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  1. Article ; Online: Understanding

    Goormaghtigh, Frédéric / Van Bambeke, Françoise

    Expert review of anti-infective therapy

    2024  Volume 22, Issue 1-3, Page(s) 87–101

    Abstract: Introduction: Staphylococcus aureus: Area covered: We give an overview of the killing mechanisms of phagocytes and of the impressive arsenal of virulence factors, toxins and stress responses deployed by : Expert opinion: Intracellular niches ... ...

    Abstract Introduction: Staphylococcus aureus
    Area covered: We give an overview of the killing mechanisms of phagocytes and of the impressive arsenal of virulence factors, toxins and stress responses deployed by
    Expert opinion: Intracellular niches represent a challenge in terms of diagnostic and treatment. Further research using ad-hoc in-vivo models and single cell approaches are needed to better understand the molecular mechanisms underlying intracellular survival and tolerance to antibiotics in order to identify strategies to eliminate these persistent bacteria.
    MeSH term(s) Humans ; Staphylococcus aureus ; Anti-Infective Agents ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Neutrophils ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2024.2303018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6106: Show issues Location:
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  2. Article ; Online: Long-term intensive care unit outbreak of carbapenemase-producing organisms associated with contaminated sink drains.

    Anantharajah, A / Goormaghtigh, F / Nguvuyla Mantu, E / Güler, B / Bearzatto, B / Momal, A / Werion, A / Hantson, P / Kabamba-Mukadi, B / Van Bambeke, F / Rodriguez-Villalobos, H / Verroken, A

    The Journal of hospital infection

    2023  Volume 143, Page(s) 38–47

    Abstract: Background: Between 2018 and 2022, a Belgian tertiary care hospital faced a growing issue with acquiring carbapenemase-producing organisms (CPO), mainly VIM-producing P. aeruginosa (PA-VIM) and NDM-producing Enterobacterales (CPE-NDM) among hospitalized ...

    Abstract Background: Between 2018 and 2022, a Belgian tertiary care hospital faced a growing issue with acquiring carbapenemase-producing organisms (CPO), mainly VIM-producing P. aeruginosa (PA-VIM) and NDM-producing Enterobacterales (CPE-NDM) among hospitalized patients in the adult intensive care unit (ICU).
    Aim: To investigate this ICU long-term CPO outbreak involving multiple species and a persistent environmental reservoir.
    Methods: Active case finding, environmental sampling, whole-genome sequencing (WGS) analysis of patient and environmental strains, and implemented control strategies were described in this study.
    Findings: From 2018 to 2022, 37 patients became colonized or infected with PA-VIM and/or CPE-NDM during their ICU stay. WGS confirmed the epidemiological link between clinical and environmental strains collected from the sink drains with clonal strain dissemination and horizontal gene transfer mediated by plasmid conjugation and/or transposon jumps. Environmental disinfection by quaternary ammonium-based disinfectant and replacement of contaminated equipment failed to eradicate environmental sources. Interestingly, efflux pump genes conferring resistance to quaternary ammonium compounds were widespread in the isolates. As removing sinks was not feasible, a combination of a foaming product degrading the biofilm and foaming disinfectant based on peracetic acid and hydrogen peroxide has been evaluated and has so far prevented recolonization of the proximal sink drain by CPO.
    Conclusion: The persistence in the hospital environment of antibiotic- and disinfectant-resistant bacteria with the ability to transfer mobile genetic elements poses a serious threat to ICU patients with a risk of shifting towards an endemicity scenario. Innovative strategies are needed to address persistent environmental reservoirs and prevent CPO transmission.
    MeSH term(s) Adult ; Humans ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Disease Outbreaks ; Anti-Bacterial Agents ; Disinfectants ; Intensive Care Units
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; Anti-Bacterial Agents ; Disinfectants
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2023.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1586: Show issues Location:
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  3. Article ; Online: Influence of pH on the activity of finafloxacin against extracellular and intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis and Francisella philomiragia and on its cellular pharmacokinetics in THP-1 monocytes.

    Chalhoub, H / Harding, S V / Tulkens, P M / Van Bambeke, F

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2019  Volume 26, Issue 9, Page(s) 1254.e1–1254.e8

    Abstract: ... by attenuated surrogates of these species (B. thailandensis, Y. pseudotuberculosis, F. philomiragia) and (b ... F. philomiragia, with finafloxacin demonstrating an additional advantage in acidic environments. ...

    Abstract Objectives: Burkholderia pseudomallei, Yersinia pestis and Francisella tularensis are facultative intracellular bacteria causing life-threatening infections. We have (a) compared the activity of finafloxacin (a fluoroquinolone in development showing improved activity at acidic pH) with that of ciprofloxacin, levofloxacin and imipenem against the extracellular and intracellular (THP-1 monocytes) forms of infection by attenuated surrogates of these species (B. thailandensis, Y. pseudotuberculosis, F. philomiragia) and (b) assessed finafloxacin cellular pharmacokinetics (accumulation, distribution, efflux).
    Methods: Bacteria in broth or in infected monocytes were exposed to antibiotics at pH 7.4 or 5.5 for 24 hr. Maximal relative efficacies (E
    Results: Extracellularly, all drugs sterilized the cultures, with finafloxacin being two to six times more potent at acidic pH. Intracellularly, E
    Conclusions: Fluoroquinolones have proven to be effective in reducing the intracellular reservoirs of B. thailandensis, Y. pseudotuberculosis and F. philomiragia, with finafloxacin demonstrating an additional advantage in acidic environments.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Burkholderia/drug effects ; Fluoroquinolones/pharmacology ; Francisella/drug effects ; Humans ; Hydrogen-Ion Concentration ; Imipenem/pharmacology ; Levofloxacin/pharmacology ; Microbial Sensitivity Tests ; Monocytes ; THP-1 Cells ; Yersinia pseudotuberculosis/drug effects
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones ; Levofloxacin (6GNT3Y5LMF) ; Imipenem (71OTZ9ZE0A) ; finafloxacin (D26OSN9Q4R)
    Language English
    Publishing date 2019-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2019.07.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  4. Article ; Online: Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?

    Coenye, T / Goeres, D / Van Bambeke, F / Bjarnsholt, T

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2018  Volume 24, Issue 6, Page(s) 570–572

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests/methods ; Microbial Sensitivity Tests/standards ; Models, Biological
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2018.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  5. Article: Entfernung von Biofilm durch Endoskopreiniger: Eine Vergleichsstudie

    Siala, W. / Van Bambeke, F. / Vanzieleghem, T.

    Hygiene & Medizin

    2017  Volume 42, Issue 9, Page(s) D114

    Language German
    Document type Article
    ZDB-ID 518696-1
    ISSN 0172-3790
    Database Current Contents Medicine

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  6. Article: Entfernung von Biofilm durch Endoskopreiniger : eine Vergleichsstudie

    Siala, W. / Bambeke, F. Van / Vanzieleghem, Thomas

    Zentralsterilisation

    2017  Volume 25, Issue 5, Page(s) 301–308

    Keywords Reinigung ; Endoskop ; Biofilm ; Medizinische Mikrobiologie ; Aufbereitung ; Desinfektion
    Language German
    Document type Article
    ZDB-ID 1174544-7
    ISSN 1612-0108 ; 0942-6086
    ISSN 1612-0108 ; 0942-6086
    Database bibnet.org

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    Zs.A 4007: Show issues Location:
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  7. Article ; Online: Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics.

    Wang, Zhifen / Vanbever, Rita / Lorent, Joseph H / Solis, Jessica / Knoop, Christiane / Van Bambeke, Françoise

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: Background: Biofilm-associated pulmonary infections pose therapeutic challenges in cystic fibrosis patients, especially when involving multiple bacterial species. Enzymatic degradation of the biofilm matrix may offer a potential solution to enhance ... ...

    Abstract Background: Biofilm-associated pulmonary infections pose therapeutic challenges in cystic fibrosis patients, especially when involving multiple bacterial species. Enzymatic degradation of the biofilm matrix may offer a potential solution to enhance antibiotic efficacy. This study investigated the repurposing of DNase I, commonly used for its mucolytic activity in cystic fibrosis, to target extracellular DNA within biofilms, as well as potential synergies with alginate lyase and broad-spectrum antibiotics in dual-species biofilms of Pseudomonas aeruginosa and Staphylococcus aureus.
    Methods: Dual-species biofilms were grown in artificial sputum medium using S. aureus and P. aeruginosa isolated by pairs from the same patients and exposed to various combinations of enzymes, meropenem, or tobramycin. Activity was assessed by measuring biofilm biomass and viable counts. Matrix degradation and decrease in bacterial load were visualized using confocal microscopy. Biofilm viscoelasticity was estimated by rheology.
    Results: Nearly complete destruction of the biofilms was achieved only if combining the enzymatic cocktail with the two antibiotics, and if using supratherapeutic levels of DNase I and high concentrations of alginate lyase. Biofilms containing non-pigmented mucoid P. aeruginosa required higher antibiotic concentrations, despite low viscoelasticity. In contrast, for biofilms with pigmented mucoid P. aeruginosa, a correlation was observed between the efficacy of different treatments and the reduction they caused in elasticity and viscosity of the biofilm.
    Conclusions: In this complex, highly drug-tolerant biofilm model, enzymes prove useful adjuvants to enhance antibiotic activity. However, the necessity for high enzyme concentrations emphasizes the need for thorough concentration-response evaluations and safety assessments before considering clinical applications.
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.02.012
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    Zs.MO 459: Show issues

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  8. Article: L'ABC des hépatites virales.

    Van Bambeke, F

    Journal de pharmacie de Belgique

    2008  Volume 63, Issue 1, Page(s) 15–20

    Abstract: Viral hepatitis has long been under-diagnosed. Hepatitis A is an acute disease, while patients infected by hepatitis B and hepatitis C viruses are likely to develop chronical infections and severe complications (cancer, cirrhosis). The current treatment ... ...

    Title translation The ABC of viral hepatitis.
    Abstract Viral hepatitis has long been under-diagnosed. Hepatitis A is an acute disease, while patients infected by hepatitis B and hepatitis C viruses are likely to develop chronical infections and severe complications (cancer, cirrhosis). The current treatment of hepatitis B and C consists in alpha interferon (preferably under its pegylated form), in combination with ribavirin for hepatitis C. The frequent and severe adverse effects of interferon-based therapy constitute, however, a major limiting factor (reactions at the injection site, flu-like syndrome, neurological disorders, ...). For hepatitis B, two alternatives are available so far, namely lamivudine and adefovir (used as a prodrug with highe oral bioavailability).
    MeSH term(s) Adenine/analogs & derivatives ; Adenine/therapeutic use ; Antiviral Agents/therapeutic use ; Hepatitis A/drug therapy ; Hepatitis A/epidemiology ; Hepatitis A/physiopathology ; Hepatitis B/drug therapy ; Hepatitis B/epidemiology ; Hepatitis B/physiopathology ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C/physiopathology ; Hepatitis, Viral, Human/drug therapy ; Hepatitis, Viral, Human/epidemiology ; Hepatitis, Viral, Human/physiopathology ; Hepatitis, Viral, Human/therapy ; Humans ; Interferon-alpha/therapeutic use ; Organophosphonates/therapeutic use ; Vaccination
    Chemical Substances Antiviral Agents ; Interferon-alpha ; Organophosphonates ; Adenine (JAC85A2161) ; adefovir dipivoxil (U6Q8Z01514)
    Language French
    Publishing date 2008-03
    Publishing country Belgium
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 840991-2
    ISSN 0047-2166
    ISSN 0047-2166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Conference proceedings: Chemical composition, direct and indirect antibacterial activity against multidrug resistant bacteria and toxicity assessment of essential oil of Cymbopogon giganteus leaves

    Toukourou, H / Sounouvou, H / Catteau, L / Toukourou, F / Van Bambeke, F / Gbaguidi, F / Quetin-Leclercq, J

    Planta Medica

    2019  Volume 85, Issue 18

    Event/congress 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, Innsbruck, Austria, 2019-09-01
    Language German
    Publishing date 2019-12-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0039-3400015
    Database Thieme publisher's database

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  10. Article: Editorial for the Special Issue "A Themed Issue in Honor of Professor Hartmut Derendorf-Outstanding Contributions in the Fields of Quantitative Clinical Pharmacology".

    Van Bambeke, Françoise / Wicha, Sebastian / Tulkens, Paul M / Zeitlinger, Markus

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Pharmacokinetics (PK) is the discipline investigating the absorption, distribution, metabolization and elimination of a drug in the body [ ... ]. ...

    Abstract Pharmacokinetics (PK) is the discipline investigating the absorption, distribution, metabolization and elimination of a drug in the body [...].
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12020353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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