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  1. Article ; Online: Multiphasic Gels: Achieving New Drug Delivery.

    Pandey, Manisha / Saraf, Shubhini A / Saraf, Shailendra K

    Current pharmaceutical design

    2024  Volume 29, Issue 40, Page(s) 3171

    MeSH term(s) Humans ; Drug Delivery Systems ; Gels ; Drug Carriers
    Chemical Substances Gels ; Drug Carriers
    Language English
    Publishing date 2024-01-03
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161282940231220112709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Book ; Online ; E-Book: Reproductive biology of angiosperms

    Pandey, A. K.

    2023  

    Abstract: ... of the important topics including: Flower structure and development Development and structure of male and ...

    Author's details Arun Pandey
    Abstract "The book is designed to introduce basics of different aspects of biology of reproduction in a concise and coherent manner. The book aims to equip students with fundamentals of biology of reproduction and update them with the most recent advances in the field of reproduction. The book has been organised in 16 chapters that introduce and explain different aspects in a stimulating manner. Each chapter is supplemented with a summary and relevant illustrations. A glossary has been added to help the students to understand some important scientific terms. The book offers comprehensive coverage of the important topics including: Flower structure and development Development and structure of male and female gametophytes Pollination biology, Fertilization and Self-incompatibility Endosperm, Embryo and Polyembryony Apomixis and Seed Biology A separate topic on experimental plant reproductive biology (experimental embryology) has been provided which includes basics of cell, tissue and organ culture, anther culture, pollen culture, flower, ovary, ovule culture, embryo culture, somatic embryogenesis, synthetic seeds, protoplast culture, and other aspects of plant biotechnology. The book aims to cater to the needs of the advanced undergraduate and post-graduate students in Botany, Forestry, Agriculture and related fields"-- Provided by publisher.
    Keywords Angiosperms/Seeds
    Subject code 582.13
    Language English
    Size 1 online resource (362 pages)
    Publisher CRC Press
    Publishing place Boca Raton, Florida
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-326009-8 ; 1-003-26009-8 ; 1-000-72925-7 ; 9781032196206 ; 978-1-00-326009-7 ; 978-1-003-26009-7 ; 978-1-000-72925-2 ; 1032196203
    DOI 10.1201/9781003260097
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: A rare case of left-sided obturator hernia diagnosed by computed tomography.

    Aryal, Manisha / Keshari, Suraj / Pandey, Archana / Pandey, Abhishek / Paudel, Ishwor

    Clinical case reports

    2023  Volume 11, Issue 5, Page(s) e7297

    Abstract: Obturator hernia is a rare condition that is difficult to detect clinically. We highlight the importance of a CT scan in establishing an early diagnosis of an obturator hernia, effective surgical intervention planning, thereby enhancing the result. ...

    Abstract Obturator hernia is a rare condition that is difficult to detect clinically. We highlight the importance of a CT scan in establishing an early diagnosis of an obturator hernia, effective surgical intervention planning, thereby enhancing the result.
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhancing periodontal defences with nanofiber treatment: recent advances and future prospects.

    Garg, Unnati / Dua, Tanya / Kaul, Shreya / Jain, Neha / Pandey, Manisha / Nagaich, Upendra

    Journal of drug targeting

    2024  , Page(s) 1–15

    Abstract: The term periodontal disease is used to define diseases characterised by inflammation and regeneration of the gums, cementum, supporting bone, and periodontal ligament. The conventional treatment involves the combination of scaling, root planning, and ... ...

    Abstract The term periodontal disease is used to define diseases characterised by inflammation and regeneration of the gums, cementum, supporting bone, and periodontal ligament. The conventional treatment involves the combination of scaling, root planning, and surgical approaches which are invasive and can pose certain challenges. Intrapocket administration of nanofibers can be used for overcoming challenges which can help in speeding up the wound repair process and can also be used to promote osteogenesis. To help make drug delivery more effective, nanofibers are an interesting solution. Nanofibers are nanosized 3D structures that can fill the pockets and have excellent mucoadhesion which prolongs their retention time on the target site. Moreover, their structure mimics the natural extracellular matrix which enables nanomaterials to sense local biological conditions and start cellular-level reprogramming to produce the necessary therapeutic efficacy. In this review, the significance of intrapocket administration of nanofibers using recent research for the management of periodontitis has been discussed in detail. Furthermore, we have discussed polymers used for the preparation of nanofibers, nanofiber production methods, and the patents associated with these developments. This comprehensive compilation of data serves as a valuable resource, consolidating recent developments in nanofiber applications for periodontitis management into one accessible platform.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2024.2321372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
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  5. Article ; Online: Identification of potential chemical biomarkers of hexaconazole using in vitro metabolite profiling in rat and human liver microsomes and in vivo confirmation through urinary excretion study in rats.

    Yahavi, C / Pandey, Anushka / Bhateria, Manisha / Warkad, Balabhau Vaijinathrao / Trivedi, Ravi Kumar / Singh, Sheelendra Pratap

    Chemosphere

    2024  , Page(s) 142123

    Abstract: Hexaconazole (HEX) is an azole fungicide widely used in agricultural practices across various countries and numerous studies have reported the toxic effects of HEX, such as endocrine disruption, immunotoxicity, neurotoxicity and carcinogenicity. Despite ... ...

    Abstract Hexaconazole (HEX) is an azole fungicide widely used in agricultural practices across various countries and numerous studies have reported the toxic effects of HEX, such as endocrine disruption, immunotoxicity, neurotoxicity and carcinogenicity. Despite its widespread agricultural use and toxic effects, the metabolism of HEX is not completely understood, and information on urinary elimination of HEX or its metabolites is limited. Therefore, in the present study, we aimed to identify HEX metabolites in rat and human liver microsomes followed by their in vivo confirmation using a urinary excretion study in rats to identify potential candidate for exposure biomarkers for human biomonitoring studies. From the in vitro assay, a total of 12 metabolites were observed, where the single oxidation metabolites (M5 and M6) were the most abundant metabolites in both rat and human liver microsomes. The triple oxidation followed by dehydration metabolite, M8 (which could also be hexaconazole acid or hydroxy keto-hexaconazole), and the double oxidation metabolite (M9) were the major metabolites found in rat urine and were detectable in rat urine longer than the parent. These metabolites increased with decreasing concentrations of HEX in the rat urine samples. Therefore, metabolites M8, M9 and M5 could be pursued further as potential biomarkers for assessing and monitoring human exposure to HEX.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.142123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Plastic waste management for sustainable environment: techniques and approaches.

    Pandey, Prashant / Dhiman, Manisha / Kansal, Ankur / Subudhi, Sarada Prasannan

    Waste disposal & sustainable energy

    2023  , Page(s) 1–18

    Abstract: Excessive exploitation, negligence, non-degradable nature, and physical and chemical properties of plastic waste have resulted in a massive pollution load into the environment. Consequently, plastic entres the food chain and can cause serious health ... ...

    Abstract Excessive exploitation, negligence, non-degradable nature, and physical and chemical properties of plastic waste have resulted in a massive pollution load into the environment. Consequently, plastic entres the food chain and can cause serious health issues in aquatic animals and humans. The present review summarizes currently reported techniques and approaches for the removal of plastic waste. Many techniques, such as adsorption, coagulation, photocatalysis, and microbial degradation, and approaches like reduction, reuse and recycling are potentially in trend and differ from each other in their efficiency and interaction mechanism. Moreover, substantial advantages and challenges associated with these techniques and approaches are highlighted to develop an understanding of the selection of possible ways for a sustainable future. Nevertheless, in addition to the reduction of plastic waste from the ecosystem, many alternative opportunities have also been explored to cash plastic waste. These fields include the synthesis of adsorbents for the removal of pollutants from aqueous and gaseous stream, their utility in clothing, waste to energy and fuel and in construction (road making). Substantial evidence can be observed in the reduction of plastic pollution from various ecosystems. In addition, it is important to develop an understanding of factors that need to be emphasized while considering alternative approaches and opportunities to cash plastic waste (like adsorbent, clothing, waste to energy and fuel). The thrust of this review is to provide readers with a comprehensive overview of the development status of techniques and approaches to overcome the global issue of plastic pollution and the outlook on the exploitation of this waste as resources.
    Language English
    Publishing date 2023-03-06
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2951499-X
    ISSN 2524-7891 ; 2524-7980
    ISSN (online) 2524-7891
    ISSN 2524-7980
    DOI 10.1007/s42768-023-00134-6
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  7. Article ; Online: Investigating the Role of Tourists and Impact of Knowledge, Behaviour, and Attitude Towards Plastic Waste Generation.

    Pandey, Prashant / Dhiman, Manisha / Chopra, Priyanka / Adlakha, Amit

    Circular economy and sustainability

    2022  , Page(s) 1–15

    Abstract: Tourism is one of the lifelines in nations for their strong economy. Through the expansion of tourism industry, enormous amounts of plastic materials are disposed that have detrimental effects on environment, animal and human health. The present study ... ...

    Abstract Tourism is one of the lifelines in nations for their strong economy. Through the expansion of tourism industry, enormous amounts of plastic materials are disposed that have detrimental effects on environment, animal and human health. The present study demonstrates the role of tourists on generation of plastic waste and further statistical approach was used to investigate the impact of knowledge, behaviour, and attitude of tourists towards generation of plastic waste. Result shows that the tourists play key role in generating plastic waste at outdoor places which is a serious issue that could block drainage ways in city which leads to many waters born disease. The study highlights that the awareness can make certain changes in plastic waste generation and can bridge the knowledge-practice gap. Moreover, the circular economy can offer opportunity to exploit plastic waste into various decorative and useful products that can generate income to local community and help to reduce plastic wastes. It is also important to highlight that the government needs to take care of surveillance in the market on using plastic bags either by sellers or consumers.
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2730-5988
    ISSN (online) 2730-5988
    DOI 10.1007/s43615-022-00216-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteases.

    Shokeen, Kamal / Pandey, Shambhavi / Shah, Manisha / Kumar, Sachin

    Virus research

    2022  Volume 318, Page(s) 198845

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presents an immense global health problem. Spike (S) protein of coronavirus is the primary determinant of its entry into the host as it consists of both receptor binding and fusion ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presents an immense global health problem. Spike (S) protein of coronavirus is the primary determinant of its entry into the host as it consists of both receptor binding and fusion domain. Besides tissue tropism, and host range, coronavirus pathogenesis are primarily controlled by the interaction of S protein with the cell receptor. Moreover, the proteolytic activation of S protein by host cell proteases plays a decisive role. The host-cell proteases have shown to be involved in the proteolysis of S protein and cleaving it into two functional subunits, S1 and S2, during the maturation process. In the present study, the interaction of the S protein of SARS-CoV-2 with different host proteases like furin, cathepsin B, and plasmin has been analyzed using molecular docking and molecular dynamics (MD) simulation. Incorporation of the furin cleavage site (R-R-A-R) in the S protein of SARS-CoV-2 has been studied by mutating the individual amino acid. MD simulation results suggest the polytropic nature of the S protein. Our analysis indicated that a single amino acid substitution in the polybasic cleavage site of S protein perturb the binding of cellular proteases. This mutation study might help to generate an attenuated SARS-CoV-2. Besides, targeting host proteases by inhibitors may result in a practical approach to stop the cellular spread of SARS-CoV-2 and develop its antiviral.
    MeSH term(s) COVID-19 ; Furin/chemistry ; Humans ; Molecular Docking Simulation ; Peptide Hydrolases/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptide Hydrolases (EC 3.4.-) ; Furin (EC 3.4.21.75)
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2022.198845
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: A Superficial Skin Scarification Method in Mice to Mimic Streptococcus pyogenes Skin Infection in Humans.

    Pandey, Manisha / Good, Michael F

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2136, Page(s) 287–301

    Abstract: Skin infections caused by Streptococcus pyogenes are a significant health concern in the tropics and among Indigenous populations of developed countries. To study the immunobiology of skin infections and to develop preventative and therapeutic measures ... ...

    Abstract Skin infections caused by Streptococcus pyogenes are a significant health concern in the tropics and among Indigenous populations of developed countries. To study the immunobiology of skin infections and to develop preventative and therapeutic measures to target these infections, an in vivo model is vital. We developed a mouse model to investigate immunity to skin infections and for testing the efficacy of several vaccine candidates. This article describes the method of induction of superficial skin infections, their progression and regression, and processing of samples to obtain critical readouts and analyses. This model could be valuable to inform clinical studies.
    MeSH term(s) Animals ; Antigens, Bacterial/immunology ; Bacterial Outer Membrane Proteins/immunology ; Carrier Proteins/immunology ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Skin/microbiology ; Streptococcal Infections/immunology ; Streptococcal Infections/metabolism ; Streptococcus pyogenes/immunology ; Streptococcus pyogenes/pathogenicity
    Chemical Substances Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Carrier Proteins
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0467-0_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The SH-SY5Y cell line: a valuable tool for Parkinson's disease drug discovery.

    Pandey, Manisha / Karmakar, Varnita / Majie, Ankit / Dwivedi, Monika / Md, Shadab / Gorain, Bapi

    Expert opinion on drug discovery

    2023  Volume 19, Issue 3, Page(s) 303–316

    Abstract: Introduction: Owing to limited efficient treatment strategies for highly prevalent and distressing Parkinson's disease (PD), an impending need emerged for deciphering new modes and mechanisms for effective management. SH-SY5Y-based : Areas covered: ... ...

    Abstract Introduction: Owing to limited efficient treatment strategies for highly prevalent and distressing Parkinson's disease (PD), an impending need emerged for deciphering new modes and mechanisms for effective management. SH-SY5Y-based
    Areas covered: Herein, the authors review the SH-SY5Y cell line and its value to PD research. The authors also provide the reader with their expert perspectives on how these developments can lead to the development of new impactful therapeutics.
    Expert opinion: Encouraged by recent research on SH-SY5Y cell lines, it was envisaged that this
    MeSH term(s) Humans ; Cell Line, Tumor ; Parkinson Disease/drug therapy ; Reproducibility of Results ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Drug Discovery
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2023.2293158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6388: Show issues Location:
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