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  1. Article ; Online: Oxygen vacancy enhanced photocatalytic activity of Cu

    Qian, Hong / Yuan, Binxia / Liu, Yuhao / Zhu, Rui / Luan, Weiling / Zhang, Chengxi

    iScience

    2024  Volume 27, Issue 5, Page(s) 109578

    Abstract: In this study, a method was developed to create oxygen vacancies in ... ...

    Abstract In this study, a method was developed to create oxygen vacancies in Cu
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109578
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  2. Article ; Online: CuS quantum dots activated DNAzyme for ratiometric electrochemical detection of telomerase activity.

    Sun, Yujie / Dong, Qi / Yang, Huan / Song, Weiling / Zhou, Hong

    Analytica chimica acta

    2023  Volume 1248, Page(s) 340884

    Abstract: Telomerase activity detection has attracted much attention concerning its importance for early cancer diagnosis. Here, we established a ratiometric electrochemical biosensor for telomerase detection based on CuS quantum dots (CuS QDs) dependent DNAzyme- ... ...

    Abstract Telomerase activity detection has attracted much attention concerning its importance for early cancer diagnosis. Here, we established a ratiometric electrochemical biosensor for telomerase detection based on CuS quantum dots (CuS QDs) dependent DNAzyme-regulated dual signals. The telomerase substrate probe was used as the linker to combine the DNA fabricated magnetic beads and CuS QDs. In this way, telomerase extended the substrate probe with repeated sequence to from hairpin structure, releasing CuS QDs as an input to DNAzyme modified electrode. DNAzyme was cleaved with high current of ferrocene (Fc) and low current of methylene blue (MB). On the basis of the obtained ratiometric signals, telomerase activity detection was achieved in the range of 1.0 × 10
    MeSH term(s) Humans ; DNA, Catalytic/chemistry ; Telomerase/metabolism ; Quantum Dots/chemistry ; DNA/chemistry ; HeLa Cells ; Biosensing Techniques ; Electrochemical Techniques ; Limit of Detection
    Chemical Substances DNA, Catalytic ; Telomerase (EC 2.7.7.49) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.340884
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  3. Article ; Online: An "off-on-off" type electrochemical biosensor for detecting multiple biomarkers with DNAzyme-mediated entropy-driven catalytic and DSN enzyme-assisted recycling amplification.

    Yang, Huan / Dong, Qi / Xu, Dandan / Feng, Xinmiao / He, Peng / Song, Weiling / Zhou, Hong

    Analytica chimica acta

    2023  Volume 1283, Page(s) 341978

    Abstract: In this work, an intelligent and versatile electrochemical biosensor was constructed to detect two types of biomarkers by utilizing "off-on-off" switching. Firstly, human apurinic/apyrimidinic endonuclease1(APE1) mediated specific cleavage of the AP site, ...

    Abstract In this work, an intelligent and versatile electrochemical biosensor was constructed to detect two types of biomarkers by utilizing "off-on-off" switching. Firstly, human apurinic/apyrimidinic endonuclease1(APE1) mediated specific cleavage of the AP site, initiating activation DNAzyme and entropy-driven catalytic (EDC) reaction. Subsequently, large amounts of ferrocene labeled single-stranded DNA was released and captured with a remarkable electrochemical signal, achieving "off-on" state. In the presence of microRNA 21(miRNA-21), the DNA/RNA heteroduplexes were formed and cleaved by duplex-specific nuclease (DSN) with recovery the target miRNA-21, causing the current suppression in an "on-off" state. This sensor achieved highly sensitive detection of APE1 and miRNA-21 with a detection limit of 2.5 mU·mL
    MeSH term(s) Humans ; DNA, Catalytic ; MicroRNAs/analysis ; Entropy ; Reproducibility of Results ; Biosensing Techniques
    Chemical Substances DNA, Catalytic ; MicroRNAs
    Language English
    Publishing date 2023-10-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2023.341978
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  4. Article ; Online: RAPID Software to the Clinical Application Value of Acute Basilar Artery Occlusion with Endovascular Treatment.

    Li, Weiling / Hong, Weijun / Wang, En / Jiang, Yiqing

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2021  Volume 30, Issue 12, Page(s) 106147

    Abstract: Objective: To investigate the clinical application value of RAPID software based on computed tomography perfusion imaging (CTP) in the endovascular treatment of acute basilar artery occlusion (BAO).: Materials and methods: The data of patients with ... ...

    Abstract Objective: To investigate the clinical application value of RAPID software based on computed tomography perfusion imaging (CTP) in the endovascular treatment of acute basilar artery occlusion (BAO).
    Materials and methods: The data of patients with acute basilar artery occlusion who received endovascular treatment in Taizhou Hospital, Zhejiang Province, between January 2020 and April 2021 were retrospectively analysed. The patients were divided into a perfusion imaging and a no-perfusion imaging group based on whether the image analysis results were obtained by RAPID software. Age, preoperative National Institute of Health stroke scale (NIHSS) score, onset to puncture time (OPT), operation methods, good prognosis at 3 months after surgery (modified Rankin scale (mRS) score ≤3), symptomatic intracranial haemorrhage (sICH) and other clinical data were compared between the two groups. Multivariate logistic regression analysis was used to identify the independent factors affecting the prognosis of BAO patients.
    Results: In total, 61 patients with acute BAO were included: 31 patients in the perfusion imaging group and 30 patients in the no-perfusion imaging group. There were no statistically significant differences between the two groups in age, NIHSS score or operation methods (all P >0.05). However, OPT and the good prognosis rate were significantly higher in the perfusion imaging group than in the no-perfusion imaging group (χ
    Conclusions: RAPID software based on CTP can be used for preoperative screening of patients with acute basilar artery occlusion to identify those suitable for endovascular treatment, which is worthy of clinical promotion.
    MeSH term(s) Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/surgery ; Basilar Artery/diagnostic imaging ; Basilar Artery/pathology ; Basilar Artery/surgery ; Endovascular Procedures ; Humans ; Mass Screening/methods ; Preoperative Care ; Retrospective Studies ; Software
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2021.106147
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    Zs.A 3519: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: RNA secondary structures in

    Hong, Weiling / Shi, Yang / Xu, Bingbing / Jin, Yongfeng

    RNA (New York, N.Y.)

    2020  Volume 26, Issue 9, Page(s) 1086–1093

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Cell Adhesion Molecules/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Evolution, Molecular ; Exons/genetics ; Nucleic Acid Conformation ; Protein Isoforms/genetics ; RNA/genetics ; RNA Splicing/genetics
    Chemical Substances Cell Adhesion Molecules ; Drosophila Proteins ; Dscam1 protein, Drosophila ; Protein Isoforms ; RNA (63231-63-0)
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.075259.120
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4777: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Polyhedral Au Nanoparticle/MoO

    Zhao, Lin / Li, Tiantian / Xu, Xinlin / Xu, Yang / Li, Dongxiang / Song, Weiling / Zhan, Tianrong / He, Peng / Zhou, Hong / Xu, Jing-Juan / Chen, Hong-Yuan

    Analytical chemistry

    2023  Volume 95, Issue 24, Page(s) 9271–9279

    Abstract: A novel homologous surface-enhanced Raman scattering (SERS)-electrochemical (EC) dual-mode biosensor based on a 3D/2D polyhedral Au nanoparticle/ ... ...

    Abstract A novel homologous surface-enhanced Raman scattering (SERS)-electrochemical (EC) dual-mode biosensor based on a 3D/2D polyhedral Au nanoparticle/MoO
    MeSH term(s) Humans ; MicroRNAs/analysis ; Gold/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; Biosensing Techniques/methods ; Spectrum Analysis, Raman/methods ; DNA/chemistry
    Chemical Substances MicroRNAs ; Gold (7440-57-5) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01062
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Engineering Assembly of Plasmonic Virus-Like Gold SERS Nanoprobe Guided by Intelligent Dual-Machine Nanodevice for High-Performance Analysis of Tetracycline.

    Xu, Xinlin / Li, Tiantian / Liu, Yue / Zhou, Luxiao / Li, Yingying / Luo, Yu / Xu, Yang / Zhao, Lin / Song, Weiling / Jiang, Degang / He, Peng / Zhou, Hong

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2309502

    Abstract: Accurate detection of trace tetracyclines (TCs) in complex matrices is of great significance for food and environmental safety monitoring. However, traditional recognition and amplification tools exhibit poor specificity and sensitivity. Herein, a novel ... ...

    Abstract Accurate detection of trace tetracyclines (TCs) in complex matrices is of great significance for food and environmental safety monitoring. However, traditional recognition and amplification tools exhibit poor specificity and sensitivity. Herein, a novel dual-machine linkage nanodevice (DMLD) is proposed for the first time to achieve high-performance analysis of TC, with a padlock aptamer component as the initiation command center, nucleic acid-encoded multispike virus-like Au nanoparticles (nMVANs) as the signal indicator, and cascade walkers circuit as the processor. The existence of spike vertices and interspike nanogaps in MVANs enables intense electromagnetic near-field focusing, allowing distinct surface-enhanced Raman scattering (SERS) activity. Moreover, through the sequential activation between multistage walker catalytic circuits, the DLMD system converts the limited TC recognition into massive engineering assemblies of SERS probes guided by DNA amplicons, resulting in synergistic enhancement of bulk plasmonic hotspot entities. The continuously guaranteed target recognition and progressively promoted signal enhancement ensure highly specific amplification analysis of TC, with a detection limit as low as 7.94 × 10
    Language English
    Publishing date 2024-01-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202309502
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  8. Article ; Online: Cost-Utility Analysis of Screening for Diabetic Retinopathy in China.

    Zhang, Yue / Bai, Weiling / Li, Ruyue / Du, Yifan / Sun, Runzhou / Li, Tao / Kang, Hong / Yang, Ziwei / Tang, Jianjun / Wang, Ningli / Liu, Hanruo

    Health data science

    2022  Volume 2022, Page(s) 9832185

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Journal Article
    ISSN 2765-8783
    ISSN (online) 2765-8783
    DOI 10.34133/2022/9832185
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  9. Article: Anti-PD-1 immunotherapy combined with stereotactic body radiation therapy and GM-CSF for the treatment of advanced malignant PEComa: A case report.

    Wang, Yunfan / Li, Weiling / Zuo, Xin / Min, Ke / Tang, Yuehua / Chen, Hong / Wang, Weimin / Zhou, Yan

    Frontiers in oncology

    2023  Volume 13, Page(s) 1045119

    Abstract: Background: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, a standard treatment regimen for PEComa has not yet been established. Radiotherapy has a synergistic effect with PD-1 inhibitors and GM- ... ...

    Abstract Background: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumour. Due to its low incidence, a standard treatment regimen for PEComa has not yet been established. Radiotherapy has a synergistic effect with PD-1 inhibitors and GM-CSF. We treated advanced malignant PEComa with a triple regimen of PD-1 inhibitor, SBRT and GM-CSF to provide better therapeutic effect.
    Case presentation: A 63-year-old woman was diagnosed with malignant PEComa after presenting with postmenopausal vaginal bleeding. Despite two surgeries, the neoplasm eventually metastasized throughout the body. We formulated triple therapy with SBRT, a PD-1 inhibitor, and GM-CSF for the patient. The patient's local symptoms were controlled at the radiotherapy site, and the lesions at the unirradiated sites were also relieved.
    Conclusions: For the first time, a triple regimen of PD-1 inhibitor, SBRT and GM-CSF was used in the treatment of malignant PEComa and achieved good efficacy. Considering the lack of prospective clinical studies in PEComa, we believe that this triple therapy is a good-quality regimen for advanced malignant PEComa.
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1045119
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  10. Article ; Online: Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy.

    He, Peng / Han, Wenhao / Bi, Cheng / Song, Weiling / Niu, Shuyan / Zhou, Hong / Zhang, Xiaoru

    ACS nano

    2021  Volume 15, Issue 4, Page(s) 6961–6976

    Abstract: The development of a theragnostic platform integrating precise diagnosis and effective treatment is significant but still extremely challenging. Herein, an integrated smart nanodevice composed of Au@ ... ...

    Abstract The development of a theragnostic platform integrating precise diagnosis and effective treatment is significant but still extremely challenging. Herein, an integrated smart nanodevice composed of Au@Cu
    MeSH term(s) Animals ; Biosensing Techniques ; Birds ; DNA ; Gold ; Metal Nanoparticles ; MicroRNAs ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Spectrum Analysis, Raman
    Chemical Substances MicroRNAs ; Gold (7440-57-5) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.0c10844
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