (PD) in older patients are scarce. The authors have systematically reviewed whether several recommended medications are superior to others and their optimal doses in this age group. Methods: A database search of studies involving patients with PD with/without agoraphobia aged ≥ 60 years was carried out using PubMed, PsycINFO, Embase, and Clinical Trials.gov, from their inception dates to 1 March 2023. Only four (published from 2002 to 2010) of the 1292 records screened were included. A risk of bias assessment was provided. This systematic review was performed using The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Results: Two studies were randomized clinical trials, whereas two were open-label, including paroxetine, citalopram, escitalopram, and sertraline; three studies reported short-term evaluations, whereas one study included a 26-week follow-up. Medications provided benefits, with good tolerability. Preliminary results suggested greater benefits of paroxetine in reducing panic attacks vs. cognitive - behavioral therapy, and an earlier decrease in PAs with escitalopram vs. citalopram. Risk of bias was considerable. Conclusions: The pharmacological management of PD in older patients has received no attention. Findings are scant, dated, and affected by methodological flaws; thus, they do not provide significant advances. |
|---|---|
| MeSH term(s) | Humans ; Aged ; Panic Disorder/drug therapy ; Paroxetine/therapeutic use ; Citalopram/therapeutic use ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; Escitalopram ; Randomized Controlled Trials as Topic |
| Chemical Substances | Paroxetine (41VRH5220H) ; Citalopram (0DHU5B8D6V) ; Selective Serotonin Reuptake Inhibitors ; Escitalopram (4O4S742ANY) |
| Language | English |
| Publishing date | 2023-09-07 |
| Publishing country | England |
| Document type | Systematic Review ; Journal Article ; Review |
| ZDB-ID | 2112534-X |
| ISSN | 1744-8360 ; 1473-7175 |
| ISSN (online) | 1744-8360 |
| ISSN | 1473-7175 |
| DOI | 10.1080/14737175.2023.2254938 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6155: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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