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  1. Book ; Thesis: Untersuchungen von Blutplättchen in frischen und gelagerten Pool-Präparaten mit dem Platelet ADhesion Assay (PADA) im Vergleich zu Apherese-Präparaten

    Althaus, Karina

    2006  

    Author's details von Karina Althaus
    Language German
    Size 55, [2] Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2006
    HBZ-ID HT014746780
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 1011 order for loan Magazin

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  2. Article ; Online: Diagnosis of Platelet Function Disorders: A Challenge for Laboratories.

    Wagner, Miriam / Uzun, Günalp / Bakchoul, Tamam / Althaus, Karina

    Hamostaseologie

    2022  Volume 42, Issue 1, Page(s) 36–45

    Abstract: In patients with normal plasmatic coagulation and bleeding tendency, platelet function defect can be assumed. Congenital platelet function defects are rare. Much more commonly they are acquired. The clinical bleeding tendency of platelet function defects ...

    Abstract In patients with normal plasmatic coagulation and bleeding tendency, platelet function defect can be assumed. Congenital platelet function defects are rare. Much more commonly they are acquired. The clinical bleeding tendency of platelet function defects is heterogeneous, which makes diagnostic approaches difficult. During the years, a large variety of tests for morphological phenotyping and functional analysis have been developed. The diagnosis of platelet function defects is based on standardized bleeding assessment tools followed by a profound morphological evaluation of the platelets. Platelet function assays like light transmission aggregation, luminoaggregometry, and impedance aggregometry followed by flow cytometry are commonly used to establish the diagnosis in these patients. Nevertheless, despite great efforts, standardization of these tests is poor and in most cases, quality control is lacking. In addition, these tests are still limited to specialized laboratories. This review summarizes the approaches to morphologic phenotyping and platelet testing in patients with suspected platelet dysfunction, beginning with a standardized bleeding score and ending with flow cytometry testing. The diagnosis of a functional defect requires a good collaboration between the laboratory and the clinician.
    MeSH term(s) Blood Platelet Disorders/diagnosis ; Blood Platelets ; Humans ; Laboratories ; Platelet Aggregation ; Platelet Function Tests
    Language English
    Publishing date 2022-02-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1700-7036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Assessment and Monitoring of Coagulation in Patients with COVID-19: A Review of Current Literature.

    Uzun, Günalp / Althaus, Karina / Hammer, Stefanie / Bakchoul, Tamam

    Hamostaseologie

    2022  

    Abstract: Coagulation abnormalities are common in patients with COVID-19 and associated with high morbidity and mortality. It became a daily challenge to navigate through these abnormal laboratory findings and deliver the best possible treatment to the patients. ... ...

    Abstract Coagulation abnormalities are common in patients with COVID-19 and associated with high morbidity and mortality. It became a daily challenge to navigate through these abnormal laboratory findings and deliver the best possible treatment to the patients. The unique character of COVID-19-induced coagulopathy necessitates not only a dynamic follow-up of the patients in terms of hemostatic findings but also the introduction of new diagnostic methods to determine the overall function of the coagulation system in real time. After the recognition of the high risk of thromboembolism in COVID-19, several professional societies published their recommendations regarding anticoagulation in patients with COVID-19. This review summarizes common hemostatic findings in COVID-19 patients and presents the societal recommendations regarding the use of coagulation laboratory findings in clinical decision-making. Although several studies have investigated coagulation parameters in patients with COVID-19, the methodological shortcomings of published studies as well as the differences in employed anticoagulation regimens that have changed over time, depending on national and international guidelines, limit the applicability of these findings in other clinical settings. Accordingly, evidence-based recommendations for diagnostics during acute COVID-19 infection are still lacking. Future studies should verify the role of coagulation parameters as well as viscoelastic methods in the management of patients with COVID-19.
    Language English
    Publishing date 2022-04-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1755-8676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Antibody-mediated platelet activation in COVID-19: A coincidence or a new mechanism of the dysregulated coagulation system?

    Althaus, Karina / Zlamal, Jan / Bakchoul, Tamam

    Journal of thrombosis and haemostasis : JTH

    2021  Volume 19, Issue 5, Page(s) 1171–1173

    MeSH term(s) Antigen-Antibody Complex ; Blood Platelets ; COVID-19 ; Critical Illness ; Humans ; Platelet Activation ; SARS-CoV-2 ; Thrombocytopenia
    Chemical Substances Antigen-Antibody Complex
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15275
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 5805: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  5. Article ; Online: No Correlation between Anti-PF4 and Anti-SARS-CoV-2 Antibodies after ChAdOx1 nCoV-19 Vaccination.

    Uzun, Günalp / Althaus, Karina / Bakchoul, Tamam

    The New England journal of medicine

    2021  Volume 385, Issue 14, Page(s) 1334–1336

    MeSH term(s) Antibodies, Viral/blood ; Autoantibodies/blood ; COVID-19 ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Humans ; Platelet Factor 4/immunology ; SARS-CoV-2/immunology ; Thrombocytopenia/etiology ; Thrombocytopenia/immunology ; Thrombosis/etiology ; Thrombosis/immunology ; Vaccination
    Chemical Substances Antibodies, Viral ; Autoantibodies ; COVID-19 Vaccines ; Platelet Factor 4 (37270-94-3) ; ChAdOx1 COVID-19 vaccine (B5S3K2V0G8)
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2111305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Conference proceedings: Investigations to Assess the Impact of Syk-Inhibition on Antibody-Mediated Desialylation: Novel Implications on Therapy for Immune Thrombocytopenia

    Singh, Anurag / Toma, Filip / Althaus, Karina / Bakchoul, Tamam

    Hämostaseologie

    2022  Volume 42, Issue S 01

    Event/congress 52. Hamburger Hämophilie Symposion, Hamburg, Germany, 2021-11-12
    Language English
    Publishing date 2022-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0042-1758499
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Characteristics Associated with COVID-19 Breakthrough Infections after Booster Vaccinations in Healthcare Workers: Insights from the TüSeRe:exact Study.

    Uzun, Günalp / Bareiß, Alan / Becker, Matthias / Althaus, Karina / Dulovic, Alex / Junker, Daniel / Schenke-Layland, Katja / Martus, Peter / Borst, Oliver / Schneiderhan-Marra, Nicole / Bakchoul, Tamam

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Diagnosis of Platelet Function Disorders: A Challenge for Laboratories

    Wagner, Miriam / Uzun, Günalp / Bakchoul, Tamam / Althaus, Karina

    Hämostaseologie

    2022  Volume 42, Issue 01, Page(s) 36–45

    Abstract: In patients with normal plasmatic coagulation and bleeding tendency, platelet function defect can be assumed. Congenital platelet function defects are rare. Much more commonly they are acquired. The clinical bleeding tendency of platelet function defects ...

    Abstract In patients with normal plasmatic coagulation and bleeding tendency, platelet function defect can be assumed. Congenital platelet function defects are rare. Much more commonly they are acquired. The clinical bleeding tendency of platelet function defects is heterogeneous, which makes diagnostic approaches difficult. During the years, a large variety of tests for morphological phenotyping and functional analysis have been developed. The diagnosis of platelet function defects is based on standardized bleeding assessment tools followed by a profound morphological evaluation of the platelets. Platelet function assays like light transmission aggregation, luminoaggregometry, and impedance aggregometry followed by flow cytometry are commonly used to establish the diagnosis in these patients. Nevertheless, despite great efforts, standardization of these tests is poor and in most cases, quality control is lacking. In addition, these tests are still limited to specialized laboratories. This review summarizes the approaches to morphologic phenotyping and platelet testing in patients with suspected platelet dysfunction, beginning with a standardized bleeding score and ending with flow cytometry testing. The diagnosis of a functional defect requires a good collaboration between the laboratory and the clinician.
    Keywords platelet function defect ; light transmission aggregometry ; inherited platelet disorder ; granule defect
    Language English
    Publishing date 2022-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1700-7036
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Assessment and Monitoring of Coagulation in Patients with COVID-19: A Review of Current Literature

    Uzun, Günalp / Althaus, Karina / Hammer, Stefanie / Bakchoul, Tamam

    Hämostaseologie

    2022  Volume 42, Issue 06, Page(s) 409–419

    Abstract: Coagulation abnormalities are common in patients with COVID-19 and associated with high morbidity and mortality. It became a daily challenge to navigate through these abnormal laboratory findings and deliver the best possible treatment to the patients. ... ...

    Abstract Coagulation abnormalities are common in patients with COVID-19 and associated with high morbidity and mortality. It became a daily challenge to navigate through these abnormal laboratory findings and deliver the best possible treatment to the patients. The unique character of COVID-19-induced coagulopathy necessitates not only a dynamic follow-up of the patients in terms of hemostatic findings but also the introduction of new diagnostic methods to determine the overall function of the coagulation system in real time. After the recognition of the high risk of thromboembolism in COVID-19, several professional societies published their recommendations regarding anticoagulation in patients with COVID-19. This review summarizes common hemostatic findings in COVID-19 patients and presents the societal recommendations regarding the use of coagulation laboratory findings in clinical decision-making. Although several studies have investigated coagulation parameters in patients with COVID-19, the methodological shortcomings of published studies as well as the differences in employed anticoagulation regimens that have changed over time, depending on national and international guidelines, limit the applicability of these findings in other clinical settings. Accordingly, evidence-based recommendations for diagnostics during acute COVID-19 infection are still lacking. Future studies should verify the role of coagulation parameters as well as viscoelastic methods in the management of patients with COVID-19.
    Keywords coagulopathy ; D-dimer ; thrombosis ; fibrinolysis
    Language English
    Publishing date 2022-04-27
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1755-8676
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: New Developments in the Pathophysiology and Management of Primary Immune Thrombocytopenia.

    Althaus, Karina / Faul, Christoph / Bakchoul, Tamam

    Hamostaseologie

    2020  Volume 41, Issue 4, Page(s) 275–282

    Abstract: Immune thrombocytopenia (ITP) is an autoimmune disease that is characterized by a significant reduction in the number of circulating platelets and frequently associated with bleeding. Although the pathogenesis of ITP is still not completely elucidated, ... ...

    Abstract Immune thrombocytopenia (ITP) is an autoimmune disease that is characterized by a significant reduction in the number of circulating platelets and frequently associated with bleeding. Although the pathogenesis of ITP is still not completely elucidated, it is largely recognized that the low platelet count observed in ITP patients is due to multiple alterations of the immune system leading to increased platelet destruction as well as impaired thrombopoiesis. The clinical manifestations and patients' response to different treatments are very heterogeneous suggesting that ITP is a group of disorders sharing common characteristics, namely, loss of immune tolerance toward platelet (and megakaryocyte) antigens and dysfunctional primary hemostasis. Management of ITP is challenging and requires intensive communication between patients and caregivers. The decision to initiate treatment should be based on the platelet count level, age of the patient, bleeding manifestation, and other factors that influence the bleeding risk in individual patients. In this review, we present recent data on the mechanisms that lead to platelet destruction in ITP with a particular focus on current findings concerning alterations of thrombopoiesis. In addition, we give an insight into the efficacy and safety of current therapies and management of ITP bleeding emergencies.
    MeSH term(s) Blood Platelets ; Humans ; Megakaryocytes ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Thrombopoiesis
    Language English
    Publishing date 2020-12-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1311-8264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1631: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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