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  1. Article: Ron Todd: a stern regulator with a low-key style.

    Bradley, T

    Kansas medicine : the journal of the Kansas Medical Society

    1992  Volume 93, Issue 6, Page(s) 170–171

    MeSH term(s) Costs and Cost Analysis ; Insurance, Health/economics ; Insurance, Health/legislation & jurisprudence ; Kansas ; Leadership ; Malpractice/economics
    Language English
    Publishing date 1992-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632509-9
    ISSN 8755-0059
    ISSN 8755-0059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 142: Show issues Location:
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  2. Book: Peptide self-assembly

    Nilsson, Bradley L. / Doran, Todd M.

    methods and protocols

    (Methods in molecular biology ; 1777 ; Springer protocols)

    2018  

    Author's details edited by Bradley L. Nilsson, Todd M. Doran
    Series title Methods in molecular biology ; 1777
    Springer protocols
    Collection
    Keywords protein self-assembly phenomena ; extracellular matrix proteins ; amyloid pathologies ; solid-state NMR ; spectroscopic
    Subject code 570
    Language English
    Size xv, 452 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019702048
    ISBN 978-1-4939-7809-0 ; 1-4939-7809-8 ; 9781493978113 ; 149397811X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -1777- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?

    Bradley, Todd / Tucker, Megan / Sampath, Venkatesh

    Pediatric research

    2024  

    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-03007-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  4. Article ; Online: Correction: Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?

    Bradley, Todd / Tucker, Megan / Sampath, Venkatesh

    Pediatric research

    2024  Volume 95, Issue 5, Page(s) 1383

    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03052-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: cis

    Park, Esther H / Ortiz, Sarah M / Liang, Todd K / Smucker, Bradley W

    IUCrData

    2024  Volume 9, Issue Pt 3, Page(s) x240191

    Abstract: The structure of the title compound, [ ... ...

    Abstract The structure of the title compound, [RuCl
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ISSN 2414-3146
    ISSN (online) 2414-3146
    DOI 10.1107/S2414314624001913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anatomy, surgical techniques, and clinical outcomes for the medial arm flap: A systematic review.

    Tweel, Madeline / Dow, Todd / Greene, Bradley / Leblanc, Martin

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2024  Volume 92, Page(s) 130–144

    Abstract: Background: The medial arm flap (MAF) has been used as a pedicle flap and free flap to reconstruct various deformities, including those of the head and neck, axilla, elbow, chest, and hand. This study reviews the anatomy of the flap, the technique of ... ...

    Abstract Background: The medial arm flap (MAF) has been used as a pedicle flap and free flap to reconstruct various deformities, including those of the head and neck, axilla, elbow, chest, and hand. This study reviews the anatomy of the flap, the technique of flap harvest, its clinical applications, and a systematic review of the current published literature.
    Methods: An online systematic review of MEDLINE, EMBASE, PubMed, and The Cochrane Library from inception to September 30, 2023, was completed. Studies that investigate the anatomy, technique or clinical outcomes of medial arm flaps were included. Clinical data extracted includes patient, defect, flap characteristics, complications, and take-back procedures. Anatomic data extracted includes anatomical variations, and vascular characteristics and patterns.
    Results: Between 1980 and 2023, 50 papers were published outlining the medial arm flap. Anatomic studies detail the anatomy of 384 medial arms, and outcomes are reported for 283 MAFs (75 free flaps and 208 pedicle flaps). The superior ulnar collateral artery is most commonly cited as the dominant arterial supply to the middle third of the medial arm. The majority of patients required reconstruction post-burn (39.2%), trauma (17.7%), and tumor excision (12.4%). MAFs were mostly used to reconstruct defects of the head and neck (41.7%), the hand and wrist (21.9%), and the elbow (16.3%). Eleven flaps (4.1%) suffered partial flap failure, and two flaps (0.7%) suffered total flap failure.
    Conclusion: This manuscript demonstrates that the MAF is a reliable and underutilized flap option with a well-hidden donor scar and a low complication rate.
    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2024.02.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.157: Show issues Location:
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  7. Article ; Online: Autoantibodies to ACE2 and immune molecules are associated with COVID-19 disease severity.

    Geanes, Eric S / McLennan, Rebecca / LeMaster, Cas / Bradley, Todd

    Communications medicine

    2024  Volume 4, Issue 1, Page(s) 47

    Abstract: Background: Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations. The mechanisms of this variable long-term immune activation are poorly defined. One feature of ...

    Abstract Background: Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations. The mechanisms of this variable long-term immune activation are poorly defined. One feature of this increased inflammation is elevated levels of proinflammatory cytokines and chemokines. Autoantibodies targeting immune factors such as cytokines, as well as the viral host cell receptor, angiotensin-converting enzyme 2 (ACE2), have been observed after SARS-CoV-2 infection. Autoantibodies to immune factors and ACE2 could interfere with normal immune regulation and lead to increased inflammation, severe COVID-19, and long-term complications.
    Methods: Here, we deeply profiled the features of ACE2, cytokine, and chemokine autoantibodies in samples from patients recovering from severe COVID-19. We measured the levels of immunoglobulin subclasses (IgG, IgA, IgM) in the peripheral blood against ACE2 and 23 cytokines and other immune molecules. We then utilized an ACE2 peptide microarray to map the linear epitopes targeted by ACE2 autoantibodies.
    Results: We demonstrate that ACE2 autoantibody levels are increased in individuals with severe COVID-19 compared with those with mild infection or no prior infection. We identify epitopes near the catalytic domain of ACE2 targeted by these antibodies. Levels of autoantibodies targeting ACE2 and other immune factors could serve as determinants of COVID-19 disease severity, and represent a natural immunoregulatory mechanism in response to viral infection.
    Conclusions: These results demonstrate that SARS-CoV-2 infection can increase autoantibody levels to ACE2 and other immune factors. The levels of these autoantibodies are associated with COVID-19 disease severity.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-024-00477-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A prognostic gene signature for predicting survival outcome in diffuse large B-cell lymphoma.

    Khanal, Santosh / Bradley, Todd

    Cancer genetics

    2021  Volume 252-253, Page(s) 87–95

    Abstract: Diffuse large B-cell lymphoma (DLBCL) is an heterogenous cancer that can have profound differences in survival outcomes. Molecular profiling has allowed for the identification of DLBCL subclasses, and together with clinical prognostic factors, such as ... ...

    Abstract Diffuse large B-cell lymphoma (DLBCL) is an heterogenous cancer that can have profound differences in survival outcomes. Molecular profiling has allowed for the identification of DLBCL subclasses, and together with clinical prognostic factors, such as the international prognostic index, have improved clinical care and survival. Despite these advances, a gene signature that is associated with overall survival (OS) and is reproducible across different DLBCL studies could better classify risk and predict OS. Here, we have identified genes that are associated with OS in DLBCL using data from the Lymphoma/Leukemia Molecular Profiling Project and developed a prognostic gene signature consisting of 33 genes that - when transformed into a risk score - can stratify individuals into high or low risk groups that have significantly different OS. The prognostic gene signature was associated with OS in multiple clinical studies, and when used in conjunction with DLBCL molecular subtype and IPI score, significantly predicted OS. Thus, we identified a potential prognostic gene signature that can discriminate high-risk from low-risk DLBCL patients.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Datasets as Topic ; Doxorubicin/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Prednisone/therapeutic use ; Prognosis ; Rituximab/therapeutic use ; Survival Rate ; Vincristine/therapeutic use
    Chemical Substances R-CHOP protocol ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599227-2
    ISSN 2210-7762
    ISSN 2210-7762
    DOI 10.1016/j.cancergen.2021.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1521: Show issues Location:
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  9. Article ; Online: Novel Therapeutic and Program-Based Approaches to Opioid Use Disorders.

    Liu, Patricia / Korthuis, P Todd / Buchheit, Bradley M

    Annual review of medicine

    2023  Volume 75, Page(s) 83–97

    Abstract: Opioid use disorder continues to drive overdose deaths in many countries, including the United States. Illicit fentanyl and its analogues have emerged as key contributors to the complications and mortality associated with opioid use disorder. Medications ...

    Abstract Opioid use disorder continues to drive overdose deaths in many countries, including the United States. Illicit fentanyl and its analogues have emerged as key contributors to the complications and mortality associated with opioid use disorder. Medications for opioid use disorder treatment, such as methadone and buprenorphine, are safe and substantially reduce opioid use, infectious complications, and mortality risk, but remain underutilized. Polysubstance use and emerging substances such as xylazine and designer benzodiazepines create additional treatment challenges. Recent clinical and policy innovations in treatment delivery, including telemedicine, bridge clinics, and expanded models for accessing methadone have the potential to increase access to life-saving care for people living with opioid use disorder.
    MeSH term(s) Humans ; United States/epidemiology ; Opioid-Related Disorders ; Methadone/therapeutic use ; Buprenorphine/therapeutic use ; Drug Overdose ; Analgesics, Opioid/therapeutic use
    Chemical Substances Methadone (UC6VBE7V1Z) ; Buprenorphine (40D3SCR4GZ) ; Analgesics, Opioid
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-050522-033924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Autoantibodies against Angiotensin-converting enzyme 2 and immune molecules are associated with COVID-19 disease severity.

    Bradley, Todd / Geanes, Eric / McLennan, Rebecca / LeMaster, Cas

    Research square

    2023  

    Abstract: Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations referred to as post-acute sequalae of COVID (PASC). The mechanisms of this variable long-term immune ... ...

    Abstract Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations referred to as post-acute sequalae of COVID (PASC). The mechanisms of this variable long-term immune activation are poorly defined. Autoantibodies targeting immune factors such as cytokines, as well as the viral host cell receptor, angiotensin-converting enzyme 2 (ACE2), have been observed after SARS-CoV-2 infection. Autoantibodies to immune factors and ACE2 could interfere with normal immune regulation and lead to increased inflammation, severe COVID-19, and long-term complications. Here, we deeply pro led the features of ACE2, cytokine, and chemokine autoantibodies in samples from patients recovering from severe COVID-19. We identified epitopes in the catalytic domain of ACE2 targeted by these antibodies, that could inhibit ACE2 function. Levels of autoantibodies targeting ACE2 and other immune factors could serve as determinants of COVID-19 disease severity, and represent a natural immunoregulatory mechanism in response to viral infection.
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3304083/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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