LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1116

Search options

  1. Book: Antipsychotic long-acting injections

    Haddad, Peter M. / Lambert, Tim / Lauriello, John

    2016  

    Author's details edited by Peter Haddad, Tim Lambert, John Lauriello
    Keywords Antipsychotic drugs--Controlled release ; Injections ; Antipsychotic Agents--therapeutic use. ; Delayed-Action Preparations--therapeutic use.
    Subject code 615.7882
    Language English
    Size xxi, 366 Seiten, Illustrationen, Diagramme, 24 cm
    Edition Second edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018937353
    ISBN 978-0-19-872947-1 ; 0-19-872947-2
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 800 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Findings from the long term career outcome study and related work

    Torre, Dario M. / Boulet, John R. / Schuwirth, Lambert

    (Military medicine ; 180,4, Suppl.)

    2015  

    Title variant Findings from the long term career outcome study (LTCOS) and related work ; Findings from the long-term career outcome study and related work
    Institution F. Edward Hébert School of Medicine
    Author's details guest ed. Dario M. Torre ; John R. Boulet ; Lambert Schuwirth. [The F. Edward Hébert School of Medicine]
    Series title Military medicine ; 180,4, Suppl.
    Collection
    Language English
    Size iv, 172 S. : graph. Darst., Kt.
    Publisher AMSUS
    Publishing place Bethesda, MD
    Publishing country United States
    Document type Book
    HBZ-ID HT018645313
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Un I Zs 546 -180,4,Suppl.- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Green Oxidation of Aromatic Hydrazide Derivatives Using an Oxoammonium Salt.

    Phadnis, Nidheesh / Molen, Jessica A / Stephens, Shannon M / Weierbach, Shayne M / Lambert, Kyle M / Milligan, John A

    The Journal of organic chemistry

    2024  Volume 89, Issue 8, Page(s) 5841–5845

    Abstract: Aromatic diazenes are often prepared by oxidation of the corresponding hydrazides using stoichiometric quantities of nonrecyclable oxidants. We developed a convenient alternative protocol for the oxidation of aromatic hydrazides using Bobbitt's salt ( ...

    Abstract Aromatic diazenes are often prepared by oxidation of the corresponding hydrazides using stoichiometric quantities of nonrecyclable oxidants. We developed a convenient alternative protocol for the oxidation of aromatic hydrazides using Bobbitt's salt (
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02752
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Locomotor efference copy signaling and gaze control: An evolutionary perspective.

    Lambert, François M / Beraneck, Mathieu / Straka, Hans / Simmers, John

    Current opinion in neurobiology

    2023  Volume 82, Page(s) 102761

    Abstract: Neural replicas of the spinal motor commands that drive locomotion have become increasingly recognized as an intrinsic neural mechanism for producing gaze-stabilizing eye movements that counteract the perturbing effects of self-generated head/body motion. ...

    Abstract Neural replicas of the spinal motor commands that drive locomotion have become increasingly recognized as an intrinsic neural mechanism for producing gaze-stabilizing eye movements that counteract the perturbing effects of self-generated head/body motion. By pre-empting reactive signaling by motion-detecting vestibular sensors, such locomotor efference copies (ECs) provide estimates of the sensory consequences of behavioral action. Initially demonstrated in amphibian larvae during spontaneous fictive swimming in deafferented in vitro preparations, direct evidence for a contribution of locomotor ECs to gaze stabilization now extends to the ancestral lamprey and to tetrapod adult frogs and mice. Supporting behavioral evidence also exists for other mammals, including humans, therefore further indicating the mechanism's conservation during vertebrate evolution. The relationship between feedforward ECs and vestibular sensory feedback in ocular movement control is variable, ranging from additive to the former supplanting the latter, depending on vestibular sensing ability, and the intensity and regularity of rhythmic locomotor movements.
    MeSH term(s) Adult ; Humans ; Animals ; Mice ; Eye ; Eye Movements ; Feedback, Sensory ; Larva ; Locomotion ; Mammals
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2023.102761
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Antibody-drug conjugates: targeted delivery and future prospects.

    Lambert, John M

    Therapeutic delivery

    2016  Volume 7, Issue 5, Page(s) 279–282

    MeSH term(s) Antineoplastic Agents/administration & dosage ; History, 20th Century ; History, 21st Century ; Humans ; Immunoconjugates/administration & dosage ; Medical Oncology/history ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents ; Immunoconjugates
    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial ; Historical Article
    ISSN 2041-6008
    ISSN (online) 2041-6008
    DOI 10.4155/tde-2016-0010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Antibody-drug conjugates come of age in oncology.

    Dumontet, Charles / Reichert, Janice M / Senter, Peter D / Lambert, John M / Beck, Alain

    Nature reviews. Drug discovery

    2023  Volume 22, Issue 8, Page(s) 641–661

    Abstract: Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of highly cytotoxic agents, potentially reducing the severity of side effects by preferentially targeting their payload to the tumour site. ADCs are being ... ...

    Abstract Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of highly cytotoxic agents, potentially reducing the severity of side effects by preferentially targeting their payload to the tumour site. ADCs are being increasingly used in combination with other agents, including as first-line cancer therapies. As the technology to produce these complex therapeutics has matured, many more ADCs have been approved or are in late-phase clinical trials. The diversification of antigenic targets as well as bioactive payloads is rapidly broadening the scope of tumour indications for ADCs. Moreover, novel vector protein formats as well as warheads targeting the tumour microenvironment are expected to improve the intratumour distribution or activation of ADCs, and consequently their anticancer activity for difficult-to-treat tumour types. However, toxicity remains a key issue in the development of these agents, and better understanding and management of ADC-related toxicities will be essential for further optimization. This Review provides a broad overview of the recent advances and challenges in ADC development for cancer treatment.
    MeSH term(s) Humans ; Immunoconjugates/pharmacology ; Immunoconjugates/therapeutic use ; Antineoplastic Agents/adverse effects ; Neoplasms/therapy ; Antibodies, Monoclonal/therapeutic use ; Tumor Microenvironment
    Chemical Substances Immunoconjugates ; Antineoplastic Agents ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/s41573-023-00709-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 334: Show issues
    Zs.MG 63: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Scaffold Hopping in Agrochemical Research: Discovery of Insecticidal 4-Pyridyl Isobenzofurans.

    Buysse, Ann M / Herbert, John / Lambert, William T / Wessels, Frank J

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 36, Page(s) 11091–11096

    Abstract: The insecticidal activity of pyridine compounds substituted at the 4-position with lipophilic groups has been reported in recent agrochemical patent applications. Encouraged by these reports, 4-pyridyl dihydroisobenzofuran(one)s were designed to test ... ...

    Abstract The insecticidal activity of pyridine compounds substituted at the 4-position with lipophilic groups has been reported in recent agrochemical patent applications. Encouraged by these reports, 4-pyridyl dihydroisobenzofuran(one)s were designed to test scaffold-hopping hypotheses with the goal of discovering new insecticidally active areas of chemistry. A series of 4-pyridyl dihydroisobenzofuran(one)s were synthesized, and their activity against key sap-feeding insect pests (silverleaf whitefly,
    MeSH term(s) Agrochemicals/pharmacology ; Animals ; Aphids ; Insecticides/chemistry ; Insecticides/pharmacology
    Chemical Substances Agrochemicals ; Insecticides
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c08273
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Neonatal Thrombocytopenia as a Presenting Finding in de novo Pyruvate Kinase Deficiency.

    Dulmovits, Brian M / Wild, K Taylor / Flibotte, John / Lambert, Michele P / Kwiatkowski, Janet / Thom, Christopher S

    Neonatology

    2023  Volume 120, Issue 5, Page(s) 661–665

    Abstract: Thrombocytopenia is a common laboratory abnormality encountered in critically ill neonates. The broad differential for thrombocytopenia, and its association with potentially severe neonatal pathology, often presents a diagnostic dilemma prompting ... ...

    Abstract Thrombocytopenia is a common laboratory abnormality encountered in critically ill neonates. The broad differential for thrombocytopenia, and its association with potentially severe neonatal pathology, often presents a diagnostic dilemma prompting extensive evaluation. Hemolysis due to red cell enzymopathies is a rare cause of neonatal thrombocytopenia that is typically brief and self-limiting. Here, we present a case of thrombocytopenia, refractory to transfusion, associated with anemia and hyperbilirubinemia in a neonate with pyruvate kinase deficiency (PKD) arising from compound heterozygous PKLR mutations. The nature of the thrombocytopenia in this patient created considerable diagnostic uncertainty, which was ultimately resolved by whole-exome sequencing. This case emphasizes that inherited red cell defects, such as PKD, are important to consider in cases of neonatal thrombocytopenia.
    MeSH term(s) Infant, Newborn ; Humans ; Thrombocytopenia, Neonatal Alloimmune ; Anemia, Hemolytic, Congenital Nonspherocytic/complications ; Anemia, Hemolytic, Congenital Nonspherocytic/diagnosis ; Anemia, Hemolytic, Congenital Nonspherocytic/genetics ; Pyruvate Metabolism, Inborn Errors/diagnosis ; Pyruvate Metabolism, Inborn Errors/genetics ; Pyruvate Metabolism, Inborn Errors/complications ; Pyruvate Kinase/genetics ; Anemia ; Infant, Newborn, Diseases
    Chemical Substances Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Case Reports ; Research Support, N.I.H., Extramural
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000531242
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 391: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Antibody-Drug Conjugates (ADCs): Magic Bullets at Last!

    Lambert, John M

    Molecular pharmaceutics

    2015  Volume 12, Issue 6, Page(s) 1701–1702

    MeSH term(s) Aniline Compounds ; Azo Compounds ; Chemistry, Pharmaceutical ; Chlorambucil ; Dialysis ; Fluorouracil ; Immune Sera ; Mercaptopurine ; Methotrexate ; Nitrogen Mustard Compounds ; Research ; Tetracycline ; Thiotepa ; Ultraviolet Rays ; Uracil Mustard ; gamma-Globulins
    Chemical Substances Aniline Compounds ; Azo Compounds ; Immune Sera ; Nitrogen Mustard Compounds ; gamma-Globulins ; Chlorambucil (18D0SL7309) ; Thiotepa (905Z5W3GKH) ; Mercaptopurine (E7WED276I5) ; Tetracycline (F8VB5M810T) ; Fluorouracil (U3P01618RT) ; Uracil Mustard (W7KQ46GJ8U) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2015-06-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.5b00302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: A Ring Expansion Approach To

    Jackson, Amy C / Olsen, James T / Sundstrom, Sasha / Lambert, Kyle M / Wood, John L

    Tetrahedron letters

    2022  Volume 99

    Abstract: A ring expansion of tetramic acids (pyrrolidine-2,4-diones) ... ...

    Abstract A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.153851
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top