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  1. Article ; Online: Modelling the effect of surface charging on plasma synthesis of ammonia using DFT.

    Lele, Aditya Dilip / Xu, Yijie / Ju, Yiguang

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 12, Page(s) 9453–9461

    Abstract: Non-equilibrium plasma has been found to have a synergistic effect on catalytic synthesis of ... ...

    Abstract Non-equilibrium plasma has been found to have a synergistic effect on catalytic synthesis of NH
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06050k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Can Natural Speech Prosody Distinguish Autism Spectrum Disorders? A Meta-Analysis.

    Ma, Wen / Xu, Lele / Zhang, Hao / Zhang, Shurui

    Behavioral sciences (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Natural speech plays a pivotal role in communication and interactions between human beings. The prosody of natural speech, due to its high ecological validity and sensitivity, has been acoustically analyzed and more recently utilized in machine learning ... ...

    Abstract Natural speech plays a pivotal role in communication and interactions between human beings. The prosody of natural speech, due to its high ecological validity and sensitivity, has been acoustically analyzed and more recently utilized in machine learning to identify individuals with autism spectrum disorders (ASDs). In this meta-analysis, we evaluated the findings of empirical studies on acoustic analysis and machine learning techniques to provide statistically supporting evidence for adopting natural speech prosody for ASD detection. Using a random-effects model, the results observed moderate-to-large pooled effect sizes for pitch-related parameters in distinguishing individuals with ASD from their typically developing (TD) counterparts. Specifically, the standardized mean difference (SMD) values for pitch mean, pitch range, pitch standard deviation, and pitch variability were 0.3528, 0.6744, 0.5735, and 0.5137, respectively. However, the differences between the two groups in temporal features could be unreliable, as the SMD values for duration and speech rate were only 0.0738 and -0.0547. Moderator analysis indicated task types were unlikely to influence the final results, whereas age groups showed a moderating role in pooling pitch range differences. Furthermore, promising accuracy rates on ASD identification were shown in our analysis of multivariate machine learning studies, indicating averaged sensitivity and specificity of 75.51% and 80.31%, respectively. In conclusion, these findings shed light on the efficacy of natural prosody in identifying ASD and offer insights for future investigations in this line of research.
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs14020090
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  3. Article: Major depressive disorder plays a vital role in the pathway from gastroesophageal reflux disease to chronic obstructive pulmonary disease: a Mendelian randomization study.

    Zou, Menglong / Zhang, Wei / Shen, Lele / Xu, Yin / Zhu, Ying

    Frontiers in genetics

    2023  Volume 14, Page(s) 1198476

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1198476
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  4. Article ; Online: DNA Adjuvant Hydrogel-Optimized Enzymatic Cascade Reaction for Tumor Chemodynamic-Immunotherapy.

    Zhao, Yan / Du, Jiangnan / Xu, Zihui / Wang, Lihua / Ma, Lan / Sun, Lele

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 10, Page(s) e2308229

    Abstract: Chemodynamic therapy (CDT) shows immense potential in cancer treatment as it not only directly kills tumor cells but also induces anti-tumor immune responses. However, the efficacy of CDT is hampered by challenges in targeting CDT catalysts specifically ... ...

    Abstract Chemodynamic therapy (CDT) shows immense potential in cancer treatment as it not only directly kills tumor cells but also induces anti-tumor immune responses. However, the efficacy of CDT is hampered by challenges in targeting CDT catalysts specifically to tumors using nanomaterials, along with the limitations of low H
    MeSH term(s) Hydrogels ; Reactive Oxygen Species ; Adjuvants, Immunologic ; Immunotherapy ; DNA
    Chemical Substances Hydrogels ; Reactive Oxygen Species ; Adjuvants, Immunologic ; DNA (9007-49-2)
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202308229
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  5. Article ; Online: Specific lipid magnetic sphere sorted CD146-positive bone marrow mesenchymal stem cells can better promote articular cartilage damage repair.

    Ren, Hanru / Zhang, Lele / Zhang, Xu / Yi, Chengqing / Wu, Lianghao

    BMC musculoskeletal disorders

    2024  Volume 25, Issue 1, Page(s) 253

    Abstract: Background: The characteristics and therapeutic potential of subtypes of bone marrow mesenchymal stem cells (BMSCs) are largely unknown. Also, the application of subpopulations of BMSCs in cartilage regeneration remains poorly characterized. The aim of ... ...

    Abstract Background: The characteristics and therapeutic potential of subtypes of bone marrow mesenchymal stem cells (BMSCs) are largely unknown. Also, the application of subpopulations of BMSCs in cartilage regeneration remains poorly characterized. The aim of this study was to explore the regenerative capacity of CD146-positive subpopulations of BMSCs for repairing cartilage defects.
    Methods: CD146-positive BMSCs (CD146 + BMSCs) were sorted by self-developed CD146-specific lipid magnetic spheres (CD146-LMS). Cell surface markers, viability, and proliferation were evaluated in vitro. CD146 + BMSCs were subjected to in vitro chondrogenic induction and evaluated for chondrogenic properties by detecting mRNA and protein expression. The role of the CD146 subpopulation of BMSCs in cartilage damage repair was assessed by injecting CD146 + BMSCs complexed with sodium alginate gel in the joints of a mouse cartilage defect model.
    Results: The prepared CD146-LMS had an average particle size of 193.7 ± 5.24 nm, an average potential of 41.9 ± 6.21 mv, and a saturation magnetization intensity of 27.2 Am
    Conclusion: The prepared CD146-LMS was able to sort out CD146 + BMSCs efficiently, and the sorted subpopulation of CD146 + BMSCs had good chondrogenic differentiation potential, which could efficiently promote the repair of articular cartilage injury, suggesting that the sorted CD146 + BMSCs subpopulation is a promising seed cell for cartilage tissue engineering.
    MeSH term(s) Animals ; Mice ; Cartilage, Articular/metabolism ; CD146 Antigen/metabolism ; Cell Differentiation ; Cells, Cultured ; Mesenchymal Stem Cells/metabolism ; Bone Marrow Cells/metabolism ; Chondrogenesis ; RNA, Messenger/metabolism ; Magnetic Phenomena ; Lipids
    Chemical Substances CD146 Antigen ; RNA, Messenger ; Lipids
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07381-6
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  6. Article: The Effect of Temperature on Molecular Structure of Medium-Rank Coal via Fourier Transform Infrared Spectroscopy.

    Wu, Meng / Qin, Yong / Qin, Yunhu / Xu, Naicen / Feng, Lele

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 20

    Abstract: Fourier transform infrared spectroscopy (FTIR) was used to study the molecular structure of four medium- and low-temperature heat-treated medium-rank coals. The FTIR spectral parameters, which consist of ... ...

    Abstract Fourier transform infrared spectroscopy (FTIR) was used to study the molecular structure of four medium- and low-temperature heat-treated medium-rank coals. The FTIR spectral parameters, which consist of CH
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16206746
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  7. Article ; Online: Correction to: Theranostic role of

    Yang, Qi / Chen, Zhao / Qiu, Yongkang / Huang, Wenpeng / Wang, Tianyao / Song, Lele / Sun, Xinyao / Li, Cuicui / Xu, Xiaojie / Kang, Lei

    European journal of nuclear medicine and molecular imaging

    2024  Volume 51, Issue 5, Page(s) 1495

    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06590-w
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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Pharmacokinetics and apparent Michaelis constant for metabolite conversion of sorafenib in healthy and hepatocellular carcinoma-bearing rats.

    Cai, Hongxin / Du, Xiaoyue / Deng, Yufeng / Cao, Dejian / Wang, Lele / Wu, Zhiguo / Zhang, Xianchao / Xu, Jinbiao / Xie, Baogang

    Bioanalysis

    2024  

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2023-0215
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  9. Article ; Online: Organizing Photosensitive and Photothermal Single-Sites Uniformly in a Trimetallic Metal-Organic Framework for Efficient Photocatalytic Hydrogen Evolution.

    Zhang, Shiqi / Lu, Lele / Jiang, Jialong / Liu, Ning / Zhao, Bin / Xu, Mingming / Cheng, Peng / Shi, Wei

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2403464

    Abstract: Effective combination of the photosensitivity and photothermal property in photocatalyst is vital to achieve the maximum light utilization for superior photocatalytic efficiency. Herein, this work successfully organizes photosensitive Cd-NS single-sites ... ...

    Abstract Effective combination of the photosensitivity and photothermal property in photocatalyst is vital to achieve the maximum light utilization for superior photocatalytic efficiency. Herein, this work successfully organizes photosensitive Cd-NS single-sites and photothermal Ni-NS single-sites uniformly at a molecular level within a tailored trimetallic metal-organic framework. The optimized Ho
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202403464
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  10. Article ; Online: Structural Characteristics and Antioxidant Mechanism of Donkey-Hide Gelatin Peptides by Molecular Dynamics Simulation

    Rong Liang / Le Xu / Chen Fan / Lele Cao / Xingfeng Guo

    Molecules, Vol 28, Iss 24, p

    2023  Volume 7975

    Abstract: This study aimed to explore the structural characteristics and antioxidant mechanism of donkey-hide gelatin peptides. After hydrolysis and ultrafiltration treatment, five gelatin peptides with different molecular weights (MWs) were obtained. Amino acid ... ...

    Abstract This study aimed to explore the structural characteristics and antioxidant mechanism of donkey-hide gelatin peptides. After hydrolysis and ultrafiltration treatment, five gelatin peptides with different molecular weights (MWs) were obtained. Amino acid analysis showed that gelatin peptides with different MWs contained a large number of amino acids, including G, P, E, N, A, and R, and differences were noted in the content of various amino acids. Fourier transform infrared spectroscopy and circular dichroism revealed that these gelatin peptides differed in terms of the peak strength of functional groups and number of secondary structures. Moreover, 26 pentapeptides/hexapeptides were identified. Among them, we investigated by molecular docking how PGPAP, which has the best antioxidant activity, may interact with the Keap1 protein. The results showed that the PGPAP-Keap1 complex had a stable conformation, and Arg415, Gly462, Phe478, and Tyr572 were the key residues involved in the binding of the peptide PGPAP to Keap1. Our results demonstrated that PGPAP could serve as a bioactive peptide with antioxidant activity.
    Keywords gelatin peptides ; antioxidant activity ; structural characteristics ; Keap1 protein ; molecular dynamics simulations ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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