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Article: A case series exploring the human milk polyclonal IgA1 response to repeated SARS-CoV-2 vaccinations by LC-MS based fab profiling.

de Graaf, Sebastiaan C / Bondt, Albert / van Rijswijck, Danique M H / Juncker, Hannah G / Mulleners, Sien J / Damen, Mirjam J A / Hoek, Max / van Keulen, Britt J / van Goudoever, Johannes B / Heck, Albert J R / Dingess, Kelly A

Frontiers in nutrition

2024 Volume 10, Page(s) 1305086

Abstract: Introduction: Upon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens that will end up in circulation. In lactating women such antibodies will also ... ...

Abstract	Introduction: Upon vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) humans will start to produce antibodies targeting virus specific antigens that will end up in circulation. In lactating women such antibodies will also end up in breastmilk, primarily in the form of secretory immunoglobulin A1 (SIgA1), the most abundant immunoglobulin (Ig) in human milk. Here we set out to investigate the SIgA1 clonal repertoire response to repeated SARS-CoV-2 vaccination, using a LC-MS fragment antigen-binding (Fab) clonal profiling approach. Methods: We analyzed the breastmilk of six donors from a larger cohort of 109 lactating mothers who received one of three commonly used SARS-CoV-2 vaccines. We quantitatively monitored the SIgA1 Fab clonal profile over 16 timepoints, from just prior to the first vaccination until 15 days after the second vaccination. Results: In all donors, we detected a population of 89-191 vaccine induced clones. These populations were unique to each donor and heterogeneous with respect to individual clonal concentrations, total clonal titer, and population size. The vaccine induced clones were dominated by persistent clones (68%) which came up after the first vaccination and were retained or reoccurred after the second vaccination. However, we also observe transient SIgA1 clones (16%) which dissipated before the second vaccination, and vaccine induced clones which uniquely emerged only after the second vaccination (16%). These distinct populations were observed in all analyzed donors, regardless of the administered vaccine. Discussion: Our findings suggest that while individual donors have highly unique human milk SIgA1 clonal profiles and a highly personalized SIgA1 response to SARS-CoV-2 vaccination, there are also commonalities in vaccine induced responses.
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1305086
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Article ; Online: Comparing Human Milk Antibody Response After 4 Different Vaccines for COVID-19.

Juncker, Hannah G / Mulleners, Sien J / Coenen, Esmée R M / van Goudoever, Johannes B / van Gils, Marit J / van Keulen, Britt J

JAMA pediatrics

2022 Volume 176, Issue 6, Page(s) 611–612

MeSH term(s)	Antibodies, Viral ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Milk, Human ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2022.0084
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Article ; Online: Human Milk Antibody Response After Combining Two Different COVID-19 Vaccines: Mix-and-Match.

Mulleners, Sien J / Juncker, Hannah G / van Gils, Marit J / van Goudoever, Johannes B / van Keulen, Britt J

Journal of human lactation : official journal of International Lactation Consultant Association

2022 Volume 38, Issue 3, Page(s) 401–406

Abstract: Background: SARS-CoV-2-specific antibodies are secreted into human milk after women are vaccinated against COVID-19, which might protect the breastfed infant. Due to several reports of severe side-effects of the Oxford-AstraZeneca ChAdOx1 (AZD1222) ... ...

Abstract	Background: SARS-CoV-2-specific antibodies are secreted into human milk after women are vaccinated against COVID-19, which might protect the breastfed infant. Due to several reports of severe side-effects of the Oxford-AstraZeneca ChAdOx1 (AZD1222) vaccine against COVID-19, some lactating women followed a heterologous vaccination schedule consisting of the first dose of AZD1222 and a second dose of an mRNA-based vaccine. However, it is unclear whether this generates a significant SARS-CoV-2-specific antibody response in human milk. Main issue: To quantify the SARS-CoV-2-specific antibody response in human milk of two lactating women receiving a heterologous vaccination schedules: AZD1222 and mRNA-based vaccine (Pfizer-BioNTech [BNT162b2] and Moderna [mRNA-1273]). Management: Both participants collected 16 samples of human milk longitudinally. SARS-CoV-2-specific Immunoglobulin A was measured using an enzyme-linked immunosorbent assay. Conclusion: Based on our results, it could be suggested that heterologous vaccination with AZD1222 and an mRNA-based vaccine can elicit a significant SARS-CoV-2 specific IgA response in human milk.
MeSH term(s)	Antibodies, Viral ; Antibody Formation ; BNT162 Vaccine ; Breast Feeding ; COVID-19/prevention & control ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Female ; Humans ; Lactation ; Milk, Human ; RNA, Messenger ; SARS-CoV-2 ; Viral Vaccines/pharmacology
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; RNA, Messenger ; Viral Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1138470-0
ISSN	1552-5732 ; 0890-3344
ISSN (online)	1552-5732
ISSN	0890-3344
DOI	10.1177/08903344221103260
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Article ; Online: The Potential Role of Nutrition in Modulating the Long-Term Consequences of Early-Life Stress.

Juncker, Hannah G / van Keulen, Britt J / Finken, Martijn J J / de Rooij, Susanne R / van Goudoever, Johannes B / Korosi, Aniko

Nestle Nutrition Institute workshop series

2022 Volume 96, Page(s) 116–129

Abstract: Stress exposure during sensitive developmental periods lastingly affects brain function and cognition and increases vulnerability to psychopathology later in life, as established in various preclinical and clinical studies. Interestingly, similar ... ...

Abstract	Stress exposure during sensitive developmental periods lastingly affects brain function and cognition and increases vulnerability to psychopathology later in life, as established in various preclinical and clinical studies. Interestingly, similar patterns are seen in children who suffer from perinatal malnutrition. Stress and malnutrition can act closely aligned and stress and nutrition interact. There is emerging evidence that specific nutritional supplementation during various time windows may ameliorate the long-lasting effects of early-life stress, although possible mechanistic insights in this process are sparsely reported. Understanding how stress exposure in early-life influences brain development, and understanding the role of nutrition in this process, is essential for the development of effective (nutritional) therapies to improve long-term health in children exposed to early-life stress. This is especially important in the situation of preterm birth where both stress exposure and malnutrition are common. Here, we will discuss the programming effects of early-life stress, the possible underlying mechanisms, how nutrients impact on this process, and the promising role of nutrition in modulating (some of) the lasting consequences of early-life stress on brain function and health in adulthood.
MeSH term(s)	Adult ; Adverse Childhood Experiences ; Child ; Cognition ; Female ; Humans ; Infant, Newborn ; Malnutrition/complications ; Nutritional Status ; Pregnancy ; Premature Birth
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000519383
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Article: Maternal Stress and Human Milk Antibodies During the COVID-19 Pandemic.

Juncker, Hannah G / Ruhé, Eliza J M / Korosi, Aniko / van Goudoever, Johannes B / van Gils, Marit J / van Keulen, Britt J

Frontiers in nutrition

2022 Volume 9, Page(s) 923501

Abstract: Importance: SARS-CoV-2: Objective: To determine whether psychological stress is increased in lactating women during the COVID-19 pandemic, and if maternal stress is associated with the level of : Design: Population-based prospective cohort study.!# ...

Abstract	Importance: SARS-CoV-2 Objective: To determine whether psychological stress is increased in lactating women during the COVID-19 pandemic, and if maternal stress is associated with the level of Design: Population-based prospective cohort study. Setting: Data collection took place in the Netherlands between October 2020 and February 2021. Participants: Lactating women living in the Netherlands were eligible to participate in this study. In total, 2310 women were included. Exposures: Stress exposure during the COVID-19 pandemic was determined using the Perceived Stress Scale (PSS) questionnaire and maternal lifetime stress was determined by the Life Stressor Checklist - revised (LSC-r) questionnaire. Main outcomes and measures: Stress experience during the COVID-19 pandemic was compared with a pre-pandemic cohort. Results: The PSS score of lactating mothers was not increased during the pandemic compared to the PSS score in the prepandemic cohort. Six hundred ninety-one participants had Conclusions and relevance: Our results suggest that lactating women in the Netherlands did not experience higher stress levels during the COVID-19 pandemic. Breastfed infants of mothers with high chronic stress levels receive lower amounts of antibodies through human milk, which possibly makes them more vulnerable to respiratory infections. This emphasizes the importance of psychological wellbeing during lactation.
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.923501
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Article: Maternal stress is associated with higher protein-bound amino acid concentrations in human milk.

Juncker, Hannah G / Naninck, Eva F G / van Keulen, Britt J / Harinck, Jolinda E / Schipper, Lidewij / Lucassen, Paul J / van Goudoever, Johannes B / de Rooij, Susanne R / Korosi, Aniko

Frontiers in nutrition

2023 Volume 10, Page(s) 1165764

Abstract: ... a potential candidate as maternal stress affects various components of HM, e.g., fat and immunoglobulin ...

Abstract	Background: Maternal stress in the postpartum period affects not only the mother but also her newborn child, who is at increased risk of developing metabolic and mental disorders later in life. The mechanisms by which stress is transmitted to the infant are not yet fully understood. Human milk (HM) is a potential candidate as maternal stress affects various components of HM, e.g., fat and immunoglobulin concentrations. To date, it is unknown whether maternal stress also affects the amino acids (AAs) in HM, even though this nutrient is of extreme importance to child health and development. This study aimed to investigate whether and how maternal stress is associated with the AA composition of HM. Methods: In this observational cohort study (Amsterdam, The Netherlands), lactating women were recruited in two study groups: a high-stress (HS) group; women whose child was hospitalized ( Results: Maternal perceived stress scores were higher in the HS group ( Conclusion: Findings from this prospective cohort study suggest that maternal stress in the postpartum period is associated with an altered human milk amino acid composition, which could play a role in the transmission of maternal stress effects to her child. The physiological implications of these stress-induced changes for infant development await future research.
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1165764
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Article ; Online: Comparing the SARS-CoV-2-specific antibody response in human milk after homologous and heterologous booster vaccinations.

Mulleners, Sien J / Juncker, Hannah G / Ruhé, Eliza J M / Korosi, Aniko / van Goudoever, Johannes B / van Gils, Marit J / van Keulen, Britt J

Communications biology

2023 Volume 6, Issue 1, Page(s) 100

Abstract: ... immunoglobulin G (IgG) in their milk. Heterologous booster vaccination resulted in milk conversion for 9 (69 ...

Abstract	Human milk contains SARS-CoV-2-specific antibodies after COVID-19 vaccination. These milk antibodies decrease several months post-vaccination. Whether booster immunization restores human milk antibody levels, potentially offering prolonged passive immunity for the infant, remains unknown. In this prospective follow-up study, we investigated the longitudinal SARS-CoV-2-specific antibody response in human milk of 26 lactating women who received a COVID-19 booster dose of an mRNA-based vaccine. Moreover, we evaluated whether the booster-induced human milk antibody response differs for participants who received a similar or different vaccine type in their primary vaccination series. All participants (100%) who received a homologous booster vaccination showed SARS-CoV-2-specific immunoglobulin A (IgA) and immunoglobulin G (IgG) in their milk. Heterologous booster vaccination resulted in milk conversion for 9 (69%) and 13 (100%) participants for IgA and IgG respectively. Findings of this study indicate that both homologous and heterologous boosting schedules have the potential to enhance SARS-CoV-2-specific IgA and IgG in human milk.
MeSH term(s)	Infant ; Humans ; Female ; Milk, Human ; SARS-CoV-2 ; Antibody Formation ; COVID-19 Vaccines ; Follow-Up Studies ; Lactation ; Prospective Studies ; COVID-19/prevention & control ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin A
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin A
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04455-4
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Article: Physical activity in lactating women influences SARS-CoV-2-specific antibodies in human milk.

Juncker, Hannah G / van Doesburg, Maritt / de Groot, Christianne J M / Pajkrt, Dasja / Korosi, Aniko / van Gils, Marit J / van Goudoever, Johannes B / van Keulen, Britt J

Heliyon

2023 Volume 9, Issue 8, Page(s) e19218

Abstract: ... Immunoglobulin A (IgA) in human milk and Immunoglobulin G (IgG) in serum.: Methods: In this prospective cross ...

Abstract	Background: Moderate exercise results in a significant increase in serum and salivary immunoglobulins. Maternal physical activity might therefore also be a factor influencing antibody levels in human milk. This study aims to determine the influence of physical activity on SARS-CoV-2-specific Immunoglobulin A (IgA) in human milk and Immunoglobulin G (IgG) in serum. Methods: In this prospective cross-sectional cohort study, all lactating women in the Netherlands were eligible to participate. SARS-CoV-2-specific IgA in human milk and IgG in serum were determined using an enzyme-linked immunosorbent assay (ELISA). Data on performed physical activity was collected using the Short Questionnaire to Assess Health enhancing physical activity (SQUASH), which includes intensity and duration of the performed activity. Findings: In total, 356 out of 2312 lactating women tested positive for SARS-CoV-2-specific antibodies in serum. Of them, 323 filled in the questionnaire and were included in the analysis. An association between the activity score and SARS-CoV-2-specific antibodies in human milk ( Interpretation: Our findings suggest that physical activity is beneficial for the levels of SARS-CoV-2-specific antibodies in human milk and serum, with the intensity of the physical activity being the most important contributor to this relationship. A higher level of antibodies in human milk might provide better immunological protection for infants against COVID-19.
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19218
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Article: The influence of a maternal vegan diet on carnitine and vitamin B2 concentrations in human milk.

Juncker, Hannah G / van den Akker, Chris H P / Meerdink, Pauline L / Korosi, Aniko / Vaz, Frédéric M / van Goudoever, Johannes B / van Keulen, Britt J

Frontiers in nutrition

2023 Volume 10, Page(s) 1107768

Abstract: Background: The maternal diet greatly influences the nutritional composition of human milk. With the rise of vegan diets by lactating mothers, there are concerns about the nutritional adequacy of their milk. Two important nutrients, vitamin B2 and ... ...

Abstract	Background: The maternal diet greatly influences the nutritional composition of human milk. With the rise of vegan diets by lactating mothers, there are concerns about the nutritional adequacy of their milk. Two important nutrients, vitamin B2 and carnitine, are mostly ingested via animal products. Objective: We investigated the influence of a vegan diet on the vitamin B2 and carnitine concentrations in milk and serum of lactating women. Methods: In this case-control study, 25 lactating mothers following an exclusive vegan diet were comparted to 25 healthy lactating mothers with an omnivorous diet without use of supplements. High-performance liquid chromatography and liquid chromatography-tandem mass spectrometry were used to measure vitamin B2 and carnitine concentrations, respectively. A linear regression model was used to determine differences in human milk and serum concentrations between study groups. Results: Vitamin B2 concentrations in human milk and serum did not differ between study groups. While the human milk free carnitine (C Conclusion: A maternal vegan diet did not affect human milk concentration of vitamin B2 and carnitine. Breastfed infants of mothers following an exclusive vegan diet therefore are likely not at increased risk of developing a vitamin B2 or carnitine deficiency.
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1107768
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Article ; Online: Comparing the SARS-CoV-2-specific antibody response in human milk after homologous and heterologous booster vaccinations

Sien J. Mulleners / Hannah G. Juncker / Eliza J. M. Ruhé / Aniko Korosi / Johannes B. van Goudoever / Marit J. van Gils / Britt J. van Keulen

Communications Biology, Vol 6, Iss 1, Pp 1-

2023 Volume 7

Abstract: The longitudinal SARS-CoV-2-specific antibody response in human milk of lactating women receiving an mRNA-based booster vaccine indicates that both homologous and heterologous boosters enhance SARS-CoV-2-specific antibodies in human milk. ...

Abstract	The longitudinal SARS-CoV-2-specific antibody response in human milk of lactating women receiving an mRNA-based booster vaccine indicates that both homologous and heterologous boosters enhance SARS-CoV-2-specific antibodies in human milk.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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