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  1. Book ; Conference proceedings: Workshop on Issues in the Design and Conduct of Clinical Trials of Antibacterial Drugs in the Treatment of Community Acquired Pneumonia

    Spellberg, Brad

    [17 and 18 January 2008, Silver Spring, Maryland]

    (Clinical infectious diseases ; 47, Suppl. 3)

    2008  

    Event/congress Workshop on Issues in the Design and Conduct of Clinical Trials of Antibacterial Drugs in the Treatment of Community Acquired Pneumonia (2008, SilverSpringMd.)
    Author's details guest ed.: Brad Spellberg
    Series title Clinical infectious diseases ; 47, Suppl. 3
    Collection
    Language English
    Size S. S105 - S265 : graph. Darst.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015794642
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Challenging Dogma in the Treatment of Childhood Infections: Oral Antibiotics and Shorter Durations.

    Tanti, Daniel C / Spellberg, Brad / McMullan, Brendan J

    The Pediatric infectious disease journal

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Are Echinocandins Superior in Efficacy to Azoles?

    Spellberg, Brad

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 70, Issue 9, Page(s) 2020–2021

    MeSH term(s) Azoles/pharmacology ; Candidiasis, Invasive ; Echinocandins/pharmacology ; Humans
    Chemical Substances Azoles ; Echinocandins
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Alignment With Market Forces: The "Re-Whithering" of Infectious Diseases.

    Spellberg, Brad

    Open forum infectious diseases

    2020  Volume 7, Issue 8, Page(s) ofaa245

    Abstract: Given constant emergence of new infectious threats, infectious diseases (ID) should be one of the most attractive medical specialties to students and trainees. Yet, ID Fellowship programs continue to not fill in the match, and ID remains among the lowest ...

    Abstract Given constant emergence of new infectious threats, infectious diseases (ID) should be one of the most attractive medical specialties to students and trainees. Yet, ID Fellowship programs continue to not fill in the match, and ID remains among the lowest paid specialties. Approximately 35 years after Dr. Petersdorf first asked the question, we find ourselves once again wondering, "Whither Infectious Diseases?" To answer this question, and align with predominant US market forces, ID experts should push for the following: (1) restrictions regarding utilization of ID diagnostics and antimicrobial agents; (2) pay-for-performance measures regarding antimicrobial prescribing rates; and (3) healthcare reform as called for by the American College of Physicians to move away from fee-for-service medicine. Einstein said, "Continuing to do the same thing over and over and expecting a different result is the definition of insanity." We must move towards alignment with market forces, to benefit our patients, society, and our colleagues.
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Shorter Is Better movement: past, present, future.

    Spellberg, Brad / Rice, Louis B

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 29, Issue 2, Page(s) 141–142

    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Editorial
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Maturing Antibiotic Mantra: "Shorter Is Still Better".

    Spellberg, Brad

    Journal of hospital medicine

    2018  Volume 13, Issue 5, Page(s) 361.362

    MeSH term(s) Anti-Bacterial Agents ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.12788/jhm.2904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: When Oral Therapy Can Replace Intravenous Antibiotics-Changing Practice as New Data Emerge.

    Heger, Astrid Heppenstall / Baden, Rachel / Spellberg, Brad

    JAMA internal medicine

    2023  Volume 183, Issue 6, Page(s) 505–506

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Administration, Intravenous ; Administration, Oral ; Practice Patterns, Physicians'
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.0923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Mucormycosis pathogenesis: Beyond Rhizopus.

    Spellberg, Brad

    Virulence

    2017  Volume 8, Issue 8, Page(s) 1481–1482

    MeSH term(s) Humans ; Mucormycosis ; Rhizopus
    Language English
    Publishing date 2017-08-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2017.1364335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Opinion-Based Recommendations: Beware the Tyranny of Experts.

    Spellberg, Brad / Shorr, Andrew F

    Open forum infectious diseases

    2021  Volume 8, Issue 11, Page(s) ofab490

    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Shorter is better: The case for short antibiotic courses for common infections in solid organ transplant recipients.

    Imlay, Hannah / Spellberg, Brad

    Transplant infectious disease : an official journal of the Transplantation Society

    2022  Volume 24, Issue 5, Page(s) e13896

    Abstract: Background: Prolonged antibiotics are associated with toxicity, selection for resistant organisms, and secondary infections such as Clostridioides difficile colitis. Emerging clinical data suggest that short courses of antibiotics can be used for common ...

    Abstract Background: Prolonged antibiotics are associated with toxicity, selection for resistant organisms, and secondary infections such as Clostridioides difficile colitis. Emerging clinical data suggest that short courses of antibiotics can be used for common bacterial infections among immune competent patients, but for many randomized controlled trials (RCTs), immunocompromised patients, including solid organ transplant recipients (SOTRs), have been excluded.
    Methods: Peer-reviewed publications were identified through PubMed and Embase searches.
    Results: We review data examining shorter antibiotic courses among immunocompetent and immunocompromised patients and the rationale for use of short antibiotic courses in SOTRs.
    Conclusion: There are known harms associated with antibiotics and, when studied, existing data do not demonstrate harm associated with shorter courses of antibiotics among SOTRs. Furthermore, several RCTs did include some immune compromised patients and found shorter therapy to result in similar clinical efficacy with diminished adverse effects. Shorter antibiotic durations should be considered in SOTRs, and questions of antibiotic duration among SOTRs should be prioritized for study in clinical trials.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Humans ; Organ Transplantation/adverse effects ; Transplant Recipients
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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