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Article: Pharmacokinetics of flunixin and its effect on prostaglandin F2 alpha metabolite concentrations after oral and intravenous administration in heifers.

Odensvik, K

Journal of veterinary pharmacology and therapeutics

1995 Volume 18, Issue 4, Page(s) 254–259

Abstract: Flunixin meglumine (FM) was administered either orally as granules or intravenously to six heifers in a two period crossover study. Single doses of 2.2 mg/kg body weight were used. Pharmacokinetic variables were calculated using statistical moment ... ...

Abstract	Flunixin meglumine (FM) was administered either orally as granules or intravenously to six heifers in a two period crossover study. Single doses of 2.2 mg/kg body weight were used. Pharmacokinetic variables were calculated using statistical moment methods. The effect exerted by flunixin was measured as changes in the basal plasma concentration of the main metabolite of prostaglandin (PG) F2 alpha. After oral FM the arithmetic means of pharmacokinetic variables were: MRT = 12.7 h; MAT = 6.3 h; Cmax = 0.9 microgram/mL; tmax = 3.5 h. The bioavailability was 60% and the mean half-life (harmonic mean) was 6.2 h. Oral administration of FM inhibited as effectively as intravenous administration the prostaglandin biosynthesis. The concentration of the PG metabolite decreased almost as rapidly as after intravenous administration. The duration of the effect was prolonged and the PG metabolite concentration was significantly lower between 10 and 30 h after oral than after intravenous administration. The results indicate that oral dosing of flunixin, in the form of granules, can be an alternative to intravenous administration for therapeutic use in cattle.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biological Availability ; Cattle/metabolism ; Chromatography, High Pressure Liquid ; Clonixin/administration & dosage ; Clonixin/analogs & derivatives ; Clonixin/pharmacokinetics ; Clonixin/therapeutic use ; Cross-Over Studies ; Dinoprost/analogs & derivatives ; Dinoprost/blood ; Estrus/blood ; Female ; Half-Life ; Injections, Intravenous/veterinary
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; 15-keto-13,14-dihydroprostaglandin F2alpha (27376-76-7) ; flunixin meglumine (8Y3JK0JW3U) ; Dinoprost (B7IN85G1HY) ; Clonixin (V7DXN0M42R)
Language	English
Publishing date	1995-08
Publishing country	England
Document type	Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/j.1365-2885.1995.tb00589.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pharmacokinetics of flunixin and its effect on prostaglandin F2 alpha metabolite concentrations after oral and intravenous administration in heifers

Odensvik, K

Journal of veterinary pharmacology and therapeutics. Aug 1995. v. 18 (4)

1995

Keywords	heifers ; flunixin ; pharmacokinetics ; oral administration ; intravenous injection ; prostaglandins ; metabolites ; arachidonic acid ; lipid metabolism ; bioavailability ; half life
Language	English
Dates of publication	1995-08
Size	p. 254-259.
Document type	Article
ZDB-ID	435216-6
ISSN	0140-7783
ISSN	0140-7783
Database	NAL-Catalogue (AGRICOLA)

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Book ; Thesis: The use of flunixin for regulation of the prostaglandin biosynthesis

Odensvik, Kristina

especially in the bovine species / \c Kristina Odensvik

1995

Keywords	animal health ; animal diseases
Language	English
Size	1 v. (various pagings) :, ill. ;, 24 cm.
Publisher	s.n
Publishing place	Uppsala, Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Thesis (doctoral)--Swedish University of Agricultural Sciences, 1995
ISBN	9157649677 ; 9789157649676
Database	NAL-Catalogue (AGRICOLA)

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Book ; Thesis: The use of flunixin for regulation of the prostaglandin biosynthesis especially in the bovine species

Odensvik, Kristina

1995

Author's details	by Kristina Odensvik
Language	English
Size	Getr. Zählung, Ill
Publisher	SLU
Publishing place	Uppsala
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Swedish Univ. of Agricultural Sciences, Diss.--Uppsala, 1995
ISBN	9157649677 ; 9789157649676
Database	Special collection on veterinary medicine and general parasitology

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Article: Prostaglandin F2alpha release associated with an embryo transfer procedure in the mare.

Kask, K / Odensvik, K / Kindahl, H

Equine veterinary journal

2004 Volume 29, Issue 4, Page(s) 286–289

Abstract: The pattern of the main metabolite of prostaglandin (PG) F2alpha was recorded following a nonsurgical embryo transfer technique in 9 mares under field conditions in Estonia. Three patterns were observed. Two of them were characterised by PG release, ... ...

Abstract	The pattern of the main metabolite of prostaglandin (PG) F2alpha was recorded following a nonsurgical embryo transfer technique in 9 mares under field conditions in Estonia. Three patterns were observed. Two of them were characterised by PG release, thereas the third was not. A tendency towards a shortened cycle was seen in 3 mares. Observations were made regarding the manipulation of the uterus as being normal or difficult to perform. In general, mares where the procedure was considered difficult were also found to have a PG release.
MeSH term(s)	Abortifacient Agents, Nonsteroidal/metabolism ; Animals ; Area Under Curve ; Dinoprost/metabolism ; Embryo Transfer/veterinary ; Female ; Horses/blood ; Pregnancy ; Pregnancy Rate ; Pregnancy, Animal/blood ; Progesterone/blood
Chemical Substances	Abortifacient Agents, Nonsteroidal ; Progesterone (4G7DS2Q64Y) ; Dinoprost (B7IN85G1HY)
Language	English
Publishing date	2004-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	41606-x
ISSN	0425-1644
ISSN	0425-1644
DOI	10.1111/j.2042-3306.1997.tb03125.x
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Article: Endocrine, metabolic and clinical effects of intravenous endotoxin injection after pre-treatment with meloxicam in heifers.

Königsson, K / Odensvik, K / Kindahl, H

Journal of veterinary medicine. A, Physiology, pathology, clinical medicine

2002 Volume 49, Issue 8, Page(s) 408–414

Abstract: Meloxicam (M), a non-steroid anti-inflammatory drug for use in animals, reduces prostaglandin (PG) synthesis by inhibiting cyclooxygenases-1 and -2. The aim of this study was to evaluate M's capability to prevent the inflammatory response elicited by ... ...

Abstract	Meloxicam (M), a non-steroid anti-inflammatory drug for use in animals, reduces prostaglandin (PG) synthesis by inhibiting cyclooxygenases-1 and -2. The aim of this study was to evaluate M's capability to prevent the inflammatory response elicited by endotoxin (ET). Furthermore, we wanted to evaluate a possible effect of M on delta13-reductase and 15-hydroxy prostanoate dehydrogenase, enzymes responsible for the initial metabolism of PGF2alpha. Four heifers acting as their own controls were used in the study. The heifers received an i.v. injection of either saline (S) or M (0.5 mg/kg) at 1.5 h before an i.v. injection of ET (50 ng/kg b.w. i.v.). The trial lasted 57 h after ET injection and blood samples were withdrawn for analyses of 15-ketodihydro-PGF2alpha (PG metabolite), cortisol, white blood cells (WBC), Fe, Zn and Ca. Clinical examinations were performed throughout the trial. In the S + ET trial, ET injection elicited a rapid increase of the PG metabolite, a prolonged cortisol release and reduced levels of WBC, Fe, Zn and Ca. General appearance and body temperature were affected. In the M + ET trial the PG release was totally abolished, the cortisol release was reduced and the clinical effect was milder, also effects on Fe, Zn and Ca were milder in the M + ET trial, but M did not prevent the pyrogenic effect of ET. In the next two trials, we injected PGF2alpha (500 ng/kg i.v.) with and without M pre-treatment. After PGF2alpha injection, plasma samples were collected for measurement of the PG metabolite. M had no effect on PGF2alpha metabolism. In conclusion, M effectively suppresses several of the inflammatory reactions seen after ET injections and has no major influence on the PGF2alpha metabolism.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Area Under Curve ; Calcium/blood ; Cattle/blood ; Cattle/metabolism ; Dinoprost/blood ; Endotoxins/pharmacology ; Female ; Hydrocortisone/blood ; Injections, Intravenous/veterinary ; Iron/blood ; Leukocyte Count/veterinary ; Meloxicam ; Thiazines/administration & dosage ; Thiazines/pharmacokinetics ; Thiazoles/administration & dosage ; Thiazoles/pharmacokinetics ; Zinc/blood
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Endotoxins ; Thiazines ; Thiazoles ; Dinoprost (B7IN85G1HY) ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP) ; Meloxicam (VG2QF83CGL) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2002-07-16
Publishing country	Germany
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632891-x
ISSN	1439-0442 ; 0931-184X ; 0721-0981
ISSN (online)	1439-0442
ISSN	0931-184X ; 0721-0981
DOI	10.1046/j.1439-0442.2002.00461.x
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Zs.B 724: Show issues

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Article: Effect of oral administration of flunixin meglumine on the inflammatory response to endotoxin in heifers.

Odensvik, K / Magnusson, U

American journal of veterinary research

1996 Volume 57, Issue 2, Page(s) 201–204

Abstract: Objective: To compare the effect of oral and IV administrations of flunixin meglumine on the endotoxin-induced inflammatory response in heifers.: Design: The study was conducted in 2 experimental sets in which heifers were exposed to low IV doses of ... ...

Abstract	Objective: To compare the effect of oral and IV administrations of flunixin meglumine on the endotoxin-induced inflammatory response in heifers. Design: The study was conducted in 2 experimental sets in which heifers were exposed to low IV doses of Escherichia coli endotoxin. Within each set, heifers were allocated to 3 treatment groups; pretreatment with flunixin meglumine orally and IV prior to endotoxin administration, or endotoxin administration only. The dose of flunixin used was the recommended therapeutic dose in cattle. Animals: 11 clinically normal heifers weighing from 400 to 640 kg. Procedure: A permanent cannula was inserted into the jugular vein on the day prior to the experiment. Blood samples were collected regularly during the experiment and analyzed for the content of prostaglandin F2 alpha metabolite, cortisol, blood mononuclear cells, and polymorphonuclear neutrophilic leukocytes and rectal temperature was measured. Results: Endotoxin administration caused clinical signs and hematologic changes characteristic of endotoxemia in cattle. Flunixin administered orally prior to experimentally induced endotoxemia exerted an effect equal to that after its IV administration. Significant increases in rectal temperature and prostaglandin F2 alpha metabolite concentrations after administration of endotoxin were abrogated when the heifers were pretreated with flunixin, irrespective of route of administration. Cortisol concentrations were lower after pretreatment with flunixin. However, flunixin did not prevent the decrease in blood mononuclear cells and polymorphonuclear neutrophilic leukocytes seen after endotoxin administration. Conclusion: Owing to no major difference in the inflammatory response between oral and IV flunixin dosing, flunixin granules may be an alternative to parenteral use in bovine practice.
MeSH term(s)	Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Body Temperature ; Cattle ; Cattle Diseases/chemically induced ; Cattle Diseases/drug therapy ; Cattle Diseases/metabolism ; Clonixin/administration & dosage ; Clonixin/analogs & derivatives ; Clonixin/therapeutic use ; Dinoprost/biosynthesis ; Dinoprost/blood ; Endotoxins/metabolism ; Endotoxins/toxicity ; Escherichia coli/metabolism ; Female ; Hydrocortisone/blood ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/veterinary ; Injections, Intravenous ; Leukocyte Count/veterinary ; Leukocytes, Mononuclear/cytology ; Neutrophils/cytology
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Endotoxins ; flunixin meglumine (8Y3JK0JW3U) ; Dinoprost (B7IN85G1HY) ; Clonixin (V7DXN0M42R) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	1996-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antibacterial drugs prescribed for dogs and cats in Sweden and Norway 1990-1998.

Odensvik, K / Grave, K / Greko, C

Acta veterinaria Scandinavica

2001 Volume 42, Issue 1, Page(s) 189–198

Abstract: The usage of veterinary antibacterial drugs in dogs and cats in Sweden and Norway for the period 1990-1998 was investigated by use of drug wholesalers' statistics. Additionally, usage of human antibacterial drugs in these species in Sweden was ... ...

Abstract	The usage of veterinary antibacterial drugs in dogs and cats in Sweden and Norway for the period 1990-1998 was investigated by use of drug wholesalers' statistics. Additionally, usage of human antibacterial drugs in these species in Sweden was investigated by use of prescription data for the period 1996-1998. On average, more than 50% of the prescribed veterinary antibacterials in Sweden were beta-lactam antibiotics. In Norway, about 75% of the preparations prescribed for dogs and cats contained sulfonamides and trimethoprim. Furthermore, the prescription data from Sweden showed a reduced usage of human antibacterials prescribed for dogs and cats since the beginning of the 1980s. Approximately 20% of the prescribed packages for dogs in the years 1996-1998 were human approved drugs. The corresponding figure for cats was 13%. The differences between the countries in the choice of antibacterial drugs can be explained by differences in the availability of approved preparations during the study period. The consumption of veterinary antibacterials in dogs and cats in Sweden during the period was in the range of 3% to 8% of the total use of veterinary antibacterials. The corresponding figures in Norway were in the range of 3% to 7%. It is of vital importance to study usage patterns of antibacterial drugs in dogs and cats in surveillance and control of bacterial resistance, but also in discussions of therapeutic appropriateness. Therefore, further research is needed in this area.
MeSH term(s)	Animals ; Anti-Infective Agents/therapeutic use ; Cat Diseases/drug therapy ; Cats ; Dog Diseases/drug therapy ; Dogs ; Drug Prescriptions/statistics & numerical data ; Drug Prescriptions/veterinary ; Drug Utilization/statistics & numerical data ; Norway ; Sweden
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2001
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	40137-7
ISSN	1751-0147 ; 0044-605X
ISSN (online)	1751-0147
ISSN	0044-605X
DOI	10.1186/1751-0147-42-189
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Article: High-performance liquid chromatography method for determination of flunixin in bovine plasma and pharmacokinetics after single and repeated doses of the drug.

Odensvik, K / Johansson, I M

American journal of veterinary research

1995 Volume 56, Issue 4, Page(s) 489–495

Abstract: A high-performance liquid chromatography method was developed for determination of flunixin in bovine plasma. The extraction procedure was easily performed and made it possible to detect low concentrations of flunixin with high accuracy. The limit of ... ...

Abstract	A high-performance liquid chromatography method was developed for determination of flunixin in bovine plasma. The extraction procedure was easily performed and made it possible to detect low concentrations of flunixin with high accuracy. The limit of quantitation was 7 ng/ml (relative standard deviation = 18% n = 10). The analytic method permits processing of 60 samples/d. Flunixin, as well as the internal standard (diclofenac sodium), belong to the group of nonsteroidal anti-inflammatory drugs, which are known to have a high degree of binding to plasma proteins. Therefore, an evaluation of several buffer systems was undertaken to optimize analytic conditions. Cattle were given 2.2 mg of flunixin melgumine/kg of body weight. In experiment 1, single injections were administered IV to 1 cow and IV and IM to 1 heifer (7 days apart), and pharmacokinetic variables were calculated. The IV data were best described by a two-compartment model. The half-life after single IV or IM administration was around 4.0 hours. In experiment 2, the decreasing flunixin concentration was determined after the last of either 4 IM injections daily (n = 3 cows) or 2 IM injections daily (n = 3 cows) administered during a 14-day postpartum period. The half-life, determined between 48 and 96 hours after the last dose, was approximately 26 hours in both groups, and flunixin could be detected in plasma up to 8 days, on average. The protein binding of flunixin was studied, using the method of equilibrium dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/blood ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Blood Specimen Collection/methods ; Blood Specimen Collection/veterinary ; Cattle ; Chromatography, High Pressure Liquid/methods ; Clonixin/administration & dosage ; Clonixin/analogs & derivatives ; Clonixin/blood ; Clonixin/pharmacokinetics ; Diclofenac/blood ; Drug Administration Schedule ; Female ; Injections, Intramuscular ; Injections, Intravenous ; Reproducibility of Results ; Sensitivity and Specificity
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Diclofenac (144O8QL0L1) ; flunixin (356IB1O400) ; Clonixin (V7DXN0M42R)
Language	English
Publishing date	1995-04
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of oral administration of flunixin meglumine on the inflammatory response to endotoxin in heifers

Odensvik, K / Magnusson, U

American journal of veterinary research. Feb 1996. v. 57 (2)

1996

Keywords	heifers ; flunixin ; oral administration ; intravenous injection ; inflammation ; endotoxins ; Escherichia coli
Language	English
Dates of publication	1996-02
Size	p. 201-204.
Document type	Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
Database	NAL-Catalogue (AGRICOLA)

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Z 3312: Show issues

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