LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article: Improved Chrysin Production by a Combination of Fermentation Factors and Elicitation from

Kamat, Siya / Kumari, Madhuree / Sajna, Kuttuvan Valappil / Singh, Sandeep Kumar / Kaushalendra / Kumar, Ajay / Jayabaskaran, C

Microorganisms

2023 Volume 11, Issue 4

Abstract: Flavonoids encompass a heterogeneous group of secondary metabolites with exceptional health benefits. Chrysin, a natural dihydroxyflavone, possesses numerous bioactive properties, such as anticancer, antioxidative, antidiabetic, anti-inflammatory, etc. ... ...

Abstract	Flavonoids encompass a heterogeneous group of secondary metabolites with exceptional health benefits. Chrysin, a natural dihydroxyflavone, possesses numerous bioactive properties, such as anticancer, antioxidative, antidiabetic, anti-inflammatory, etc. However, using traditional sources of chrysin involves extracting honey from plants, which is non-scalable, unsustainable, and depends on several factors, including geography, climatic conditions, and the season, which limits its production at a larger scale. Recently, microbial production of desirable metabolites has garnered attention due to the cost-effectiveness, easy scale-up, sustainability, and low emission of waste. We previously reported for the first time the chrysin-producing marine endophytic fungus
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11040999
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2.

Sajna, Kuttuvan Valappil / Kamat, Siya

Cytotherapy

2020 Volume 23, Issue 2, Page(s) 101–110

Abstract: In view of devastating effects of COVID-19 on human life, there is an urgent need for the licened vaccines or therapeutics for the SARS-CoV-2 infection. Age-old passive immunization with protective antibodies to neutralize the virus is one of the ... ...

Abstract	In view of devastating effects of COVID-19 on human life, there is an urgent need for the licened vaccines or therapeutics for the SARS-CoV-2 infection. Age-old passive immunization with protective antibodies to neutralize the virus is one of the strategies for emergency prophylaxis and therapy for coronavirus disease 2019 (COVID-19). In this review, the authors discuss up-to-date advances in immune-based therapy for COVID-19. The use of convalescent plasma therapy as the first line of defense to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been established, with encouraging results. Monoclonal antibodies (mAbs) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein or block the interaction between SARS-CoV-2 RBD and the human angiotensin-converting enzyme 2 receptor have been found to be very promising as a countermeasure for tackling the SARS-CoV-2 infection, and clinical trials are underway. Considering the counterproductive antibody-dependent enhancement of the virus, mAbs therapy that is safe and efficacious, even in people with underlying conditions, will be a significant breakthrough. In addition, emerging immunotherapeutic interventions using nanobodies and cellular immunotherapy are promising avenues for tackling the COVID-19 pandemic. The authors also discuss the implication of mAbs as mediators of cytokine storm syndrome to modify the immune response of COVID-19 patients, thus reducing the fatality rate of COVID-19 infection.
MeSH term(s)	Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/therapy ; Humans ; Immunization, Passive ; Immunomodulation ; Pandemics/prevention & control ; SARS-CoV-2/immunology ; COVID-19 Serotherapy
Chemical Substances	Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-08-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2020.08.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5601: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antiproliferative Role of Secondary Metabolites From Aspergillus unguis AG 1.1 (G) Isolated From Marine Macroalgae Enteromorpha sp. by Inducing Intracellular ROS Production and Mitochondrial Membrane Potential Loss Leading to Apoptosis

Kuttuvan Valappil Sajna / Siya Kamat / Chelliah Jayabaskaran

Frontiers in Marine Science, Vol

2020 Volume 7

Abstract: Drug resistance to the classically used chemotherapeutic drugs is the major challenge in their treatment of cancer needing the discovery of novel anticancer drugs. In terms of finding novel therapeutics, endophytes are quite promising as they are an ... ...

Abstract	Drug resistance to the classically used chemotherapeutic drugs is the major challenge in their treatment of cancer needing the discovery of novel anticancer drugs. In terms of finding novel therapeutics, endophytes are quite promising as they are an excellent source of novel structures, which exhibit bioactivity. The present study demonstrated a dose-dependent antiproliferative activity of mycelial-derived secondary metabolites from a macroalgae associated endophyte Aspergillus unguis AG 1.1 (G). The antiproliferative activity of A. unguis mycelial extract (AUME) was observed on different human cancer cell lines. PI live/dead assay further confirmed the cytotoxic potential of the mycelial extract. Furthermore, AUME caused mitochondrial membrane aberration and generated ROS production as well indicating its potential to induce cell death by apoptosis. The metabolic profiling of the mycelial extract using GC-MS and LC-MS/MS revealed the presence of fatty acids, a benzoquinolinone derivative, imidazolidinedione derivative, diethyl phthalate and phthalate acid ester, a difuraxanthone, two prenylxanthone analogs and a phthalide derivative and some unknown metabolites. Presence of 4-(4-Hydroxy-3,5-dimethoxy-phenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one, 1-hydroxy-3,5-dimethoxy-2-prenylxanthone, 1,6-dihydroxy-3-methoxy-2-prenylxanthone and 3-butylidene-7-hydroxyphthalide in AUME could be correlated to the notable cytotoxicity exhibited by the endophyte. The additional presence of many unidentified compounds heightened the prospects of finding some novel bioactive metabolites. Our results indicated that secondary metabolites produced by A. unguis AG 1.1 (G) have therapeutic potential as anticancer agents.
Keywords	secondary metabolites ; anticancer ; Aspergillus unguis ; GC-MS ; LC-MS/MS ; endophytes ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	500
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2

Sajna, Kuttuvan Valappil / Kamat, Siya

Cytotherapy

Abstract	In view of devastating effects of COVID-19 on human life, there is an urgent need for the licened vaccines or therapeutics for the SARS-CoV-2 infection. Age-old passive immunization with protective antibodies to neutralize the virus is one of the strategies for emergency prophylaxis and therapy for coronavirus disease 2019 (COVID-19). In this review, the authors discuss up-to-date advances in immune-based therapy for COVID-19. The use of convalescent plasma therapy as the first line of defense to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been established, with encouraging results. Monoclonal antibodies (mAbs) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein or block the interaction between SARS-CoV-2 RBD and the human angiotensin-converting enzyme 2 receptor have been found to be very promising as a countermeasure for tackling the SARS-CoV-2 infection, and clinical trials are underway. Considering the counterproductive antibody-dependent enhancement of the virus, mAbs therapy that is safe and efficacious, even in people with underlying conditions, will be a significant breakthrough. In addition, emerging immunotherapeutic interventions using nanobodies and cellular immunotherapy are promising avenues for tackling the COVID-19 pandemic. The authors also discuss the implication of mAbs as mediators of cytokine storm syndrome to modify the immune response of COVID-19 patients, thus reducing the fatality rate of COVID-19 infection.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #735227
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Marine endophytes from the Indian coasts: The untapped sources of sustainable anticancer drug discovery

Kamat, Siya / Kumari, Madhuree / Sajna, Kuttuvan Valappil / Shruthi Mohan / Jayabaskaran, C.

Sustainable chemistry and pharmacy. 2022 Mar. 15,

2022

Abstract: For centuries, the Indian outlook on medicines has had foundations in the exploration of her rich biodiversity. Today, natural product (NP) research delivers an ample chemical space for drug discovery for almost every pathological condition. However, ... ...

Abstract	For centuries, the Indian outlook on medicines has had foundations in the exploration of her rich biodiversity. Today, natural product (NP) research delivers an ample chemical space for drug discovery for almost every pathological condition. However, endophytes have emerged as a pandora's box of therapeutic secondary metabolites to resolve ecological, sustainability, and cost concerns. Marine sources of endophytes have garnered attention in the pharmaceutical sector, exemplified by increased FDA-approved marine drugs. With chemotherapy being the most common treatment for cancer patients, the need for novel drugs is steeping high. Endophytes from marine sources present a diverse natural productome for anticancer leads, especially for resistant cancers. For the first time, this review highlights the sustainable biotechnological potential of marine endophytes from the 3000 km long Indian coastline, a biogeographic zone. We also discuss the new cell death mechanisms and targets for marine anticancer drugs, emphasizing endophytes isolated from the Indian coasts. The advances in the NP yield enhancement strategies and possible chemical modifications on the product to reduce the complexity and increase the specificity for higher therapeutic value, followed by the challenges and prospects, are also reviewed.
Keywords	antineoplastic agents ; biodiversity ; cell death ; coasts ; drug therapy ; endophytes ; geographical distribution ; green chemistry ; secondary metabolites
Language	English
Dates of publication	2022-0315
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ISSN	2352-5541
DOI	10.1016/j.scp.2022.100675
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Endophytic fungus, Chaetomium globosum, associated with marine green alga, a new source of Chrysin.

Kamat, Siya / Kumari, Madhuree / Sajna, Kuttuvan Valappil / Jayabaskaran, C

Scientific reports

2020 Volume 10, Issue 1, Page(s) 18726

Abstract: The marine ecosystem is an extraordinary reserve of pharmaceutically important, bioactive compounds even in this "synthetic age". Marine algae-associated endophytic fungi have gained prominence as an important source of bioactive compounds. This study ... ...

Abstract	The marine ecosystem is an extraordinary reserve of pharmaceutically important, bioactive compounds even in this "synthetic age". Marine algae-associated endophytic fungi have gained prominence as an important source of bioactive compounds. This study was conducted on secondary metabolites of Chaetomium globosum-associated with marine green alga Chaetomorpha media from the Konkan coastline, India. Its ethyl acetate extract (CGEE) exhibited an IC
MeSH term(s)	A549 Cells ; Biomass ; Chaetomium/chemistry ; Chlorophyta/microbiology ; Chromatography, Thin Layer ; Drug Discovery ; Drug Screening Assays, Antitumor ; Ecosystem ; Endophytes/chemistry ; Fermentation ; Flavonoids/chemistry ; Gas Chromatography-Mass Spectrometry ; HEK293 Cells ; HeLa Cells ; Humans ; India ; Inhibitory Concentration 50 ; MCF-7 Cells ; Magnetic Resonance Spectroscopy ; Reactive Oxygen Species/metabolism ; Solvents
Chemical Substances	Flavonoids ; Reactive Oxygen Species ; Solvents ; chrysin (3CN01F5ZJ5)
Language	English
Publishing date	2020-10-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-72497-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Endophytic fungus, Chaetomium globosum, associated with marine green alga, a new source of Chrysin

Siya Kamat / Madhuree Kumari / Kuttuvan Valappil Sajna / C. Jayabaskaran

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 17

Abstract: Abstract The marine ecosystem is an extraordinary reserve of pharmaceutically important, bioactive compounds even in this “synthetic age”. Marine algae-associated endophytic fungi have gained prominence as an important source of bioactive compounds. This ...

Abstract	Abstract The marine ecosystem is an extraordinary reserve of pharmaceutically important, bioactive compounds even in this “synthetic age”. Marine algae-associated endophytic fungi have gained prominence as an important source of bioactive compounds. This study was conducted on secondary metabolites of Chaetomium globosum-associated with marine green alga Chaetomorpha media from the Konkan coastline, India. Its ethyl acetate extract (CGEE) exhibited an IC50 value of 7.9 ± 0.1 µg/mL on MCF-7 cells. CGEE exhibited G2M phase cell cycle arrest, ROS production and MMP loss in MCF-7 cells. The myco-components in CGEE contributing to the cytotoxicity were found by Gas Chromatography/Mass Spectrometry analyses. Chrysin, a dihydroxyflavone was one of the forty-six myco-components which is commonly found in honey, propolis and passionflower extracts. The compound was isolated and characterized as fungal chrysin using HPLC, UV–Vis spectroscopy, LC–MS, IR and NMR analyses by comparing with standard chrysin. The purified compound exhibited an IC50 value of 49.0 ± 0.6 µM while that of standard chrysin was 48.5 ± 1.6 µM in MCF-7 cells. It induced apoptosis, G1 phase cell cycle arrest, MMP loss, and ROS production. This is the first report of chrysin from an alternative source with opportunities for yield enhancement.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Crude oil biodegradation aided by biosurfactants from Pseudozyma sp. NII 08165 or its culture broth.

Sajna, Kuttuvan Valappil / Sukumaran, Rajeev Kumar / Gottumukkala, Lalitha Devi / Pandey, Ashok

Bioresource technology

2015 Volume 191, Page(s) 133–139

Abstract: The aim of this work was to evaluate the biosurfactants produced by the yeast Pseudozyma sp. NII 08165 for enhancing the degradation of crude oil by a model hydrocarbon degrading strain, Pseudomonas putida MTCC 1194. Pseudozyma biosurfactants were ... ...

Abstract	The aim of this work was to evaluate the biosurfactants produced by the yeast Pseudozyma sp. NII 08165 for enhancing the degradation of crude oil by a model hydrocarbon degrading strain, Pseudomonas putida MTCC 1194. Pseudozyma biosurfactants were supplemented at various concentrations to the P. putida culture medium containing crude oil as sole carbon source. Supplementation of the biosurfactants enhanced the degradation of crude oil by P. putida; the maximum degradation of hydrocarbons was observed with a 2.5 mg L(-1) supplementation of biosurfactants. Growth inhibition constant of the Pseudozyma biosurfactants was 11.07 mg L(-1). It was interesting to note that Pseudozyma sp. NII 08165 alone could also degrade diesel and kerosene. Culture broth of Pseudozyma containing biosurfactants resulted up to ∼46% improvement in degradation of C10-C24 alkanes by P. putida. The enhancement in degradation efficiency of the bacterium with the culture broth supplementation was even more pronounced than that with relatively purer biosurfactants.
MeSH term(s)	Alkanes/chemistry ; Biodegradation, Environmental ; Hydrocarbons/chemistry ; Petroleum/microbiology ; Pseudomonas putida/chemistry ; Soil Microbiology ; Surface-Active Agents/chemistry
Chemical Substances	Alkanes ; Hydrocarbons ; Petroleum ; Surface-Active Agents
Language	English
Publishing date	2015-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2015.04.126
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 3258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Studies on structural and physical characteristics of a novel exopolysaccharide from Pseudozyma sp. NII 08165.

Sajna, Kuttuvan Valappil / Sukumaran, Rajeev K / Gottumukkala, Lalitha Devi / Jayamurthy, Himani / Dhar, Kiran S / Pandey, Ashok

International journal of biological macromolecules

2013 Volume 59, Page(s) 84–89

Abstract: The aim of this work was to study the production of exopolysaccharide (EPS) from a novel ustilaginomycetes yeast strain Pseudozyma sp. NII 08165. The culture produced 3.5g/l EPS on fourth day of fermentation in a glucose-based medium. The structural ... ...

Abstract	The aim of this work was to study the production of exopolysaccharide (EPS) from a novel ustilaginomycetes yeast strain Pseudozyma sp. NII 08165. The culture produced 3.5g/l EPS on fourth day of fermentation in a glucose-based medium. The structural characterization revealed that the EPS was a polymer of glucose, galactose and mannose in the ratio of 2.4:5.0:2.6 with a molecular weight of 1.7MDa. The pseudoplastic behaviour of aqueous EPS with a thermal stability up to 220°C indicated its potential utility as a thickening or gelling agent in food industry. SEM studies of the EPS showed that it had compact film-like structure, which could make it a useful in preparing plasticized films. The AFM studies showed that EPS had spike-shaped microstructure. Physical properties of the exopolysaccharide determined further indicated its possible potential in different industrial applications.
MeSH term(s)	Culture Media ; Fermentation ; Fungal Polysaccharides/biosynthesis ; Fungal Polysaccharides/chemistry ; Fungal Polysaccharides/isolation & purification ; Galactose/chemistry ; Glucose/chemistry ; Hot Temperature ; Mannose/chemistry ; Microscopy, Atomic Force ; Microscopy, Electron, Scanning ; Molecular Weight ; Ustilaginales/chemistry ; Ustilaginales/growth & development ; Ustilaginales/metabolism
Chemical Substances	Culture Media ; Fungal Polysaccharides ; Glucose (IY9XDZ35W2) ; Mannose (PHA4727WTP) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2013-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2013.04.025
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Rice straw hydrolysate to fuel and volatile fatty acid conversion by Clostridium sporogenes BE01: bio-electrochemical analysis of the electron transport mediators involved

Gottumukkala, Lalitha Devi / Kuttuvan Valappil, Sajna / Pandey, Ashok / Sarkar, Omprakash / Sukumaran, Rajeev Kumar / Venkata Mohan, S

Green chemistry. 2015 May 12, v. 17, no. 5

2015

Abstract: Clostridium sporogenes BE01, a non-acetone forming butanol producer, can produce hydrogen and volatile fatty acids (VFAs) during butanol fermentation from rice straw hydrolysate. Bio-electrochemical analysis revealed the changes that occurred in the ... ...

Abstract	Clostridium sporogenes BE01, a non-acetone forming butanol producer, can produce hydrogen and volatile fatty acids (VFAs) during butanol fermentation from rice straw hydrolysate. Bio-electrochemical analysis revealed the changes that occurred in the redox microenvironment and electron transport mediators during fermentation at different pH and CaCO3 concentrations. CaCO3 played a very important role in enhancing the production of hydrogen, volatile fatty acids and solvents by stimulating the changes in the electron transport system. The electron transport system mediated by NAD/NADH, flavins, Fe–S clusters, protein bound FAD, and cytochrome complex in C. sporogenes BE01 was analysed by cyclic voltammetry (CV). Electrokinetic analysis revealed that the favorability for redox reactions increased with an increase in pH, and the polarization resistance reduced significantly with CaCO3 supplementation.
Keywords	butanol ; calcium carbonate ; Clostridium sporogenes ; electron transfer ; fermentation ; flavins ; green chemistry ; hydrogen ; hydrolysates ; NAD (coenzyme) ; pH ; rice straw ; solvents ; volatile fatty acids
Language	English
Dates of publication	2015-0512
Size	p. 3047-3058.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/c5gc00310e
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito