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Article ; Online: Chebulinic Acid: An Incipient Anticancer Agent.

Aashima / Rathi, Mehak / Shilpi / Akash / Kaur, Kamaljeet / Kriplani, Priyanka / Guarve, Kumar

Recent patents on anti-cancer drug discovery

2023 Volume 19, Issue 3, Page(s) 298–307

Abstract: Background: Terminalia chebula (T. chebula: Objective: The objective of this current study is to give an overview of the recent literature and patents of : Methods: Present research and patents highlighting the anti-cancer potential of : Results! ...

Abstract	Background: Terminalia chebula (T. chebula Objective: The objective of this current study is to give an overview of the recent literature and patents of Methods: Present research and patents highlighting the anti-cancer potential of Results: Both Conclusion: Anti-cancer potential of
MeSH term(s)	Humans ; Fruit ; Patents as Topic ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Hydrolyzable Tannins
Chemical Substances	chebulinic acid (18942-26-2) ; Plant Extracts ; Antineoplastic Agents ; Hydrolyzable Tannins
Language	English
Publishing date	2023-08-21
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2250820-X
ISSN	2212-3970 ; 1574-8928
ISSN (online)	2212-3970
ISSN	1574-8928
DOI	10.2174/1574892819666230821110429
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Article ; Online: Correlation Between Body Mass Index and Sleep Quality among Indian Doctors

Harpreet Singh Gulati / Kamaljeet Kaur / Jasveen Kaur / Ambica Wadhwa / Mamta Sharma

International Journal of Anatomy Radiology and Surgery, Vol 12, Iss 3, Pp AO15-AO

A Descriptive Study

2023 Volume 19

Abstract: Introduction: In the current scenario, clinicians are constantly subjected to high workload coupled with enormous amount of stress which can lead to both derangement of sleep and accumulation of body fat. Since they are the central pillar of healthcare ... ...

Abstract	Introduction: In the current scenario, clinicians are constantly subjected to high workload coupled with enormous amount of stress which can lead to both derangement of sleep and accumulation of body fat. Since they are the central pillar of healthcare industry, the health of doctors themselves is an extremely important factor in pursuit of a healthy and disease free society. Aim: To determine the effect of Body Mass Index (BMI) on quality of sleep in clinicians and to establish a relation between obesity and sleep pattern of clinicians. Materials and Methods: The present descriptive study was conducted on 400 doctors working in Outpatient Department (OPD) clinics of various departments at Punjab Institute of Medical Sciences, Jalandhar and OPDs of NIMS Hospital, Jaipur, India, from July 2019 to June 2021. BMI was calculated as ratio of weight (kg) to the square of height (m). Sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI) questionnaire as a Global Pittsburgh Sleep Quality Index. BMI and sleep quality were checked for inter-relationship using various statistical methods like Chi- square test, Analysis of Variance (ANOVA), student t-test and Pearson’s correlation. Results: In the present study, 200 were males and 200 were females. Most of the participants were in the age group of 41- 50 years. A 51.4% of participants with BMI >25 kg/m2 had poor sleep quality which was significantly higher when compared with participants with BMI <25 kg/m2 (33.5%). Sleep quality had no significant bearing with gender. Further, it was found that surgical specialists had poorer sleep when compared with their medical counterparts. Conclusion: The results of the present study showed a significant association and linear correlation between sleep quality and overweight/obesity status. This information serves as an awareness and warning signal for the clinicians to safeguard their own health.
Keywords	clinicians ; medical ; obesity ; overweight ; surgical ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Surgery ; RD1-811
Subject code	796
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	JCDR Research and Publications Pvt. Ltd.
Document type	Article ; Online
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Book ; Online: Performance evaluation of the Alphasense OPC-N3 and Plantower PMS5003 sensor in measuring dust events in the Salt Lake Valley, Utah

Kaur, Kamaljeet / Kelly, Kerry E.

eISSN: 1867-8548

2022

Abstract: As the changing climate expands the extent of arid and semi-arid lands, the number, severity of, and health effects associated with dust events are likely to increase. However, regulatory measurements capable of capturing dust (PM 10 , particulate matter ...

Abstract	As the changing climate expands the extent of arid and semi-arid lands, the number, severity of, and health effects associated with dust events are likely to increase. However, regulatory measurements capable of capturing dust (PM 10 , particulate matter smaller than 10 µm in diameter) are sparse, sparser than measurements of PM 2.5 (PM smaller than 2.5 µm in diameter). Although low-cost sensors could supplement regulatory monitors, as numerous studies have shown for PM 2.5 concentration, most of these sensors are not effective at measuring PM 10 despite claims by sensor manufacturers. This study focuses on the Salt Lake Valley, adjacent to the Great Salt Lake, which recently reached historic lows exposing 1865 km 2 of dry lakebed. It evaluated the field performance of the Plantower PMS 5003, a common low-cost PM sensor, and the Alphasense OPC-N3, a promising candidate for low-cost measurement of PM 10 , against a federal equivalent method (FEM, beta attenuation) and research measurements (GRIMM aerosol spectrophotometer) at three different locations. During a month-long field study that included five dust events in the Salt Lake Valley with PM 10 concentrations reaching 311 µg/m 3 , the OPC-N3 exhibited strong correlation with FEM PM 10 measurements (R 2 = 0.865, RMSE = 12.4 µg/m 3 ) and GRIMM (R 2 = 0.937, RMSE = 17.7 µg/m 3 ). The PMS sensor exhibited poor to moderate correlations (R 2 <0.49, RMSE = 33–45 µg/m 3 ) with reference/research monitors and severely underestimated the PM 10 concentrations (slope <0.099) for PM 10 . We also evaluated a PM-ratio-based correction method to improve the estimated PM 10 concentration from PMS sensors. After applying this method, PMS PM 10 concentrations correlated reasonably well with FEM measurements (R 2 > 0.63) and GRIMM measurements (R 2 > 0.76), and the RMSE decreased to 15–25 µg/m 3 . Our results suggest that it may be possible to obtain better resolved spatial estimates of PM 10 concentration using a combination of PMS sensors (often publicly available ...
Subject code	333 ; 290
Language	English
Publishing date	2022-12-02
Publishing country	de
Document type	Book ; Online
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Article ; Online: Partitioning Schemes used for Context Storage using Non Relational Databases. A Review

Kamaljeet kaur

International Journal of Computer Trends and Technology, Vol 4, Iss 6, Pp 1937-

2013 Volume 1943

Abstract: NoSQL (Not only SQL) is a database used to store large amounts of data. NoSQL databases are distributed, non-relational, open source and are horizontally scalable (in linear way). NoSQL does not follow property of ACID as follow in SQL. Improving the ... ...

Abstract	NoSQL (Not only SQL) is a database used to store large amounts of data. NoSQL databases are distributed, non-relational, open source and are horizontally scalable (in linear way). NoSQL does not follow property of ACID as follow in SQL. Improving the performance of a database system is one of the key research issues now a day. As publications of context is rising day by day. So to handle increasing dataload, we use partitioning schemes. In this paper we discussed about partitioning schemes, existing work which comprises XCOA-XMPP context architecture which explains how the context is stored using non relational databases as we employs vertical partitioning scheme which gives better results as compared to horizontal partitioning to handle better dataload and to improve performance in all tradeoffusing non relational databases as an approach. So we proposed an algorithm which comprises vertical partitioning scheme using couchdb as a non relational database which gives better results as compared to existing work in context management platform.
Keywords	Non Relational Databases ; Horizontal Partitioning ; Vertical Partitioning ; Partitioning Schemes. ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	004
Publishing date	2013-06-01T00:00:00Z
Publisher	Seventh Sense Research Group
Document type	Article ; Online
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Article ; Online: Dihydrotestosterone in Amyotrophic lateral sclerosis-The missing link?

Sawal, Nishit / Kaur, Jasbinder / Kaur, Kamaljeet / Gombar, Satinder

Brain and behavior

2020 Volume 10, Issue 11, Page(s) e01645

Abstract: Objective: Testosterone has been postulated to be involved in ALS causation.: Materials and methods: CSF levels of free testosterone and dihydrotestosterone were measured in 13 ALS patients [7 males, 6 females] and 22 controls [12 males, 10 females].! ...

Abstract	Objective: Testosterone has been postulated to be involved in ALS causation. Materials and methods: CSF levels of free testosterone and dihydrotestosterone were measured in 13 ALS patients [7 males, 6 females] and 22 controls [12 males, 10 females]. Results: CSF free testosterone levels did not show any significant differences but CSF dihydrotestosterone levels were significantly decreased in all male and female ALS patients. Conclusions: DHT is probably integral to survival of motor neurons. In patients predisposed to develop ALS, there is possibly a sort of "testosterone resistance" at level of blood-brain barrier [BBB] existing right from birth and is likely the result of dysfunctional transport protein involved in testosterone transfer across the BBB. In these patients, lesser amount of testosterone is able to breach the BBB and enter the central neural axis. Lesser amount of testosterone is available to 5 α reductase in the anterior pituitary to be converted to DHT and lesser amount of DHT is generated. There is inadequate negative feedback suppression of LH at the level of anterior pituitary by DHT. As a result of higher LH levels, testosterone levels rise in the peripheral testosterone fraction [the fraction outside the BBB] and this explains the various physical attributes of ALS patients like lower Ratio of the index and ring finger lengths (2D:4D ratio), increased incidence of early onset alopecia etc. This deficiency of DHT leads to motor neuron death causing ALS.
MeSH term(s)	Amyotrophic Lateral Sclerosis ; Dihydrotestosterone ; Female ; Fingers ; Humans ; Male ; Motor Neurons ; Testosterone
Chemical Substances	Dihydrotestosterone (08J2K08A3Y) ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.1645
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Article: Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells

Kaur, Kamaljeet / Mohammadpour, Raziye / Ghandehari, Hamidreza / Reilly, Christopher A. / Paine, Robert / Kelly, Kerry E.

Atmospheric environment. 2022 May 18,

2022

Abstract: Atmospheric aging of combustion particles alters their chemical composition and morphology. Previous studies have reported differences in toxicological responses after exposure to fresh versus aged particles, with chemical composition being the prime ... ...

Abstract	Atmospheric aging of combustion particles alters their chemical composition and morphology. Previous studies have reported differences in toxicological responses after exposure to fresh versus aged particles, with chemical composition being the prime suspect behind the differences. However, less is known about the contribution of morphological differences in atmospherically aged particles to toxicological responses, possibly due to the difficulty in resolving the two properties (composition and morphology) that change simultaneously. This study altered the shape of lab-generated combustion particles, without affecting the chemical composition, from fractal-like to a more compact spherical shape, using a water condensation-evaporation method. The two shapes were exposed to a co-culture of human airway epithelial (A549) and differentiated human monocyte (THP-1) cells at air-liquid interface (ALI) conditions. The particles with different shapes were deposited using an electrostatic field-based ALI chamber. For the same mass dose, both shapes were internalized by cells, induced a pro-inflammatory response (IL-8 and TNFα), and enhanced CYP1A1 gene expression compared to air controls. The more compact spherical particles (representative of atmospherically aged particles) induced more early apoptosis and release of TNFα compared to the more fractal-like particles. These results suggest a contribution of morphology to the increased toxicity of aged combustion-derived particles.
Keywords	apoptosis ; chemical composition ; coculture ; combustion ; environment ; epithelium ; gene expression ; humans ; inflammation ; interleukin-8 ; liquid-air interface ; lungs ; macrophages ; monocytes ; toxicity ; toxicology
Language	English
Dates of publication	2022-0518
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2022.119194
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells.

Kaur, Kamaljeet / Mohammadpour, Raziye / Ghandehari, Hamidreza / Reilly, Christopher A / Paine, Robert / Kelly, Kerry E

Atmospheric environment (Oxford, England : 1994)

2022 Volume 284

Abstract	Atmospheric aging of combustion particles alters their chemical composition and morphology. Previous studies have reported differences in toxicological responses after exposure to fresh versus aged particles, with chemical composition being the prime suspect behind the differences. However, less is known about the contribution of morphological differences in atmospherically aged particles to toxicological responses, possibly due to the difficulty in resolving the two properties (composition and morphology) that change simultaneously. This study altered the shape of lab-generated combustion particles, without affecting the chemical composition, from fractal-like to a more compact spherical shape, using a water condensation-evaporation method. The two shapes were exposed to a co-culture of human airway epithelial (A549) and differentiated human monocyte (THP-1) cells at air-liquid interface (ALI) conditions. The particles with different shapes were deposited using an electrostatic field-based ALI chamber. For the same mass dose, both shapes were internalized by cells, induced a pro-inflammatory response (IL-8 and TNFα), and enhanced CYP1A1 gene expression compared to air controls. The more compact spherical particles (representative of atmospherically aged particles) induced more early apoptosis and release of TNFα compared to the more fractal-like particles. These results suggest a contribution of morphology to the increased toxicity of aged combustion-derived particles.
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	216368-8
ISSN	1352-2310 ; 0004-6981
ISSN	1352-2310 ; 0004-6981
DOI	10.1016/j.atmosenv.2022.119194
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Article ; Online: Feasibility of a High-Volume Filter Sampler for Detecting SARS-CoV-2 RNA in COVID-19 Patient Rooms.

Wilson, Amanda M / Kaur, Kamaljeet / Jones, Rachael M / Kelly, Kerry E

Annals of work exposures and health

2021 Volume 66, Issue 2, Page(s) 276–280

Abstract: Aerosolization of SARS-CoV-2 by COVID-19 patients can put healthcare workers and susceptible individuals at risk of infection. Air sampling for SARS-CoV-2 has been conducted in healthcare settings, but methods vary widely and there is need for ... ...

Abstract	Aerosolization of SARS-CoV-2 by COVID-19 patients can put healthcare workers and susceptible individuals at risk of infection. Air sampling for SARS-CoV-2 has been conducted in healthcare settings, but methods vary widely and there is need for improvement. The objective of this study was to evaluate the feasibility of using a high-volume filter sampler, BioCapture z720, to detect SARS-CoV-2 in COVID-19 patient rooms in a medical intensive care unit, a dedicated COVID-19 ward, and at nurses' stations. In some locations, the BioSpot-VIVAS, known for high efficiency in the collection of virus-containing bioaerosols, was also operated. The samples were processed for SARS-CoV-2 RNA with multi-plex nested polymerase chain reaction. One of 28 samples collected with the high-volume filter sampler was positive for SARS-CoV-2; all 6 samples collected with BioSpot-VIVAS were negative for SARS-CoV-2. The high-volume filter sampler was more portable and less intrusive in patient rooms than the BioSpot-VIVAS, but limits of detection remain unknown for this device. This study will inform future work to evaluate the reliability of these types of instruments and inform best practices for their use in healthcare environments for SARS-CoV-2 air sampling.
MeSH term(s)	COVID-19 ; Feasibility Studies ; Humans ; Occupational Exposure ; Patients' Rooms ; RNA, Viral/genetics ; Reproducibility of Results ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2885096-8
ISSN	2398-7316 ; 2398-7308
ISSN (online)	2398-7316
ISSN	2398-7308
DOI	10.1093/annweh/wxab100
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Article ; Online: Knowledge, attitude, and practice of mothers regarding immunization.

Kaur, Rubleen / Jassal, Diksha / Sharma, Naveenta / Kaur, Kamaljeet / Kaur, Sukhjot / Thakur, Manjula / Saini, Sushma K / Gupta, Madhu / Sharma, Anjali

Indian journal of pharmacology

2021 Volume 53, Issue 4, Page(s) 336–338

MeSH term(s)	Adult ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Mothers ; Vaccination ; Young Adult
Language	English
Publishing date	2021-09-07
Publishing country	India
Document type	Letter
ZDB-ID	605829-2
ISSN	1998-3751 ; 0253-7613
ISSN (online)	1998-3751
ISSN	0253-7613
DOI	10.4103/ijp.IJP_486_18
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Article ; Online: Erratum to: Enhanced biosurfactant production through cloning of three genes and role of esterase in biosurfactant release.

Sekhon, Kamaljeet Kaur / Khanna, Sunil / Cameotra, Swaranjit Singh

Microbial cell factories

2017 Volume 16, Issue 1, Page(s) 147

Language	English
Publishing date	2017-08-22
Publishing country	England
Document type	Journal Article ; Published Erratum
ISSN	1475-2859
ISSN (online)	1475-2859
DOI	10.1186/s12934-017-0761-2
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